期刊文献+
共找到4篇文章
< 1 >
每页显示 20 50 100
miRNA标志物对肺癌远处转移的预测价值 被引量:1
1
作者 丛靖靖 王安娜 +6 位作者 王英嘉 李昕格 皮俊健 刘凯静 张洪杰 闫晓燕 李红梅 《中国肺癌杂志》 CSCD 北大核心 2024年第12期919-930,共12页
背景与目的 肺癌是全球癌症相关死亡的主要原因,非小细胞肺癌(non-small cell lung cancer,NSCLC)是最常见的肺癌亚型。一半以上的NSCLC患者在诊断时已经发生转移,预后差。因此,有必要寻找新的生物标志物,用于预测NSCLC远处转移(distant... 背景与目的 肺癌是全球癌症相关死亡的主要原因,非小细胞肺癌(non-small cell lung cancer,NSCLC)是最常见的肺癌亚型。一半以上的NSCLC患者在诊断时已经发生转移,预后差。因此,有必要寻找新的生物标志物,用于预测NSCLC远处转移(distant metastasis, DM),以便指导后续治疗,从而改善NSCLC患者的预后。大量研究已经证实,微小RNAs(microRNAs, miRNAs)在肺癌组织中异常表达,对肿瘤的发生、进展起着重要作用。本研究的目的是鉴定DM和无远处转移(non-distant metastasis, NDM)的肺腺癌组织中差异表达的miRNAs,构建预测肺腺癌DM的miRNA标志物。方法 从癌症基因组图谱(The Cancer Genome Atlas, TCGA)数据库中下载肺腺癌患者的miRNAs表达数据及临床信息。应用生物信息学方法分析数据,包括R语言中的edgeR包、Kaplan-Meier曲线、受试者工作特征(receiver operating characteristic, ROC)曲线以及多种在线分析工具等。结果 DM组与NDM组间共鉴定出12个差异表达的miRNAs,筛选出8个miRNAs用于构建miRNAs标志物(miR-377-5p、miR-381-5p、miR-490-5p、miR-519d-5p、miR-3136-5p、miR-320e、miR-2355-5p、miR-6784-5p)。该miRNAs标志物预测DM的效能良好,ROC曲线下面积(area under the curve, AUC)为0.831。Logistic回归分析显示此miRNAs标志物是肺腺癌DM的独立危险因素。接下来,预测了8个miRNAs的靶基因,富集分析显示这些靶基因富集在多种通路,包括肿瘤通路、单纯疱疹病毒I型感染通路、PI3K-Akt通路、MAPK通路、Ras通路等。结论 此miRNAs标志物预测肺腺癌DM效能良好,有望成为肺腺癌DM的预测指标。 展开更多
关键词 肺腺癌 远处转移 miRNA标志物 预测效能 富集分析
暂未订购
HYBRID REGULARIZED CONE-BEAM RECONSTRUCTION FOR AXIALLY SYMMETRIC OBJECT TOMOGRAPHY
2
作者 xinge li Suhua WEI +1 位作者 Haibo XU Chong CHEN 《Acta Mathematica Scientia》 SCIE CSCD 2022年第1期403-419,共17页
In this paper,we consider 3 D tomographic reconstruction for axially symmetric objects from a single radiograph formed by cone-beam X-rays.All contemporary density reconstruction methods in high-energy X-ray radiograp... In this paper,we consider 3 D tomographic reconstruction for axially symmetric objects from a single radiograph formed by cone-beam X-rays.All contemporary density reconstruction methods in high-energy X-ray radiography are based on the assumption that the cone beam can be treated as fan beams located at parallel planes perpendicular to the symmetric axis,so that the density of the whole object can be recovered layer by layer.Considering the relationship between different layers,we undertake the cone-beam global reconstruction to solve the ambiguity effect at the material interfaces of the reconstruction results.In view of the anisotropy of classical discrete total variations,a new discretization of total variation which yields sharp edges and has better isotropy is introduced in our reconstruction model.Furthermore,considering that the object density consists of continually changing parts and jumps,a high-order regularization term is introduced.The final hybrid regularization model is solved using the alternating proximal gradient method,which was recently applied in image processing.Density reconstruction results are presented for simulated radiographs,which shows that the proposed method has led to an improvement in terms of the preservation of edge location. 展开更多
关键词 high-energy X-ray radiography cone-beam global reconstruction inverse problem total variation alternating proximal gradient method
在线阅读 下载PDF
A multi-material diagnosis method based on high-energy proton radiography
3
作者 Feng Chen Haibo Xu +2 位作者 Junhui Shi xinge li Na Zheng 《Matter and Radiation at Extremes》 SCIE EI CSCD 2023年第4期47-54,共8页
Diagnosis of fluids is extremely significant at high temperatures and high pressures.As an advanced imaging technique,high-energy proton radiography has great potential for application to the diagnosis of high-density... Diagnosis of fluids is extremely significant at high temperatures and high pressures.As an advanced imaging technique,high-energy proton radiography has great potential for application to the diagnosis of high-density fluids.In high-energy proton radiography,an angular collimator can control the proton flux and thus enable material diagnosis and reconstruction of density.In this paper,we propose a multimaterial diagnostic method using angular collimators.The method is verified by reconstructing the density distribution from the proton flux obtained via theoretical calculations and numerical simulations.We simulate a 20 GeV proton imaging system using the Geant4 software toolkit and obtain the characteristic parameters of single-material objects.We design several concentric spherical objects to verify the method.We discuss its application to detonation tests.The results show that this method can determine the material and boundary information about each component of a multi-material object.Thus,it can be used to diagnose a mixed material and reconstruct densities in a detonation. 展开更多
关键词 density. method. METHOD
在线阅读 下载PDF
Evaluation of the nutritional value of corn contaminated with deoxynivalenol and irradiated with electron beam and its effects on growth performance,nutrient digestibility,serum parameters,and intestinal permeability in piglets
4
作者 Zhongyuan Du Haojian Chi +3 位作者 xinge li Daiwen Chen Junning Pu Bing Yu 《Animal Nutrition》 2025年第3期311-320,共10页
Deoxynivalenol(DON)negatively affects the growth of piglets.Electron beam irradiation(EBI)has the potential to reduce the DON content in feeds.However,the quantitative effects of DON contamination and EBI on the nutri... Deoxynivalenol(DON)negatively affects the growth of piglets.Electron beam irradiation(EBI)has the potential to reduce the DON content in feeds.However,the quantitative effects of DON contamination and EBI on the nutritional value of corn remain unclear,as does the impact of this corn on piglet feeding.These experiments explored the effect of DON contamination and EBI treatment on the nutritional value of corn and the feeding effects of this corn on piglets.In Exp.1,40 piglets(initial weight:14.88±1.92 kg)were allotted to five experimental diets with eight replicates per diet.Five diets included four types of corn diets:normal corn(NC),DON-contaminated corn(DON-C),EBI-treated NC(EBI-NC),and EBI-treated DON-C(EBI-DON-C),and a nitrogen-free diet formulated to determine the basal endogenous loss of amino acids.In Exp.2,56 piglets(initial weight:7.58±0.35 kg)were randomly allocated to treatments arranged in a 2×2 factorial arrangement,with two types of corn(NC vs.DON-C)and two corn treatments(without EBI vs.EBI).There were four diets and seven replicate pens per diet,with two pigs per pen.The study found that both DON contamination and EBI treatment decreased the effective energy value of corn(P<0.05),and EBI treatment also decreased the standardized ileal digestibility(SID)of most amino acids(P<0.05),whereas DON contamination had no negative effect on the SID of amino acids(Exp.1).In Exp.2,EBI-treated corn(EBI-C)increased the average daily gain(P=0.001)and average daily feed intake(P<0.001),while increased feed conversion ratio(FCR)(P<0.001)and decreased nutrient digestibility(P<0.05).DON-C had a positive impact on FCR(P=0.005).Neither EBI-C nor DON-C affected serum biochemical parameters(P>0.05).However,DON-C may induce oxidative stress,impair immune function,and disrupt intestinal barrier.In conclusion,EBI reduced the DON content of DON-C,while impacted the nutritional value of corn.Furthermore,DON-C reduced the antioxidant capacity and immune function of piglets to some extent,although it did not affect their growth performance. 展开更多
关键词 Electron beam irradiation Corn Deoxynivalenol Piglet Nutritional value Feeding effects
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部