Prostate cancer(PCa)is characterized by high incidence and propensity for easy metastasis,presenting significant challenges in clinical diagnosis and treatment.Tumor microenvironment(TME)-responsive nanomaterials prov...Prostate cancer(PCa)is characterized by high incidence and propensity for easy metastasis,presenting significant challenges in clinical diagnosis and treatment.Tumor microenvironment(TME)-responsive nanomaterials provide a promising prospect for imaging-guided precision therapy.Considering that tumor-derived alkaline phosphatase(ALP)is over-expressed in metastatic PCa,it makes a great chance to develop a theranostics system with ALP responsive in the TME.Herein,an ALP-responsive aggregationinduced emission luminogens(AIEgens)nanoprobe AMNF self-assembly was designed for enhancing the diagnosis and treatment of metastatic PCa.The nanoprobe exhibited self-aggregation in the presence of ALP resulted in aggregation-induced fluorescence,and enhanced accumulation and prolonged retention period at the tumor site.In terms of detection,the fluorescence(FL)/computed tomography(CT)/magnetic resonance(MR)multi-mode imaging effect of nanoprobe was significantly improved post-aggregation,enabling precise diagnosis through the amalgamation of multiple imaging modes.Enhanced CT/MR imaging can achieve assist preoperative tumor diagnosis,and enhanced FL imaging technology can achieve“intraoperative visual navigation”,showing its potential application value in clinical tumor detection and surgical guidance.In terms of treatment,AMNF showed strong absorption in the near infrared region after aggregation,which improved the photothermal treatment effect.Overall,our work developed an effective aggregation-enhanced theranostic strategy for ALP-related cancers.展开更多
Tongue squamous cell carcinoma(TSCC)is a prevalent malignancy that afflicts the head and neck area and presents a high incidence of metastasis and invasion.Accurate diagnosis and effective treatment are essential for ...Tongue squamous cell carcinoma(TSCC)is a prevalent malignancy that afflicts the head and neck area and presents a high incidence of metastasis and invasion.Accurate diagnosis and effective treatment are essential for enhancing the quality of life and the survival rates of TSCC patients.The current treatment modalities for TSCC frequently suffer from a lack of specificity and efficacy.Nanoparticles with diagnostic and photothermal therapeutic properties may offer a new approach for the targeted therapy of TSCC.However,inadequate accumulation of photosensitizers at the tumor site diminishes the efficacy of photothermal therapy(PTT).This study modified gold nanodots(AuNDs)with the TSCC-targeting peptide HN-1 to improve the selectivity and therapeutic effects of PTT.The Au-HN-1 nanosystem effectively targeted the TSCC cells and was rapidly delivered to the tumor tissues compared to the AuN Ds.The enhanced accumulation of photosensitizing agents at tumor sites achieved significant PTT effects in a mouse model of TSCC.Moreover,owing to its stable long-term fluorescence and high X-ray attenuation coefficient,the Au-HN-1 nanosystem can be used for fluorescence and computed tomography imaging of TSCC,rendering it useful for early tumor detection and accurate delineation of surgical margins.In conclusion,Au-HN-1 represents a promising nanomedicine for imaging-based diagnosis and targeted PTT of TSCC.展开更多
The healing of diabetic wounds poses a significant healthcare burden due to persistent inflammation,M1 macrophage aggregation,and high glucose levels in the microenvironment.Previous studies have demonstrated that imm...The healing of diabetic wounds poses a significant healthcare burden due to persistent inflammation,M1 macrophage aggregation,and high glucose levels in the microenvironment.Previous studies have demonstrated that immunomodulatory hydrogel dressings can facilitate diabetic wound healing.However,current immunomodulatory hydrogels require costly and complex treatments such as cell therapy and cytokines.Herein,a hierarchical hydrogel dressing with continuous biochemical gradient based on glycyrrhizic acid(GA) was constructed to modulate immunomodulatory processes in diabetic wounds.The hydrogels present many desirable features,such as tunable mechanical properties,broad antibacterial ability,outstanding conductive,transparent,and self-adhesive properties.The resultant hydrogel can promote diabetic wound healing by preventing bacterial infection,promoting macrophage polarization,improving the inflammatory microenvironment,and inducing angiogenesis and neurogenesis.Furthermore,electrical stimulation(ES) can further promote the healing of chronic diabetic wounds,providing valuable guidance for relevant clinical practice.展开更多
Objective:To evaluate preoperative serum calcium concentration and investigate the association between calcium level and positive peritoneal cytology in endometrial carcinoma(EC).Methods:A total of 510 patients who we...Objective:To evaluate preoperative serum calcium concentration and investigate the association between calcium level and positive peritoneal cytology in endometrial carcinoma(EC).Methods:A total of 510 patients who were diagnosed with EC and had surgery were initially enrolled in this study at Peking University People's Hospital between January 2012 and December 2016.Clinical characteristics and preoperative serum calcium,albumin,carbohydrate antigen(CA)125,CA19-9,carcinoembryonic antigen(CEA)were extracted from patient records and evaluated according to postoperative peritoneal cytology.Predictive factors were assessed with Cox univariate and multivariate analyses.Factors selected from multivariate analysis results were used to build a predictive model.Results:A total of 510 patients are identified in our database and 444 patients who fulfilled inclusion and exclusion criteria are included in this study.Univariate analysis revealed that ionized calcium concentration was closely related to positive peritoneal cytology,tumor grade and lymph-vascular space invasion(LVSI).Moreover,peritoneal cytology was significantly associated with hypertension,tubal ligation,serum CA125,CA19-9,CEA and ionized calcium level.Multivariate analysis revealed that albumin-adjusted calcium level,CA125 and tubal ligation were independent predictive factors of positive peritoneal cytology(P<0.05).A combination of ionized calcium level with the other two indexes yielded significantly great area under the curve(AUC=0.824).Conclusions:This study enhanced the value of preoperative ionized calcium level.We also identified several potential biomarkers to predict positive peritoneal cytology in EC patients before surgery.展开更多
Prolonged activation of nuclear factor(NF)-кB signaling significantly contributes to the development of colorectal cancer(CRC).New therapeutic opportunities are emerging from targeting this distorted cell signaling t...Prolonged activation of nuclear factor(NF)-кB signaling significantly contributes to the development of colorectal cancer(CRC).New therapeutic opportunities are emerging from targeting this distorted cell signaling transduction.Here,we discovered the critical role of RING finger 138(RNF138)in CRC tumorigenesis through regulating the NF-кB signaling,which is independent of its Ubiquitin-E3 ligase activity involved in DNA damage response.RNF138^(−/−) mice were hyper-susceptible to the switch from colitis to aggressive malignancy,which coincided with sustained aberrant NF-кB signaling in the colonic cells.Furthermore,RNF138 suppresses the activation of NF-кB signaling pathway through preventing the translocation of NIK and IKK-Beta Binding Protein(NIBP)to the cytoplasm,which requires the ubiquitin interaction motif(UIM)domain.More importantly,we uncovered a significant correlation between poor prognosis and the downregulation of RNF138 associated with reinforced NF-кB signaling in clinical settings,raising the possibility of RNF138 dysregulation as an indicator for the therapeutic intervention targeting NF-кB signaling.Using the xenograft models built upon either RNF138-dificient CRC cells or the cells derived from the RNF138-dysregulated CRC patients,we demonstrated that the inhibition of NF-кB signaling effectively hampered tumor growth.Overall,our work defined the pathogenic role of aberrant NF-кB signaling due to RNF138 downregulation in the cascade events from the colitis switch to colonic neoplastic transformation and progression,and also highlights the possibility of targeting the NF-кB signaling in treating specific subtypes of CRC indicated by RNF138-ablation.展开更多
The term environmental innovation system refers to an innovation network composed of enterprises,universities,and research institutions involved in the development and diffusion of environmental technology,with the pa...The term environmental innovation system refers to an innovation network composed of enterprises,universities,and research institutions involved in the development and diffusion of environmental technology,with the participation of a government.An environmental innovation system not only exerts important impact on the achievement of carbon neutrality but also affects social and economic activities.Investigations on environmental innovation system performance constantly assume a singlestage independent system while ignoring its internal structure.However,such systems are composed of environmental innovation research and development(R&D)and environmental innovation conversion subsystems.A two-stage data envelopment analysis(DEA)model is developed in this study to analyze the efficiency of Chinese regional environmental innovation system by opening the"black box"and considering shared resources.Empirical results indicated that China presents high overall environmental innovation efficiency although some regions need to improve.Regions with low efficiencies in both environmental innovation R&D(EIR)and environmental innovation conversion(EIC)subsystems should expand their investment in and strengthen the management of environmental innovation resources.Regions with low EIR efficiency should improve the absorption and transformation of environmental innovation achievements.Regions with low EIC efficiency should increase investment in the commercialization of environmental innovation achievements and encourage green economy industries,such as new energy,art,tourism,and environmental protection.展开更多
Objective The International Federation of Gynecology and Obstetrics(FIGO)released a new stagingfor endometrial cancer(EC),which revised the FIG02009 staging to include histopathological andmolecular features.The purpo...Objective The International Federation of Gynecology and Obstetrics(FIGO)released a new stagingfor endometrial cancer(EC),which revised the FIG02009 staging to include histopathological andmolecular features.The purpose of this study was to validate the prognostic accuracy of the new staging and discuss its clinical applicability.Methods In this single-centre retrospective study,540 patients with primary surgically treated early-stage EC were enrolled and staged according to FIG02009/2023.Kaplan-Meier survival analysis was used to compare for prognostic differentiation.Cox regression was used to identify potential prognostic indicators.Results A total of 81 patients underwent staging shifts,allstage elevation.The prognosis difference between new stages I and Il was more significant.The new staging was more predictive of death postoperatively.Lesion maximum diameter(LMD)was one of the independent risk factors associated with prognosis.Taking LMD=5.70 cm as the cut-off value could further differentiate patients with divergent prognoseswithin FIG02023stage IIC.Conclusion FIG02023 stagingdemonstrated greater prognostic accuracy.In addition,LMD may be another critical factor affecting prognosis.展开更多
Distributed photovoltaic generators(DPGs) have been integrated into the medium/low voltage distribution network widely. Due to the randomness and fluctuation of DPG, however, the distribution and direction of power fl...Distributed photovoltaic generators(DPGs) have been integrated into the medium/low voltage distribution network widely. Due to the randomness and fluctuation of DPG, however, the distribution and direction of power flow changed frequently some days. Therefore, more attention is needed to ensure the safe operation of the distribution network. The installation of energy storage systems(ESSs) can help the network withstand thefluctuations caused by DPG. Based on the discrete Fourier transform method, this paper presents an ESS capacity allocation strategy for the medium/low voltage distribution network with DPG. The reliability scenario models are created via Latin hypercube sampling with Cholesky decomposition and scenario reduction. Numerical results show that the proposed strategy can reduce the power flow fluctuation with less ESS capacity, and increase the penetration capacity of DPG in the distribution network while maintaining the quality of the power supply.展开更多
A novel control scheme is presented to eliminate the negative effects of communication disturbances,which introduces active disturbance rejection control(ADRC)in the control strategy design to achieve the objectives o...A novel control scheme is presented to eliminate the negative effects of communication disturbances,which introduces active disturbance rejection control(ADRC)in the control strategy design to achieve the objectives of the restoration of the bus voltage and the sharing of the power even in the presence of disturbances and delays in communication.Simultaneously,its dynamic disturbance decoupling feature is used to realise the decoupling between power and voltage,so that the proposed controller only exchanges power information with its neighbours,reducing the communication burden and simplifying control structure.The control performance of the strategy is verified by employing steady-state analysis.The impact of controller parameters is studied by establishing a small signal model.Finally,both simulation cases and experimental tests prove the feasibility of this scheme.展开更多
There are stillchallenges in applying drug nanocarriers for in situ sustained macrophage targeting and regulation,due to the rapid clearance of nanocarriers and burst drug release invivo.Herein,a nanomicellehydrogel m...There are stillchallenges in applying drug nanocarriers for in situ sustained macrophage targeting and regulation,due to the rapid clearance of nanocarriers and burst drug release invivo.Herein,a nanomicellehydrogel microsphere,characterized by its macrophage-targeted nanosized secondary structure that allows it to accurately bind to M1 macrophages through active endocytosis,is employed for in situ sustained macrophage targeting and regulation,and addresses the insufficient osteoarthritis therapeutic efficacy caused by rapid clearance of drug nanocarriers.The 3-dimensional structure of a microsphere can prevent the rapid escape and clearance of a nanomicelle,thus keeping it in joints,while the ligand-guided secondary structure can carry drugs to accurately target and enter M1 macrophages,and release drugs via the transition from hydrophobicity to hydrophilicity of nanomicelles under inflammatory stimulation inside the macrophages.展开更多
The combinatorial optimization problem(COP),which aims to find the optimal solution in discrete space,is fundamental in various fields.Unfortunately,many COPs are NP-complete,and require much more time to solve as the...The combinatorial optimization problem(COP),which aims to find the optimal solution in discrete space,is fundamental in various fields.Unfortunately,many COPs are NP-complete,and require much more time to solve as the problem scale increases.Troubled by this,researchers may prefer fast methods even if they are not exact,so approximation algorithms,heuristic algorithms,and machine learning have been proposed.Some works proposed chaotic simulated annealing(CSA)based on the Hopfield neural network and did a good job.However,CSA is not something that current general-purpose processors can handle easily,and there is no special hardware for it.To efficiently perform CSA,we propose a software and hardware co-design.In software,we quantize the weight and output using appropriate bit widths,and then modify the calculations that are not suitable for hardware implementation.In hardware,we design a specialized processing-in-memory hardware architecture named COPPER based on the memristor.COPPER is capable of efficiently running the modified quantized CSA algorithm and supporting the pipeline further acceleration.The results show that COPPER can perform CSA remarkably well in both speed and energy.展开更多
Endometrial cancer(EC)is one of the most prominent malignancies in gynecology.Unfortunately,despite these advancements in understanding EC pathogenesis,mortality rates have not decreased.Traction force(TF)refers to en...Endometrial cancer(EC)is one of the most prominent malignancies in gynecology.Unfortunately,despite these advancements in understanding EC pathogenesis,mortality rates have not decreased.Traction force(TF)refers to endogenous mechanical forces exerted by cells.1 These forces act on the extracellular matrix and the extracellular tumor microenvironment through focal adhesions,thereby regulating cell proliferation and migration.However,the TF characteristics of endometrial cancer cells and their heterogeneity remain unclear.展开更多
Community security and risk management is essential for urban governance.To identify community risks more accurately,the space-time characteristics of community burglary cases in a community located in C city are anal...Community security and risk management is essential for urban governance.To identify community risks more accurately,the space-time characteristics of community burglary cases in a community located in C city are analyzed in this study based on data from 2018 to 2020 using the hot police theory.The results are as follows:(1)In terms of time,the occurrence of theft cases is closely related to seasonal changes and daily work and rest and is affected by social activities.(2)In terms of space,the type of community and surrounding environment affect the generation and distribution of household theft hotspots,while urban planning and reconstruction cause the dissipation and transfer of hotspots.Therefore,to prevent and control risk,infrastructure and urban environment renovation should be carried out,community governance efficiency should be improved,and police work mode should be transformed to avoid potential hotspots,except for targeted interventions on existing hotspots.展开更多
This paper reports a numerical research on MEMS(microelectromechanical system)micronozzles through multiphysics coupling simulation along with design optimization based on simulation results.The micronozzle,which is a...This paper reports a numerical research on MEMS(microelectromechanical system)micronozzles through multiphysics coupling simulation along with design optimization based on simulation results.The micronozzle,which is a core component of the electrothermal microthruster,features a micron-scale geometry,a 2-dimensional(2D)Laval configuration,a rectangular cross section,and a highly thermal conductive silicon wall due to MEMS fabrication.As a result,viscous loss in the flow field and heat transfer to the nozzle wall can strongly influence nozzle performance,namely,thrust force and specific impulse.To accurately understand the flow field inside the micronozzle and how the highly thermal conductive silicon wall interacts with gas flow,a numerical simulation that couples fluid dynamics field and solid heat transfer field is employed in the research.The influence of different structural parameters on micronozzle performance is then investigated to set a basis for design optimization.The optimum design of the linear expander micronozzle is obtained through constrained optimization by linear approximation.To further improve micronozzle performance,the bell-shaped expander is adapted.The optimization result shows that the bell-shaped expander is not suitable for micronozzle featuring 2D Laval configuration,and the reason behind the phenomenon is thoroughly discussed.展开更多
Purpose A high-precision beam monitor system based on silicon carbide PIN sensor is designed for the 1.6 GeV proton beam of China Spallation Neutron Source.The conceptual design of the beam monitor system is composed ...Purpose A high-precision beam monitor system based on silicon carbide PIN sensor is designed for the 1.6 GeV proton beam of China Spallation Neutron Source.The conceptual design of the beam monitor system is composed of front-end electronics with SiC PIN sensor and readout system.Method The charge collection efficiency of the SiC PIN sensor after proton radiation is studied with 80 MeV proton beam.98%charge will be collected by the SiC PIN sensor after the system running one year,which can meet requirements of beam monitoring.Research on the performance of the front-end electronics and readout system is completed for better data acquisition.The front-end electronics is studied to figure out the effect of feedback resistor.The readout system can deal with signal with sampling rate of 5 GHz,and the data acquisition rate is 1 Hz.Results The uncertainty of proton beam fluence is below 0.68%in the beam monitor system.Conclusion The results reveal that the beam monitor system can be used for the 1.6 GeV proton beam of China Spallation Neutron Source.展开更多
Aqueous zinc-ion batteries provide a most promising alternative to the existing lithium-ion batteries due to their high theoretical capacity,intrinsic safety,and low cost.However,commercializing aqueous zinc-ion batte...Aqueous zinc-ion batteries provide a most promising alternative to the existing lithium-ion batteries due to their high theoretical capacity,intrinsic safety,and low cost.However,commercializing aqueous zinc-ion batteries suffer from dendritic growth and side reactions on the surface of metallic zinc,resulting in poor reversibility.To overcome this critical challenge,here,we report a one-step ultrafast laser processing method for fabricating three-dimensional micro-/nanostructures on zinc anodes to optimize zinc nucleation and deposition processes.It is demonstrated that the three-dimensional micro-/nanostructure with increased specific surface area significantly reduces nucleation overpotential,as well as preferentially absorbs zinc ions to prevent dendritic protuberances and corrosion.As a result,the presence of threedimensional micro-/nanostructures on the zinc metal delivers stable zinc plating/stripping beyond 2500 h(2 mA cm-2/1 mAh cm-2)in symmetric cells,a high Coulombic efficiency(99.71%)in half cells,and moreover an improved capacity retention(71.8%)is also observed in full cells.Equally intriguingly,the pouch cell with three-dimensional micro-/nanostructures can operate across various bending states without severely compromising performance.This work provides an effective strategy to construct ultrafine and high-precision three-dimensional micro-/nanostructures achieving highperformance zinc metal anodes and is expected to be of immediate benefit to other metal-based electrodes.展开更多
基金supported by Natural Science Foundation of Jilin Province(No.SKL202302002)Key Research and Development project of Jilin Provincial Science and Technology Department(No.20210204142YY)+2 种基金The Science and Technology Development Program of Jilin Province(No.2020122256JC)Beijing Kechuang Medical Development Foundation Fund of China(No.KC2023-JX-0186BQ079)Talent Reserve Program(TRP),the First Hospital of Jilin University(No.JDYY-TRP-2024007)。
文摘Prostate cancer(PCa)is characterized by high incidence and propensity for easy metastasis,presenting significant challenges in clinical diagnosis and treatment.Tumor microenvironment(TME)-responsive nanomaterials provide a promising prospect for imaging-guided precision therapy.Considering that tumor-derived alkaline phosphatase(ALP)is over-expressed in metastatic PCa,it makes a great chance to develop a theranostics system with ALP responsive in the TME.Herein,an ALP-responsive aggregationinduced emission luminogens(AIEgens)nanoprobe AMNF self-assembly was designed for enhancing the diagnosis and treatment of metastatic PCa.The nanoprobe exhibited self-aggregation in the presence of ALP resulted in aggregation-induced fluorescence,and enhanced accumulation and prolonged retention period at the tumor site.In terms of detection,the fluorescence(FL)/computed tomography(CT)/magnetic resonance(MR)multi-mode imaging effect of nanoprobe was significantly improved post-aggregation,enabling precise diagnosis through the amalgamation of multiple imaging modes.Enhanced CT/MR imaging can achieve assist preoperative tumor diagnosis,and enhanced FL imaging technology can achieve“intraoperative visual navigation”,showing its potential application value in clinical tumor detection and surgical guidance.In terms of treatment,AMNF showed strong absorption in the near infrared region after aggregation,which improved the photothermal treatment effect.Overall,our work developed an effective aggregation-enhanced theranostic strategy for ALP-related cancers.
基金supported by the Science and Technology Projects of Jilin Provincial Department of Science and Technology(Grant/Award Numbers:20240305037YY)National Key Research and Development Program of China(2021YFC2400603)+1 种基金the Joint Funds of the National Natural Science Foundation of China(Grant No.U23A20269)the Jilin University young teachers and students cross-disciplinary training project(Grant No.2023-JCXK-08,2024-JCXK-07)。
文摘Tongue squamous cell carcinoma(TSCC)is a prevalent malignancy that afflicts the head and neck area and presents a high incidence of metastasis and invasion.Accurate diagnosis and effective treatment are essential for enhancing the quality of life and the survival rates of TSCC patients.The current treatment modalities for TSCC frequently suffer from a lack of specificity and efficacy.Nanoparticles with diagnostic and photothermal therapeutic properties may offer a new approach for the targeted therapy of TSCC.However,inadequate accumulation of photosensitizers at the tumor site diminishes the efficacy of photothermal therapy(PTT).This study modified gold nanodots(AuNDs)with the TSCC-targeting peptide HN-1 to improve the selectivity and therapeutic effects of PTT.The Au-HN-1 nanosystem effectively targeted the TSCC cells and was rapidly delivered to the tumor tissues compared to the AuN Ds.The enhanced accumulation of photosensitizing agents at tumor sites achieved significant PTT effects in a mouse model of TSCC.Moreover,owing to its stable long-term fluorescence and high X-ray attenuation coefficient,the Au-HN-1 nanosystem can be used for fluorescence and computed tomography imaging of TSCC,rendering it useful for early tumor detection and accurate delineation of surgical margins.In conclusion,Au-HN-1 represents a promising nanomedicine for imaging-based diagnosis and targeted PTT of TSCC.
基金supported by Natural Science Foundation of Jilin Province(No.SKL202302002)。
文摘The healing of diabetic wounds poses a significant healthcare burden due to persistent inflammation,M1 macrophage aggregation,and high glucose levels in the microenvironment.Previous studies have demonstrated that immunomodulatory hydrogel dressings can facilitate diabetic wound healing.However,current immunomodulatory hydrogels require costly and complex treatments such as cell therapy and cytokines.Herein,a hierarchical hydrogel dressing with continuous biochemical gradient based on glycyrrhizic acid(GA) was constructed to modulate immunomodulatory processes in diabetic wounds.The hydrogels present many desirable features,such as tunable mechanical properties,broad antibacterial ability,outstanding conductive,transparent,and self-adhesive properties.The resultant hydrogel can promote diabetic wound healing by preventing bacterial infection,promoting macrophage polarization,improving the inflammatory microenvironment,and inducing angiogenesis and neurogenesis.Furthermore,electrical stimulation(ES) can further promote the healing of chronic diabetic wounds,providing valuable guidance for relevant clinical practice.
基金supported by National Natural Science Foundation of China (No. 81874108, No. 81802607)
文摘Objective:To evaluate preoperative serum calcium concentration and investigate the association between calcium level and positive peritoneal cytology in endometrial carcinoma(EC).Methods:A total of 510 patients who were diagnosed with EC and had surgery were initially enrolled in this study at Peking University People's Hospital between January 2012 and December 2016.Clinical characteristics and preoperative serum calcium,albumin,carbohydrate antigen(CA)125,CA19-9,carcinoembryonic antigen(CEA)were extracted from patient records and evaluated according to postoperative peritoneal cytology.Predictive factors were assessed with Cox univariate and multivariate analyses.Factors selected from multivariate analysis results were used to build a predictive model.Results:A total of 510 patients are identified in our database and 444 patients who fulfilled inclusion and exclusion criteria are included in this study.Univariate analysis revealed that ionized calcium concentration was closely related to positive peritoneal cytology,tumor grade and lymph-vascular space invasion(LVSI).Moreover,peritoneal cytology was significantly associated with hypertension,tubal ligation,serum CA125,CA19-9,CEA and ionized calcium level.Multivariate analysis revealed that albumin-adjusted calcium level,CA125 and tubal ligation were independent predictive factors of positive peritoneal cytology(P<0.05).A combination of ionized calcium level with the other two indexes yielded significantly great area under the curve(AUC=0.824).Conclusions:This study enhanced the value of preoperative ionized calcium level.We also identified several potential biomarkers to predict positive peritoneal cytology in EC patients before surgery.
基金supported by CAMS Innovation Fund for Medical Sciences(CIFMS,2021-I2M-1-066,2017-I2M-4-002 to H.Z.,2021-I2M-1-019 to W.S.,2021-1-I2M-014 to C.Z.L.)the National Natural Science Foundation of China(81972311,82141127 and 81672461 to H.Z.,81672472,and 31970794 to W.S.,81570780 to C.Z.L.,32000586 to K.L.)+4 种基金the Nonprofit Central Research Institute Fund of Chinese Academy of Medical Sciences(2019PT310026 to H.Z.)Sanming Project of Medicine in Shenzhen(SZSM202011010 to H.Z.)the National Key Research and Development Program of China(2018YFC1003500 to W.S.)the State Key Laboratory Special fund from the Ministry of Science(2060204 to W.S.)the State Key Project on Infection Diseases of China(2017ZX10201021-007-003 to H.Z.).
文摘Prolonged activation of nuclear factor(NF)-кB signaling significantly contributes to the development of colorectal cancer(CRC).New therapeutic opportunities are emerging from targeting this distorted cell signaling transduction.Here,we discovered the critical role of RING finger 138(RNF138)in CRC tumorigenesis through regulating the NF-кB signaling,which is independent of its Ubiquitin-E3 ligase activity involved in DNA damage response.RNF138^(−/−) mice were hyper-susceptible to the switch from colitis to aggressive malignancy,which coincided with sustained aberrant NF-кB signaling in the colonic cells.Furthermore,RNF138 suppresses the activation of NF-кB signaling pathway through preventing the translocation of NIK and IKK-Beta Binding Protein(NIBP)to the cytoplasm,which requires the ubiquitin interaction motif(UIM)domain.More importantly,we uncovered a significant correlation between poor prognosis and the downregulation of RNF138 associated with reinforced NF-кB signaling in clinical settings,raising the possibility of RNF138 dysregulation as an indicator for the therapeutic intervention targeting NF-кB signaling.Using the xenograft models built upon either RNF138-dificient CRC cells or the cells derived from the RNF138-dysregulated CRC patients,we demonstrated that the inhibition of NF-кB signaling effectively hampered tumor growth.Overall,our work defined the pathogenic role of aberrant NF-кB signaling due to RNF138 downregulation in the cascade events from the colitis switch to colonic neoplastic transformation and progression,and also highlights the possibility of targeting the NF-кB signaling in treating specific subtypes of CRC indicated by RNF138-ablation.
基金This research was financially supported by the National Natural Science Foundation of China(Grant Nos.71904084,71971203,71571173,and 71921001)the Philosophy and Social Science Foundation in Colleges and Universities in Jiangsu Province(Grant No.2020SJA0340)+3 种基金the Major Programme of National Social Science Foundation of China(Grant No.21&ZD110)Postdoctoral Science Foundation of China(Grant No.2020TQ0145)the Natural Science Foundation for Jiangsu Province(Grant No.BK20190427)the Innovation and Entrepreneurship Foundation for Doctor of Jiangsu Province,the Four Batch Talent Programs of China,and the Fundamental Research Funds for the Central Universities(Grant No.WK2040160028).
文摘The term environmental innovation system refers to an innovation network composed of enterprises,universities,and research institutions involved in the development and diffusion of environmental technology,with the participation of a government.An environmental innovation system not only exerts important impact on the achievement of carbon neutrality but also affects social and economic activities.Investigations on environmental innovation system performance constantly assume a singlestage independent system while ignoring its internal structure.However,such systems are composed of environmental innovation research and development(R&D)and environmental innovation conversion subsystems.A two-stage data envelopment analysis(DEA)model is developed in this study to analyze the efficiency of Chinese regional environmental innovation system by opening the"black box"and considering shared resources.Empirical results indicated that China presents high overall environmental innovation efficiency although some regions need to improve.Regions with low efficiencies in both environmental innovation R&D(EIR)and environmental innovation conversion(EIC)subsystems should expand their investment in and strengthen the management of environmental innovation resources.Regions with low EIR efficiency should improve the absorption and transformation of environmental innovation achievements.Regions with low EIC efficiency should increase investment in the commercialization of environmental innovation achievements and encourage green economy industries,such as new energy,art,tourism,and environmental protection.
基金National Key Research and Development Program of China(2022YFC2704405).
文摘Objective The International Federation of Gynecology and Obstetrics(FIGO)released a new stagingfor endometrial cancer(EC),which revised the FIG02009 staging to include histopathological andmolecular features.The purpose of this study was to validate the prognostic accuracy of the new staging and discuss its clinical applicability.Methods In this single-centre retrospective study,540 patients with primary surgically treated early-stage EC were enrolled and staged according to FIG02009/2023.Kaplan-Meier survival analysis was used to compare for prognostic differentiation.Cox regression was used to identify potential prognostic indicators.Results A total of 81 patients underwent staging shifts,allstage elevation.The prognosis difference between new stages I and Il was more significant.The new staging was more predictive of death postoperatively.Lesion maximum diameter(LMD)was one of the independent risk factors associated with prognosis.Taking LMD=5.70 cm as the cut-off value could further differentiate patients with divergent prognoseswithin FIG02023stage IIC.Conclusion FIG02023 stagingdemonstrated greater prognostic accuracy.In addition,LMD may be another critical factor affecting prognosis.
基金supported by National Natural Science Foundation of China(No.51367004)National Basic Research Program of China(973 Program)(No.2013CB228205)
文摘Distributed photovoltaic generators(DPGs) have been integrated into the medium/low voltage distribution network widely. Due to the randomness and fluctuation of DPG, however, the distribution and direction of power flow changed frequently some days. Therefore, more attention is needed to ensure the safe operation of the distribution network. The installation of energy storage systems(ESSs) can help the network withstand thefluctuations caused by DPG. Based on the discrete Fourier transform method, this paper presents an ESS capacity allocation strategy for the medium/low voltage distribution network with DPG. The reliability scenario models are created via Latin hypercube sampling with Cholesky decomposition and scenario reduction. Numerical results show that the proposed strategy can reduce the power flow fluctuation with less ESS capacity, and increase the penetration capacity of DPG in the distribution network while maintaining the quality of the power supply.
基金supported by the National Natural Science Foundation of China(81901365 and 82003284)the Department of Finance of Jilin Province(2019SRCJ005 and 2020SCZT051)+2 种基金Jilin Science and Technology Agency Funds in China(20210402001GH)the Key Research and Development Project of Jilin Provincial Science and Technology Department(20210204142YY)the Norman Bethune Program of Jilin University(2022B44).
基金National Natural Science Foundation of China,Grant/Award Number:52277211Start-up Fund of North China University of Technology,Grant/Award Number:110051360023XN224-24。
文摘A novel control scheme is presented to eliminate the negative effects of communication disturbances,which introduces active disturbance rejection control(ADRC)in the control strategy design to achieve the objectives of the restoration of the bus voltage and the sharing of the power even in the presence of disturbances and delays in communication.Simultaneously,its dynamic disturbance decoupling feature is used to realise the decoupling between power and voltage,so that the proposed controller only exchanges power information with its neighbours,reducing the communication burden and simplifying control structure.The control performance of the strategy is verified by employing steady-state analysis.The impact of controller parameters is studied by establishing a small signal model.Finally,both simulation cases and experimental tests prove the feasibility of this scheme.
基金funded by the National Key Research and Development Program of China(2020YFA0908200)the National Natural Science Foundation of China(52103174,52273133,and 82202686)+4 种基金the Shanghai Pujiang Program(2021PJD044)the Shanghai Municipal Heaith and Family Planning Commission(2022XD055)the China Postdoctoral Science Foundation(2022T150420 and 2022M712100)the Shanghai Jiading District Health Committee(2022-QN-05)the GuangCi Professorship Program of Ruijin Hospital Shanghai Jiao Tong University School of Medicine.
文摘There are stillchallenges in applying drug nanocarriers for in situ sustained macrophage targeting and regulation,due to the rapid clearance of nanocarriers and burst drug release invivo.Herein,a nanomicellehydrogel microsphere,characterized by its macrophage-targeted nanosized secondary structure that allows it to accurately bind to M1 macrophages through active endocytosis,is employed for in situ sustained macrophage targeting and regulation,and addresses the insufficient osteoarthritis therapeutic efficacy caused by rapid clearance of drug nanocarriers.The 3-dimensional structure of a microsphere can prevent the rapid escape and clearance of a nanomicelle,thus keeping it in joints,while the ligand-guided secondary structure can carry drugs to accurately target and enter M1 macrophages,and release drugs via the transition from hydrophobicity to hydrophilicity of nanomicelles under inflammatory stimulation inside the macrophages.
基金Project supported by the National Natural Science Foundation of China(Nos.61832020,62032001,92064006,and 62274036)the Beijing Academy of Artificial Intelligence(BAAI)of Chinathe 111 Project of China(No.B18001)。
文摘The combinatorial optimization problem(COP),which aims to find the optimal solution in discrete space,is fundamental in various fields.Unfortunately,many COPs are NP-complete,and require much more time to solve as the problem scale increases.Troubled by this,researchers may prefer fast methods even if they are not exact,so approximation algorithms,heuristic algorithms,and machine learning have been proposed.Some works proposed chaotic simulated annealing(CSA)based on the Hopfield neural network and did a good job.However,CSA is not something that current general-purpose processors can handle easily,and there is no special hardware for it.To efficiently perform CSA,we propose a software and hardware co-design.In software,we quantize the weight and output using appropriate bit widths,and then modify the calculations that are not suitable for hardware implementation.In hardware,we design a specialized processing-in-memory hardware architecture named COPPER based on the memristor.COPPER is capable of efficiently running the modified quantized CSA algorithm and supporting the pipeline further acceleration.The results show that COPPER can perform CSA remarkably well in both speed and energy.
基金the National Natural Science Foundation of China(No.82103419,and 82230050)the Research and Development Fund of Peking University People’s Hospital,Beijing,China(No.RS2021-05,and RDY2021-13).
文摘Endometrial cancer(EC)is one of the most prominent malignancies in gynecology.Unfortunately,despite these advancements in understanding EC pathogenesis,mortality rates have not decreased.Traction force(TF)refers to endogenous mechanical forces exerted by cells.1 These forces act on the extracellular matrix and the extracellular tumor microenvironment through focal adhesions,thereby regulating cell proliferation and migration.However,the TF characteristics of endometrial cancer cells and their heterogeneity remain unclear.
基金supportedbyBasicfoundationof Pp-SUC(2020JKF203)National Natural ScienceFoundation1of China(71904193,72204155)+1 种基金Beijing Social Science Foundation(19jdglb031)soft science project of the Ministry of Public Security(2019llygjadx020).
文摘Community security and risk management is essential for urban governance.To identify community risks more accurately,the space-time characteristics of community burglary cases in a community located in C city are analyzed in this study based on data from 2018 to 2020 using the hot police theory.The results are as follows:(1)In terms of time,the occurrence of theft cases is closely related to seasonal changes and daily work and rest and is affected by social activities.(2)In terms of space,the type of community and surrounding environment affect the generation and distribution of household theft hotspots,while urban planning and reconstruction cause the dissipation and transfer of hotspots.Therefore,to prevent and control risk,infrastructure and urban environment renovation should be carried out,community governance efficiency should be improved,and police work mode should be transformed to avoid potential hotspots,except for targeted interventions on existing hotspots.
基金The financial support for this project is from the National Natural Science Foundation of China(grant no.62001502)National Natural Science Foundation of China(grant no.52005505)+1 种基金China National Funds for Distinguished Young Scientists(grant no.11725211)Young Elite Scientists Sponsorship Program by CAST(grant no.2021QNRC001).
文摘This paper reports a numerical research on MEMS(microelectromechanical system)micronozzles through multiphysics coupling simulation along with design optimization based on simulation results.The micronozzle,which is a core component of the electrothermal microthruster,features a micron-scale geometry,a 2-dimensional(2D)Laval configuration,a rectangular cross section,and a highly thermal conductive silicon wall due to MEMS fabrication.As a result,viscous loss in the flow field and heat transfer to the nozzle wall can strongly influence nozzle performance,namely,thrust force and specific impulse.To accurately understand the flow field inside the micronozzle and how the highly thermal conductive silicon wall interacts with gas flow,a numerical simulation that couples fluid dynamics field and solid heat transfer field is employed in the research.The influence of different structural parameters on micronozzle performance is then investigated to set a basis for design optimization.The optimum design of the linear expander micronozzle is obtained through constrained optimization by linear approximation.To further improve micronozzle performance,the bell-shaped expander is adapted.The optimization result shows that the bell-shaped expander is not suitable for micronozzle featuring 2D Laval configuration,and the reason behind the phenomenon is thoroughly discussed.
基金supported by the National Natural Science Foundation of China(No.12305207,No.11961141014,No.12375184,No.12205321)the State Key Laboratory of Particle Detection and Electronics(No.SKLPDE-ZZ-202312,No.SKLPDE-KF-202313,No.SKLPDE-KF-202401)the Natural Science Foundation of Shandong Province Youth Fund(No.ZR202111120161).
文摘Purpose A high-precision beam monitor system based on silicon carbide PIN sensor is designed for the 1.6 GeV proton beam of China Spallation Neutron Source.The conceptual design of the beam monitor system is composed of front-end electronics with SiC PIN sensor and readout system.Method The charge collection efficiency of the SiC PIN sensor after proton radiation is studied with 80 MeV proton beam.98%charge will be collected by the SiC PIN sensor after the system running one year,which can meet requirements of beam monitoring.Research on the performance of the front-end electronics and readout system is completed for better data acquisition.The front-end electronics is studied to figure out the effect of feedback resistor.The readout system can deal with signal with sampling rate of 5 GHz,and the data acquisition rate is 1 Hz.Results The uncertainty of proton beam fluence is below 0.68%in the beam monitor system.Conclusion The results reveal that the beam monitor system can be used for the 1.6 GeV proton beam of China Spallation Neutron Source.
基金support of the National Key Research and Development Program(No.2023YFB4605102)National Natural Science Foundation of China(No.52105437)+2 种基金Heilongjiang Touyan Team(No.HITTY-20190036)Shanghai Aerospace Science and Technology Innovation Fund(No.SAST2021-067)National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(Grant RS-2023-00235596,RS-2023-00243788).
文摘Aqueous zinc-ion batteries provide a most promising alternative to the existing lithium-ion batteries due to their high theoretical capacity,intrinsic safety,and low cost.However,commercializing aqueous zinc-ion batteries suffer from dendritic growth and side reactions on the surface of metallic zinc,resulting in poor reversibility.To overcome this critical challenge,here,we report a one-step ultrafast laser processing method for fabricating three-dimensional micro-/nanostructures on zinc anodes to optimize zinc nucleation and deposition processes.It is demonstrated that the three-dimensional micro-/nanostructure with increased specific surface area significantly reduces nucleation overpotential,as well as preferentially absorbs zinc ions to prevent dendritic protuberances and corrosion.As a result,the presence of threedimensional micro-/nanostructures on the zinc metal delivers stable zinc plating/stripping beyond 2500 h(2 mA cm-2/1 mAh cm-2)in symmetric cells,a high Coulombic efficiency(99.71%)in half cells,and moreover an improved capacity retention(71.8%)is also observed in full cells.Equally intriguingly,the pouch cell with three-dimensional micro-/nanostructures can operate across various bending states without severely compromising performance.This work provides an effective strategy to construct ultrafine and high-precision three-dimensional micro-/nanostructures achieving highperformance zinc metal anodes and is expected to be of immediate benefit to other metal-based electrodes.
