Personalized healthcare monitoring is a transformative tool for preventing potential risks and enhancing health status,particularly through molecular-level insights.Advances in nanotechnology,smart devices,and artific...Personalized healthcare monitoring is a transformative tool for preventing potential risks and enhancing health status,particularly through molecular-level insights.Advances in nanotechnology,smart devices,and artificial intelligence(AI)have revolutionized personalized healthcare,especially in point-of-care testing(POCT),enabling early detection and timely intervention.Recently,surface-enhanced Raman spectroscopy(SERS)technology,particularly with flexible chips,has shown immense promise in this field due to its in situ,rapid,specific,and efficient detection capabilities.In this review,we highlight recent advancements in flexible SERS chips for personalized healthcare monitoring,demonstrating their effectiveness in target sampling and detection.Importantly,we provide a comprehensive overview of potential applications of flexible SERS chips in personalized healthcare,address current challenges,and propose future development directions.We also explore the future development of miniaturized Raman devices to broaden their applications in personalized healthcare monitoring.Additionally,we underscore the important role of AI in enhancing data processing and analysis.Our aim is to offer a thorough guide on integrating SERS into personalized healthcare monitoring,promising a new era of health management.展开更多
Plasmon-free surface-enhanced Raman scattering(SERS)substrates have attracted tremendous attention for their abundant sources,excellent chemical stability,superior biocompatibility,good signal uniformity,and unique se...Plasmon-free surface-enhanced Raman scattering(SERS)substrates have attracted tremendous attention for their abundant sources,excellent chemical stability,superior biocompatibility,good signal uniformity,and unique selectivity to target molecules.Recently,researchers have made great progress in fabricating novel plasmon-free SERS substrates and exploring new enhancement strategies to improve their sensitivity.This review summarizes the recent developments of plasmon-free SERS substrates and specially focuses on the enhancement mechanisms and strategies.Furthermore,the promising applications of plasmon-free SERS substrates in biomedical diagnosis,metal ions and organic pollutants sensing,chemical and biochemical reactions monitoring,and photoelectric characterization are introduced.Finally,current challenges and future research opportunities in plasmon-free SERS substrates are briefly discussed.展开更多
Noble-metal-free surface-enhanced Raman scattering(SERS)substrates have attracted great attention for their abundant sources,good signal uniformity,superior biocompatibility,and high chemical stability.However,the lac...Noble-metal-free surface-enhanced Raman scattering(SERS)substrates have attracted great attention for their abundant sources,good signal uniformity,superior biocompatibility,and high chemical stability.However,the lack of controllable synthesis and fabrication of noble-metal-free substrates with high SERS activity impedes their practical applications.Herein,we propose a general strategy to fabricate a series of planar transition-metal nitride(TMN)SERS chips via an ambient temperature sputtering deposition route.For the first time,tungsten nitride(WN)and tantalum nitride(TaN)are used as SERS materials.These planar TMN chips show remarkable Raman enhancement factors(EFs)with~105 owing to efficient photoinduced charge transfer process between TMN chips and probe molecules.Further,structural engineering of these TMN chips is used to improve their SERS activity.Benefiting from the synergistic effect of charge transfer process and electric field enhancement by constructing a nanocavity structure,the Raman EF of WN nanocavity chips could be greatly improved to~1.29×10^(7),which is an order of magnitude higher than that of planar chips.Moreover,we also design the WN/monolayer MoS2 heterostructure chips.With the increase of surface electron density on the upper WN and more exciton resonance transitions in the heterostructure,a~1.94×10^(7)level EF and a 5×10^(-10)M level detection limit could be achieved.Our results provide important guidance for the structural design of ultrasensitive noble-metal-free SERS chips.展开更多
Van der Waals heterojunctions(vdWHs)provide an excellent material system for the research of heterojunction-enhanced Raman scattering(HERS)due to their complexity and diversity.However,the traditional two-dimensional ...Van der Waals heterojunctions(vdWHs)provide an excellent material system for the research of heterojunction-enhanced Raman scattering(HERS)due to their complexity and diversity.However,the traditional two-dimensional vdWHs are not conducive to the full utilization of near-field light due to the limitation of single dimension.Herein,we fabricate T-shaped mixed-dimensional SnSe_(2)/ReS_(2) vdWHs via chemical vapor deposition and wetting transfer method,and demonstrate that the mixed-dimensional vdWHs can be used as ultrasensitive HERS chips based on the effective photo-induced charge transfer.Besides,the radiative energy transfer effect enhanced by near-field light further magnifies the HERS signals,improving the detection limit of rhodamine 6G(R6G)to femtomolar level.Furthermore,we demonstrate that the ultrasensitive screening of crystal violet in multicomponent solutions adsorbed on SnSe_(2)/ReS_(2) vdWHs can be achieved by adjusting the laser wavelength,which has not been achieved by noble metal materials.This work provides new insights into the mixed-dimensional vdWHs and demonstrates the great application potential of T-shaped heterojunctions.展开更多
Flexible strain sensors have been extensively used in human motion detection,medical aids,electronic skins,and other civilian or military fields.Conventional strain sensors made of metal or semiconductor materials suf...Flexible strain sensors have been extensively used in human motion detection,medical aids,electronic skins,and other civilian or military fields.Conventional strain sensors made of metal or semiconductor materials suffer from insufficient stretchability and sensitivity,imposing severe constraints on their utilization in wearable devices.Herein,we design a flexible strain sensor based on biphasic hydrogel via an in-situ polymerization method,which possesses superior electrical response and mechanical performance.External stress could prompt the formation of conductive microchannels within the biphasic hydrogel,which originates from the interaction between the conductive water phase and the insulating oil phase.The device performance could be optimized by carefully regulating the volume ratio of the oil/water phase.Consequently,the flexible strain sensor with oil phase ratio of 80%demonstrates the best sensitivity with gauge factor of 33 upon a compressive strain range of 10%,remarkable electrical stability of 100 cycles,and rapid resistance response of 190 ms.Furthermore,the human motions could be monitored by this flexible strain sensor,thereby highlighting its potential for seamless integration into wearable devices.展开更多
基金T.Q.acknowledges the National Natural Science Foundation of China(grant no.12374370)X.F.acknowledges the National Natural Science Foundation of China(grant no.12404451)+3 种基金the Natural Science Foundation of Jiangsu Province(grant no.BK20230807)Jiangsu Funding Program for Excellent Postdoctoral Talent(grant no.2024ZB532)the Postdoctoral Fellowship Program of CPSF(grant no.GZC20240264)Q.H.acknowledges the Open Research Fund of Key Laboratory of Quantum Materials and Devices(Southeast University),Ministry of Education.
文摘Personalized healthcare monitoring is a transformative tool for preventing potential risks and enhancing health status,particularly through molecular-level insights.Advances in nanotechnology,smart devices,and artificial intelligence(AI)have revolutionized personalized healthcare,especially in point-of-care testing(POCT),enabling early detection and timely intervention.Recently,surface-enhanced Raman spectroscopy(SERS)technology,particularly with flexible chips,has shown immense promise in this field due to its in situ,rapid,specific,and efficient detection capabilities.In this review,we highlight recent advancements in flexible SERS chips for personalized healthcare monitoring,demonstrating their effectiveness in target sampling and detection.Importantly,we provide a comprehensive overview of potential applications of flexible SERS chips in personalized healthcare,address current challenges,and propose future development directions.We also explore the future development of miniaturized Raman devices to broaden their applications in personalized healthcare monitoring.Additionally,we underscore the important role of AI in enhancing data processing and analysis.Our aim is to offer a thorough guide on integrating SERS into personalized healthcare monitoring,promising a new era of health management.
基金the National Natural Science Foundation of China(Grant No.11874108)the National Key R&D Program of China(Grant No.2017YFA0403600)。
文摘Plasmon-free surface-enhanced Raman scattering(SERS)substrates have attracted tremendous attention for their abundant sources,excellent chemical stability,superior biocompatibility,good signal uniformity,and unique selectivity to target molecules.Recently,researchers have made great progress in fabricating novel plasmon-free SERS substrates and exploring new enhancement strategies to improve their sensitivity.This review summarizes the recent developments of plasmon-free SERS substrates and specially focuses on the enhancement mechanisms and strategies.Furthermore,the promising applications of plasmon-free SERS substrates in biomedical diagnosis,metal ions and organic pollutants sensing,chemical and biochemical reactions monitoring,and photoelectric characterization are introduced.Finally,current challenges and future research opportunities in plasmon-free SERS substrates are briefly discussed.
基金This work was supported by the National Natural Science Foundation of China(No.11874108).
文摘Noble-metal-free surface-enhanced Raman scattering(SERS)substrates have attracted great attention for their abundant sources,good signal uniformity,superior biocompatibility,and high chemical stability.However,the lack of controllable synthesis and fabrication of noble-metal-free substrates with high SERS activity impedes their practical applications.Herein,we propose a general strategy to fabricate a series of planar transition-metal nitride(TMN)SERS chips via an ambient temperature sputtering deposition route.For the first time,tungsten nitride(WN)and tantalum nitride(TaN)are used as SERS materials.These planar TMN chips show remarkable Raman enhancement factors(EFs)with~105 owing to efficient photoinduced charge transfer process between TMN chips and probe molecules.Further,structural engineering of these TMN chips is used to improve their SERS activity.Benefiting from the synergistic effect of charge transfer process and electric field enhancement by constructing a nanocavity structure,the Raman EF of WN nanocavity chips could be greatly improved to~1.29×10^(7),which is an order of magnitude higher than that of planar chips.Moreover,we also design the WN/monolayer MoS2 heterostructure chips.With the increase of surface electron density on the upper WN and more exciton resonance transitions in the heterostructure,a~1.94×10^(7)level EF and a 5×10^(-10)M level detection limit could be achieved.Our results provide important guidance for the structural design of ultrasensitive noble-metal-free SERS chips.
基金supported by the National Natural Science Foundation of China(No.11874108).
文摘Van der Waals heterojunctions(vdWHs)provide an excellent material system for the research of heterojunction-enhanced Raman scattering(HERS)due to their complexity and diversity.However,the traditional two-dimensional vdWHs are not conducive to the full utilization of near-field light due to the limitation of single dimension.Herein,we fabricate T-shaped mixed-dimensional SnSe_(2)/ReS_(2) vdWHs via chemical vapor deposition and wetting transfer method,and demonstrate that the mixed-dimensional vdWHs can be used as ultrasensitive HERS chips based on the effective photo-induced charge transfer.Besides,the radiative energy transfer effect enhanced by near-field light further magnifies the HERS signals,improving the detection limit of rhodamine 6G(R6G)to femtomolar level.Furthermore,we demonstrate that the ultrasensitive screening of crystal violet in multicomponent solutions adsorbed on SnSe_(2)/ReS_(2) vdWHs can be achieved by adjusting the laser wavelength,which has not been achieved by noble metal materials.This work provides new insights into the mixed-dimensional vdWHs and demonstrates the great application potential of T-shaped heterojunctions.
基金China Postdoctoral Science Foundation(Grant No.2021M700773)the Jiangsu Planned Projects for Postdoctoral Research Funds(Grant No.2021K509C)。
文摘Flexible strain sensors have been extensively used in human motion detection,medical aids,electronic skins,and other civilian or military fields.Conventional strain sensors made of metal or semiconductor materials suffer from insufficient stretchability and sensitivity,imposing severe constraints on their utilization in wearable devices.Herein,we design a flexible strain sensor based on biphasic hydrogel via an in-situ polymerization method,which possesses superior electrical response and mechanical performance.External stress could prompt the formation of conductive microchannels within the biphasic hydrogel,which originates from the interaction between the conductive water phase and the insulating oil phase.The device performance could be optimized by carefully regulating the volume ratio of the oil/water phase.Consequently,the flexible strain sensor with oil phase ratio of 80%demonstrates the best sensitivity with gauge factor of 33 upon a compressive strain range of 10%,remarkable electrical stability of 100 cycles,and rapid resistance response of 190 ms.Furthermore,the human motions could be monitored by this flexible strain sensor,thereby highlighting its potential for seamless integration into wearable devices.
