AIM:To summarize and quantitatively evaluate vasculature alteration of foveal zone in systemic lupus erythematosus(SLE)patients by secondary literature analysis.METHODS:A systematic search of PubMed,Embase,Web of Scie...AIM:To summarize and quantitatively evaluate vasculature alteration of foveal zone in systemic lupus erythematosus(SLE)patients by secondary literature analysis.METHODS:A systematic search of PubMed,Embase,Web of Science,Cochrane Library,CBM,CNKI WanFang Data and VIP was conducted.Studies were about retinal vessel density in SLE patients from January 2000 to April 2023 and valid data were extracted.The Joanna Briggs Institute(JBI)critical appraisal checklist was used to evaluate the cross-sectional studies and prospective studies.The measurement data for combined effect size were weighted mean difference(WMD)and 95%confidence interval(CI).The heterogeneity was evaluated by I2 test.The fixed-effect model was adopted when P>0.1 or I2<50%,and random-effect model was adopted in the contrary.Subgroup and sensitivity analysis were utilized to analyze the sources of heterogeneity.The publication bias was evaluated by Egger tests and funnel plots.RESULTS:A total of 14 studies with 445 subjects and 441 healthy controls from 9 countries were enrolled and 11 studies were included in Meta-analysis.The JBI scores of studies were no less than 14 points.The Metaanalysis results indicated that mean parafoveal superficial vessel density(SVD;WMD=-1.22,95%CI:-1.67,-0.76),mean perifoveal SVD(WMD=-1.42,95%CI:-1.95,-0.89),mean whole SVD(WMD=-1.66,95%CI:-2.53,-0.79),mean parafoveal deep vessel density(WMD=-1.67,95%CI:-2.75,-0.59)and mean whole deep vessel density(WMD=-4.09,95%CI:-7.67,-0.52)was significantly lower than the control,while mean foveal SVD(WMD=-1.71,95%CI:-4.65,1.24),mean foveal avascular zone(FAZ)area(WMD=0.04,95%CI:-0.01,0.09)and mean acircularity index(AI;WMD=0.00,95%CI:-0.02,0.02)were not different between SLE patients and controls.Subgroup analysis indicated that the heterogeneity in SVD was partially due to the scanning area.Ocellus or binoculus data contributed partially to the heterogeneity in parafoveal deep vessel density and FAZ area.Sensitivity analysis indicated that the results were robust after changing the analysis model except for foveal SVD and FAZ area.There was no bias in included studies except whole SVD.CONCLUSION:Parafoveal superficial and deep vessel density are significantly lower in SLE patients while FAZ area and AI are not different between SLE patients and the control.展开更多
FeS2/Fe composites were mechanochemically prepared with iron powder and pyrite for the stabilization of ferrite arsenate sludge(FAS).The effects of preparation parameters on stabilization performance were investigated...FeS2/Fe composites were mechanochemically prepared with iron powder and pyrite for the stabilization of ferrite arsenate sludge(FAS).The effects of preparation parameters on stabilization performance were investigated.The results show that the optimum conditions are FeS2/Fe molar ratio of 5:5,milling time of 2 h,ball-to-material mass ratio of 15:1 and milling with stainless steel ball.Then,the composites were characterized by XRD,SEM,FTIR,etc.The physicochemical properties of FeS2/Fe mixture change dramatically,which is responsible for its excellent performance.Finally,the stabilization process of FAS was optimized.When the FAS is mixed with composites at mass ratio of 4:1 and milled for 30 min,the As leaching concentration of FAS can be reduced from 639.15 to 4.74 mg/L with the stabilization ratio of 99.2%.展开更多
文摘AIM:To summarize and quantitatively evaluate vasculature alteration of foveal zone in systemic lupus erythematosus(SLE)patients by secondary literature analysis.METHODS:A systematic search of PubMed,Embase,Web of Science,Cochrane Library,CBM,CNKI WanFang Data and VIP was conducted.Studies were about retinal vessel density in SLE patients from January 2000 to April 2023 and valid data were extracted.The Joanna Briggs Institute(JBI)critical appraisal checklist was used to evaluate the cross-sectional studies and prospective studies.The measurement data for combined effect size were weighted mean difference(WMD)and 95%confidence interval(CI).The heterogeneity was evaluated by I2 test.The fixed-effect model was adopted when P>0.1 or I2<50%,and random-effect model was adopted in the contrary.Subgroup and sensitivity analysis were utilized to analyze the sources of heterogeneity.The publication bias was evaluated by Egger tests and funnel plots.RESULTS:A total of 14 studies with 445 subjects and 441 healthy controls from 9 countries were enrolled and 11 studies were included in Meta-analysis.The JBI scores of studies were no less than 14 points.The Metaanalysis results indicated that mean parafoveal superficial vessel density(SVD;WMD=-1.22,95%CI:-1.67,-0.76),mean perifoveal SVD(WMD=-1.42,95%CI:-1.95,-0.89),mean whole SVD(WMD=-1.66,95%CI:-2.53,-0.79),mean parafoveal deep vessel density(WMD=-1.67,95%CI:-2.75,-0.59)and mean whole deep vessel density(WMD=-4.09,95%CI:-7.67,-0.52)was significantly lower than the control,while mean foveal SVD(WMD=-1.71,95%CI:-4.65,1.24),mean foveal avascular zone(FAZ)area(WMD=0.04,95%CI:-0.01,0.09)and mean acircularity index(AI;WMD=0.00,95%CI:-0.02,0.02)were not different between SLE patients and controls.Subgroup analysis indicated that the heterogeneity in SVD was partially due to the scanning area.Ocellus or binoculus data contributed partially to the heterogeneity in parafoveal deep vessel density and FAZ area.Sensitivity analysis indicated that the results were robust after changing the analysis model except for foveal SVD and FAZ area.There was no bias in included studies except whole SVD.CONCLUSION:Parafoveal superficial and deep vessel density are significantly lower in SLE patients while FAZ area and AI are not different between SLE patients and the control.
基金Projects(2018YFC1900305,2018YFC1903301)supported by the National Key R&D Program of ChinaProject(51825403)supported by the National Natural Science Foundation for Distinguished Young Scholars of China+1 种基金Project(51634010)supported by the National Natural Science Foundation of ChinaProject(2017RS3010)supported by the Science and Technology Program of Hunan Province,China
文摘FeS2/Fe composites were mechanochemically prepared with iron powder and pyrite for the stabilization of ferrite arsenate sludge(FAS).The effects of preparation parameters on stabilization performance were investigated.The results show that the optimum conditions are FeS2/Fe molar ratio of 5:5,milling time of 2 h,ball-to-material mass ratio of 15:1 and milling with stainless steel ball.Then,the composites were characterized by XRD,SEM,FTIR,etc.The physicochemical properties of FeS2/Fe mixture change dramatically,which is responsible for its excellent performance.Finally,the stabilization process of FAS was optimized.When the FAS is mixed with composites at mass ratio of 4:1 and milled for 30 min,the As leaching concentration of FAS can be reduced from 639.15 to 4.74 mg/L with the stabilization ratio of 99.2%.
