背景:周围神经损伤会对患者造成不同程度的功能障碍,并且长节段周围神经缺损的修复重建缺乏有效的治疗手段。近年来,组织工程学逐渐应用于长节段周围神经缺损的修复中,但研究的热点与发展动态不明。目的:使用文献计量学软件分析近20年...背景:周围神经损伤会对患者造成不同程度的功能障碍,并且长节段周围神经缺损的修复重建缺乏有效的治疗手段。近年来,组织工程学逐渐应用于长节段周围神经缺损的修复中,但研究的热点与发展动态不明。目的:使用文献计量学软件分析近20年来国内外在周围神经组织工程学的研究热点和趋势变化。方法:使用CiteSpace 6.2R6软件对Web of Science数据库和中国知网中2004-2024年发表的周围神经组织工程学文献进行高被引分析和关键词分析,其中关键词分析包括关键词共现分析、关键词聚类分析、关键词时间轴分析和关键词突现分析。结果与结论:从Web of Science数据库和中国知网中各纳入了2961和1171篇文献,Web of Science数据库该领域的发文量存在波动但呈现逐年递增的趋势,中国知网该领域的发文量每年相差不大。Web of Science数据库中该领域引用前10的文献大多为综述型文章。结合Web of Science数据库和中国知网关键词分析结果,发现近20年来研究较多的神经组织工程学材料包括丝素蛋白、胶原蛋白、壳聚糖、聚己内酯、聚乳酸、石墨烯等,研究较多材料中的生化线索包括嗅鞘细胞、施万细胞、干细胞、神经生长因子等,引入外部物理因子使用最多的是在材料中施加电刺激,神经组织工程学技术研究较多的是静电纺丝技术和3D打印技术。展开更多
A novel series of resveratrol derivatives were synthesized according to Wittig-Horner reaction with 3,5-dihydroxybenzyl alcohol or 3,5-dimethoxybenzyl alcohol or 4-hydroxybenzyl alcohol as raw material and the inhibit...A novel series of resveratrol derivatives were synthesized according to Wittig-Horner reaction with 3,5-dihydroxybenzyl alcohol or 3,5-dimethoxybenzyl alcohol or 4-hydroxybenzyl alcohol as raw material and the inhibitory activities on breast carcinoma (MDA-MB-231) and gastric carcinoma cell lines (SGC-7901) in vitro were evaluated by the standard methyl thiazole tetrazolium (MTT) method. The result of biological test shows that some of resveratrol derivatives possess stronger anti-cancer activities than 5-FU. Compound 5c shows the strongest activity against breast carcinoma (MDA-MB-231) and gastric carcinoma cell lines (SGC-7901) with IC50 value of 50.19 ± 1.02 μM, 122.68.27 ± 2.04 μM, compared to that IC50 value of 5-FU is 98.59±3.61 μM,156.74±6.16 μM, respectively.展开更多
The actively heated fiber-optic(AHFO)technology has emerged as a frontier and hotspot in soil water content measurement,offering advantages such as easy installation,large-scale distributed measurement capability,and ...The actively heated fiber-optic(AHFO)technology has emerged as a frontier and hotspot in soil water content measurement,offering advantages such as easy installation,large-scale distributed measurement capability,and resistance to electromagnetic interference.However,current AHFO water content sensors fail to simultaneously achieve high precision,applicability for deep soil,and automated real-time monitoring,thereby limiting their development and application.Therefore,this study introduces a novel actively heated fiber Bragg grating(AH-FBG)cable.Laboratory tests were conducted to assess the heating uniformity of the AH-FBG cable and to establish the temperature characteristic value(T_(t))-soil water content(θ)calibration formula for water content measurement.Subsequently,AH-FBG cables were deployed for in situ soil water content monitoring in a test pit on the Loess Plateau.Through two-year monitoring data verified the accuracy of the AH-FBG cable and elucidated the spatiotemporal distribution of in situ loess water content.Laboratory results demonstrated superior heating uniformity of AHFBG cable,with a T_(t) standard deviation of approximately 0.3℃.In the field,the AH-FBG cable exhibited excellent performance in soil water content measurement,achieving a high accuracy of 0.023 cm^(3)/cm^(3).Further analysis revealed that the θ fluctuation predominantly occurred within a 10 m depth from the soil surface,with an overall upward trend over the two-year monitoring period;the response of shallow θ to precipitation was significant but exhibited increasing hysteresis with depth;frequent precipitation significantly enhanced water infiltration depth.This study provides technical guidance for highprecision,quasi-distributed,automated and real-time water content measurement of deep soil.展开更多
Propolis is a resinous complex mixture made from plant resins collected by worker bees and mixed with their own secretions.It is rich in polyphenols and flavonoids and thus has a wide range of biological activities an...Propolis is a resinous complex mixture made from plant resins collected by worker bees and mixed with their own secretions.It is rich in polyphenols and flavonoids and thus has a wide range of biological activities and is considered a functional source for promoting human health.However,propolis and its bioactive compounds have poor water solubility,rapid and intense metabolism,and low oral bioavailability,which limits their wide application.In this paper,the main bioactive substances in propolis were summarized,and the biological characteristics and therapeutic potential of propolis and its bioactive substances were discussed.In addition,this paper discussed the factors affecting the bioavailability of propolis and its functional ingredients,focusing on the research progress in improving the bioavailability and bioactivity of propolis and its functional ingredients using nanoencapsulation technology.Finally,the current situation of the global propolis market and the applications of propolis products in the pharmaceutical,food,cosmetic and other industrial fields were discussed,providing useful references for promoting the development of the propolis industry.展开更多
文摘背景:周围神经损伤会对患者造成不同程度的功能障碍,并且长节段周围神经缺损的修复重建缺乏有效的治疗手段。近年来,组织工程学逐渐应用于长节段周围神经缺损的修复中,但研究的热点与发展动态不明。目的:使用文献计量学软件分析近20年来国内外在周围神经组织工程学的研究热点和趋势变化。方法:使用CiteSpace 6.2R6软件对Web of Science数据库和中国知网中2004-2024年发表的周围神经组织工程学文献进行高被引分析和关键词分析,其中关键词分析包括关键词共现分析、关键词聚类分析、关键词时间轴分析和关键词突现分析。结果与结论:从Web of Science数据库和中国知网中各纳入了2961和1171篇文献,Web of Science数据库该领域的发文量存在波动但呈现逐年递增的趋势,中国知网该领域的发文量每年相差不大。Web of Science数据库中该领域引用前10的文献大多为综述型文章。结合Web of Science数据库和中国知网关键词分析结果,发现近20年来研究较多的神经组织工程学材料包括丝素蛋白、胶原蛋白、壳聚糖、聚己内酯、聚乳酸、石墨烯等,研究较多材料中的生化线索包括嗅鞘细胞、施万细胞、干细胞、神经生长因子等,引入外部物理因子使用最多的是在材料中施加电刺激,神经组织工程学技术研究较多的是静电纺丝技术和3D打印技术。
文摘A novel series of resveratrol derivatives were synthesized according to Wittig-Horner reaction with 3,5-dihydroxybenzyl alcohol or 3,5-dimethoxybenzyl alcohol or 4-hydroxybenzyl alcohol as raw material and the inhibitory activities on breast carcinoma (MDA-MB-231) and gastric carcinoma cell lines (SGC-7901) in vitro were evaluated by the standard methyl thiazole tetrazolium (MTT) method. The result of biological test shows that some of resveratrol derivatives possess stronger anti-cancer activities than 5-FU. Compound 5c shows the strongest activity against breast carcinoma (MDA-MB-231) and gastric carcinoma cell lines (SGC-7901) with IC50 value of 50.19 ± 1.02 μM, 122.68.27 ± 2.04 μM, compared to that IC50 value of 5-FU is 98.59±3.61 μM,156.74±6.16 μM, respectively.
基金supported by the National Natural Science Foundation of China(Grant Nos.42307189 and 42030701)the China Postdoctoral Science Foundation(Grant No.2023M740974).
文摘The actively heated fiber-optic(AHFO)technology has emerged as a frontier and hotspot in soil water content measurement,offering advantages such as easy installation,large-scale distributed measurement capability,and resistance to electromagnetic interference.However,current AHFO water content sensors fail to simultaneously achieve high precision,applicability for deep soil,and automated real-time monitoring,thereby limiting their development and application.Therefore,this study introduces a novel actively heated fiber Bragg grating(AH-FBG)cable.Laboratory tests were conducted to assess the heating uniformity of the AH-FBG cable and to establish the temperature characteristic value(T_(t))-soil water content(θ)calibration formula for water content measurement.Subsequently,AH-FBG cables were deployed for in situ soil water content monitoring in a test pit on the Loess Plateau.Through two-year monitoring data verified the accuracy of the AH-FBG cable and elucidated the spatiotemporal distribution of in situ loess water content.Laboratory results demonstrated superior heating uniformity of AHFBG cable,with a T_(t) standard deviation of approximately 0.3℃.In the field,the AH-FBG cable exhibited excellent performance in soil water content measurement,achieving a high accuracy of 0.023 cm^(3)/cm^(3).Further analysis revealed that the θ fluctuation predominantly occurred within a 10 m depth from the soil surface,with an overall upward trend over the two-year monitoring period;the response of shallow θ to precipitation was significant but exhibited increasing hysteresis with depth;frequent precipitation significantly enhanced water infiltration depth.This study provides technical guidance for highprecision,quasi-distributed,automated and real-time water content measurement of deep soil.
基金supported by the National Natural Science Foundation of China(31972087)the earmarked fund for China Agriculture Research System-Bee(CARS-44-KXJ17)the Science and Technology Innovation Project of Chinese Academy of Agricultural Sciences(CAAS-ASTIP-2021-IAR)。
文摘Propolis is a resinous complex mixture made from plant resins collected by worker bees and mixed with their own secretions.It is rich in polyphenols and flavonoids and thus has a wide range of biological activities and is considered a functional source for promoting human health.However,propolis and its bioactive compounds have poor water solubility,rapid and intense metabolism,and low oral bioavailability,which limits their wide application.In this paper,the main bioactive substances in propolis were summarized,and the biological characteristics and therapeutic potential of propolis and its bioactive substances were discussed.In addition,this paper discussed the factors affecting the bioavailability of propolis and its functional ingredients,focusing on the research progress in improving the bioavailability and bioactivity of propolis and its functional ingredients using nanoencapsulation technology.Finally,the current situation of the global propolis market and the applications of propolis products in the pharmaceutical,food,cosmetic and other industrial fields were discussed,providing useful references for promoting the development of the propolis industry.
