背景:周围神经损伤会对患者造成不同程度的功能障碍,并且长节段周围神经缺损的修复重建缺乏有效的治疗手段。近年来,组织工程学逐渐应用于长节段周围神经缺损的修复中,但研究的热点与发展动态不明。目的:使用文献计量学软件分析近20年...背景:周围神经损伤会对患者造成不同程度的功能障碍,并且长节段周围神经缺损的修复重建缺乏有效的治疗手段。近年来,组织工程学逐渐应用于长节段周围神经缺损的修复中,但研究的热点与发展动态不明。目的:使用文献计量学软件分析近20年来国内外在周围神经组织工程学的研究热点和趋势变化。方法:使用CiteSpace 6.2R6软件对Web of Science数据库和中国知网中2004-2024年发表的周围神经组织工程学文献进行高被引分析和关键词分析,其中关键词分析包括关键词共现分析、关键词聚类分析、关键词时间轴分析和关键词突现分析。结果与结论:从Web of Science数据库和中国知网中各纳入了2961和1171篇文献,Web of Science数据库该领域的发文量存在波动但呈现逐年递增的趋势,中国知网该领域的发文量每年相差不大。Web of Science数据库中该领域引用前10的文献大多为综述型文章。结合Web of Science数据库和中国知网关键词分析结果,发现近20年来研究较多的神经组织工程学材料包括丝素蛋白、胶原蛋白、壳聚糖、聚己内酯、聚乳酸、石墨烯等,研究较多材料中的生化线索包括嗅鞘细胞、施万细胞、干细胞、神经生长因子等,引入外部物理因子使用最多的是在材料中施加电刺激,神经组织工程学技术研究较多的是静电纺丝技术和3D打印技术。展开更多
A novel series of resveratrol derivatives were synthesized according to Wittig-Horner reaction with 3,5-dihydroxybenzyl alcohol or 3,5-dimethoxybenzyl alcohol or 4-hydroxybenzyl alcohol as raw material and the inhibit...A novel series of resveratrol derivatives were synthesized according to Wittig-Horner reaction with 3,5-dihydroxybenzyl alcohol or 3,5-dimethoxybenzyl alcohol or 4-hydroxybenzyl alcohol as raw material and the inhibitory activities on breast carcinoma (MDA-MB-231) and gastric carcinoma cell lines (SGC-7901) in vitro were evaluated by the standard methyl thiazole tetrazolium (MTT) method. The result of biological test shows that some of resveratrol derivatives possess stronger anti-cancer activities than 5-FU. Compound 5c shows the strongest activity against breast carcinoma (MDA-MB-231) and gastric carcinoma cell lines (SGC-7901) with IC50 value of 50.19 ± 1.02 μM, 122.68.27 ± 2.04 μM, compared to that IC50 value of 5-FU is 98.59±3.61 μM,156.74±6.16 μM, respectively.展开更多
The actively heated fiber-optic(AHFO)technology has emerged as a frontier and hotspot in soil water content measurement,offering advantages such as easy installation,large-scale distributed measurement capability,and ...The actively heated fiber-optic(AHFO)technology has emerged as a frontier and hotspot in soil water content measurement,offering advantages such as easy installation,large-scale distributed measurement capability,and resistance to electromagnetic interference.However,current AHFO water content sensors fail to simultaneously achieve high precision,applicability for deep soil,and automated real-time monitoring,thereby limiting their development and application.Therefore,this study introduces a novel actively heated fiber Bragg grating(AH-FBG)cable.Laboratory tests were conducted to assess the heating uniformity of the AH-FBG cable and to establish the temperature characteristic value(T_(t))-soil water content(θ)calibration formula for water content measurement.Subsequently,AH-FBG cables were deployed for in situ soil water content monitoring in a test pit on the Loess Plateau.Through two-year monitoring data verified the accuracy of the AH-FBG cable and elucidated the spatiotemporal distribution of in situ loess water content.Laboratory results demonstrated superior heating uniformity of AHFBG cable,with a T_(t) standard deviation of approximately 0.3℃.In the field,the AH-FBG cable exhibited excellent performance in soil water content measurement,achieving a high accuracy of 0.023 cm^(3)/cm^(3).Further analysis revealed that the θ fluctuation predominantly occurred within a 10 m depth from the soil surface,with an overall upward trend over the two-year monitoring period;the response of shallow θ to precipitation was significant but exhibited increasing hysteresis with depth;frequent precipitation significantly enhanced water infiltration depth.This study provides technical guidance for highprecision,quasi-distributed,automated and real-time water content measurement of deep soil.展开更多
文摘背景:周围神经损伤会对患者造成不同程度的功能障碍,并且长节段周围神经缺损的修复重建缺乏有效的治疗手段。近年来,组织工程学逐渐应用于长节段周围神经缺损的修复中,但研究的热点与发展动态不明。目的:使用文献计量学软件分析近20年来国内外在周围神经组织工程学的研究热点和趋势变化。方法:使用CiteSpace 6.2R6软件对Web of Science数据库和中国知网中2004-2024年发表的周围神经组织工程学文献进行高被引分析和关键词分析,其中关键词分析包括关键词共现分析、关键词聚类分析、关键词时间轴分析和关键词突现分析。结果与结论:从Web of Science数据库和中国知网中各纳入了2961和1171篇文献,Web of Science数据库该领域的发文量存在波动但呈现逐年递增的趋势,中国知网该领域的发文量每年相差不大。Web of Science数据库中该领域引用前10的文献大多为综述型文章。结合Web of Science数据库和中国知网关键词分析结果,发现近20年来研究较多的神经组织工程学材料包括丝素蛋白、胶原蛋白、壳聚糖、聚己内酯、聚乳酸、石墨烯等,研究较多材料中的生化线索包括嗅鞘细胞、施万细胞、干细胞、神经生长因子等,引入外部物理因子使用最多的是在材料中施加电刺激,神经组织工程学技术研究较多的是静电纺丝技术和3D打印技术。
文摘A novel series of resveratrol derivatives were synthesized according to Wittig-Horner reaction with 3,5-dihydroxybenzyl alcohol or 3,5-dimethoxybenzyl alcohol or 4-hydroxybenzyl alcohol as raw material and the inhibitory activities on breast carcinoma (MDA-MB-231) and gastric carcinoma cell lines (SGC-7901) in vitro were evaluated by the standard methyl thiazole tetrazolium (MTT) method. The result of biological test shows that some of resveratrol derivatives possess stronger anti-cancer activities than 5-FU. Compound 5c shows the strongest activity against breast carcinoma (MDA-MB-231) and gastric carcinoma cell lines (SGC-7901) with IC50 value of 50.19 ± 1.02 μM, 122.68.27 ± 2.04 μM, compared to that IC50 value of 5-FU is 98.59±3.61 μM,156.74±6.16 μM, respectively.
基金supported by the National Natural Science Foundation of China(Grant Nos.42307189 and 42030701)the China Postdoctoral Science Foundation(Grant No.2023M740974).
文摘The actively heated fiber-optic(AHFO)technology has emerged as a frontier and hotspot in soil water content measurement,offering advantages such as easy installation,large-scale distributed measurement capability,and resistance to electromagnetic interference.However,current AHFO water content sensors fail to simultaneously achieve high precision,applicability for deep soil,and automated real-time monitoring,thereby limiting their development and application.Therefore,this study introduces a novel actively heated fiber Bragg grating(AH-FBG)cable.Laboratory tests were conducted to assess the heating uniformity of the AH-FBG cable and to establish the temperature characteristic value(T_(t))-soil water content(θ)calibration formula for water content measurement.Subsequently,AH-FBG cables were deployed for in situ soil water content monitoring in a test pit on the Loess Plateau.Through two-year monitoring data verified the accuracy of the AH-FBG cable and elucidated the spatiotemporal distribution of in situ loess water content.Laboratory results demonstrated superior heating uniformity of AHFBG cable,with a T_(t) standard deviation of approximately 0.3℃.In the field,the AH-FBG cable exhibited excellent performance in soil water content measurement,achieving a high accuracy of 0.023 cm^(3)/cm^(3).Further analysis revealed that the θ fluctuation predominantly occurred within a 10 m depth from the soil surface,with an overall upward trend over the two-year monitoring period;the response of shallow θ to precipitation was significant but exhibited increasing hysteresis with depth;frequent precipitation significantly enhanced water infiltration depth.This study provides technical guidance for highprecision,quasi-distributed,automated and real-time water content measurement of deep soil.
