Impact statement Helicobacter pylori is a major gastric pathogen with increasing antibiotic resistance,creating an urgent need for new therapeutic strategies.We screened 37 pure compounds and 9 herbal extracts for ant...Impact statement Helicobacter pylori is a major gastric pathogen with increasing antibiotic resistance,creating an urgent need for new therapeutic strategies.We screened 37 pure compounds and 9 herbal extracts for anti-H.pylori activity and identified berberrubine as the most potent agent,with a minimum inhibitory concentration of 11μg/ml.展开更多
Curcumin,a safe natural yellow pigment with a wide range of pharmacological activities,is used both in herbal drugs and as a food coloring agents.Studies have shown that curcumin would suffer from extensive metabolism...Curcumin,a safe natural yellow pigment with a wide range of pharmacological activities,is used both in herbal drugs and as a food coloring agents.Studies have shown that curcumin would suffer from extensive metabolism in vivoand the predominant metabolic pathways are reduction and conjugation.In order to comprehensively study the metabolism and enrich the metabolic profile of cxurcumin in vivo,we carried out this research.A systematic method with highly sensitive UPLC-Q/TOF-MS was established to analyze different biological samples of rats after展开更多
基金funded by the National Natural Science Foundation of China(Nos.82030116 and 32170117)SKLMT Frontiers and Challenges Project(No.SKLMTFCP-2023-01)。
文摘Impact statement Helicobacter pylori is a major gastric pathogen with increasing antibiotic resistance,creating an urgent need for new therapeutic strategies.We screened 37 pure compounds and 9 herbal extracts for anti-H.pylori activity and identified berberrubine as the most potent agent,with a minimum inhibitory concentration of 11μg/ml.
基金partly supported by National Natural Science Foundation of China(No.81430095)also by Special National Program on Key Basic Research Project(No.2014CB560706)
文摘Curcumin,a safe natural yellow pigment with a wide range of pharmacological activities,is used both in herbal drugs and as a food coloring agents.Studies have shown that curcumin would suffer from extensive metabolism in vivoand the predominant metabolic pathways are reduction and conjugation.In order to comprehensively study the metabolism and enrich the metabolic profile of cxurcumin in vivo,we carried out this research.A systematic method with highly sensitive UPLC-Q/TOF-MS was established to analyze different biological samples of rats after
