The improved quantum molecular dynamics model was employed to study the ^(238)U+^(238)U multinucleon transfer reaction at E_(c.m.)=833 Me V in this work.The influence of the orientation effect on the nuclear deformati...The improved quantum molecular dynamics model was employed to study the ^(238)U+^(238)U multinucleon transfer reaction at E_(c.m.)=833 Me V in this work.The influence of the orientation effect on the nuclear deformation at the contact moment,the composite system lifetime,the transfer rate and the fragment production mechanism are investigated.Statistical analysis reveals that at the contact moment,the orientation of the projectile and the target have less influence on each other and retain their respective initial characteristics to some extent.For collision parameters less than 6 fm,significant differences are observed in composite system lifetime and transfer rate under different orientation configurations;however,the orientation effect gradually diminishes with increasing collision parameters.Additionally,it is found that transfer reactions dominate when the collision parameter b≤6 fm,while elastic and inelastic scattering events increase rapidly as the collision parameter exceeds 6 fm.Within the range of 10≤b≤13 fm,the transfer probability for side–side collisions is significantly higher compared to other cases.展开更多
Copper(Cu)-bearing stainless steel has testified its effectiveness to reduce the risk of bacterial infections.However,its antibacterial mechanism is still controversial.Therefore,three 430 ferritic stainless steels wi...Copper(Cu)-bearing stainless steel has testified its effectiveness to reduce the risk of bacterial infections.However,its antibacterial mechanism is still controversial.Therefore,three 430 ferritic stainless steels with different Cu contents are selected to conduct deeper research by the way of bacterial inactivation from two aspects of material and biology.Hereinto,electrochemical and antibacterial results show that the increase in Cu content simultaneously improves the corrosion resistance and antibacterial property of 430 stainless steel.In addition,it is found that Escherichia coli(E.coli)on the surface 430 Cu-bearing stainless steel by the dry method of inoculation possesses a rapid inactivation ability.X-ray photoelectron spectroscopy(XPS)aids with ion chelation experiments prove that Cu(Ⅰ)plays a more crucial role in the contact-killing efficiency than Cu(Ⅱ),resulting from more production of reactive oxygen species(ROS).展开更多
The multinucleon transfer reaction in the collisions of 40 Ca+^124 Sn at Ec.m.= 128.5 MeV is investigated using the improved quantum molecular dynamics model. The measured angular distributions and isotopic distributi...The multinucleon transfer reaction in the collisions of 40 Ca+^124 Sn at Ec.m.= 128.5 MeV is investigated using the improved quantum molecular dynamics model. The measured angular distributions and isotopic distributions of the products are reproduced reasonably well by the calculations. The multinucleon transfer reactions of 40 Ca+^112 Sn, 58 Ni+^112 Sn, 106 Cd+^112 Sn, and 48 Ca+^112 Sn are also studied. This demonstrates that the combinations of neutron-deficient projectile and target are advantageous for the production of exotic neutron-deficient nuclei near N,Z =50. The charged particles’ emission plays an important role at small impact parameters in the de-excitation processes of the system. The production cross sections of the exotic neutron-deficient nuclei in multinucleon transfer reactions are much larger than those measured in the fragmentation and fusion-evaporation reactions. Several new neutron-deficient nuclei can be produced in the 106 Cd+^112 Sn reaction. The corresponding production cross sections for the new neutron-deficient nuclei,101,112 Sb,103 Te,and 106,107) I,are 2.0 nb,4.1 nb,6.5 nb,0.4 μb and 1.0 μb,respectively.展开更多
Background： Dendritic cells are professional antigen-presenting cells found in an immature state in epithelia and interstitial space, where they capture antigens such as pathogens or damaged tissue. Matrix metallopep...Background： Dendritic cells are professional antigen-presenting cells found in an immature state in epithelia and interstitial space, where they capture antigens such as pathogens or damaged tissue. Matrix metallopeptidase 13 （MMP- 13）, a member of the collagenase subfamily, is involved in many different cellular processes and is expressed in murine bone marrow-derived dendritic cells （DCs）. The function of MMP-13 in DCs is not well understood. Here, we investigated the effect of MMP-13 on DC maturation, apoptosis, and phagocytosis. Methods： Bone marrow-derived dendritic cells were obtained fiom C57BL/6 mice. One short-interfering RNA specific for MMP- 13 was used to transfect DCs. MMP-13-silenced DCs and control DCs were prepared, and apoptosis was measured using real-time polymerase chain reaction and Western blotting. MMP-13-silenced DCs and control DCs were analyzed for surface expression of CD80 and CD86 and phagocytosis capability using flow cytometry. Results： Compared to the control DCs, MMP- 13-silenced DCs increased expression of anti-apoptosis-related genes, BAGl （control group vs. MMP-13-silenced group： 4.08 ± 0.60 vs. 6.11 ± 0.87, P = 0.008）, BCL-2 （control group vs. MMP-13-silenced group： 7.54 ± 0.76 vs. 9.54 ± 1.29, P = 0.036）, and TP73 （control group vs. MMP- 13-silenced group： 4.33 ± 0.29 vs. 5.60 ±0.32, P = 0.001 ） and decreased apoptosis-related genes, CASPI （control group vs. MMP- 13-silenced group： 3.79±0.67 vs. 2.54±0.39, P - 0.019）, LTBR （control group vs. MMP- 13-silenced group： 9.23 ±1.25 vs. 6.24 ± 1.15, P = 0.012）, and CASP4 （control group vs. MMP-13-silenced group： 2.07 ± 0.56 vs. 0.35 ±0.35, P = 0.002）. Protein levels confirmed the same expression pattern. MMP- 13-silenced groups decreased expression of CD86 on DCs; however, there was no statistical difference in CD80 surface expression. Furthermore, MMP-13-silenced groups exhibited weaker phagocytosis capability. Conclusion： These results indicate that MMP-13 inhibition dampens DC maturation, apoptosis, and phagocytosis.展开更多
基金supported by the Natural Science Foundation of Guangxi under Grant No.2024GXNSFBA010377,No.2022GXNSFBA035528,No.2023GXNSFBA026008Guangxi Science and Technology Base and Special Talent Program under Grant No.Guike AD22035060+2 种基金the Central Government Guides Local Scientific and Technological Development Fund Projects under Grant No.Guike ZY22096024the National Natural Science Foundation of China under Grant No.12135004,No.11635003 No.11961141004,No.12365016the Innovation Project of Guangxi Graduate Education Grant No.YCBZ2023060.
文摘The improved quantum molecular dynamics model was employed to study the ^(238)U+^(238)U multinucleon transfer reaction at E_(c.m.)=833 Me V in this work.The influence of the orientation effect on the nuclear deformation at the contact moment,the composite system lifetime,the transfer rate and the fragment production mechanism are investigated.Statistical analysis reveals that at the contact moment,the orientation of the projectile and the target have less influence on each other and retain their respective initial characteristics to some extent.For collision parameters less than 6 fm,significant differences are observed in composite system lifetime and transfer rate under different orientation configurations;however,the orientation effect gradually diminishes with increasing collision parameters.Additionally,it is found that transfer reactions dominate when the collision parameter b≤6 fm,while elastic and inelastic scattering events increase rapidly as the collision parameter exceeds 6 fm.Within the range of 10≤b≤13 fm,the transfer probability for side–side collisions is significantly higher compared to other cases.
基金This work was financially supported by the National Key Research and Development Program of China(No.2016YFB0300205)the Youth Innovation Promotion Association CAS(No.2018221).
文摘Copper(Cu)-bearing stainless steel has testified its effectiveness to reduce the risk of bacterial infections.However,its antibacterial mechanism is still controversial.Therefore,three 430 ferritic stainless steels with different Cu contents are selected to conduct deeper research by the way of bacterial inactivation from two aspects of material and biology.Hereinto,electrochemical and antibacterial results show that the increase in Cu content simultaneously improves the corrosion resistance and antibacterial property of 430 stainless steel.In addition,it is found that Escherichia coli(E.coli)on the surface 430 Cu-bearing stainless steel by the dry method of inoculation possesses a rapid inactivation ability.X-ray photoelectron spectroscopy(XPS)aids with ion chelation experiments prove that Cu(Ⅰ)plays a more crucial role in the contact-killing efficiency than Cu(Ⅱ),resulting from more production of reactive oxygen species(ROS).
基金Supported by National Natural Science Foundation of China(11635003,11025524,11161130520)the National Basic Research Program of China(2010CB832903)the European Commissions 7th Framework Programme(FP7-PEOPLE-2010-IRSES)(269131)
文摘The multinucleon transfer reaction in the collisions of 40 Ca+^124 Sn at Ec.m.= 128.5 MeV is investigated using the improved quantum molecular dynamics model. The measured angular distributions and isotopic distributions of the products are reproduced reasonably well by the calculations. The multinucleon transfer reactions of 40 Ca+^112 Sn, 58 Ni+^112 Sn, 106 Cd+^112 Sn, and 48 Ca+^112 Sn are also studied. This demonstrates that the combinations of neutron-deficient projectile and target are advantageous for the production of exotic neutron-deficient nuclei near N,Z =50. The charged particles’ emission plays an important role at small impact parameters in the de-excitation processes of the system. The production cross sections of the exotic neutron-deficient nuclei in multinucleon transfer reactions are much larger than those measured in the fragmentation and fusion-evaporation reactions. Several new neutron-deficient nuclei can be produced in the 106 Cd+^112 Sn reaction. The corresponding production cross sections for the new neutron-deficient nuclei,101,112 Sb,103 Te,and 106,107) I,are 2.0 nb,4.1 nb,6.5 nb,0.4 μb and 1.0 μb,respectively.
文摘Background： Dendritic cells are professional antigen-presenting cells found in an immature state in epithelia and interstitial space, where they capture antigens such as pathogens or damaged tissue. Matrix metallopeptidase 13 （MMP- 13）, a member of the collagenase subfamily, is involved in many different cellular processes and is expressed in murine bone marrow-derived dendritic cells （DCs）. The function of MMP-13 in DCs is not well understood. Here, we investigated the effect of MMP-13 on DC maturation, apoptosis, and phagocytosis. Methods： Bone marrow-derived dendritic cells were obtained fiom C57BL/6 mice. One short-interfering RNA specific for MMP- 13 was used to transfect DCs. MMP-13-silenced DCs and control DCs were prepared, and apoptosis was measured using real-time polymerase chain reaction and Western blotting. MMP-13-silenced DCs and control DCs were analyzed for surface expression of CD80 and CD86 and phagocytosis capability using flow cytometry. Results： Compared to the control DCs, MMP- 13-silenced DCs increased expression of anti-apoptosis-related genes, BAGl （control group vs. MMP-13-silenced group： 4.08 ± 0.60 vs. 6.11 ± 0.87, P = 0.008）, BCL-2 （control group vs. MMP-13-silenced group： 7.54 ± 0.76 vs. 9.54 ± 1.29, P = 0.036）, and TP73 （control group vs. MMP- 13-silenced group： 4.33 ± 0.29 vs. 5.60 ±0.32, P = 0.001 ） and decreased apoptosis-related genes, CASPI （control group vs. MMP- 13-silenced group： 3.79±0.67 vs. 2.54±0.39, P - 0.019）, LTBR （control group vs. MMP- 13-silenced group： 9.23 ±1.25 vs. 6.24 ± 1.15, P = 0.012）, and CASP4 （control group vs. MMP-13-silenced group： 2.07 ± 0.56 vs. 0.35 ±0.35, P = 0.002）. Protein levels confirmed the same expression pattern. MMP- 13-silenced groups decreased expression of CD86 on DCs; however, there was no statistical difference in CD80 surface expression. Furthermore, MMP-13-silenced groups exhibited weaker phagocytosis capability. Conclusion： These results indicate that MMP-13 inhibition dampens DC maturation, apoptosis, and phagocytosis.
