Tertiary alcohols are generally considered difficult to oxidize.However,in this work,it was found that catalyzed by (NH_(4))_(2)Ce(NO_(3))_(6)(CAN)and in the presence of catalytic trifluoroacetic acid(TFA),the selecti...Tertiary alcohols are generally considered difficult to oxidize.However,in this work,it was found that catalyzed by (NH_(4))_(2)Ce(NO_(3))_(6)(CAN)and in the presence of catalytic trifluoroacetic acid(TFA),the selective oxidative C-C bond cleavage of tertiary alcohols could be achieved using O_(2) flow to produce carbonyl compounds.The benefits of this method include the use of simple and inexpensive catalysts,as well as the environmentally friendly nature of the process.This research significantly broadens the scope of alcohol oxidation chemistry.Since alcohol oxidation reactions involving C-C bond cleavage have potential applications as the key unit reaction in certain industrial processes,this finding holds significant promise for organic chemical engineering.展开更多
基金We thank the Cooperation Project of Yangzhou City with Yangzhou University(No.YZ2023209)Jiaxing Key Laboratory for Creation of Animal Models&Synthesis of Lead Compounds of New Drug(No.jxsz21006)Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)for financial support.
文摘Tertiary alcohols are generally considered difficult to oxidize.However,in this work,it was found that catalyzed by (NH_(4))_(2)Ce(NO_(3))_(6)(CAN)and in the presence of catalytic trifluoroacetic acid(TFA),the selective oxidative C-C bond cleavage of tertiary alcohols could be achieved using O_(2) flow to produce carbonyl compounds.The benefits of this method include the use of simple and inexpensive catalysts,as well as the environmentally friendly nature of the process.This research significantly broadens the scope of alcohol oxidation chemistry.Since alcohol oxidation reactions involving C-C bond cleavage have potential applications as the key unit reaction in certain industrial processes,this finding holds significant promise for organic chemical engineering.
