With the gradual end of the coronavirus disease 2019(COVID-19)pandemic,the reconstruction of students’mental health is urgently necessary.Digital interventions offer advantages such as high accessibility,anonymity,an...With the gradual end of the coronavirus disease 2019(COVID-19)pandemic,the reconstruction of students’mental health is urgently necessary.Digital interventions offer advantages such as high accessibility,anonymity,and accurate identification,which can promote the reconstruction of students’mental health through the provision of psychological support platforms,psychological assessment tools,and online mental health activities.However,we recognize that digital interventions must undergo many adjustments,and corresponding ethical norms require further clarification.It is crucial for different stakeholders to collaborate and work toward maximizing the effectiveness of digital interventions for the reconstruction of mental health after the COVID-19 pandemic.展开更多
Ependymal cells line the wall of cerebral ventricles and ensure the unidirectional cerebrospinal fluid(CSF)flow by beating their motile cilia coordinately.The ependymal denudation or ciliary dysfunction causes hydroce...Ependymal cells line the wall of cerebral ventricles and ensure the unidirectional cerebrospinal fluid(CSF)flow by beating their motile cilia coordinately.The ependymal denudation or ciliary dysfunction causes hydrocephalus.Here,we report that the deficiency of regulator of Gprotein signaling 22(RGS22)results in severe congenital hydrocephalus in both mice and rats.Interestingly,RGS22 is specifically expressed in ependymal cells within the brain.Using conditional knock-out mice,we further demonstrate that the deletion of Rgs22 exclusively in nervous system is sufficient to induce hydrocephalus.Mechanistically,we show that Rgs22 deficiency leads to the ependymal denudation and impaired ciliogenesis.This phenomenon can be attributed to the excessive activation of lysophosphatidic acid receptor(LPAR)signaling under Rgs22^(-/-)condition,as the LPAR blockade effectively alleviates hydrocephalus in Rgs22^(-/-)rats.Therefore,our findings unveil a previously unrecognized role of RGS22 in the central nervous system,and present RGS22 as a potential diagnostic and therapeutic target for hydrocephalus.展开更多
Transparent conductive films that are based on nanowire networks are essential to construct flexible,wearable,and even stretchable electronics.However,large-scale precise micropatterning,especially with regard to the ...Transparent conductive films that are based on nanowire networks are essential to construct flexible,wearable,and even stretchable electronics.However,large-scale precise micropatterning,especially with regard to the controllability of the organizing orientation of nanowires,is a critical challenge.Herein,we proposed a liquid film rupture self-assembly approach for manufacturing transparent conductive films with microstructure arrays based on a highly ordered nanowire network.The large-scale microstructure conductive films were fabricated through air-liquid interface self-assembly and liquid film rupture self-assembly.Six typical micropattern morphologies,including square,hexagon,circle,serpentine,etc.,were prepared to reveal the universal applicability of the proposed approach.The homogeneity and controllability of this approach were verified for multiple assemblies.With the assembly cycles increasing,the optical transmittance decreases slightly.In addition,theoretical model analysis is carried out,and the analytical formula of the speed of the film moving with the surface tension and the density of the liquid film is presented.Finally,the feasibility of this approach for piezoresistive strain sensors is verified.This fabrication approach demonstrated a cost-effective and efficient method for precisely arranging nanowires,which is useful in transparent and wearable applications.展开更多
Wearable electronics play a crucial role in advancing the rapid development of artificial intelligence,and as an attractive future vision,all-in-one wearable microsystems integrating powering,sensing,actuating and oth...Wearable electronics play a crucial role in advancing the rapid development of artificial intelligence,and as an attractive future vision,all-in-one wearable microsystems integrating powering,sensing,actuating and other functional components on a single chip have become an appealing tendency.Herein,we propose a wearable thermoelectric generator(ThEG)with a novel double-chain configuration to simultaneously realize sustainable energy harvesting and multi-functional sensing.In contrast to traditional single-chain ThEGs with the sole function of thermal energy harvesting,each individual chain of the developed double-chain thermoelectric generator(DC-ThEG)can be utilized to scavenge heat energy,and moreover,the combination of the two chains can be employed as functional sensing electrodes at the same time.The mature mass-fabrication technology of screen printing was successfully introduced to print n-type and p-type thermoelectric inks atop a polymeric substrate to form thermocouples to construct two independent chains,which makes this DC-ThEG flexible,high-performance and cost-efficient.The emerging material of silk fibroin was employed to cover the gap of the fabricated two chains to serve as a functional layer for sensing the existence of liquid water molecules in the air and the temperature.The powering and sensing functions of the developed DC-ThEG and their interactions were systematically studied via experimental measurements,which proved the DC-ThEG to be a robust multi-functional power source with a 151 mV open-circuit voltage.In addition,it was successfully demonstrated that this DC-ThEG can convert heat energy to achieve a 3.3 V output,matching common power demands of wearable electronics,and harvest biothermal energy to drive commercial electronics(i.e.,a calculator).The integration approach of powering and multi-functional sensing based on this new double-chain configuration might open a new chapter in advanced thermoelectric generators,especially in the applications of all-in-one self-powered microsystems.展开更多
As one of the promising human–machine interfaces,wearable sensors play an important role in modern society,which advances the development of wearable fields,especially in the promising applications of electronic skin...As one of the promising human–machine interfaces,wearable sensors play an important role in modern society,which advances the development of wearable fields,especially in the promising applications of electronic skin(e-skin),robotics,prosthetics,healthcare.In the last decades,wearable sensors tend to be capable of attractive capabilities such as miniaturization,multifunction,smart integration,wearable properties such as lightweight,flexibility,stretchability,conformability for wider applications.In this work,we developed a stretchable multifunctional sensor based on porous silver nanowire/silicone rubber conductive film(P-AgNW/SR).Its unique structural configuration,i.e.,an assembly of the P-AgNW/SR with good conductivity,stability,resistance response,the insulated silicone rubber layer,provided the feasibility for realizing multiple sensing capabilities.Specifically,porous microstructures of the P-AgNW/SR made the device to be used for pressure sensing,exhibiting outstanding dynamic and static resistive responsive behaviors and having a maximum sensitivity of 9.062%∙N^(−1) in a continuous compressive force range of~16 N.With the merit of the good piezoresistive property of AgNW/SR networks embedded into the surface of micropores of the P-AgNW/SR,the device was verified to be a temperature sensor for detecting temperature changes in the human body and environment.The temperature sensor had good sensitivity of 0.844%∙℃^(−1),high linearity of 0.999 in the range of 25–125℃,remarkable dynamic stability.Besides,the developed sensor was demonstrated to be a single electrode-triboelectric sensor for active sensing,owing to the unique assembly of the conductive PAgNW/SR electrode and the silicone rubber friction layer.Based on the coupling effect of the triboelectrification and electrostatic induction,the generated electrical signals could be used to sense the human motions,according to the quantitative correlation between the human motions and the features in amplitude and waveform of the output signals.Thus,the developed stretchable sensor successfully achieved the integration of two types of passive sensing capabilities,i.e.,pressure and temperature sensing,and one type of active sensing capability,i.e.,triboelectric sensing,demonstrating the feasibility of monitoring multiple variables of the human body and environment.展开更多
Wireless sensor network nodes are widely used in wearable devices,consumer electronics,and industrial electronics and are a crucial component of the Internet of Things(IoT).Recently,advanced power technology with sust...Wireless sensor network nodes are widely used in wearable devices,consumer electronics,and industrial electronics and are a crucial component of the Internet of Things(IoT).Recently,advanced power technology with sustainable energy supply and pollution-free characteristics has become a popular research focus.Herein,to realize an unattended and reliable power supply unit suitable for distributed IoT systems,we develop a high-performance triboelectricelectromagnetic hybrid nanogenerator(TEHNG)to harvest mechanical energy.The TEHNG achieves a high load power of 21.8 mW by implementing improvements of material optimization,configuration optimization and pyramid microstructure design.To realize a self-powered integrated microsystem,a power management module,energy storage module,sensing signal processing module,and microcontroller unit are integrated into the TEHNG.Furthermore,an all-in-one wireless multisensing microsystem comprising the TEHNG,the abovementioned integrated functional circuit and three sensors(temperature,pressure,and ultraviolet)is built.The milliwatt microsystem operates continuously with the TEHNG as the only power supply,achieving self-powered operations of sensing environmental variables and transmitting wireless data to a terminal in real time.This shows tremendous application potential in the IoT field.展开更多
基金Supported by the Tianjin Philosophy and Social Science Planning Project“Research on Value-added Evaluation of Career Adaptability for Engineering Students Oriented towards Outstanding Engineers”,No.TJJXQN22-001.
文摘With the gradual end of the coronavirus disease 2019(COVID-19)pandemic,the reconstruction of students’mental health is urgently necessary.Digital interventions offer advantages such as high accessibility,anonymity,and accurate identification,which can promote the reconstruction of students’mental health through the provision of psychological support platforms,psychological assessment tools,and online mental health activities.However,we recognize that digital interventions must undergo many adjustments,and corresponding ethical norms require further clarification.It is crucial for different stakeholders to collaborate and work toward maximizing the effectiveness of digital interventions for the reconstruction of mental health after the COVID-19 pandemic.
基金supported by grants from the China National Natural Science Foundation(82130052 and 81925017 to Tao Li,82001690 to Hong Cai)。
文摘Ependymal cells line the wall of cerebral ventricles and ensure the unidirectional cerebrospinal fluid(CSF)flow by beating their motile cilia coordinately.The ependymal denudation or ciliary dysfunction causes hydrocephalus.Here,we report that the deficiency of regulator of Gprotein signaling 22(RGS22)results in severe congenital hydrocephalus in both mice and rats.Interestingly,RGS22 is specifically expressed in ependymal cells within the brain.Using conditional knock-out mice,we further demonstrate that the deletion of Rgs22 exclusively in nervous system is sufficient to induce hydrocephalus.Mechanistically,we show that Rgs22 deficiency leads to the ependymal denudation and impaired ciliogenesis.This phenomenon can be attributed to the excessive activation of lysophosphatidic acid receptor(LPAR)signaling under Rgs22^(-/-)condition,as the LPAR blockade effectively alleviates hydrocephalus in Rgs22^(-/-)rats.Therefore,our findings unveil a previously unrecognized role of RGS22 in the central nervous system,and present RGS22 as a potential diagnostic and therapeutic target for hydrocephalus.
基金supported by the National Natural Science Foundation of China(Nos.62074029,61905035,61971108,62004029,51905554)the National Key Research and Development Program of China(No.2022YFB3206100)+3 种基金the Key R&D Program of Sichuan Province(Nos.2022JDTD0020,2020ZHCG0038)the Sichuan Science and Technology Program(Nos.2020JDJQ0036,2019YJ0198,2020YJ0015)the Natural Science Foundation of Sichuan(No.2022NSFSC1941)the Fundamental Research Funds for the Central Universities(No.ZYGX2019Z002).
文摘Transparent conductive films that are based on nanowire networks are essential to construct flexible,wearable,and even stretchable electronics.However,large-scale precise micropatterning,especially with regard to the controllability of the organizing orientation of nanowires,is a critical challenge.Herein,we proposed a liquid film rupture self-assembly approach for manufacturing transparent conductive films with microstructure arrays based on a highly ordered nanowire network.The large-scale microstructure conductive films were fabricated through air-liquid interface self-assembly and liquid film rupture self-assembly.Six typical micropattern morphologies,including square,hexagon,circle,serpentine,etc.,were prepared to reveal the universal applicability of the proposed approach.The homogeneity and controllability of this approach were verified for multiple assemblies.With the assembly cycles increasing,the optical transmittance decreases slightly.In addition,theoretical model analysis is carried out,and the analytical formula of the speed of the film moving with the surface tension and the density of the liquid film is presented.Finally,the feasibility of this approach for piezoresistive strain sensors is verified.This fabrication approach demonstrated a cost-effective and efficient method for precisely arranging nanowires,which is useful in transparent and wearable applications.
基金This work is financially supported by the National Natural Science Foundation of China(No.61804023)the Key R&D Program of Sichuan Province(No.2018GZ0527)+1 种基金the Sichuan Science and Technology Program(2019YJ0198)the Fundamental Research Funds for the Central Universities(No.ZYGX2019Z002).
文摘Wearable electronics play a crucial role in advancing the rapid development of artificial intelligence,and as an attractive future vision,all-in-one wearable microsystems integrating powering,sensing,actuating and other functional components on a single chip have become an appealing tendency.Herein,we propose a wearable thermoelectric generator(ThEG)with a novel double-chain configuration to simultaneously realize sustainable energy harvesting and multi-functional sensing.In contrast to traditional single-chain ThEGs with the sole function of thermal energy harvesting,each individual chain of the developed double-chain thermoelectric generator(DC-ThEG)can be utilized to scavenge heat energy,and moreover,the combination of the two chains can be employed as functional sensing electrodes at the same time.The mature mass-fabrication technology of screen printing was successfully introduced to print n-type and p-type thermoelectric inks atop a polymeric substrate to form thermocouples to construct two independent chains,which makes this DC-ThEG flexible,high-performance and cost-efficient.The emerging material of silk fibroin was employed to cover the gap of the fabricated two chains to serve as a functional layer for sensing the existence of liquid water molecules in the air and the temperature.The powering and sensing functions of the developed DC-ThEG and their interactions were systematically studied via experimental measurements,which proved the DC-ThEG to be a robust multi-functional power source with a 151 mV open-circuit voltage.In addition,it was successfully demonstrated that this DC-ThEG can convert heat energy to achieve a 3.3 V output,matching common power demands of wearable electronics,and harvest biothermal energy to drive commercial electronics(i.e.,a calculator).The integration approach of powering and multi-functional sensing based on this new double-chain configuration might open a new chapter in advanced thermoelectric generators,especially in the applications of all-in-one self-powered microsystems.
基金the National Natural Science Foundation of China(Nos.62074029,61905035,61971108,62004029,and 51905554)the Key Research and Development Program of Sichuan Province(Nos.2022JDTD0020,2022YFG0163,and 2020ZHCG0038)+1 种基金the Sichuan Science and Technology Program(No.2020YJ0015)the Fundamental Research Funds for the Central Universities(No.ZYGX2019Z002).
文摘As one of the promising human–machine interfaces,wearable sensors play an important role in modern society,which advances the development of wearable fields,especially in the promising applications of electronic skin(e-skin),robotics,prosthetics,healthcare.In the last decades,wearable sensors tend to be capable of attractive capabilities such as miniaturization,multifunction,smart integration,wearable properties such as lightweight,flexibility,stretchability,conformability for wider applications.In this work,we developed a stretchable multifunctional sensor based on porous silver nanowire/silicone rubber conductive film(P-AgNW/SR).Its unique structural configuration,i.e.,an assembly of the P-AgNW/SR with good conductivity,stability,resistance response,the insulated silicone rubber layer,provided the feasibility for realizing multiple sensing capabilities.Specifically,porous microstructures of the P-AgNW/SR made the device to be used for pressure sensing,exhibiting outstanding dynamic and static resistive responsive behaviors and having a maximum sensitivity of 9.062%∙N^(−1) in a continuous compressive force range of~16 N.With the merit of the good piezoresistive property of AgNW/SR networks embedded into the surface of micropores of the P-AgNW/SR,the device was verified to be a temperature sensor for detecting temperature changes in the human body and environment.The temperature sensor had good sensitivity of 0.844%∙℃^(−1),high linearity of 0.999 in the range of 25–125℃,remarkable dynamic stability.Besides,the developed sensor was demonstrated to be a single electrode-triboelectric sensor for active sensing,owing to the unique assembly of the conductive PAgNW/SR electrode and the silicone rubber friction layer.Based on the coupling effect of the triboelectrification and electrostatic induction,the generated electrical signals could be used to sense the human motions,according to the quantitative correlation between the human motions and the features in amplitude and waveform of the output signals.Thus,the developed stretchable sensor successfully achieved the integration of two types of passive sensing capabilities,i.e.,pressure and temperature sensing,and one type of active sensing capability,i.e.,triboelectric sensing,demonstrating the feasibility of monitoring multiple variables of the human body and environment.
基金This work is financially supported by the National Natural Science Foundation of China(No.62074029,No.61804023,No.61971108)the National Key Research and Development Program of China(No.2022YFB3206100)+3 种基金the Key R&D Program of Sichuan Province(No.2022JDTD0020,No.2020ZHCG0038)the Sichuan Science and Technology Program(No.2020YJ0015)the Fundamental Research Funds for the Central Universities(No.ZYGX2019Z002)D.-L.W.and P.H.contributed equally to this work.
文摘Wireless sensor network nodes are widely used in wearable devices,consumer electronics,and industrial electronics and are a crucial component of the Internet of Things(IoT).Recently,advanced power technology with sustainable energy supply and pollution-free characteristics has become a popular research focus.Herein,to realize an unattended and reliable power supply unit suitable for distributed IoT systems,we develop a high-performance triboelectricelectromagnetic hybrid nanogenerator(TEHNG)to harvest mechanical energy.The TEHNG achieves a high load power of 21.8 mW by implementing improvements of material optimization,configuration optimization and pyramid microstructure design.To realize a self-powered integrated microsystem,a power management module,energy storage module,sensing signal processing module,and microcontroller unit are integrated into the TEHNG.Furthermore,an all-in-one wireless multisensing microsystem comprising the TEHNG,the abovementioned integrated functional circuit and three sensors(temperature,pressure,and ultraviolet)is built.The milliwatt microsystem operates continuously with the TEHNG as the only power supply,achieving self-powered operations of sensing environmental variables and transmitting wireless data to a terminal in real time.This shows tremendous application potential in the IoT field.
