As a potential adsorption material,it is still a challenge for activated carbon fiber(ACF)in efficient adsorption of ethanol due to its nonpolar surface,which is mainly emitted from the grain drying industry.This stud...As a potential adsorption material,it is still a challenge for activated carbon fiber(ACF)in efficient adsorption of ethanol due to its nonpolar surface,which is mainly emitted from the grain drying industry.This study prepared surface polarity-modified ACF using the heteroatom doping method.The modified ACF possessed a richer array of strongly polar oxygen/nitrogen-containing functional groups(primarily phenolic hydroxyl and lactone groups),a larger specific surface are1,and a more developed micropore structure.The adsorption capacities of ethanol for O-ACF and N-ACF were 4.110 mmol/g and 1.698 mmol/g,respectively,which were 11.3 times and 4.7 times those of unmodified ACF.This was a significant improvement over our previous work(0.363 mmol/g).The improvement of adsorption capacity for the N-ACF was mainly due to the higher specific surface are1,greater number of micropores(more adsorption sites)and abundant existence of defects,whereas,for O-ACF,the improvement mainly relied on the abundant presence of oxygen-containing functional groups on the surface.However,water had a negative effect on the adsorption of ethanol for the modified ACF due to competitive adsorption and the disappearance of capillary condensation.It was further revealed that the adsorption process of ethanol and water was quite different.It obeyed the linear driving force(LDF)model for ethanol adsorption,however,the intraparticle diffusion(IPD)model for water adsorption.展开更多
Objectives:Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia and Philadelphia-like B-cell acute lymphoblastic leukemia(Ph+/Ph-like ALL)constitute the majority of relapsed/refractory B-ALL(R/R B-ALL)...Objectives:Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia and Philadelphia-like B-cell acute lymphoblastic leukemia(Ph+/Ph-like ALL)constitute the majority of relapsed/refractory B-ALL(R/R B-ALL)cases,highlighting an urgent need to discover new therapeutic targets.This study aims to elucidate the mechanisms underlying poor prognosis in Ph+/Ph-like ALL through transcriptome sequencing and functional cytological assays,with the goal of informing new clinical treatment strategies.Results:Transcriptomic analysis of Ph+/Ph-like ALL patients revealed that low expression of P2X Purinoceptor 1(P2RX1)was associated with unfavorable outcomes.Specifically,patients with poor prognosis and low P2RX1 expression exhibited downregulation of genes involved in energy and calcium metabolism pathways,along with upregulation of genes governing key cellular processes such as cell proliferation(e.g.,MYC),cell cycle progression(e.g.,CCND2),and apoptosis inhibition(e.g.,DASP6).Cellular experiments demonstrated that SUP-B15 cells overexpressing P2RX1 displayed elevated intracellular levels of ATP,calcium,and glucose,together with enhanced glycolytic capacity,compared to empty vector controls.Treatment of SUP-B15 cells with dexamethasone(Dex),Imatinib,or their combination significantly suppressed proliferation and promoted apoptosis,which was accompanied by increases in intracellular ATP,calcium,and glucose.Moreover,exogenous ATP administration(a P2RX1 agonist)enhanced apoptosis and inhibited proliferation in control cells.Conversely,treatment with NF449(a P2RX1 inhibitor)increased proliferation in both P2RX1-overexpressing and control SUP-B15 cells.Conclusion:Our findings indicate that P2RX1 may exert this function through modulating energy metabolism and calcium homeostasis,resulting in elevated intracellular calcium levels.Sustained elevation of calcium promotes apoptosis,whereas exogenous ATP activates P2RX1,enhances calcium influx,and attenuates the suppression of apoptosis associated with P2RX1 underexpression,ultimately correlating with improved treatment response.展开更多
As the wall rock of the Aketas gold deposit,the Aketas granite is about 45 km away from Fuyun County, Xinjiang Province. The zircon weighted mean U–Pb age of the Aketas granite is 309.0 ± 4.7 Ma, indicating that...As the wall rock of the Aketas gold deposit,the Aketas granite is about 45 km away from Fuyun County, Xinjiang Province. The zircon weighted mean U–Pb age of the Aketas granite is 309.0 ± 4.7 Ma, indicating that the Aketas granite was emplaced during the late Carboniferous. The Aketas granite belongs to the High-K calcalkaline series, with Si O2 content from 63.00 to 68.20 %,K2 O content from 3.06 to 4.49 % and Na2 O content from4.14 to 6.02 %. The Alkaline Ratio(AR) of the Aketas granite is high, from 1.89 to 3.47, and is 2.95 on average.The Aketas granite has lowPREE(92.42–122.73 ppm)and highPLREE/PHREE ratios(6.54–11.88). For the trace elements, the Aketas granite is enriched in LILE(Rb,U, Th, K) and incompatible elements, and marked depleted in HFSE(Nb, Ta, P, Ti). The geochemical characteristics of the Aketas granite suggest that it is a typical I-type and volcanic arc granite, and that the crystallization of clinopyroxene and hornblende is notable during the magmatic evolution. In combination with the regional tectonic studies, we propose that the emplacement of the Aketas granite implies the Altai and East Junggar area was still dominated by a subduction system at *309 Ma.展开更多
BACKGROUND： Experimental data indicate that human growth-associated protein 43 mRNA expression coincides with axonal growth during nerve ganglion development; while neurocan, secreted from astrocytes, can inhibit spr...BACKGROUND： Experimental data indicate that human growth-associated protein 43 mRNA expression coincides with axonal growth during nerve ganglion development; while neurocan, secreted from astrocytes, can inhibit sprouting and elongation of the axonal growth cone. OBJECTIVE： To verify regulatory effects of cyclovirobuxine D （CVB-D） extracted from Chinese box branchlet on human growth-associated protein 43 （GAP-43）, and neurocan expression in brain tissue of stroke-prone renovascular hypertensive （RHRSP） rats, at different time points after cerebral ischemia/reperfusion. DESIGN： Randomized grouping design and controlled animal study. SETTING： This study was performed at the Center of Guangdong Hospital of Traditional Chinese Medicine （a national key laboratory） from March 2003 to September 2006. MATERIALS： 100 healthy male Sprague-Dawley rats, aged 2 3 months and weighing 90-120 g, were selected for this study. CVB-D was provided by Nanjing Xiaoying Pharmaceutical Factory （Batch number： 307701）. METHODS： The initial tip of renal arteries was clamped bilaterally for 10 weeks to establish the RHRSP model. 100 RHRSP rats were randomly divided into 4 groups： naive group （n = 10）, sham surgery group （n = 10）, CVB-D group （n = 40）, and lesion group （n = 40）. Rats in the naive group did not undergo any treatment, and cervical vessels of rats in the sham surgery group were exposed, but not blocked. The right middle cerebral artery of rats in the CVB-D group and lesion group were occluded to establish cerebral ischemia. Rats in the CVB-D group were intraperitoneally injected with CVB-D （6.48 mg/kg） every day and with saline （1.5 mL/injection） twice a day. Rats in the lesion group were intraperitoneally injected with saline （2 mL/injection）. MAIN OUTCOME MEASURES： Immunohistochemistry was applied to detect GAP-43 and neurocan expression in the ischemic penumbra region of CVB-D and lesion brains at 2 hours post-cerebral ischemia and at 1, 7, 14, and 30 days post-perfusion （n = 10 at each time point）. Similarly, GAP-43 and neurocan expression was detected in the right hemisphere of naive and sham-operated animals. The results were expressed as positive cells. RESULTS： A total of 100 rats were included in the final analysis. The number of GAP-43 positive cells increased in the CVB-D group 1, 7, 14, and 30 days post-cerebral ischemia/perfusion compared to the lesion group, as indicated by a significant difference between the CVB-D and lesion group （P 〈 0.054）.01）. The number of neurocan-positive cells decreased in the CVB-D group on the first day compared to the model group; however, there was no significant difference between the two groups （P 〉 0.05）. On post-ischemia days 7, 14, and 30, the number of neurocan-positive cells in the CVB-D group was significantly less than in the lesion group （P 〈 0.05）. Both, GAP-43 and neurocan expression was not detectable in brains of naive and sham-operated animals. CONCLUSION： CVB-D treatment up-regulated GAP-43 expression and down-regulated neurocan expression in the ischemic region of RHRSP rats.展开更多
Background: Aging-induced cardiac hypertrophy and reduced skeletal muscle strength contribute to increased disease risk and life burden in the elderly. FNDC5 acts as a protective muscle factor in both cardiac and skel...Background: Aging-induced cardiac hypertrophy and reduced skeletal muscle strength contribute to increased disease risk and life burden in the elderly. FNDC5 acts as a protective muscle factor in both cardiac and skeletal muscle. This study aims to examine the relationship between cardiac FNDC5 and aging-related cardiac hypertrophy and decreased skeletal muscle strength. Methods: Male young C57BL/6 mice (5 months old, n = 6) and aged mice (21 months old, n = 6) were utilized in the study and housed in a specific pathogen-free (SPF) environment. Prior to the experiment, grip strength tests were performed on the mice, and heart tissues were collected for morphological analysis, including the assessment of peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α) and fibronectin type III-containing structural domain 5 (FNDC5) protein levels. Furthermore, myosin heavy chain II (MyHC II), skeletal muscle-specific transcription factor (MyoD), muscle RING-finger protein-1 (MuRF1), and FNDC5 levels were evaluated in the quadriceps muscle. The correlations between heart weight and FNDC5 expression levels, as well as skeletal muscle indices in the mice, were subsequently analyzed. Result: Aging leads to cardiac hypertrophy and reduced expression of PGC-1α and FNDC5 proteins. Concurrently, there is a decline in the strength of skeletal muscle, along with decreased expression of MyHC II and increased expression of MURF1 and MyoD. Correlation analysis demonstrated strong positive associations between myocardial FNDC5 protein levels and limb grip strength, as well as MyHC II, and strong negative associations with MyoD and MuRF1. Conclusion: There may be a significant association between aging-induced cardiac hypertrophy and decreased skeletal muscle strength, with FNDC5 potentially playing a crucial role as a regulatory molecule facilitating communication between the heart and skeletal muscle.展开更多
Photonic neural networks have garnered significant attention in recent years due to their ultra-high computational speed,broad bandwidth,and parallel processing capabilities.However,compared to conventional electronic...Photonic neural networks have garnered significant attention in recent years due to their ultra-high computational speed,broad bandwidth,and parallel processing capabilities.However,compared to conventional electronic nonlinear activa-tion function(NAF),progress on efficient and easily implementable optical nonlinear activation function(ONAF)was barely reported.To address this issue,we proposed a programmable,low-loss ONAF device based on a silicon micro-ring resonator capped with the Antimony selenide(Sb_(2)Se_(3))thin films,and with indium tin oxide(ITO)used as the microheater.Leveraging our self-developed phase-transformation kinetic and optical models,we successfully simulated the phase-transition behavior of Sb_(2)Se_(3)and three different ONAFs—ELU,ReLU,and radial basis function(RBF)were achieved according to discernible optical responses of proposed devices under different phase-change extents.Classification results from the Fashion MNIST dataset demonstrated that these ONAFs can be considered as appropriate substitutes for traditional NAF.This indicated the bright prospect of the proposed device for nonlinear activation function in future photonic neural networks.展开更多
Large-scale deployment of carbon dioxide(CO_(2))removal technology is an essential step to cope with global warming and achieve carbon neutrality.Direct air capture(DAC)has recently received increasing attention given...Large-scale deployment of carbon dioxide(CO_(2))removal technology is an essential step to cope with global warming and achieve carbon neutrality.Direct air capture(DAC)has recently received increasing attention given the high flexibility to remove CO_(2)from discrete sources.Porous materials with adjustable pore characteristics are promising sorbents with low or no latent heat of vaporization.This review article has summarized the recent development of porous sorbents for DAC,with a focus of pore engineering strategy and adsorption mechanism.Physisorbents such as zeolites,porous carbons,metal-organic frameworks(MOFs),and amine-modified chemisorbents have been discussed and their challenges in practical application have been analyzed.At last,future directions have been proposed,and it is expected to inspire collaborations from chemistry,environment,material science and engineering communities.展开更多
Discrete fracture network(DFN)commonly existing in natural rock masses plays an important role in geological complexity which can influence rock fracturing behaviour during fluid injection.This paper simulated the hyd...Discrete fracture network(DFN)commonly existing in natural rock masses plays an important role in geological complexity which can influence rock fracturing behaviour during fluid injection.This paper simulated the hydraulic fracturing process in lab-scale coal samples with DFNs and the induced seismic activities by the discrete element method(DEM).The effects of DFNs on hydraulic fracturing,induced seismicity and elastic property changes have been concluded.Denser DFNs can comprehensively decrease the peak injection pressure and injection duration.The proportion of strong seismic events increases first and then decreases with increasing DFN density.In addition,the relative modulus of the rock mass is derived innovatively from breakdown pressure,breakdown fracture length and the related initiation time.Increasing DFN densities among large(35–60 degrees)and small(0–30 degrees)fracture dip angles show opposite evolution trends in relative modulus.The transitional point(dip angle)for the opposite trends is also proportionally affected by the friction angle of the rock mass.The modelling results have much practical meaning to infer the density and geometry of pre-existing fractures and the elastic property of rock mass in the field,simply based on the hydraulic fracturing and induced seismicity monitoring data.展开更多
The good combination of mechanical and wear properties for cemented carbides is crucial.In this work,the wear behavior of functionally graded cemented carbide(FGCC)and non-graded cemented carbide(CC),with CoNiFeCr mul...The good combination of mechanical and wear properties for cemented carbides is crucial.In this work,the wear behavior of functionally graded cemented carbide(FGCC)and non-graded cemented carbide(CC),with CoNiFeCr multi-principal-element alloy(MPEA)binder,has been investigated by performing sliding wear tests and composition characterization.The results showed that compared with CC,FGCC had higher hardness,stronger fracture toughness,better wear performance,and similar TRS.FGCCs exhibited lower wear rates(3.44×10^(−7)–6.95×10^(−6)mm^(3)/(N m))and coefficients of friction(COFs)(0.27–0.39)than CCs from RT to 600℃due to mitigation of multiple risks caused by binder removal,fragmentation and pull-out of WC grains,high-temperature oxidation and softening.In the low-temperature wear stage,the MPEA binder underwent dynamic recrystallization(DRX)and twinning deformation before removing from the surface.The binder removal caused dislocation pile-ups and stacking faults(SFs)to form under high stress,resulting in fragmentation and pull-out of WC grains.The low-temperature wear was dominated by abrasive wear and adhesive wear,with a low wear rate and a high and unstable COF.In the high-temperature wear stage,initial pitting oxidation of WC grains generated many subgrain boundaries,reducing heat transfer and exacerbating oxidation,resulting in an oxide layer enriched with WO3,Mx Oy,and MWO4.High-temperature wear was dominated by oxidation wear and high-temperature softening,with a high wear rate and a low and smooth COF.The results from the present study do not only provide theoretical guidance for an understanding of the antiwear mechanism of WC-CoNiFeCr,but also a new approach for the preparation of cemented carbides with high wear resistance.展开更多
Manganese(Mn)has been characterized as an environmental pollutant.Excessive releases of Mn due to human activities have increased Mn levels in the environment over the years,posing a threat to human health and the env...Manganese(Mn)has been characterized as an environmental pollutant.Excessive releases of Mn due to human activities have increased Mn levels in the environment over the years,posing a threat to human health and the environment.Long-term exposure to high concentrations of Mn can induce neurotoxicity.Therefore,toxicological studies on Mn are of paramount importance.Mn induces oxidative stress through affecting the level of reactive oxygen species(ROS),and the overabundance of ROS further triggers ferroptosis.Additionally,Mn^(2+) was found to be a novel activator of the cyclic guanosine-adenosine synthase(cGAS)−stimulator of interferon genes(STING)pathway in the innateimmune system.Thus,we speculate thatMn exposuremay promote ROS production by activating the cGAS−STING pathway,which further induces oxidative stress and ferroptosis,and ultimately triggers Mn neurotoxicity.This review discusses the mechanism between Mn-induced oxidative stress and ferroptosis via activation of the cGAS−STING pathway,which may offer a prospective direction for future in-depth studies on the mechanism of Mn neurotoxicity.展开更多
Karst fractures serve as crucial seepage channels and storage spaces for carbonate natural gas reservoirs,and electrical image logs are vital data for visualizing and characterizing such fractures.However,the conventi...Karst fractures serve as crucial seepage channels and storage spaces for carbonate natural gas reservoirs,and electrical image logs are vital data for visualizing and characterizing such fractures.However,the conventional approach of identifying fractures using electrical image logs predominantly relies on manual processes that are not only time-consuming but also highly subjective.In addition,the heterogeneity and strong dissolution tendency of karst carbonate reservoirs lead to complexity and variety in fracture geometry,which makes it difficult to accurately identify fractures.In this paper,the electrical image logs network(EILnet)da deep-learning-based intelligent semantic segmentation model with a selective attention mechanism and selective feature fusion moduledwas created to enable the intelligent identification and segmentation of different types of fractures through electrical logging images.Data from electrical image logs representing structural and induced fractures were first selected using the sliding window technique before image inpainting and data augmentation were implemented for these images to improve the generalizability of the model.Various image-processing tools,including the bilateral filter,Laplace operator,and Gaussian low-pass filter,were also applied to the electrical logging images to generate a multi-attribute dataset to help the model learn the semantic features of the fractures.The results demonstrated that the EILnet model outperforms mainstream deep-learning semantic segmentation models,such as Fully Convolutional Networks(FCN-8s),U-Net,and SegNet,for both the single-channel dataset and the multi-attribute dataset.The EILnet provided significant advantages for the single-channel dataset,and its mean intersection over union(MIoU)and pixel accuracy(PA)were 81.32%and 89.37%,respectively.In the case of the multi-attribute dataset,the identification capability of all models improved to varying degrees,with the EILnet achieving the highest MIoU and PA of 83.43%and 91.11%,respectively.Further,applying the EILnet model to various blind wells demonstrated its ability to provide reliable fracture identification,thereby indicating its promising potential applications.展开更多
基金supported by the National Key R&D Program of China(Nos.2022YFB4101500 and 2022YFE0209500)the National Natural Science Foundation of China(Nos.22276191 and 21976177)the Qinghai Province Air Pollution Assessment and Fine Management Support Project,and the University of Chinese Academy of Science.
文摘As a potential adsorption material,it is still a challenge for activated carbon fiber(ACF)in efficient adsorption of ethanol due to its nonpolar surface,which is mainly emitted from the grain drying industry.This study prepared surface polarity-modified ACF using the heteroatom doping method.The modified ACF possessed a richer array of strongly polar oxygen/nitrogen-containing functional groups(primarily phenolic hydroxyl and lactone groups),a larger specific surface are1,and a more developed micropore structure.The adsorption capacities of ethanol for O-ACF and N-ACF were 4.110 mmol/g and 1.698 mmol/g,respectively,which were 11.3 times and 4.7 times those of unmodified ACF.This was a significant improvement over our previous work(0.363 mmol/g).The improvement of adsorption capacity for the N-ACF was mainly due to the higher specific surface are1,greater number of micropores(more adsorption sites)and abundant existence of defects,whereas,for O-ACF,the improvement mainly relied on the abundant presence of oxygen-containing functional groups on the surface.However,water had a negative effect on the adsorption of ethanol for the modified ACF due to competitive adsorption and the disappearance of capillary condensation.It was further revealed that the adsorption process of ethanol and water was quite different.It obeyed the linear driving force(LDF)model for ethanol adsorption,however,the intraparticle diffusion(IPD)model for water adsorption.
基金supported by Guangdong Province Basic and Applied Basic Research Fund Project(2023A1515220104)Open Fund of Key Laboratory of Hepatoaplenic Surgery,Ministry of Education(Award Number:GPKF202407).
文摘Objectives:Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia and Philadelphia-like B-cell acute lymphoblastic leukemia(Ph+/Ph-like ALL)constitute the majority of relapsed/refractory B-ALL(R/R B-ALL)cases,highlighting an urgent need to discover new therapeutic targets.This study aims to elucidate the mechanisms underlying poor prognosis in Ph+/Ph-like ALL through transcriptome sequencing and functional cytological assays,with the goal of informing new clinical treatment strategies.Results:Transcriptomic analysis of Ph+/Ph-like ALL patients revealed that low expression of P2X Purinoceptor 1(P2RX1)was associated with unfavorable outcomes.Specifically,patients with poor prognosis and low P2RX1 expression exhibited downregulation of genes involved in energy and calcium metabolism pathways,along with upregulation of genes governing key cellular processes such as cell proliferation(e.g.,MYC),cell cycle progression(e.g.,CCND2),and apoptosis inhibition(e.g.,DASP6).Cellular experiments demonstrated that SUP-B15 cells overexpressing P2RX1 displayed elevated intracellular levels of ATP,calcium,and glucose,together with enhanced glycolytic capacity,compared to empty vector controls.Treatment of SUP-B15 cells with dexamethasone(Dex),Imatinib,or their combination significantly suppressed proliferation and promoted apoptosis,which was accompanied by increases in intracellular ATP,calcium,and glucose.Moreover,exogenous ATP administration(a P2RX1 agonist)enhanced apoptosis and inhibited proliferation in control cells.Conversely,treatment with NF449(a P2RX1 inhibitor)increased proliferation in both P2RX1-overexpressing and control SUP-B15 cells.Conclusion:Our findings indicate that P2RX1 may exert this function through modulating energy metabolism and calcium homeostasis,resulting in elevated intracellular calcium levels.Sustained elevation of calcium promotes apoptosis,whereas exogenous ATP activates P2RX1,enhances calcium influx,and attenuates the suppression of apoptosis associated with P2RX1 underexpression,ultimately correlating with improved treatment response.
基金financially supported by the Mineral Prospecting and Assessment project, CGS (1212011085020)the National Nature Science Foundation of China (40972066)
文摘As the wall rock of the Aketas gold deposit,the Aketas granite is about 45 km away from Fuyun County, Xinjiang Province. The zircon weighted mean U–Pb age of the Aketas granite is 309.0 ± 4.7 Ma, indicating that the Aketas granite was emplaced during the late Carboniferous. The Aketas granite belongs to the High-K calcalkaline series, with Si O2 content from 63.00 to 68.20 %,K2 O content from 3.06 to 4.49 % and Na2 O content from4.14 to 6.02 %. The Alkaline Ratio(AR) of the Aketas granite is high, from 1.89 to 3.47, and is 2.95 on average.The Aketas granite has lowPREE(92.42–122.73 ppm)and highPLREE/PHREE ratios(6.54–11.88). For the trace elements, the Aketas granite is enriched in LILE(Rb,U, Th, K) and incompatible elements, and marked depleted in HFSE(Nb, Ta, P, Ti). The geochemical characteristics of the Aketas granite suggest that it is a typical I-type and volcanic arc granite, and that the crystallization of clinopyroxene and hornblende is notable during the magmatic evolution. In combination with the regional tectonic studies, we propose that the emplacement of the Aketas granite implies the Altai and East Junggar area was still dominated by a subduction system at *309 Ma.
基金the grants from Guangdong Province Administration of Traditional Chinese Medicine, No.103142
文摘BACKGROUND： Experimental data indicate that human growth-associated protein 43 mRNA expression coincides with axonal growth during nerve ganglion development; while neurocan, secreted from astrocytes, can inhibit sprouting and elongation of the axonal growth cone. OBJECTIVE： To verify regulatory effects of cyclovirobuxine D （CVB-D） extracted from Chinese box branchlet on human growth-associated protein 43 （GAP-43）, and neurocan expression in brain tissue of stroke-prone renovascular hypertensive （RHRSP） rats, at different time points after cerebral ischemia/reperfusion. DESIGN： Randomized grouping design and controlled animal study. SETTING： This study was performed at the Center of Guangdong Hospital of Traditional Chinese Medicine （a national key laboratory） from March 2003 to September 2006. MATERIALS： 100 healthy male Sprague-Dawley rats, aged 2 3 months and weighing 90-120 g, were selected for this study. CVB-D was provided by Nanjing Xiaoying Pharmaceutical Factory （Batch number： 307701）. METHODS： The initial tip of renal arteries was clamped bilaterally for 10 weeks to establish the RHRSP model. 100 RHRSP rats were randomly divided into 4 groups： naive group （n = 10）, sham surgery group （n = 10）, CVB-D group （n = 40）, and lesion group （n = 40）. Rats in the naive group did not undergo any treatment, and cervical vessels of rats in the sham surgery group were exposed, but not blocked. The right middle cerebral artery of rats in the CVB-D group and lesion group were occluded to establish cerebral ischemia. Rats in the CVB-D group were intraperitoneally injected with CVB-D （6.48 mg/kg） every day and with saline （1.5 mL/injection） twice a day. Rats in the lesion group were intraperitoneally injected with saline （2 mL/injection）. MAIN OUTCOME MEASURES： Immunohistochemistry was applied to detect GAP-43 and neurocan expression in the ischemic penumbra region of CVB-D and lesion brains at 2 hours post-cerebral ischemia and at 1, 7, 14, and 30 days post-perfusion （n = 10 at each time point）. Similarly, GAP-43 and neurocan expression was detected in the right hemisphere of naive and sham-operated animals. The results were expressed as positive cells. RESULTS： A total of 100 rats were included in the final analysis. The number of GAP-43 positive cells increased in the CVB-D group 1, 7, 14, and 30 days post-cerebral ischemia/perfusion compared to the lesion group, as indicated by a significant difference between the CVB-D and lesion group （P 〈 0.054）.01）. The number of neurocan-positive cells decreased in the CVB-D group on the first day compared to the model group; however, there was no significant difference between the two groups （P 〉 0.05）. On post-ischemia days 7, 14, and 30, the number of neurocan-positive cells in the CVB-D group was significantly less than in the lesion group （P 〈 0.05）. Both, GAP-43 and neurocan expression was not detectable in brains of naive and sham-operated animals. CONCLUSION： CVB-D treatment up-regulated GAP-43 expression and down-regulated neurocan expression in the ischemic region of RHRSP rats.
文摘Background: Aging-induced cardiac hypertrophy and reduced skeletal muscle strength contribute to increased disease risk and life burden in the elderly. FNDC5 acts as a protective muscle factor in both cardiac and skeletal muscle. This study aims to examine the relationship between cardiac FNDC5 and aging-related cardiac hypertrophy and decreased skeletal muscle strength. Methods: Male young C57BL/6 mice (5 months old, n = 6) and aged mice (21 months old, n = 6) were utilized in the study and housed in a specific pathogen-free (SPF) environment. Prior to the experiment, grip strength tests were performed on the mice, and heart tissues were collected for morphological analysis, including the assessment of peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α) and fibronectin type III-containing structural domain 5 (FNDC5) protein levels. Furthermore, myosin heavy chain II (MyHC II), skeletal muscle-specific transcription factor (MyoD), muscle RING-finger protein-1 (MuRF1), and FNDC5 levels were evaluated in the quadriceps muscle. The correlations between heart weight and FNDC5 expression levels, as well as skeletal muscle indices in the mice, were subsequently analyzed. Result: Aging leads to cardiac hypertrophy and reduced expression of PGC-1α and FNDC5 proteins. Concurrently, there is a decline in the strength of skeletal muscle, along with decreased expression of MyHC II and increased expression of MURF1 and MyoD. Correlation analysis demonstrated strong positive associations between myocardial FNDC5 protein levels and limb grip strength, as well as MyHC II, and strong negative associations with MyoD and MuRF1. Conclusion: There may be a significant association between aging-induced cardiac hypertrophy and decreased skeletal muscle strength, with FNDC5 potentially playing a crucial role as a regulatory molecule facilitating communication between the heart and skeletal muscle.
基金supported by the National Natural Science Foundation of China(Grant Nos.62104114,62404111)Natural Science Foundation of Jiangsu Province(Grant Nos.BK20240635,BZ2021031)+4 种基金Opening Project of Advanced Integrated Circuit Package and Testing Research Center of Jiangsu Province(Grant No.NTIKFJJ202303)Natural Science Foundation of the Jiangsu Higher Education Institutions of China(Grant No.24KJB510025)Natural Science Research Start-up Foundation of Recruiting Talents of Nanjing University of Posts and Telecommunications(Grant Nos.NY223157,NY223156)Natural Science Foundation of Nanjing University of Posts and Telecommunications(Grant No.NY224140)Project funded by China Postdoctoral Science Foundation(Grant No.2023M732916).
文摘Photonic neural networks have garnered significant attention in recent years due to their ultra-high computational speed,broad bandwidth,and parallel processing capabilities.However,compared to conventional electronic nonlinear activa-tion function(NAF),progress on efficient and easily implementable optical nonlinear activation function(ONAF)was barely reported.To address this issue,we proposed a programmable,low-loss ONAF device based on a silicon micro-ring resonator capped with the Antimony selenide(Sb_(2)Se_(3))thin films,and with indium tin oxide(ITO)used as the microheater.Leveraging our self-developed phase-transformation kinetic and optical models,we successfully simulated the phase-transition behavior of Sb_(2)Se_(3)and three different ONAFs—ELU,ReLU,and radial basis function(RBF)were achieved according to discernible optical responses of proposed devices under different phase-change extents.Classification results from the Fashion MNIST dataset demonstrated that these ONAFs can be considered as appropriate substitutes for traditional NAF.This indicated the bright prospect of the proposed device for nonlinear activation function in future photonic neural networks.
基金financial support from the National Natural Science Foundation of China(Nos.22278011,22225803,22038001 and 22108007)Beijing Natural Science Foundation(No.Z230023)+1 种基金The Science&Technology Project of Beijing Municipal Education Committee(No.KZ201810005004)Beijing Nova Program(No.Z211100002121094)。
文摘Large-scale deployment of carbon dioxide(CO_(2))removal technology is an essential step to cope with global warming and achieve carbon neutrality.Direct air capture(DAC)has recently received increasing attention given the high flexibility to remove CO_(2)from discrete sources.Porous materials with adjustable pore characteristics are promising sorbents with low or no latent heat of vaporization.This review article has summarized the recent development of porous sorbents for DAC,with a focus of pore engineering strategy and adsorption mechanism.Physisorbents such as zeolites,porous carbons,metal-organic frameworks(MOFs),and amine-modified chemisorbents have been discussed and their challenges in practical application have been analyzed.At last,future directions have been proposed,and it is expected to inspire collaborations from chemistry,environment,material science and engineering communities.
基金Australian Research Council Linkage Program(LP200301404)for sponsoring this researchthe financial support provided by the State Key Laboratory of Geohazard Prevention and Geoenvironment Protection(Chengdu University of Technology,SKLGP2021K002)National Natural Science Foundation of China(52374101,32111530138).
文摘Discrete fracture network(DFN)commonly existing in natural rock masses plays an important role in geological complexity which can influence rock fracturing behaviour during fluid injection.This paper simulated the hydraulic fracturing process in lab-scale coal samples with DFNs and the induced seismic activities by the discrete element method(DEM).The effects of DFNs on hydraulic fracturing,induced seismicity and elastic property changes have been concluded.Denser DFNs can comprehensively decrease the peak injection pressure and injection duration.The proportion of strong seismic events increases first and then decreases with increasing DFN density.In addition,the relative modulus of the rock mass is derived innovatively from breakdown pressure,breakdown fracture length and the related initiation time.Increasing DFN densities among large(35–60 degrees)and small(0–30 degrees)fracture dip angles show opposite evolution trends in relative modulus.The transitional point(dip angle)for the opposite trends is also proportionally affected by the friction angle of the rock mass.The modelling results have much practical meaning to infer the density and geometry of pre-existing fractures and the elastic property of rock mass in the field,simply based on the hydraulic fracturing and induced seismicity monitoring data.
基金financially supported by the National Key Research and Development Program of China(No.2021YFB3701800)Special funding support for the Yuelu Mountain National University Science and Technology City“Ranking the Top of the List”Research Project:(Tunnel Boring Machine High-performance Long-life Cutting Tools)the State Key Laboratory of Powder Metallurgy,Central South University,Changsha,China.
文摘The good combination of mechanical and wear properties for cemented carbides is crucial.In this work,the wear behavior of functionally graded cemented carbide(FGCC)and non-graded cemented carbide(CC),with CoNiFeCr multi-principal-element alloy(MPEA)binder,has been investigated by performing sliding wear tests and composition characterization.The results showed that compared with CC,FGCC had higher hardness,stronger fracture toughness,better wear performance,and similar TRS.FGCCs exhibited lower wear rates(3.44×10^(−7)–6.95×10^(−6)mm^(3)/(N m))and coefficients of friction(COFs)(0.27–0.39)than CCs from RT to 600℃due to mitigation of multiple risks caused by binder removal,fragmentation and pull-out of WC grains,high-temperature oxidation and softening.In the low-temperature wear stage,the MPEA binder underwent dynamic recrystallization(DRX)and twinning deformation before removing from the surface.The binder removal caused dislocation pile-ups and stacking faults(SFs)to form under high stress,resulting in fragmentation and pull-out of WC grains.The low-temperature wear was dominated by abrasive wear and adhesive wear,with a low wear rate and a high and unstable COF.In the high-temperature wear stage,initial pitting oxidation of WC grains generated many subgrain boundaries,reducing heat transfer and exacerbating oxidation,resulting in an oxide layer enriched with WO3,Mx Oy,and MWO4.High-temperature wear was dominated by oxidation wear and high-temperature softening,with a high wear rate and a low and smooth COF.The results from the present study do not only provide theoretical guidance for an understanding of the antiwear mechanism of WC-CoNiFeCr,but also a new approach for the preparation of cemented carbides with high wear resistance.
基金supported by Lanzhou Youth Science and Technology Talent Innovation Project(No.2023-QN-60)the Startup Fund for the Construction of the Double First-Class Project,Lanzhou University,China(No.561121203)+2 种基金the National Natural Science Foundation of China(No.31802256)the Medical Innovation and Development Project of Lanzhou University(No.lzuyxcx-2022-196)the Science Fund for Distinguished Young Scholars of Gansu Province(No.20JR5RA579).
文摘Manganese(Mn)has been characterized as an environmental pollutant.Excessive releases of Mn due to human activities have increased Mn levels in the environment over the years,posing a threat to human health and the environment.Long-term exposure to high concentrations of Mn can induce neurotoxicity.Therefore,toxicological studies on Mn are of paramount importance.Mn induces oxidative stress through affecting the level of reactive oxygen species(ROS),and the overabundance of ROS further triggers ferroptosis.Additionally,Mn^(2+) was found to be a novel activator of the cyclic guanosine-adenosine synthase(cGAS)−stimulator of interferon genes(STING)pathway in the innateimmune system.Thus,we speculate thatMn exposuremay promote ROS production by activating the cGAS−STING pathway,which further induces oxidative stress and ferroptosis,and ultimately triggers Mn neurotoxicity.This review discusses the mechanism between Mn-induced oxidative stress and ferroptosis via activation of the cGAS−STING pathway,which may offer a prospective direction for future in-depth studies on the mechanism of Mn neurotoxicity.
基金the National Natural Science Foundation of China(42472194,42302153,and 42002144)the Fundamental Research Funds for the Central Univer-sities(22CX06002A).
文摘Karst fractures serve as crucial seepage channels and storage spaces for carbonate natural gas reservoirs,and electrical image logs are vital data for visualizing and characterizing such fractures.However,the conventional approach of identifying fractures using electrical image logs predominantly relies on manual processes that are not only time-consuming but also highly subjective.In addition,the heterogeneity and strong dissolution tendency of karst carbonate reservoirs lead to complexity and variety in fracture geometry,which makes it difficult to accurately identify fractures.In this paper,the electrical image logs network(EILnet)da deep-learning-based intelligent semantic segmentation model with a selective attention mechanism and selective feature fusion moduledwas created to enable the intelligent identification and segmentation of different types of fractures through electrical logging images.Data from electrical image logs representing structural and induced fractures were first selected using the sliding window technique before image inpainting and data augmentation were implemented for these images to improve the generalizability of the model.Various image-processing tools,including the bilateral filter,Laplace operator,and Gaussian low-pass filter,were also applied to the electrical logging images to generate a multi-attribute dataset to help the model learn the semantic features of the fractures.The results demonstrated that the EILnet model outperforms mainstream deep-learning semantic segmentation models,such as Fully Convolutional Networks(FCN-8s),U-Net,and SegNet,for both the single-channel dataset and the multi-attribute dataset.The EILnet provided significant advantages for the single-channel dataset,and its mean intersection over union(MIoU)and pixel accuracy(PA)were 81.32%and 89.37%,respectively.In the case of the multi-attribute dataset,the identification capability of all models improved to varying degrees,with the EILnet achieving the highest MIoU and PA of 83.43%and 91.11%,respectively.Further,applying the EILnet model to various blind wells demonstrated its ability to provide reliable fracture identification,thereby indicating its promising potential applications.
