A series of leaching and electrochemical experiments were conducted to elucidate the critical role of hydrogen sulfide(H_(2)S)in copper-driven reduction of chalcopyrite.Results demonstrate that in the absence of H_(2)...A series of leaching and electrochemical experiments were conducted to elucidate the critical role of hydrogen sulfide(H_(2)S)in copper-driven reduction of chalcopyrite.Results demonstrate that in the absence of H_(2)S,metallic copper converts chalcopyrite into bornite(Cu_(5)FeS_(4)).However,the introduction of H_(2)S promotes the formation of chalcocite(Cu_(2)S)by altering the oxidation pathway of copper.Electrochemical analysis demonstrates that the presence of H₂S significantly reduces the corrosion potential of copper from 0.251 to−0.223 V(vs SHE),reaching the threshold necessary for the formation of Cu_(2)S.Nevertheless,excessive H_(2)S triggers sulfate reduction via the reaction of 8Cu+H_(2)SO_(4)+3H_(2)S=4Cu_(2)S+4H_(2)O(ΔG=−519.429 kJ/mol at 50℃),leading to inefficient copper utilization.展开更多
The application of industrial solid wastes as environmentally functional materials for air pollutants control has gained much attention in recent years due to its potential to reduce air pollution in a cost-effective ...The application of industrial solid wastes as environmentally functional materials for air pollutants control has gained much attention in recent years due to its potential to reduce air pollution in a cost-effective manner.In this review,we investigate the development of industrialwaste-based functional materials for various gas pollutant removal and consider the relevant reaction mechanism according to different types of industrial solid waste.We see a recent effort towards achieving high-performance environmental functional materials via chemical or physical modification,in which the active components,pore size,and phase structure can be altered.The review will discuss the potential of using industrial solid wastes,these modified materials,or synthesized materials from raw waste precursors for the removal of air pollutants,including SO_(2),NO_(x),Hg^(0),H_(2)S,VOCs,and CO_(2).The challenges still need to be addressed to realize this potential and the prospects for future research fully.The suggestions for future directions include determining the optimal composition of these materials,calculating the real reaction rate and turnover frequency,developing effective treatment methods,and establishing chemical component databases of raw industrial solid waste for catalysts/adsorbent preparation.展开更多
Background:The outcomes of pediatric patients with acute lymphoblastic leukemia(ALL)remain far less than favorable.While apigenin is an anti-cancer agent,studies on the mechanism by which it regulates ALL cell cycle p...Background:The outcomes of pediatric patients with acute lymphoblastic leukemia(ALL)remain far less than favorable.While apigenin is an anti-cancer agent,studies on the mechanism by which it regulates ALL cell cycle progression are inadequate.Ferroptosis and AMP-activated protein kinase(AMPK)signaling are important processes for ALL patients.However,it remains unclear whether apigenin works by affecting AMPK and apoptosis.Materials and Methods:SUP-B15 and T-cell Jurkat ALL cells were treated with apigenin,and cell viability and apoptosis were measured using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)and terminal deoxynucleotidyl transferase dUTP nick end labeling(TUNEL)assays,respectively.The thiobarbituric acid-reactive substances(TBARS)assay was used to evaluate lipid peroxidation.Intracellular Fe2+levels were measured using a commercial kit.Corresponding proteins were detected by western blotting.Results:Results showed that apigenin reduced cell viability and the levels of Ki67 and proliferating cell nuclear antigen(PCNA)expression in a concentration-dependent manner in both types of ALL cells.Apigenin also exerted anti-apoptotic effects on SUP-B15 and Jurkat cells.Apigenin activated AMP-activated protein kinase(AMPK)signaling and induced ferroptosis,and those effects were attenuated by inhibition of AMPK.Eventually,the reduced cell proliferation and increased cell apoptosis caused by apigenin in ALL cells were partly abolished by AMPK inhibition.Conclusion:In summary,apigenin exerted anti-leukemia activity in ALL cells,and that effect was partially achieved by activation of AMPK signaling.Our findings suggest apigenin as a potential drug for treatment of ALL.展开更多
Conductive polymer foam(CPF)with excellent compressibility and variable resistance has promising applications in electromagnetic interference(EMI)shielding and other integrated functions for wearable electronics.Howev...Conductive polymer foam(CPF)with excellent compressibility and variable resistance has promising applications in electromagnetic interference(EMI)shielding and other integrated functions for wearable electronics.However,its insufficient change amplitude of resistance with compressive strain generally leads to a degradation of shielding performance during deformation.Here,an innovative loading strategy of conductive materials on polymer foam is proposed to significantly increase the contact probability and contact area of conductive components under compression.Unique inter-skeleton conductive films are constructed by loading alginate-decorated magnetic liquid metal on the polymethacrylate films hanged between the foam skeleton(denoted as AMLM-PM foam).Traditional point contact between conductive skeletons under compression is upgraded to planar contact between conductive films.Therefore,the resistance change of AMLM-PM reaches four orders of magnitude under compression.Moreover,the inter-skeleton conductive films can improve the mechanical strength of foam,prevent the leakage of liquid metal and increase the scattering area of EM wave.AMLM-PM foam has strain-adaptive EMI shielding performance and shows compression-enhanced shielding effectiveness,solving the problem of traditional CPFs upon compression.The upgrade of resistance response also enables foam to achieve sensitive pressure sensing over a wide pressure range and compression-regulated Joule heating function.展开更多
Stomata are tiny pores on the plant leaf surface that regulate the exchange of water and gases between the plant and the external environment.They are crucial for photosynthesis,water use efficiency(WUE),and the plant...Stomata are tiny pores on the plant leaf surface that regulate the exchange of water and gases between the plant and the external environment.They are crucial for photosynthesis,water use efficiency(WUE),and the plant’s ability to adapt to environmental changes.Stomatal movement is vital for understanding how plants adapt to environmental stress and optimize resource utilization.Changes in environmental conditions,especially the quality and intensity of light throughout the day,affect stomatal dynamics and diurnal behavior,which in turn impact photosynthetic efficiency and water-use efficiency.In this review,we summarize the biophysical principles and mechanisms of stomatal movement regulated by ion transport at the plasma membrane,vacuolar membrane and metabolic activity through persulfidation or S-nitrosylation modifications.Specifically,we focus on recent progress in the regulation of stomatal movement by different light qualities,and summarize the photochemical and biochemical events underlying photoreceptors as well as the knowledge of novel regulatory functions and signaling in the multilayer control of stomatal movement and environmental adaptation.Furthermore,as rising global temperatures and increased water needs of farming methods are expected to escalate future crop losses,we explore the potential of smart LED lighting and gene editing technology in enhancing photosynthetic efficiency and water-use efficiency,leading to increased crop biomass and higher crop yields.展开更多
Organophosphorus pesticides(OPPs)in foods pose a serious threat to human health,motivating the development of novel analytical methods for their rapid detection and quantification.A magnetic covalent organic framework...Organophosphorus pesticides(OPPs)in foods pose a serious threat to human health,motivating the development of novel analytical methods for their rapid detection and quantification.A magnetic covalent organic framework(M-COF)adsorbent for the magnetic solid-phase extraction(MSPE)of OPPs from foods was reported.M-COF was synthesized by the Schiff base condensation reaction of 1,3,5-tris(4-aminophenyl)benzene and 4,4-biphenyldicarboxaldehyde on the surface of amino-functionalized magnetic nanoparticles.Density functional theory(DFT)calculations showed that adsorption of OPPs onto the surface of M-COF involved hydrophobic effects,van der Waals interactions,π-πinteractions,halogen-N bonding,and hydrogen bonding.Combined with gas chromatography-mass spectrometry(GC-MS)technology,the MSPE method features low limits of detection for OPPs(0.002-0.015μg/L),good reproducibility(1.45%-6.14%),wide linear detection range(0.01-1μg/L,R≥0.9935),and satisfactory recoveries(87.3%-110.4%).The method was successfully applied for the trace analysis of OPPs in spiked fruit juices.展开更多
The inefficiency of photocatalytic overall water splitting is well documented and has been extensively studied.However,a crucial aspect of this process,the side reaction,has often been overlooked.In this study,we inve...The inefficiency of photocatalytic overall water splitting is well documented and has been extensively studied.However,a crucial aspect of this process,the side reaction,has often been overlooked.In this study,we investigate the impact of side reactions on photocatalytic overall water splitting by monitoring factors such as dissolved oxygen,reactive oxygen species,and hydrogen peroxide.Further insights into the side reaction are obtained through the introduction of a platinum cocatalyst.Our findings reveal that dissolved oxygen significantly contributes to the side reaction by promoting the production of hydrogen peroxide.This byproduct is generated at the expense of electrons needed for the hydrogen evolution reaction,thereby reducing the overall efficiency of photocatalytic water splitting.This article aims to provide guidance on future research directions in the field of water splitting,with a particular emphasis on photocatalysis.展开更多
Periplocin,periplocymarin and periplogenin are the main active components of Cortex Periplocae.The most cytotoxic constituent of Cortex Periplocae,periplocin is an alpha cardiac glycoside with a steroid core and an un...Periplocin,periplocymarin and periplogenin are the main active components of Cortex Periplocae.The most cytotoxic constituent of Cortex Periplocae,periplocin is an alpha cardiac glycoside with a steroid core and an unsaturated five-membered lactone ring structure.Periplocymarin is a secondary alpha cardiac glycoside,which is produced by removing one molecule of glucose from periplocin,and periplogenin is the glycosidic portion and the basic unit of periplocin and periplocymarin.These three cardiac glycosides,by virtue of their unique pharmacological activities and mechanisms of action,mediate signaling pathways,mainly the retinoblastoma and p53 signaling pathways,and regulate cell cycle proteins,thereby hindering the proliferation of cancer cells and altering the cell cycle process.These glycosides also regulate caspase proteins by mediating endogenous and exogenous pathways,thereby inducing the apoptosis of cancer cells.This minireview focuses on the inhibitory effects of periplocin,periplocymarin and periplogenin on cancer,and explores their potential antitumor mechanisms.展开更多
High-pressure die-cast(HPDC)magnesium(Mg)and aluminum alloys enable vehicle lightweighting while reducing manufacturing costs by simplifying part assembly.The increasing use of super-large castings in electric vehicle...High-pressure die-cast(HPDC)magnesium(Mg)and aluminum alloys enable vehicle lightweighting while reducing manufacturing costs by simplifying part assembly.The increasing use of super-large castings in electric vehicles enhances structural reliability and cost efficiency.However,HPDC Mg alloys face challenges related to casting defects such as porosity,cold shuts,and oxides.These defects influence tensile strength and ductility,depending on their location and size.This study employs finite element(FE)modeling to investigate how a dominant large pore,its position,and the sample size affect the ductility of thin-walled HPDC Mg.Motivated by the ductility variations reported in literature and the experimental findings on AM60 castings,synthetic microstructure-based models are used to assess the effects of different pore sizes and locations.The results indicate the presence of three different regions based on the large pore size and model size:1)a region dominated by the effects of the large pore,2)a plateau region dominated by pore interactions,and 3)a transient region between these two effects.A threshold distance from the sample edge (d≈0.9√D·L)is proposed,within which a large pore can significantly reduce ductility.Additionally,large pores near edges contribute to ductility variations in Mg castings.展开更多
Based on available records,a comprehensive overview of the biodiversity and geographical distribution of Collembola in China is presented.A total of 735 species,155 genera and 20 families were recorded in the checklis...Based on available records,a comprehensive overview of the biodiversity and geographical distribution of Collembola in China is presented.A total of 735 species,155 genera and 20 families were recorded in the checklist,including current name information,synonyms,geographical records,and bibliographic references.Taxonomic notes were added where necessary and Chinese translations were provided for genera and families.The following new combinations are proposed:Rambutsinella grinnellia(Wang,Chen&Christiansen,2004)comb.nov.for Pseudosinella grinnellia Wang,Chen&Christiansen 2004;Rambutsinella hui(Wang,Chen&Christiansen,2003)comb.nov.for Pseudosinella hui Wang,Chen&Christiansen 2003;and Rambutsinella tridentifera(Rusek,1971)comb.nov.for Pseudosinella tridentifera Rusek 1971.In addition,certain species have been merged with their synonyms.This checklist includes articles published up to August 2023.展开更多
Designing anion-dominated weak solvation structures is often achieved by elevating the concentration of Li salts.However,this is accompanied by the increase in the cost.Herein,a medium concentration electrolyte (1 M) ...Designing anion-dominated weak solvation structures is often achieved by elevating the concentration of Li salts.However,this is accompanied by the increase in the cost.Herein,a medium concentration electrolyte (1 M) with weak solvation structures is established by the multi-anion strategy.Multiple anions in the electrolyte strengthen the anion-solvent interactions through stronger ion–dipole interactions.This reduces the quantity of free solvent and improves the reduction resistance of solvents.In addition,the Li ion–solvent interaction is weakened,facilitating the anions to enter the solvation sheaths of Li ions.This multi-anion-dominated weak solvation structures boost Li ion diffusion in the electrolyte,accelerate the desolvation process of Li ions,and induce inorganic-rich solid electrolyte interphase and uniform Li deposition.An average Coulombic efficiency of 99.1%for repeated Li plating/stripping can be achieved.Li||LiNi_(0.5)Co_(0.2)Mn_(0.3)O_(2) cells with a high cathode loading of 3.0 m A h cm^(-2) can maintain a capacity retention as high as 95% after 150 cycles.This finding provides novel standpoints to modulate the interaction of solvation structures and extend the lifespan of high-energy–density Li metal batteries.展开更多
In this study,non-thermal plasma(NTP)was employed to modify the Cu/TiO_(2)adsorbent to efficiently purify H_(2)S in low-temperature and micro-oxygen environments.The effects of Cu loading amounts and atmospheres of NT...In this study,non-thermal plasma(NTP)was employed to modify the Cu/TiO_(2)adsorbent to efficiently purify H_(2)S in low-temperature and micro-oxygen environments.The effects of Cu loading amounts and atmospheres of NTP treatment on the adsorption-oxidation performance of the adsorbents were investigated.The NTP modification successfully boosted the H_(2)S removal capacity to varying degrees,and the optimized adsorbent treated by air plasma(Cu/TiO_(2)-Air)attained the best H_(2)S breakthrough capacity of 113.29 mg H_(2)S/gadsorbent,which was almost 5 times higher than that of the adsorbent without NTP modification.Further studies demonstrated that the superior performance of Cu/TiO_(2)-Air was attributed to increased mesoporous volume,more exposure of active sites(CuO)and functional groups(amino groups and hydroxyl groups),enhanced Ti-O-Cu interaction,and the favorable ratio of active oxygen species.Additionally,the X-ray diffraction(XRD)and X-ray photoelectron spectroscopy(XPS)results indicated the main reason for the deactivationwas the consumption of the active components(CuO)and the agglomeration of reaction products(CuS and SO_(4)^(2−))occupying the active sites on the surface and the inner pores of the adsorbents.展开更多
The giant African snail(Achatina fulica)is an invasive species served as potential vectors for antibiotic resistance genes(ARGs)and potential human bacterial pathogens.Currently,urban green spaces receive extensive or...The giant African snail(Achatina fulica)is an invasive species served as potential vectors for antibiotic resistance genes(ARGs)and potential human bacterial pathogens.Currently,urban green spaces receive extensive organic manure additions as part of their management,may intensify the biological contamination potential of these snail vectors,thereby increasing the risk of biological pollution in green spaces.However,the specific impacts of this practice on the microbial ecology of these invasive species remain poorly understood.Here,we investigated the effects of organic manure application on the gut microbiome of giant African snails,focusing on ARGs,bacterial community structure,and potential human bacterial pathogens.Microcosm experiments compared snail gut microbiomes in different treatments(Soil:soil samples collected after manure amendment,before any snail exposure.Feces:fecal samples collected from snails that lived on manure-amended soil.Control:fecal samples collected from snails that lived on unamended soil)using 16S r RNA high-throughput sequencing and metagenomic analysis.Our results show that manure application significantly altered gut bacterial community structure and increased ARG diversity by enriching specific high-risk ARGs(such as sul1 and sul2 in the Feces group increased by 2.89 and 2.43 times,respectively,compared to the Control group),and the introduction of eight novel ARG subtypes,despite decreasing overall ARG abundance.Moreover,the relative abundance of potential human pathogens,particularly Pseudomonadaceae,was greatly increased by manure application.These findings reveal that organic manure application in urban green spaces can potentially enhances their role as reservoirs and vectors of ARGs and human pathogens.展开更多
Objective:To screen and identify the key active molecules,signaling pathways,and therapeutic targets of Shuxuening(SXN)injection for treating liver cirrhosis(LC)and to evaluate its therapeutic potential using a mouse ...Objective:To screen and identify the key active molecules,signaling pathways,and therapeutic targets of Shuxuening(SXN)injection for treating liver cirrhosis(LC)and to evaluate its therapeutic potential using a mouse model.Methods:Target genes of SXN and LC were retrieved from public databases,and enrichment analysis was performed.A proteineprotein interaction(PPI)network was constructed using the Search Tool for the Retrieval of Interacting Genes/Proteins(STRING),and hub genes were identified using Molecular Complex Detection(MCODE).LC was induced in rats and mice via intraperitoneal injections of diethylnitrosamine and carbon tetrachloride(CCl4)for 12 weeks.Starting at week 7,SXN was administered intraperitoneally to the mice in the treatment group.Serum and liver tissues of the mice were collected for the detection of indicators,pathological staining,and expression analysis of hub targets using quantitative real-time polymerase chain reaction(qRT-PCR).Results:We identified 368 overlapping genes(OLGs)between SXN and LC targets.These OLGs were subsequently used to build a PPI network and to screen for hub genes.Enrichment analysis showed that these genes were associated with cancer-related pathways,including phosphoinositide-3-kinase/Akt and mitogen-activated protein kinase signaling and various cellular processes,such as responses to chemicals and metabolic regulation.In vivo experiments demonstrated that SXN treatment significantly improved liver function and pathology in CCl4-induced LC mice by reducing inflammation and collagen deposition.Furthermore,qRT-PCR demonstrated that SXN regulated the expression of MAPK8,AR and CASP3 in the livers of LC mice.Conclusion:This study highlighted the therapeutic effects of SXN in alleviating LC using both bioinformatics and experimental methods.The observed effect was associated with modulation of hub gene expression,particularly MAPK8,and CASP3.展开更多
Gastropods,as one of the most common invertebrates in shallow marine environments,were heavily impacted by the Permian–Triassic mass extinction(PTME),with severe loss of diversity and remarkable dwarfism of body size...Gastropods,as one of the most common invertebrates in shallow marine environments,were heavily impacted by the Permian–Triassic mass extinction(PTME),with severe loss of diversity and remarkable dwarfism of body size.Here,we report a new gastropod fauna from the Permian-Triassic carbonates of Zuodeng,Guangxi Province,South China.Five species belonging to five genera and two indeterminate taxa are identified.The Zuodeng fauna is dominated by Paleozoic holdover taxa,including Holopea teres,Protostylus sp.,and Wannerispira shangganensis although most of them are found in the basal Triassic microbialites.Three gastropod communities have been recognized by cluster analysis.Further morphological analyses show that the changing pattern of disparity,with diversity decreasing from communityⅡtoⅢ,fits the interior-reduction model.In addition,the morphospace of community in microbialites is higher than those in non-microbialite bearing beds at Zuodeng,shedding new light on the ecological role of microbialites during the Permian–Triassic environmental stress.展开更多
Background:In recent years,there has been a growing trend in the utilization of observational studies that make use of routinely collected healthcare data(RCD).These studies rely on algorithms to identify specific hea...Background:In recent years,there has been a growing trend in the utilization of observational studies that make use of routinely collected healthcare data(RCD).These studies rely on algorithms to identify specific health conditions(e.g.,diabetes or sepsis)for statistical analyses.However,there has been substantial variation in the algorithm development and validation,leading to frequently suboptimal performance and posing a significant threat to the validity of study findings.Unfortunately,these issues are often overlooked.Methods:We systematically developed guidance for the development,validation,and evaluation of algorithms designed to identify health status(DEVELOP-RCD).Our initial efforts involved conducting both a narrative review and a systematic review of published studies on the concepts and methodological issues related to algorithm development,validation,and evaluation.Subsequently,we conducted an empirical study on an algorithm for identifying sepsis.Based on these findings,we formulated specific workflow and recommendations for algorithm development,validation,and evaluation within the guidance.Finally,the guidance underwent independent review by a panel of 20 external experts who then convened a consensus meeting to finalize it.Results:A standardized workflow for algorithm development,validation,and evaluation was established.Guided by specific health status considerations,the workflow comprises four integrated steps:assessing an existing algorithm’s suitability for the target health status;developing a new algorithm using recommended methods;validating the algorithm using prescribed performance measures;and evaluating the impact of the algorithm on study results.Additionally,13 good practice recommendations were formulated with detailed explanations.Furthermore,a practical study on sepsis identification was included to demonstrate the application of this guidance.Conclusions:The establishment of guidance is intended to aid researchers and clinicians in the appropriate and accurate development and application of algorithms for identifying health status from RCD.This guidance has the potential to enhance the credibility of findings from observational studies involving RCD.展开更多
This study employed a wet impregnation method to synthesize five types of Cu/HZSM-5 adsorbents with Si/Al ratios of 25,50,85,200,and 300,used for the removal of H_(2)S in lowtemperature,low-oxygen environments.The imp...This study employed a wet impregnation method to synthesize five types of Cu/HZSM-5 adsorbents with Si/Al ratios of 25,50,85,200,and 300,used for the removal of H_(2)S in lowtemperature,low-oxygen environments.The impact of different Si/Al ratios on the adsorption oxidative performance of Cu_(30)/HZSM-5–85 adsorbents was investigated.According to the performance test results,Cu_(30)/HZSM-5–85 exhibited the highest breakthrough capacity,reaching 231.75 mg H_(2)S/g_(sorbent).Cu/HZSM-5 sorbent maintains a strong ability to remove H_(2)S even under humid conditions and shows excellent water resistance.XRD,BET,and XPS results revealed that CuO is the primary active species,with Cu_(30)/HZSM-5–85 having the largest surface area and highest CuO content,providing more active sites for H_(2)S adsorption.H_(2)-TPR and O_(2)-TPD results confirmed that Cu_(30)/HZSM-5–85 sorbent exhibits outstanding redox properties and oxygen storage capacity,contributing to excellent oxygen transferability in the molecular sieve adsorption-oxidation process.With notable characteristics such as a large surface area,high desulfurization efficiency,and water resistance,Cu_(30)/HZSM-5–85 sorbents hold significant importance for industrial applications.展开更多
From a life cycle perspective,the material flow analysis is utilized to investigate the lithium material flows in international trade from 2000 to 2019.The results reveal that at the global level,the total volume of l...From a life cycle perspective,the material flow analysis is utilized to investigate the lithium material flows in international trade from 2000 to 2019.The results reveal that at the global level,the total volume of lithium trade grew rapidly,reaching 121116 t in 2019.Lithium trade was dominated by lithium minerals,lithium carbonate and lithium hydroxide rather than final lithium products,indicating an immaturity in global lithium industry.At the intercontinental level,Asia’s import trade and Oceania’s export trade led the world,accounting for 81.22%and 39.68%,respectively.At the national level,China,Japan and Korea became the main importers,while Chile and Australia were the main exporters.In addition,China’s trade volume far exceeded that of the United States.China’s exports were dominated by lithium-ion batteries,while the United States mainly imported lithium-ion batteries,proving that the development of China’s lithium industry was relatively faster.展开更多
基金financially supported by the National Key Research and Development Program of China (No. 2022YFC2105300)。
文摘A series of leaching and electrochemical experiments were conducted to elucidate the critical role of hydrogen sulfide(H_(2)S)in copper-driven reduction of chalcopyrite.Results demonstrate that in the absence of H_(2)S,metallic copper converts chalcopyrite into bornite(Cu_(5)FeS_(4)).However,the introduction of H_(2)S promotes the formation of chalcocite(Cu_(2)S)by altering the oxidation pathway of copper.Electrochemical analysis demonstrates that the presence of H₂S significantly reduces the corrosion potential of copper from 0.251 to−0.223 V(vs SHE),reaching the threshold necessary for the formation of Cu_(2)S.Nevertheless,excessive H_(2)S triggers sulfate reduction via the reaction of 8Cu+H_(2)SO_(4)+3H_(2)S=4Cu_(2)S+4H_(2)O(ΔG=−519.429 kJ/mol at 50℃),leading to inefficient copper utilization.
基金supported by National Natural Science Foundation of China(Grant No.52270106 and 22266021)Yunnan Major Scientific and Technological Projects(grant No.202202AG050005)Yunnan Fundamental Research Projects(grant No.202201AT070116).
文摘The application of industrial solid wastes as environmentally functional materials for air pollutants control has gained much attention in recent years due to its potential to reduce air pollution in a cost-effective manner.In this review,we investigate the development of industrialwaste-based functional materials for various gas pollutant removal and consider the relevant reaction mechanism according to different types of industrial solid waste.We see a recent effort towards achieving high-performance environmental functional materials via chemical or physical modification,in which the active components,pore size,and phase structure can be altered.The review will discuss the potential of using industrial solid wastes,these modified materials,or synthesized materials from raw waste precursors for the removal of air pollutants,including SO_(2),NO_(x),Hg^(0),H_(2)S,VOCs,and CO_(2).The challenges still need to be addressed to realize this potential and the prospects for future research fully.The suggestions for future directions include determining the optimal composition of these materials,calculating the real reaction rate and turnover frequency,developing effective treatment methods,and establishing chemical component databases of raw industrial solid waste for catalysts/adsorbent preparation.
基金supported by The National Natural Science Foundation of China(No.31902283)Research Foundation for Master students at the Affiliated Hospital of Zunyi Medical College(No.22-2018).
文摘Background:The outcomes of pediatric patients with acute lymphoblastic leukemia(ALL)remain far less than favorable.While apigenin is an anti-cancer agent,studies on the mechanism by which it regulates ALL cell cycle progression are inadequate.Ferroptosis and AMP-activated protein kinase(AMPK)signaling are important processes for ALL patients.However,it remains unclear whether apigenin works by affecting AMPK and apoptosis.Materials and Methods:SUP-B15 and T-cell Jurkat ALL cells were treated with apigenin,and cell viability and apoptosis were measured using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)and terminal deoxynucleotidyl transferase dUTP nick end labeling(TUNEL)assays,respectively.The thiobarbituric acid-reactive substances(TBARS)assay was used to evaluate lipid peroxidation.Intracellular Fe2+levels were measured using a commercial kit.Corresponding proteins were detected by western blotting.Results:Results showed that apigenin reduced cell viability and the levels of Ki67 and proliferating cell nuclear antigen(PCNA)expression in a concentration-dependent manner in both types of ALL cells.Apigenin also exerted anti-apoptotic effects on SUP-B15 and Jurkat cells.Apigenin activated AMP-activated protein kinase(AMPK)signaling and induced ferroptosis,and those effects were attenuated by inhibition of AMPK.Eventually,the reduced cell proliferation and increased cell apoptosis caused by apigenin in ALL cells were partly abolished by AMPK inhibition.Conclusion:In summary,apigenin exerted anti-leukemia activity in ALL cells,and that effect was partially achieved by activation of AMPK signaling.Our findings suggest apigenin as a potential drug for treatment of ALL.
基金supported by National Key Research and Development Program of China(2021YBF3501304)National Natural Science Foundation of China(52222106,52371171,51971008,52121001)Natural Science Foundation of Beijing Municipality(2212033).
文摘Conductive polymer foam(CPF)with excellent compressibility and variable resistance has promising applications in electromagnetic interference(EMI)shielding and other integrated functions for wearable electronics.However,its insufficient change amplitude of resistance with compressive strain generally leads to a degradation of shielding performance during deformation.Here,an innovative loading strategy of conductive materials on polymer foam is proposed to significantly increase the contact probability and contact area of conductive components under compression.Unique inter-skeleton conductive films are constructed by loading alginate-decorated magnetic liquid metal on the polymethacrylate films hanged between the foam skeleton(denoted as AMLM-PM foam).Traditional point contact between conductive skeletons under compression is upgraded to planar contact between conductive films.Therefore,the resistance change of AMLM-PM reaches four orders of magnitude under compression.Moreover,the inter-skeleton conductive films can improve the mechanical strength of foam,prevent the leakage of liquid metal and increase the scattering area of EM wave.AMLM-PM foam has strain-adaptive EMI shielding performance and shows compression-enhanced shielding effectiveness,solving the problem of traditional CPFs upon compression.The upgrade of resistance response also enables foam to achieve sensitive pressure sensing over a wide pressure range and compression-regulated Joule heating function.
基金funded by the National Natural Science Foundation of China(Grant Nos.32272698,32441072,32122081)National Key Research and Development Program of China(Grant No.2023YFF1002000)+4 种基金Liaoning Province Youth Science Foundation A-Class Project(formerly Liaoning Natural Science Foundation Outstanding Youth Project,Grant No.2025-JQ-05)Liaoning Province’s Future Industry Frontier Technology Project(Grant Nos.2025JH2/101330184 and 2025JH2/101330185)National Postdoctoral Program for Innovative Talents(Grant No.BX20250016)Open Project Program of State Key Laboratory of Crop Stress Biology for Arid Areas of China(Grant No.SKLCSRHPKF2025017)HAAFS Science and Technology Innovation Special Project(Grant No.2023KJCXZX-JZS-10).
文摘Stomata are tiny pores on the plant leaf surface that regulate the exchange of water and gases between the plant and the external environment.They are crucial for photosynthesis,water use efficiency(WUE),and the plant’s ability to adapt to environmental changes.Stomatal movement is vital for understanding how plants adapt to environmental stress and optimize resource utilization.Changes in environmental conditions,especially the quality and intensity of light throughout the day,affect stomatal dynamics and diurnal behavior,which in turn impact photosynthetic efficiency and water-use efficiency.In this review,we summarize the biophysical principles and mechanisms of stomatal movement regulated by ion transport at the plasma membrane,vacuolar membrane and metabolic activity through persulfidation or S-nitrosylation modifications.Specifically,we focus on recent progress in the regulation of stomatal movement by different light qualities,and summarize the photochemical and biochemical events underlying photoreceptors as well as the knowledge of novel regulatory functions and signaling in the multilayer control of stomatal movement and environmental adaptation.Furthermore,as rising global temperatures and increased water needs of farming methods are expected to escalate future crop losses,we explore the potential of smart LED lighting and gene editing technology in enhancing photosynthetic efficiency and water-use efficiency,leading to increased crop biomass and higher crop yields.
基金supported by Key Research and Development Project of Shandong Province(2021ZDSYS12)National Natural Science Foundation of China(22076086,21777089)+3 种基金Taishan Scholar Program of Shandong Province(ts20190948)Shandong Province Science and Technology Small and Medium Enterprises Innovation Ability Enhancement Project(2023TSGC0689,2023TSGC0055)Natural Science Foundation of Shandong Province(ZR2021MB086,ZR2023QB035)Jinan City University and Institute Innovation Team Project(2021GXRC061,20228045,202333027)。
文摘Organophosphorus pesticides(OPPs)in foods pose a serious threat to human health,motivating the development of novel analytical methods for their rapid detection and quantification.A magnetic covalent organic framework(M-COF)adsorbent for the magnetic solid-phase extraction(MSPE)of OPPs from foods was reported.M-COF was synthesized by the Schiff base condensation reaction of 1,3,5-tris(4-aminophenyl)benzene and 4,4-biphenyldicarboxaldehyde on the surface of amino-functionalized magnetic nanoparticles.Density functional theory(DFT)calculations showed that adsorption of OPPs onto the surface of M-COF involved hydrophobic effects,van der Waals interactions,π-πinteractions,halogen-N bonding,and hydrogen bonding.Combined with gas chromatography-mass spectrometry(GC-MS)technology,the MSPE method features low limits of detection for OPPs(0.002-0.015μg/L),good reproducibility(1.45%-6.14%),wide linear detection range(0.01-1μg/L,R≥0.9935),and satisfactory recoveries(87.3%-110.4%).The method was successfully applied for the trace analysis of OPPs in spiked fruit juices.
基金supported by the National Key Research and Development Program of China(No.2022YFB3803600)the National Natural Science Foundation of China(Nos.22202187,22361142704,22238009,U24A2071,and 52272290)+4 种基金the National Postdoctoral Program for Innovative Talents(No.BX2021275)the Natural Science Foundation of Hubei Province of China(No.2022CFA001)the Project funded by China Postdoctoral Science Foundation(No.2022M712957)the Postdoctoral Funding Program of Hubei Province.Chuanbiao Bie and Bicheng Zhu would like to thank the China Scholarship Council(CSC)for its financial supportsupport from Australian Research Council Discovery Early Career Award(No.DE220100429).
文摘The inefficiency of photocatalytic overall water splitting is well documented and has been extensively studied.However,a crucial aspect of this process,the side reaction,has often been overlooked.In this study,we investigate the impact of side reactions on photocatalytic overall water splitting by monitoring factors such as dissolved oxygen,reactive oxygen species,and hydrogen peroxide.Further insights into the side reaction are obtained through the introduction of a platinum cocatalyst.Our findings reveal that dissolved oxygen significantly contributes to the side reaction by promoting the production of hydrogen peroxide.This byproduct is generated at the expense of electrons needed for the hydrogen evolution reaction,thereby reducing the overall efficiency of photocatalytic water splitting.This article aims to provide guidance on future research directions in the field of water splitting,with a particular emphasis on photocatalysis.
基金Supported by Traditional Chinese Medicine Science and Technology Project of Shandong Province,China,No.M-2023131The Science and Technology Development Fund Project of the Affiliated Hospital of Xuzhou Medical University,China,No.XYFM202348.
文摘Periplocin,periplocymarin and periplogenin are the main active components of Cortex Periplocae.The most cytotoxic constituent of Cortex Periplocae,periplocin is an alpha cardiac glycoside with a steroid core and an unsaturated five-membered lactone ring structure.Periplocymarin is a secondary alpha cardiac glycoside,which is produced by removing one molecule of glucose from periplocin,and periplogenin is the glycosidic portion and the basic unit of periplocin and periplocymarin.These three cardiac glycosides,by virtue of their unique pharmacological activities and mechanisms of action,mediate signaling pathways,mainly the retinoblastoma and p53 signaling pathways,and regulate cell cycle proteins,thereby hindering the proliferation of cancer cells and altering the cell cycle process.These glycosides also regulate caspase proteins by mediating endogenous and exogenous pathways,thereby inducing the apoptosis of cancer cells.This minireview focuses on the inhibitory effects of periplocin,periplocymarin and periplogenin on cancer,and explores their potential antitumor mechanisms.
基金funded by the Department of Energy Office of Vehicle Technologies under the Automotive Lightweighting Materials Program。
文摘High-pressure die-cast(HPDC)magnesium(Mg)and aluminum alloys enable vehicle lightweighting while reducing manufacturing costs by simplifying part assembly.The increasing use of super-large castings in electric vehicles enhances structural reliability and cost efficiency.However,HPDC Mg alloys face challenges related to casting defects such as porosity,cold shuts,and oxides.These defects influence tensile strength and ductility,depending on their location and size.This study employs finite element(FE)modeling to investigate how a dominant large pore,its position,and the sample size affect the ductility of thin-walled HPDC Mg.Motivated by the ductility variations reported in literature and the experimental findings on AM60 castings,synthetic microstructure-based models are used to assess the effects of different pore sizes and locations.The results indicate the presence of three different regions based on the large pore size and model size:1)a region dominated by the effects of the large pore,2)a plateau region dominated by pore interactions,and 3)a transient region between these two effects.A threshold distance from the sample edge (d≈0.9√D·L)is proposed,within which a large pore can significantly reduce ductility.Additionally,large pores near edges contribute to ductility variations in Mg castings.
基金supported by the National Science and Technology Fundamental Resources Investigation Program of China(2018FY100300)National Natural Science Foundation of China(31970434 and 32270470)。
文摘Based on available records,a comprehensive overview of the biodiversity and geographical distribution of Collembola in China is presented.A total of 735 species,155 genera and 20 families were recorded in the checklist,including current name information,synonyms,geographical records,and bibliographic references.Taxonomic notes were added where necessary and Chinese translations were provided for genera and families.The following new combinations are proposed:Rambutsinella grinnellia(Wang,Chen&Christiansen,2004)comb.nov.for Pseudosinella grinnellia Wang,Chen&Christiansen 2004;Rambutsinella hui(Wang,Chen&Christiansen,2003)comb.nov.for Pseudosinella hui Wang,Chen&Christiansen 2003;and Rambutsinella tridentifera(Rusek,1971)comb.nov.for Pseudosinella tridentifera Rusek 1971.In addition,certain species have been merged with their synonyms.This checklist includes articles published up to August 2023.
基金funded by National Natural Science Foundation of China (22379072, 92372111, 22179070)the Startup Foundation for Introducing Talent of NUIST (2022r038)+1 种基金the Jiangsu Specially Appointed Professor Program, the Natural Science Foundation of Jiangsu Province (BK20220073)the Fundamental Research Funds for the Central Universities (RF1028623157)。
文摘Designing anion-dominated weak solvation structures is often achieved by elevating the concentration of Li salts.However,this is accompanied by the increase in the cost.Herein,a medium concentration electrolyte (1 M) with weak solvation structures is established by the multi-anion strategy.Multiple anions in the electrolyte strengthen the anion-solvent interactions through stronger ion–dipole interactions.This reduces the quantity of free solvent and improves the reduction resistance of solvents.In addition,the Li ion–solvent interaction is weakened,facilitating the anions to enter the solvation sheaths of Li ions.This multi-anion-dominated weak solvation structures boost Li ion diffusion in the electrolyte,accelerate the desolvation process of Li ions,and induce inorganic-rich solid electrolyte interphase and uniform Li deposition.An average Coulombic efficiency of 99.1%for repeated Li plating/stripping can be achieved.Li||LiNi_(0.5)Co_(0.2)Mn_(0.3)O_(2) cells with a high cathode loading of 3.0 m A h cm^(-2) can maintain a capacity retention as high as 95% after 150 cycles.This finding provides novel standpoints to modulate the interaction of solvation structures and extend the lifespan of high-energy–density Li metal batteries.
基金supported by the National Natural Science Foundation of China (Nos.52260013,51968034,and 21876071)the Yunnan Major Scientific and Technological Projects (No.202202AG050005).
文摘In this study,non-thermal plasma(NTP)was employed to modify the Cu/TiO_(2)adsorbent to efficiently purify H_(2)S in low-temperature and micro-oxygen environments.The effects of Cu loading amounts and atmospheres of NTP treatment on the adsorption-oxidation performance of the adsorbents were investigated.The NTP modification successfully boosted the H_(2)S removal capacity to varying degrees,and the optimized adsorbent treated by air plasma(Cu/TiO_(2)-Air)attained the best H_(2)S breakthrough capacity of 113.29 mg H_(2)S/gadsorbent,which was almost 5 times higher than that of the adsorbent without NTP modification.Further studies demonstrated that the superior performance of Cu/TiO_(2)-Air was attributed to increased mesoporous volume,more exposure of active sites(CuO)and functional groups(amino groups and hydroxyl groups),enhanced Ti-O-Cu interaction,and the favorable ratio of active oxygen species.Additionally,the X-ray diffraction(XRD)and X-ray photoelectron spectroscopy(XPS)results indicated the main reason for the deactivationwas the consumption of the active components(CuO)and the agglomeration of reaction products(CuS and SO_(4)^(2−))occupying the active sites on the surface and the inner pores of the adsorbents.
基金supported by the National Natural Science Foundation of China(Nos.32361143523 and 42407166)the National Key Research and Development Program of China(No.2023YFF1304600)+2 种基金Ningbo S&T project(No.2021-DST-004)the International Partnership Program of Chinese Academy of Sciences(No.322GJHZ2022028FN)the fellowship of China Postdoctoral Science Foundation(No.2022T150635)。
文摘The giant African snail(Achatina fulica)is an invasive species served as potential vectors for antibiotic resistance genes(ARGs)and potential human bacterial pathogens.Currently,urban green spaces receive extensive organic manure additions as part of their management,may intensify the biological contamination potential of these snail vectors,thereby increasing the risk of biological pollution in green spaces.However,the specific impacts of this practice on the microbial ecology of these invasive species remain poorly understood.Here,we investigated the effects of organic manure application on the gut microbiome of giant African snails,focusing on ARGs,bacterial community structure,and potential human bacterial pathogens.Microcosm experiments compared snail gut microbiomes in different treatments(Soil:soil samples collected after manure amendment,before any snail exposure.Feces:fecal samples collected from snails that lived on manure-amended soil.Control:fecal samples collected from snails that lived on unamended soil)using 16S r RNA high-throughput sequencing and metagenomic analysis.Our results show that manure application significantly altered gut bacterial community structure and increased ARG diversity by enriching specific high-risk ARGs(such as sul1 and sul2 in the Feces group increased by 2.89 and 2.43 times,respectively,compared to the Control group),and the introduction of eight novel ARG subtypes,despite decreasing overall ARG abundance.Moreover,the relative abundance of potential human pathogens,particularly Pseudomonadaceae,was greatly increased by manure application.These findings reveal that organic manure application in urban green spaces can potentially enhances their role as reservoirs and vectors of ARGs and human pathogens.
基金Our study was funded by the Clinical Research Special Fund of Wu Jieping Medical Foundation(320.6750.2022-25-8)the Fundamental Research Funds for the Cornell University(2024-JYBXJSJJ042 and 2024-JYB-JBZD-058).
文摘Objective:To screen and identify the key active molecules,signaling pathways,and therapeutic targets of Shuxuening(SXN)injection for treating liver cirrhosis(LC)and to evaluate its therapeutic potential using a mouse model.Methods:Target genes of SXN and LC were retrieved from public databases,and enrichment analysis was performed.A proteineprotein interaction(PPI)network was constructed using the Search Tool for the Retrieval of Interacting Genes/Proteins(STRING),and hub genes were identified using Molecular Complex Detection(MCODE).LC was induced in rats and mice via intraperitoneal injections of diethylnitrosamine and carbon tetrachloride(CCl4)for 12 weeks.Starting at week 7,SXN was administered intraperitoneally to the mice in the treatment group.Serum and liver tissues of the mice were collected for the detection of indicators,pathological staining,and expression analysis of hub targets using quantitative real-time polymerase chain reaction(qRT-PCR).Results:We identified 368 overlapping genes(OLGs)between SXN and LC targets.These OLGs were subsequently used to build a PPI network and to screen for hub genes.Enrichment analysis showed that these genes were associated with cancer-related pathways,including phosphoinositide-3-kinase/Akt and mitogen-activated protein kinase signaling and various cellular processes,such as responses to chemicals and metabolic regulation.In vivo experiments demonstrated that SXN treatment significantly improved liver function and pathology in CCl4-induced LC mice by reducing inflammation and collagen deposition.Furthermore,qRT-PCR demonstrated that SXN regulated the expression of MAPK8,AR and CASP3 in the livers of LC mice.Conclusion:This study highlighted the therapeutic effects of SXN in alleviating LC using both bioinformatics and experimental methods.The observed effect was associated with modulation of hub gene expression,particularly MAPK8,and CASP3.
基金supported by the National Natural Science Foundation of China(Nos.41730320,42030513)。
文摘Gastropods,as one of the most common invertebrates in shallow marine environments,were heavily impacted by the Permian–Triassic mass extinction(PTME),with severe loss of diversity and remarkable dwarfism of body size.Here,we report a new gastropod fauna from the Permian-Triassic carbonates of Zuodeng,Guangxi Province,South China.Five species belonging to five genera and two indeterminate taxa are identified.The Zuodeng fauna is dominated by Paleozoic holdover taxa,including Holopea teres,Protostylus sp.,and Wannerispira shangganensis although most of them are found in the basal Triassic microbialites.Three gastropod communities have been recognized by cluster analysis.Further morphological analyses show that the changing pattern of disparity,with diversity decreasing from communityⅡtoⅢ,fits the interior-reduction model.In addition,the morphospace of community in microbialites is higher than those in non-microbialite bearing beds at Zuodeng,shedding new light on the ecological role of microbialites during the Permian–Triassic environmental stress.
基金supported by the National Natural Science Foundation of China(82225049,72104155)the Sichuan Provincial Central Government Guides Local Science and Technology Development Special Project(2022ZYD0127)the 1·3·5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(ZYGD23004).
文摘Background:In recent years,there has been a growing trend in the utilization of observational studies that make use of routinely collected healthcare data(RCD).These studies rely on algorithms to identify specific health conditions(e.g.,diabetes or sepsis)for statistical analyses.However,there has been substantial variation in the algorithm development and validation,leading to frequently suboptimal performance and posing a significant threat to the validity of study findings.Unfortunately,these issues are often overlooked.Methods:We systematically developed guidance for the development,validation,and evaluation of algorithms designed to identify health status(DEVELOP-RCD).Our initial efforts involved conducting both a narrative review and a systematic review of published studies on the concepts and methodological issues related to algorithm development,validation,and evaluation.Subsequently,we conducted an empirical study on an algorithm for identifying sepsis.Based on these findings,we formulated specific workflow and recommendations for algorithm development,validation,and evaluation within the guidance.Finally,the guidance underwent independent review by a panel of 20 external experts who then convened a consensus meeting to finalize it.Results:A standardized workflow for algorithm development,validation,and evaluation was established.Guided by specific health status considerations,the workflow comprises four integrated steps:assessing an existing algorithm’s suitability for the target health status;developing a new algorithm using recommended methods;validating the algorithm using prescribed performance measures;and evaluating the impact of the algorithm on study results.Additionally,13 good practice recommendations were formulated with detailed explanations.Furthermore,a practical study on sepsis identification was included to demonstrate the application of this guidance.Conclusions:The establishment of guidance is intended to aid researchers and clinicians in the appropriate and accurate development and application of algorithms for identifying health status from RCD.This guidance has the potential to enhance the credibility of findings from observational studies involving RCD.
基金supported by the National Natural Science Foundation of China(Nos.52270106 and 22266021)Yunnan Major Scientific and Technological Projects(No.202202AG050005)Yunnan Fundamental Research Projects(No.202201AT070116).
文摘This study employed a wet impregnation method to synthesize five types of Cu/HZSM-5 adsorbents with Si/Al ratios of 25,50,85,200,and 300,used for the removal of H_(2)S in lowtemperature,low-oxygen environments.The impact of different Si/Al ratios on the adsorption oxidative performance of Cu_(30)/HZSM-5–85 adsorbents was investigated.According to the performance test results,Cu_(30)/HZSM-5–85 exhibited the highest breakthrough capacity,reaching 231.75 mg H_(2)S/g_(sorbent).Cu/HZSM-5 sorbent maintains a strong ability to remove H_(2)S even under humid conditions and shows excellent water resistance.XRD,BET,and XPS results revealed that CuO is the primary active species,with Cu_(30)/HZSM-5–85 having the largest surface area and highest CuO content,providing more active sites for H_(2)S adsorption.H_(2)-TPR and O_(2)-TPD results confirmed that Cu_(30)/HZSM-5–85 sorbent exhibits outstanding redox properties and oxygen storage capacity,contributing to excellent oxygen transferability in the molecular sieve adsorption-oxidation process.With notable characteristics such as a large surface area,high desulfurization efficiency,and water resistance,Cu_(30)/HZSM-5–85 sorbents hold significant importance for industrial applications.
基金supported by the National Natural Science Foundation of China(Nos.71671187,71874210,71633006)the Natural Science Foundation of Hunan Province,China(No.2024JJ6539)+1 种基金the National Social Science Fund of China(No.22&ZD098)the Social Sciences Fund of Hunan Province,China(No.24YBQ138)。
文摘From a life cycle perspective,the material flow analysis is utilized to investigate the lithium material flows in international trade from 2000 to 2019.The results reveal that at the global level,the total volume of lithium trade grew rapidly,reaching 121116 t in 2019.Lithium trade was dominated by lithium minerals,lithium carbonate and lithium hydroxide rather than final lithium products,indicating an immaturity in global lithium industry.At the intercontinental level,Asia’s import trade and Oceania’s export trade led the world,accounting for 81.22%and 39.68%,respectively.At the national level,China,Japan and Korea became the main importers,while Chile and Australia were the main exporters.In addition,China’s trade volume far exceeded that of the United States.China’s exports were dominated by lithium-ion batteries,while the United States mainly imported lithium-ion batteries,proving that the development of China’s lithium industry was relatively faster.
