Brain-computer interfaces(BCIs)represent an emerging technology that facilitates direct communication between the brain and external devices.In recent years,numerous review articles have explored various aspects of BC...Brain-computer interfaces(BCIs)represent an emerging technology that facilitates direct communication between the brain and external devices.In recent years,numerous review articles have explored various aspects of BCIs,including their fundamental principles,technical advancements,and applications in specific domains.However,these reviews often focus on signal processing,hardware development,or limited applications such as motor rehabilitation or communication.This paper aims to offer a comprehensive review of recent electroencephalogram(EEG)-based BCI applications in the medical field across 8 critical areas,encompassing rehabilitation,daily communication,epilepsy,cerebral resuscitation,sleep,neurodegenerative diseases,anesthesiology,and emotion recognition.Moreover,the current challenges and future trends of BCIs were also discussed,including personal privacy and ethical concerns,network security vulnerabilities,safety issues,and biocompatibility.展开更多
This study investigates the relationship between pesticide metabolites and kidney function in solar greenhouse workers,a group with potentially higher chronic kidney disease(CKD)risk compared to general farmers.A tota...This study investigates the relationship between pesticide metabolites and kidney function in solar greenhouse workers,a group with potentially higher chronic kidney disease(CKD)risk compared to general farmers.A total of 279 workers participated,with pesticide metabolites(AMPA,DMP,DEP,DMDTP,GLY,and DEDTP)measured in their urine.展开更多
生物修复作为经济有效、绿色可持续的修复技术,在有机污染土壤和地下水修复上具有广阔的应用前景。基于Web of Science核心数据库,通过文献计量可视化应用软件VOSviewer和CiteSpace,分析了1990-2020年有机污染土壤和地下水生物修复领域...生物修复作为经济有效、绿色可持续的修复技术,在有机污染土壤和地下水修复上具有广阔的应用前景。基于Web of Science核心数据库,通过文献计量可视化应用软件VOSviewer和CiteSpace,分析了1990-2020年有机污染土壤和地下水生物修复领域的研究热点及趋势。结果表明,有机污染土壤和地下水生物修复领域的论文发表数量呈增长趋势,发文总量最多的国家是美国和中国,但是2012年后中国年发文量快速增加,并位居第一。该领域的相关研究主要发表在Chemosphere、Environmental Science&Technology、Science of the Total Environment等top期刊上。全球研究机构中中国科学院发文量最多,但是来自美国加州大学的总被引频次和h-index最高。发文量最多的是来自英国兰卡斯特大学的学者Semple教授,我国发文量最多的是来自中国科学院南京土壤研究所的骆永明研究员。下一步研究重点和热点:针对复合污染土壤和地下水,研发新型耦合强化生物修复技术,采用先进的分子生物学方法探索功能微生物及其功能基因,阐明生物降解机理,明确原位污染土壤和地下水的靶向性调控机制。展开更多
BACKGROUND Esophageal squamous cell carcinoma(ESCC)is a cancer with a poor prognosis,characterized by distinct geographical distribution and family clustering.AIM To investigate if ethnic differences(Han vs Kazakh)cau...BACKGROUND Esophageal squamous cell carcinoma(ESCC)is a cancer with a poor prognosis,characterized by distinct geographical distribution and family clustering.AIM To investigate if ethnic differences(Han vs Kazakh)cause molecular variations in ESCC patients via genomic sequencing 299 samples.METHODS Here,we sequenced samples from 299 ESCC patients collected from Henan Key Laboratory for Esophageal Cancer Research and National Key Laboratory of Metabolic Dysregulation and Esophageal Cancer Prevention and Treatment,The First Affiliated Hospital of Zhengzhou University,including Han and Kazakh ethnic groups,and performed a genomic comparative analysis of these two ethnic cohorts.RESULTS ESCC patients of Kazakh ethnicity present with a later age of onset compared to Han.Kazakh patients exhibit a slightly higher tumor mutation burden compared to their Han counterparts.Three genes GIGYF1,CACNA1D,and ACOT11 exhibited mutation frequencies threefold higher in Kazakh patients than in Han.This enrichment may be associated with Kazakhs’adaptation to cold climates and consumption of high-calorie diets.Among Han patients,the apolipoprotein B messenger RNA-editing enzyme catalytic polypeptide(APOBEC)-associated single base substitutions(SBS)13 mutational signature is more prevalent,whereas SBS6,indicative of DNA mismatch repair deficiency,is more common in Kazakh patients.Additionally,Han Chinese patients with APOBEC-enriched tumors exhibit a significantly higher mutation load than those without.Moreover,patients lacking the APOBEC signature demonstrate superior survival probability compared to the APOBEC-enriched group.CONCLUSION Living environment and diet are major factors in the development of ESCC.Genomic difference may provide guidance for the formulation of clinical treatment plans for ESCC from different ethnics regions.展开更多
Due to the fast-paced redevelopment of contaminated sites in developing countries,there is a lack of appropriate quantitative approaches to evaluate sustainability for the selection of remedial alternatives.In this st...Due to the fast-paced redevelopment of contaminated sites in developing countries,there is a lack of appropriate quantitative approaches to evaluate sustainability for the selection of remedial alternatives.In this study,an integrated evaluation approach for sustainability assessment was developed and applied to the site remediation of a former large-scale iron and steel manufacturing facility in China.This approach incorporated remedial duration as a distinct tier within a multi-criteria decision analysis framework.The traditional environmental,economic,and social assessments,consisting of 15 categories and 50 indicators for no action alternative,one in situ alternative,and three ex situ alternatives,were performed as the first-tier evaluation,which was then integrated with the second-tier evaluation on the remedial duration.The findings revealed that advanced in situ remediation was associated with a long duration of remedial activities,preventing stakeholders from attaining timely benefits after successful land redevelopment.Furthermore,the evaluation of sustainable remediation was correlated with sustainable development goals(SDG),supporting the conclusion that on-site/off-site treatment alternative performed well in both sustainability and timely redevelopment demands.The scoring of alternatives was further validated through uncertainty analysis,which demonstrated that the on-site/off-site treatment alternative had the highest probability of attaining the best sustainability performance.In addition,sensitivity analysis revealed that remedial duration had the strongest correlation and sensitivity in the integrated evaluation.By integrating SDG targets with the concept of sustainable remediation,this study promotes the greatest net benefit from implementing a sustainable and resilient remediation strategy.Practically,this study proposed an integrated model to promote sustainable remediation outcomes for contaminated sites in fast-developing countries and markets,while considering the constraints of remedial duration and the pursuit of ecological functions.展开更多
Chromatin modifications,including histone acetylation,play essential roles in regulating flowering.The CBP/p300 family HISTONE ACETYLTRANSFERASE 1(HAC1),which mediates histone acetylation,promotes the process of flora...Chromatin modifications,including histone acetylation,play essential roles in regulating flowering.The CBP/p300 family HISTONE ACETYLTRANSFERASE 1(HAC1),which mediates histone acetylation,promotes the process of floral transition;however,the precise mechanism remains largely unclear.Specifically,how HAC1 is involved in the flowering regulatory network and which genes are the direct targets of HAC1 during flowering regulation are still unknown.In this study,we elucidate the critical function of HAC1 in promoting flowering via exerting active epigenetic markers at two key floral integrators,FLOWERING LOCUS T(FT)and SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1(SOC1),thereby regulating their expression to trigger the flowering process.We show that HAC1 physically interacts with CONSTANS(CO)in vivo and in vitro.Chromatin immunoprecipitation results indicate that HAC1 directly binds to the FT and SOC1 loci.Loss of HAC1 impairs CO-mediated transcriptional activation of FT and SOC1 in promoting flowering.Moreover,CO mutation leads to the decreased enrichment of HAC1 at FT and SOC1,indicating that CO recruits HAC1 to FT and SOC1.Finally,HAC1,as well as CO,is required for the elevated histone acetylation level at FT and SOC1.Taken together,our finding reveals that HAC1-mediated histone acetylation boots flowering via a CO-dependent activation of FT and SOC1.展开更多
The integration of machine learning and electrocatalysis presents nota ble advancements in designing and predicting the performance of chiral materials for hydrogen evolution reactions(HER).This study utilizes theoret...The integration of machine learning and electrocatalysis presents nota ble advancements in designing and predicting the performance of chiral materials for hydrogen evolution reactions(HER).This study utilizes theoretical calculations and machine learning techniques to assess the HER performance of both chiral and achiral M-N-SWCNTs(M=In,Bi,and Sb)single-atom catalysts(SACs).The stability preferences of metal atoms are dependent on chirality when interacting with chiral SWCNTs.The HER activity of the right-handed In-N-SWCNT is 5.71 times greater than its achiral counterpart,whereas the left-handed In-N-SWCNT exhibits a 5.12-fold enhancement.The calculated hydrogen adsorption free energy for the right-handed In-N-SWCNT reaches as low as-0.02 eV.This enhancement is attributed to the symmetry breaking in spin density distribution,transitioning from C_(2V)in achiral SACs to C_(2)in chiral SACs,which facilitates active site transfer and enhances local spin density.Right-handed M-N-SWCNTs exhibit superiorα-electron separation and transport efficiency relative to left-handed variants,owing to the chiral induced spin selectivity(CISS)effect,with spin-upα-electron density reaching 3.43×10^(-3)e/Bohr^(3)at active sites.Machine learning provides deeper insights,revealing that the interplay of weak spatial electronic effects and appropriate curvature-chirality effects significantly enhances HER performance.A weaker spatial electronic effect correlates with higher HER activity,larger exchange current density,and higher turnover frequency.The curvature-chirality effect undersco res the influence of intrinsic structures on HER performance.These findings offer critical insights into the role of chirality in electrocatalysis and propose innovative approaches for optimizing HER through chirality.展开更多
To meet the demand for enhanced energy density and improved safety in batteries,anode-free aqueous zinc metal batteries(AF-AZMBs)have garnered significant research interest and attention.Compared with conventional aqu...To meet the demand for enhanced energy density and improved safety in batteries,anode-free aqueous zinc metal batteries(AF-AZMBs)have garnered significant research interest and attention.Compared with conventional aqueous Zn batteries,AF-AZMBs provide higher theoretical energy density,a more simplified structural design,and improved cost-effectiveness.However,AF-AZMBs are confronted with severe capacity degradation and lifespan reduction due to the absence of an excess zinc inventory.In recent years,extensive research efforts have been devoted to addressing these challenges,resulting in significant advancements.Therefore,there is highly warranted for a comprehensive discussion on AF-AZMBs.Herein,this review provides a thorough analysis and in-depth investigation of recent developments in AF-AZMBs from the perspectives of current collectors,electrolytes,and cathodes.Specifically,the working mechanisms and advantageous features of AF-AZMBs are summarized.The major scientific issues affecting capacity degradation and lifespan reduction are discussed,including inhomogeneous Zn deposition/stripping kinetics,unstable SEI layer,and irreversible cathode material loss.Furthermore,the corresponding strategies to address these issues are highlighted,such as anodic current collector design,electrolyte engineering,and cathodic modification.Finally,several promising directions are explored for the future advancement of AF-AZMBs,including developing high-performance Zn-rich cathodes,regulating solid-state electrolytes,and designing dual-electrode-free zinc-metal batteries.Additionally,exploring advanced characterization and analysis techniques and optimizing pouch cells under practical operating conditions are also mentioned,highlighting the urgent need for further research to address existing bottlenecks.展开更多
Soil health is defined as“the ability of the soil to sustain the productivity,diversity,and environmental services of terrestrial ecosystems”by the Intergovernmental Technical Panel on Soils of the FAO.This concept ...Soil health is defined as“the ability of the soil to sustain the productivity,diversity,and environmental services of terrestrial ecosystems”by the Intergovernmental Technical Panel on Soils of the FAO.This concept is increasingly being recognized as an actionable platform for diverse stakeholders in modern society.Despite the critical roles of soil in supporting agriculture,sustaining ecosystems,and mitigating climate change,soil health has long been undervalued and often overlooked.As we look to the future,prioritizing soil health is essential to ensuring food security,environmental sustainability,and the well-being of future generations.展开更多
基金supported by the National Key R&D Program of China(2021YFF1200602)the National Science Fund for Excellent Overseas Scholars(0401260011)+3 种基金the National Defense Science and Technology Innovation Fund of Chinese Academy of Sciences(c02022088)the Tianjin Science and Technology Program(20JCZDJC00810)the National Natural Science Foundation of China(82202798)the Shanghai Sailing Program(22YF1404200).
文摘Brain-computer interfaces(BCIs)represent an emerging technology that facilitates direct communication between the brain and external devices.In recent years,numerous review articles have explored various aspects of BCIs,including their fundamental principles,technical advancements,and applications in specific domains.However,these reviews often focus on signal processing,hardware development,or limited applications such as motor rehabilitation or communication.This paper aims to offer a comprehensive review of recent electroencephalogram(EEG)-based BCI applications in the medical field across 8 critical areas,encompassing rehabilitation,daily communication,epilepsy,cerebral resuscitation,sleep,neurodegenerative diseases,anesthesiology,and emotion recognition.Moreover,the current challenges and future trends of BCIs were also discussed,including personal privacy and ethical concerns,network security vulnerabilities,safety issues,and biocompatibility.
基金supported by the Beijing Natural Science Foundation,China(7234402)the Natural Science Foundation of Gansu Province(20JR10RA421).
文摘This study investigates the relationship between pesticide metabolites and kidney function in solar greenhouse workers,a group with potentially higher chronic kidney disease(CKD)risk compared to general farmers.A total of 279 workers participated,with pesticide metabolites(AMPA,DMP,DEP,DMDTP,GLY,and DEDTP)measured in their urine.
文摘生物修复作为经济有效、绿色可持续的修复技术,在有机污染土壤和地下水修复上具有广阔的应用前景。基于Web of Science核心数据库,通过文献计量可视化应用软件VOSviewer和CiteSpace,分析了1990-2020年有机污染土壤和地下水生物修复领域的研究热点及趋势。结果表明,有机污染土壤和地下水生物修复领域的论文发表数量呈增长趋势,发文总量最多的国家是美国和中国,但是2012年后中国年发文量快速增加,并位居第一。该领域的相关研究主要发表在Chemosphere、Environmental Science&Technology、Science of the Total Environment等top期刊上。全球研究机构中中国科学院发文量最多,但是来自美国加州大学的总被引频次和h-index最高。发文量最多的是来自英国兰卡斯特大学的学者Semple教授,我国发文量最多的是来自中国科学院南京土壤研究所的骆永明研究员。下一步研究重点和热点:针对复合污染土壤和地下水,研发新型耦合强化生物修复技术,采用先进的分子生物学方法探索功能微生物及其功能基因,阐明生物降解机理,明确原位污染土壤和地下水的靶向性调控机制。
基金Supported by the National Natural Science Foundation of China,No.U1301227National Major Science and Technology Projects,No.2024ZD05209060Henan Province Jointly Built Science and Technology Key Projects,No.LHGJ20210337.
文摘BACKGROUND Esophageal squamous cell carcinoma(ESCC)is a cancer with a poor prognosis,characterized by distinct geographical distribution and family clustering.AIM To investigate if ethnic differences(Han vs Kazakh)cause molecular variations in ESCC patients via genomic sequencing 299 samples.METHODS Here,we sequenced samples from 299 ESCC patients collected from Henan Key Laboratory for Esophageal Cancer Research and National Key Laboratory of Metabolic Dysregulation and Esophageal Cancer Prevention and Treatment,The First Affiliated Hospital of Zhengzhou University,including Han and Kazakh ethnic groups,and performed a genomic comparative analysis of these two ethnic cohorts.RESULTS ESCC patients of Kazakh ethnicity present with a later age of onset compared to Han.Kazakh patients exhibit a slightly higher tumor mutation burden compared to their Han counterparts.Three genes GIGYF1,CACNA1D,and ACOT11 exhibited mutation frequencies threefold higher in Kazakh patients than in Han.This enrichment may be associated with Kazakhs’adaptation to cold climates and consumption of high-calorie diets.Among Han patients,the apolipoprotein B messenger RNA-editing enzyme catalytic polypeptide(APOBEC)-associated single base substitutions(SBS)13 mutational signature is more prevalent,whereas SBS6,indicative of DNA mismatch repair deficiency,is more common in Kazakh patients.Additionally,Han Chinese patients with APOBEC-enriched tumors exhibit a significantly higher mutation load than those without.Moreover,patients lacking the APOBEC signature demonstrate superior survival probability compared to the APOBEC-enriched group.CONCLUSION Living environment and diet are major factors in the development of ESCC.Genomic difference may provide guidance for the formulation of clinical treatment plans for ESCC from different ethnics regions.
基金supported by the National Natural Science Foundation of China(No.32061133001)we acknowledged the cooperation between China and the European Union through the EiCLaR project(European Union's Horizon 2020,N°965945)+1 种基金In addition,this study was supported by the Eco-Environmental Engineering Research Center of the China State Construction Engineering Corporation(Soil Remediation Technology and Equipment)(No.CSCEC-PT-009)the Shandong Leading Green Industry Development Corporation,China(Green Industry and Environmental Safety Innovation and Entrepreneurship Community of Shandong Province)(No.2023-LSGTT-CX-004).
文摘Due to the fast-paced redevelopment of contaminated sites in developing countries,there is a lack of appropriate quantitative approaches to evaluate sustainability for the selection of remedial alternatives.In this study,an integrated evaluation approach for sustainability assessment was developed and applied to the site remediation of a former large-scale iron and steel manufacturing facility in China.This approach incorporated remedial duration as a distinct tier within a multi-criteria decision analysis framework.The traditional environmental,economic,and social assessments,consisting of 15 categories and 50 indicators for no action alternative,one in situ alternative,and three ex situ alternatives,were performed as the first-tier evaluation,which was then integrated with the second-tier evaluation on the remedial duration.The findings revealed that advanced in situ remediation was associated with a long duration of remedial activities,preventing stakeholders from attaining timely benefits after successful land redevelopment.Furthermore,the evaluation of sustainable remediation was correlated with sustainable development goals(SDG),supporting the conclusion that on-site/off-site treatment alternative performed well in both sustainability and timely redevelopment demands.The scoring of alternatives was further validated through uncertainty analysis,which demonstrated that the on-site/off-site treatment alternative had the highest probability of attaining the best sustainability performance.In addition,sensitivity analysis revealed that remedial duration had the strongest correlation and sensitivity in the integrated evaluation.By integrating SDG targets with the concept of sustainable remediation,this study promotes the greatest net benefit from implementing a sustainable and resilient remediation strategy.Practically,this study proposed an integrated model to promote sustainable remediation outcomes for contaminated sites in fast-developing countries and markets,while considering the constraints of remedial duration and the pursuit of ecological functions.
基金supported by the National Natural Science Foundation of China to Z.L.(32300474)and to C.L.(32470346 and 32270362)the Guangdong Basic and Applied Basic Research Foundation to C.L.(2024A1515010612)the Fundamental Research Funds for the Central Universities to X.S.(24qnpy078).
文摘Chromatin modifications,including histone acetylation,play essential roles in regulating flowering.The CBP/p300 family HISTONE ACETYLTRANSFERASE 1(HAC1),which mediates histone acetylation,promotes the process of floral transition;however,the precise mechanism remains largely unclear.Specifically,how HAC1 is involved in the flowering regulatory network and which genes are the direct targets of HAC1 during flowering regulation are still unknown.In this study,we elucidate the critical function of HAC1 in promoting flowering via exerting active epigenetic markers at two key floral integrators,FLOWERING LOCUS T(FT)and SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1(SOC1),thereby regulating their expression to trigger the flowering process.We show that HAC1 physically interacts with CONSTANS(CO)in vivo and in vitro.Chromatin immunoprecipitation results indicate that HAC1 directly binds to the FT and SOC1 loci.Loss of HAC1 impairs CO-mediated transcriptional activation of FT and SOC1 in promoting flowering.Moreover,CO mutation leads to the decreased enrichment of HAC1 at FT and SOC1,indicating that CO recruits HAC1 to FT and SOC1.Finally,HAC1,as well as CO,is required for the elevated histone acetylation level at FT and SOC1.Taken together,our finding reveals that HAC1-mediated histone acetylation boots flowering via a CO-dependent activation of FT and SOC1.
基金the full support of the National Natural Science Foundation of China(62071154,51272052 and50902040)the Natural Science Foundation of Heilongjiang Province of China(LH2020B011 and LH2019B006)the Scientific Research Projects of Basic Scientific Research Operational Expenses of Heilongjiang Provincial Colleges and Universities(2021-KYYWF-0171)。
文摘The integration of machine learning and electrocatalysis presents nota ble advancements in designing and predicting the performance of chiral materials for hydrogen evolution reactions(HER).This study utilizes theoretical calculations and machine learning techniques to assess the HER performance of both chiral and achiral M-N-SWCNTs(M=In,Bi,and Sb)single-atom catalysts(SACs).The stability preferences of metal atoms are dependent on chirality when interacting with chiral SWCNTs.The HER activity of the right-handed In-N-SWCNT is 5.71 times greater than its achiral counterpart,whereas the left-handed In-N-SWCNT exhibits a 5.12-fold enhancement.The calculated hydrogen adsorption free energy for the right-handed In-N-SWCNT reaches as low as-0.02 eV.This enhancement is attributed to the symmetry breaking in spin density distribution,transitioning from C_(2V)in achiral SACs to C_(2)in chiral SACs,which facilitates active site transfer and enhances local spin density.Right-handed M-N-SWCNTs exhibit superiorα-electron separation and transport efficiency relative to left-handed variants,owing to the chiral induced spin selectivity(CISS)effect,with spin-upα-electron density reaching 3.43×10^(-3)e/Bohr^(3)at active sites.Machine learning provides deeper insights,revealing that the interplay of weak spatial electronic effects and appropriate curvature-chirality effects significantly enhances HER performance.A weaker spatial electronic effect correlates with higher HER activity,larger exchange current density,and higher turnover frequency.The curvature-chirality effect undersco res the influence of intrinsic structures on HER performance.These findings offer critical insights into the role of chirality in electrocatalysis and propose innovative approaches for optimizing HER through chirality.
基金supported by the National Natural Science Foundation of China(22209006)the Fundamental Research Funds for the Central Universities(buctrc202307)the Natural Science Foundation of Shandong Province(ZR2022QE009)。
文摘To meet the demand for enhanced energy density and improved safety in batteries,anode-free aqueous zinc metal batteries(AF-AZMBs)have garnered significant research interest and attention.Compared with conventional aqueous Zn batteries,AF-AZMBs provide higher theoretical energy density,a more simplified structural design,and improved cost-effectiveness.However,AF-AZMBs are confronted with severe capacity degradation and lifespan reduction due to the absence of an excess zinc inventory.In recent years,extensive research efforts have been devoted to addressing these challenges,resulting in significant advancements.Therefore,there is highly warranted for a comprehensive discussion on AF-AZMBs.Herein,this review provides a thorough analysis and in-depth investigation of recent developments in AF-AZMBs from the perspectives of current collectors,electrolytes,and cathodes.Specifically,the working mechanisms and advantageous features of AF-AZMBs are summarized.The major scientific issues affecting capacity degradation and lifespan reduction are discussed,including inhomogeneous Zn deposition/stripping kinetics,unstable SEI layer,and irreversible cathode material loss.Furthermore,the corresponding strategies to address these issues are highlighted,such as anodic current collector design,electrolyte engineering,and cathodic modification.Finally,several promising directions are explored for the future advancement of AF-AZMBs,including developing high-performance Zn-rich cathodes,regulating solid-state electrolytes,and designing dual-electrode-free zinc-metal batteries.Additionally,exploring advanced characterization and analysis techniques and optimizing pouch cells under practical operating conditions are also mentioned,highlighting the urgent need for further research to address existing bottlenecks.
文摘Soil health is defined as“the ability of the soil to sustain the productivity,diversity,and environmental services of terrestrial ecosystems”by the Intergovernmental Technical Panel on Soils of the FAO.This concept is increasingly being recognized as an actionable platform for diverse stakeholders in modern society.Despite the critical roles of soil in supporting agriculture,sustaining ecosystems,and mitigating climate change,soil health has long been undervalued and often overlooked.As we look to the future,prioritizing soil health is essential to ensuring food security,environmental sustainability,and the well-being of future generations.
