Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations...Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations,and functional implications of RIPK family members across various cancers.Methods:We collected multi-omics data from The Cancer Genome Atlas and other public databases,including gene expression,copy number variation(CNV),mutation,methylation,tumor mutation burden(TMB),and microsatellite instability(MSI).Differential expression and survival analyses were performed using DESeq2 and Cox proportional hazards models.CNV and mutation data were analyzed with GISTIC2 and Mutect2,and methylation data with the ChAMP package.Correlations with TMB and MSI were assessed using Pearson coefficients,and gene set enrichment analysis was conducted with the MSigDB Hallmark gene sets.Results:RIPK family members show significant differential expression in various cancers,with RIPK1 and RIPK4 frequently altered.Survival analysis reveals heterogeneous impacts on overall survival.CNV and mutation analyses identify high alteration frequencies for RIPK2 and RIPK7,affecting gene expression.RIPK1 and RIPK7 are hypermethylated in several cancers,inversely correlating with RIPK3 expression.RIPK1,RIPK2,RIPK5,RIPK6,and RIPK7 correlate positively with TMB,while RIPK3 shows negative correlations in some cancers.MSI analysis indicates associations with DNA mismatch repair.G ene set enrichment analysis highlights immune-related pathway enrichment for RIPK1,RIPK2,RIPK3,and RIPK6,and cell proliferation and DNA repair pathways for RIPK4 and RIPK5.RIPK family members showed heterogeneous alterations across cancers:for example,RIPK7 was mutated in up to~15%of u terine c orpus e ndometrial c arcinoma and l ung s quamous c ell c arcinoma cases,and RIPK1 and RIPK7 exhibited frequent promoter hypermethylation in multiple tumor types.Several genes displayed context-dependent associations with overall survival and with TMB/MSI.Conclusion:This pan-cancer analysis of the RIPK family reveals their diverse roles and potential as biomarkers and therapeutic targets.The findings emphasize the importance of RIPK genes in tumorigenesis and suggest context-dependent functions across cancer types.Further studies are needed to explore their mechanisms in cancer development and clinical applications.展开更多
We investigate the effects of temperature on the structural evolution and clustering in the hypernucleus,taking_(Λ)^(21)Ne as an example,in the framework of deformed finite-temperature Skyrme-Hartree-Fock.The SkI4 Sk...We investigate the effects of temperature on the structural evolution and clustering in the hypernucleus,taking_(Λ)^(21)Ne as an example,in the framework of deformed finite-temperature Skyrme-Hartree-Fock.The SkI4 Skyrme force is employed for nucleon-nucleon interaction,while the NSC97f force is used for the hyperon-nucleon interaction.It is found that the system exhibits a strongly deformed ground state with pronouncedα-cluster correlations and localized density distributions at low temperatures.As temperature increases,nuclear deformation weakens,the nuclear density spreads over the surface,and clustering gradually diminishes and vanishes entirely at T≈2.8 MeV.This is because that the thermal excitations lower the Fermi surface and enhance single-particle level splitting.In particular,owing to the lower excitation threshold of hyperons in the hypernuclear system,the hyperon radii exhibit a stronger temperature dependence than the nucleons.We further analyze the temperature-dependent changes in deformation,single-Λbinding energy,and entropy,providing new insights into the thermal evolution of the hypernuclear structure.展开更多
Polymyxin B,which is a last-line antibiotic for extensively drug-resistant Gram-negative bacterial infections,became available in China in Dec.2017.As dose adjustments are based solely on clinical experience of risk t...Polymyxin B,which is a last-line antibiotic for extensively drug-resistant Gram-negative bacterial infections,became available in China in Dec.2017.As dose adjustments are based solely on clinical experience of risk toxicity,treatment failure,and emergence of resistance,there is an urgent clinical need to perform therapeutic drug monitoring(TDM)to optimize the use of polymyxin B.It is thus necessary to standardize operating procedures to ensure the accuracy of TDM and provide evidence for their rational use.We report a consensus on TDM guidelines for polymyxin B,as endorsed by the Infection and Chemotherapy Committee of the Shanghai Medical Association and the Therapeutic Drug Monitoring Committee of the Chinese Pharmacological Society.The consensus panel was composed of clinicians,pharmacists,and microbiologists from different provinces in China and Australia who made recommendations regarding target concentrations,sample collection,reporting,and explanation of TDM results.The guidelines provide the first-ever consensus on conducting TDM of polymyxin B,and are intended to guide optimal clinical use.展开更多
The presence of aluminum(Al^(3+))and fluoride(F^(−))ions in the environment can be harmful to ecosystems and human health,highlighting the need for accurate and efficient monitoring.In this paper,an innovative approac...The presence of aluminum(Al^(3+))and fluoride(F^(−))ions in the environment can be harmful to ecosystems and human health,highlighting the need for accurate and efficient monitoring.In this paper,an innovative approach is presented that leverages the power of machine learning to enhance the accuracy and efficiency of fluorescence-based detection for sequential quantitative analysis of aluminum(Al^(3+))and fluoride(F^(−))ions in aqueous solutions.The proposed method involves the synthesis of sulfur-functionalized carbon dots(C-dots)as fluorescence probes,with fluorescence enhancement upon interaction with Al^(3+)ions,achieving a detection limit of 4.2 nmol/L.Subsequently,in the presence of F^(−)ions,fluorescence is quenched,with a detection limit of 47.6 nmol/L.The fingerprints of fluorescence images are extracted using a cross-platform computer vision library in Python,followed by data preprocessing.Subsequently,the fingerprint data is subjected to cluster analysis using the K-means model from machine learning,and the average Silhouette Coefficient indicates excellent model performance.Finally,a regression analysis based on the principal component analysis method is employed to achieve more precise quantitative analysis of aluminum and fluoride ions.The results demonstrate that the developed model excels in terms of accuracy and sensitivity.This groundbreaking model not only showcases exceptional performance but also addresses the urgent need for effective environmental monitoring and risk assessment,making it a valuable tool for safeguarding our ecosystems and public health.展开更多
Background:Acute liver injury(ALI)requires rapid hepatic regeneration to avert fatal liver failure.As key mechanisms,systemic metabolic remodeling and inter-organ crosstalk are critical for this regenerative process.S...Background:Acute liver injury(ALI)requires rapid hepatic regeneration to avert fatal liver failure.As key mechanisms,systemic metabolic remodeling and inter-organ crosstalk are critical for this regenerative process.Skeletal muscle,as a major metabolic organ system,undergoes significant remodeling during ALI.However,its specific regulatory contributions remain largely uncharacterized.Methods:Partial(2/3)hepatectomy and acetaminophen were used to induce ALI in male mice.RNA-sequencing(RNA-seq),assay for transposase-accessible chromatin by sequencing(ATAC-seq),chromatin immunoprecipitation,luciferase assay,Western blotting,TUNEL assay,immunohistochemistry,and phase separation assays were performed to reveal the transcriptional axis involved.Serum fibroblast growth factor binding protein 1(FGFBP1)protein levels in ALI patients were assessed via enzyme-linked immunosorbent assay.Results:Integrated analysis of RNA-seq and ATAC-seq following ALI identifies glucocorticoid(GC)signaling-mediated regulation of fibroblast growth factor 6(FGF6)in skeletal muscle metabolism.Muscle-specific knockdown of GC receptor(GR)exacerbates ALI and suppresses liver regeneration.Fgf6-knockout mice exhibited improved ALI and enhanced liver regeneration,with intramuscular injection of FGF6-neutralizing antibody rescuing the detrimental effects induced by GR knockdown.Further analysis of the FGF6 downstream target revealed that FGF6 regulates FGFBP1 expression through extracellular signal regulated kinase-activating transcription factor 3 signaling.Moreover,FGF6 regulates the heparin-dependent release kinetics of FGFBP1 by perturbing its liquid-liquid phase separation(LLPS)-driven condensate dynamics at the plasma membrane.Circulating FGFBP1 subsequently interacts with hepatic FGF5 through LLPS mechanisms to regulate liver regeneration.Conclusion:Our results demonstrate a molecular mechanism by which muscle-liver crosstalk can initiate and sustain liver regeneration via the FGF6-FGFBP1/FGF5 axis,providing a potential therapeutic target and treatment strategy for ALI.展开更多
The practical application of energy-dense lithium(Li)metal batteries is severely hindered by the lack of suitable electrolytes.Weakening solvent coordination to enhance Li+kinetics has become a critical principle in e...The practical application of energy-dense lithium(Li)metal batteries is severely hindered by the lack of suitable electrolytes.Weakening solvent coordination to enhance Li+kinetics has become a critical principle in electrolyte design.Here,we propose an electrolyte design strategy that weakens Li^(+)-solvent coordination through the synergistic drag effects of dual diluents.Specifically,the-CF_(2)H group in ethyl 1,1,2,2-tetrafluoroethyl ether(ETE)forms hydrogen bonds with the oxygen atom in 1,2-dimethoxyethane(DME),while the electron-donating-N=and C_(2)H_(5)O-groups in ethoxy(pentafluoro)cyclotriphosphazene(PFPN)coordinate synergistically with Li^(+).The combined effects of hydrogen bonding between ETE and DME,along with the coordination of PFPN with Li^(+),weaken the Li^(+)-DME interaction and promote anion-enriched solvation structure,thereby facilitating Li^(+)desolvation process and forming an inorganic-rich solid-electrolyte interphase.In a Li metal battery with a 30μm ultrathin Li anode and high-loading LiNi_(0.5)Co_(0.2)Mn_(0.3)O_(2)cathode(23.5 mg cm^(-2)),80% of capacity was achieved after 430 cycles at 4.3 V and 84% after 310 cycles at 4.5 V.Furthermore,a 331 mAh pouch cell achieved 148 cycles with 94.9% of capacity retention.展开更多
A simulate daily oriental dietary pattern(a blend of lard and soybean oil)was performed in this research to investigate influence on liver and kidney function.Sixty mice were randomly divided into 6 groups with diets ...A simulate daily oriental dietary pattern(a blend of lard and soybean oil)was performed in this research to investigate influence on liver and kidney function.Sixty mice were randomly divided into 6 groups with diets of different fat added oils respectively for 12 weeks.Malondialdehyde and uric acid contents in mice fed with blended oil were significantly lower than in those fed only with soybean oil and lard due to the improved activities of antioxidant enzymes.Daily use of a blend of lard with soybean oil significantly increased antioxidant capacity,reduced lipid peroxidation of liver and serum uric acid production,thus protected liver and renal function.It also suggests that the oriental dietary pattern might reduce the risk of gout.展开更多
Atomic-scale doping strategies and structure design play pivotal roles in tailoring the electronic structure and physicochemical property of electromagnetic wave absorption(EMWA)materials.However,the relationship betw...Atomic-scale doping strategies and structure design play pivotal roles in tailoring the electronic structure and physicochemical property of electromagnetic wave absorption(EMWA)materials.However,the relationship between configuration and electromagnetic(EM)loss mechanism has remained elusive.Herein,drawing inspiration from the DNA transcription process,we report the successful synthesis of novel in situ Mn/N co-doped helical carbon nanotubes with ultrabroad EMWA capability.Theoretical calculation and EM simulation confirm that the orbital coupling and spin polarization of the Mn–N4–C configuration,along with cross polarization generated by the helical structure,endow the helical converters with enhanced EM loss.As a result,HMC-8 demonstrates outstanding EMWA performance,achieving a minimum reflection loss of−63.13 dB at an ultralow thickness of 1.29 mm.Through precise tuning of the graphite domain size,HMC-7 achieves an effective absorption bandwidth(EAB)of 6.08 GHz at 2.02 mm thickness.Furthermore,constructing macroscale gradient metamaterials enables an ultrabroadband EAB of 12.16 GHz at a thickness of only 5.00 mm,with the maximum radar cross section reduction value reaching 36.4 dB m2.This innovative approach not only advances the understanding of metal–nonmetal co-doping but also realizes broadband EMWA,thus contributing to the development of EMWA mechanisms and applications.展开更多
Vortex levitation attains non-contact handling by injecting air through a tangential nozzle into a cylindrical cup generating the swirling flow. The precessing of the swirling flow causes pressure fluctuation. This ph...Vortex levitation attains non-contact handling by injecting air through a tangential nozzle into a cylindrical cup generating the swirling flow. The precessing of the swirling flow causes pressure fluctuation. This phenomenon becomes apparent as the gap between the cup and workpiece increases, which significantly disturbs the stability of conveyance. In this paper, suppression of pressure fluctuation by a cylindrical column that stabilizes the vortex levitation is described and its mechanism is mentioned. According to the experimental set up, the pressure was measured at the center of the workpiece and the wall of the cup;velocity field under the work piece was visualized by PIV. The result suggested that the larger diameter column denoted the effect on suppression of the fluctuation because the precessing of the swirling flow became stable. On the other hand, variation of the column thickness had insignificant effect on suppressing the fluctuation, but sucking force became weakened since the swirling velocity decreased.展开更多
Microbial growth causes lamb spoilage.This study explored the spoilage ability of Latilactobacillus sakei,Serratia proteamaculans and Hafnia proteus in vacuum-packed raw lamb,including growth ability,degradation of pr...Microbial growth causes lamb spoilage.This study explored the spoilage ability of Latilactobacillus sakei,Serratia proteamaculans and Hafnia proteus in vacuum-packed raw lamb,including growth ability,degradation of protein and lipid,and change of volatile organic compounds(VOCs)profile,meanwhile screened the key VOCs produced by the targeted strains with meat background excluding,finally confirmed the volatile spoilage marker of vacuum-packaged lamb by comparing with our previous work.The results showed that L.sakei,S.proteamaculans and H.proteus had excellent growth ability.L.sakei inoculated group significantly reduced the pH value,showed higher trichloroacetic acid-soluble peptides content,and excellently degraded sarcoplasmic and myofibrillar proteins.About free amino acids,L.sakei significantly degraded serine,arginine and aspartic acid,while S.proteamaculans and H.proteus significantly degraded serine and lysine.In addition,L.sakei had the strongest effect on promoting free fatty acid production,followed by S.proteamaculans and finally H.proteus.Evaluating from various indicators,the co-culture of the three strains did not have any effect.The key volatiles produced by L.sakei were 1-hexanol,acetic acid and hexanoic acid,S.proteamaculans produced 1-hexanol and acetoin,and H.proteus produced 1-hexanol,acetic acid and acetoin.In the end,1-hexanol,hexanoic acid and acetoin were proven to be spoilage markers for vacuum-packaged and chilled lamb.This study can provide fundamental information for inhibiting and rapid identification of spoilage in vacuum-packaged lamb.展开更多
In the traditional blast furnace(BF)ironmaking process in China,a notable deviation exists between the theoretical and actual yield of hot metal,leading to unexpected iron loss and restricting the improvement of produ...In the traditional blast furnace(BF)ironmaking process in China,a notable deviation exists between the theoretical and actual yield of hot metal,leading to unexpected iron loss and restricting the improvement of production capacity,which cannot adapt to the increasingly intensified smelting rhythm.Focusing on a BF in a Chinese steel enterprise,a deep neural network algorithm was designed to model the impact of multiple parameters on actual yield of hot metal in a single BF smelting cycle,successfully accomplishing the theoretical computation and real-time prediction of yield of hot metal for subsequent,unknown BF smelting cycle.Test results show that the proposed algorithm demonstrates an impressive prediction accuracy of 86.7% within an error range of±10 t and can swiftly complete the training and convergence process in 32.5 s.By integrating prediction results with Nomogram,a regulatory mechanism was engineered to minimize the deviation between theoretical and actual yield of hot metal.This mechanism ensures the yield enhancement of hot metal through dynamic adjustments of BF operational parameters.Industrial-scale application experiments confirmed that the intelligent operation and optimization system,developed in the laboratory,can maintain the yield deviation of hot metal within a stable range of 30 t,achieving a maximum reduction in iron loss rate of 17.65%compared to that before system operation.The findings provide robust support for the yield increase and efficiency improvement of the experimental BF.展开更多
Vat photopolymerization(VPP)3D printing is an optimized technology for complex-shaped ceramic cores,in which the solid loading of ceramic slurries greatly infiuences the microstructure and property of the final cerami...Vat photopolymerization(VPP)3D printing is an optimized technology for complex-shaped ceramic cores,in which the solid loading of ceramic slurries greatly infiuences the microstructure and property of the final ceramic parts.However,the high solid loading of slurries is highly limited by the high viscosity.In this study,silica-based ceramic core slurries with solid loading up to 68vol.%were achieved by the composition design to optimize the performance,considering the curing,rheological,and double bond conversion rate.The slurries demonstrate superior curing and rheological performance with mass ratio of monomers being 3:2 and mass fraction of BYK111 being 4wt.%.Afterwards,the impact of solid loading on the morphology and mechanical properties was investigated.As the solid loading increases,the microstructure becomes gradually dense,leading to an improved flexural strength of 19.5 MPa.Additionally,the sintering shrinkage becomes more uniform,satisfying the casting requirements effectively.This work serves as a guide for the preparation of ceramic slurries with a high solid loading.展开更多
Micro-nano Earth Observation Satellite(MEOS)constellation has the advantages of low construction cost,short revisit cycle,and high functional density,which is considered a promising solution for serving rapidly growin...Micro-nano Earth Observation Satellite(MEOS)constellation has the advantages of low construction cost,short revisit cycle,and high functional density,which is considered a promising solution for serving rapidly growing observation demands.The observation Scheduling Problem in the MEOS constellation(MEOSSP)is a challenging issue due to the large number of satellites and tasks,as well as complex observation constraints.To address the large-scale and complicated MEOSSP,we develop a Two-Stage Scheduling Algorithm based on the Pointer Network with Attention mechanism(TSSA-PNA).In TSSA-PNA,the MEOS observation scheduling is decomposed into a task allocation stage and a single-MEOS scheduling stage.In the task allocation stage,an adaptive task allocation algorithm with four problem-specific allocation operators is proposed to reallocate the unscheduled tasks to new MEOSs.Regarding the single-MEOS scheduling stage,we design a pointer network based on the encoder-decoder architecture to learn the optimal singleMEOS scheduling solution and introduce the attention mechanism into the encoder to improve the learning efficiency.The Pointer Network with Attention mechanism(PNA)can generate the single-MEOS scheduling solution quickly in an end-to-end manner.These two decomposed stages are performed iteratively to search for the solution with high profit.A greedy local search algorithm is developed to improve the profits further.The performance of the PNA and TSSA-PNA on singleMEOS and multi-MEOS scheduling problems are evaluated in the experiments.The experimental results demonstrate that PNA can obtain the approximate solution for the single-MEOS scheduling problem in a short time.Besides,the TSSA-PNA can achieve higher observation profits than the existing scheduling algorithms within the acceptable computational time for the large-scale MEOS scheduling problem.展开更多
BACKGROUND The clinical metastasis rate of lung cancer is tremendously low in gastrointestinal tract.Individuals enduring small intestine metastasis of lung cancer are normally featured by less desirable prognosis and...BACKGROUND The clinical metastasis rate of lung cancer is tremendously low in gastrointestinal tract.Individuals enduring small intestine metastasis of lung cancer are normally featured by less desirable prognosis and shorter survival than those with me-tastasis in other parts of the body.As a consequence,it holds crucial significance to conduct early diagnosis and development of systematic treatment for patients with gastrointestinal metastasis in lung cancer.In this case,a 59-year-old female patient,diagnosed with lung adenocarcinoma,experienced intestinal obstruction attributable to subsequent small intestinal metastasis.Imaging confirmed the metastasis to the small intestine after the adenocarcinoma diagnosis,ultimately giving rise to advanced-stage intestinal obstruction.Conservative treatment proved ineffective,progressing to intestinal perforation in the later stages.This resulted in peritonitis and infectious toxic shock and other serious clinical manifestations.Aggressive surgical resection mitigated the risk of disease progression and even fatality,which tremendously ameliorated the patient’s prognosis and prolonged her survival.CONCLUSION Patients enduring lung cancer who exhibit acute abdominal symptoms should be mindful of the potential for small intestinal metastasis.Intestinal perforation typically occurs in advanced stages of the disease.Moreover,and aggressive surgical treatment can mitigate the risk of multifarious complications such as peritonitis,infectious toxic shock,and even fatality.展开更多
Herein,a ternary supramolecular assembly(BPP-BQ?CB[8]-SCD)is successfully constructed by a bromophenylpyridine-tethered-bromoisoquinoline(BPP-BQ),cucurbit[8]uril(CB[8])and sulfonatedβ-cyclodextrin(SCD)via successive ...Herein,a ternary supramolecular assembly(BPP-BQ?CB[8]-SCD)is successfully constructed by a bromophenylpyridine-tethered-bromoisoquinoline(BPP-BQ),cucurbit[8]uril(CB[8])and sulfonatedβ-cyclodextrin(SCD)via successive assembling way,exhibiting progressively enhanced green roomtemperature phosphorescence(RTP).The self-aggregates of BPP-BQ?CB[8]-SCD accommodate an energy acceptor rhodamine B(Rh B)to form a light-harvesting system(BPP-BQ?CB[8]-SCD@Rh B)with further enhanced yellow long-lifetime luminescence with large Stokes shift based on triplet-singlet F?rster resonance energy transfer(TS-FRET).Crucially,the introduction of a photoactive diarylethene achieves the long-lived photoluminescence of BPP-BQ?CB[8]-SCD@Rh B to be switched with the efficiency of up to98%through logically ordered lowering/enhancing RTP performance of the energy donor and intercepting/restoring TS-FRET pathway,when stimulated by host-vip competition and light illumination in sequence.Moreover,BPP-BQ?CB[8]-SCD@Rh B is evenly doped into polyvinyl alcohol or polyacrylamide to obtain high-performance luminescent films with long afterglow.The abovementioned logically ordered stimulus-switched long-lived emission enables the light-harvesting system in both solution and solid state to be applied in high-security-level information encryption and transformation,and anticounterfeiting.展开更多
For the longitudinal midcourse guidance problem of a cruise-glide integrated hypersonic vehicle(CGHV),an analytical method based on optimal control theory is proposed.This method constructs a guidance dynamics model f...For the longitudinal midcourse guidance problem of a cruise-glide integrated hypersonic vehicle(CGHV),an analytical method based on optimal control theory is proposed.This method constructs a guidance dynamics model for such vehicles,using aerodynamic load as the control variable,and introduces a framework for solving the guidance laws.This framework unifies the design process of guidance laws for both the glide and cruise phases.By decomposing the longitudinal guidance task into position control and velocity control,and minimizing energy consumption as the objective function,the method provides an analytical solution for velocity control load through the calculation of costate variables.This approach requires only the current state and terminal state parameters to determine the guidance law solution.Furthermore,by transforming path constraints into aerodynamic load constraints and solving backwards to obtain the angle of attack,bank angle,and throttle setting,this method ensures a smooth transition from the glide phase to the cruise phase,guaranteeing the successful completion of the guidance task.Finally,the effectiveness and practicality of the proposed method are validated through case simulations and analysis.展开更多
Cover cropping is a diversifying agricultural practice that can improve soil structure and function by altering the underground litter diversity and soil microbial communities.Here,we tested how a wheat cover crop alt...Cover cropping is a diversifying agricultural practice that can improve soil structure and function by altering the underground litter diversity and soil microbial communities.Here,we tested how a wheat cover crop alters the decomposition of cucumber root litter.A three-year greenhouse litterbag decomposition experiment showed that a wheat cover crop accelerates the decomposition of cucumber root litter.A microcosm litterbag experiment further showed that wheat litter and the soil microbial community could improve cucumber root litter decomposition.Moreover,the wheat cover crop altered the abundances and diversities of soil bacterial and fungal communities,and enriched several putative keystone operational taxonomic units(OTUs),such as Bacillus sp.OTU1837 and Mortierella sp.OTU1236,that were positively related to the mass loss of cucumber root litter.The representative bacterial and fungal strains B186 and M3 were isolated and cultured.In vitro decomposition tests demonstrated that both B186 and M3 had cucumber root litter decomposition activity and a stronger effect was found when they were co-incubated.Overall,a wheat cover crop accelerated cucumber root litter decomposition by altering the soil microbial communities,particularly by stimulating certain putative keystone taxa,which provides a theoretical basis for using cover crops to promote sustainable agricultural development.展开更多
Solid-state batteries(SSBs)with high-capacity Si anodes have been regarded as one of the most promising candidates to meet the large scale energy storage and electrical vehicles due to its intrinsic safety and potenti...Solid-state batteries(SSBs)with high-capacity Si anodes have been regarded as one of the most promising candidates to meet the large scale energy storage and electrical vehicles due to its intrinsic safety and potential high energy density.However,Si suffers from poor electrical conductivity and huge volume change and particles fracture during lithiaiotn and delithiation,which induces low practical energy density.In addition,the SSBs are often operated at high temperature due to the poor physical contact and huge resistance between Si and solid-state electrolyte(SSE).To improve the bulk electronic/ionic conductivity of Si and its interfacial compatibility with SSE,herein,a binder free and self-supporting Si/C film was developed.The monolithic carbon not only enhance the electric conductivity but also release huge stress during lithiation and delithiation.In addition,paired with the flexible and soft poly(vinylidene fluoride)-co-hexafluoropropylene(PVDF-HFP)and Li_(1.3)A_(l0.3)Ti_(1.7)(PO_(4))_(3)(LATP)solid-state electrolyte,a LiF-rich and electrochemical stable solid-electrolyte interphase(SEI)layer is in-situ engineered.The fast bulk and interfacial ionic transportation as well as the mechanical integrity of MSi enable high performance SSBs at room temperature.As a result,high specific capacity of 2137 m Ah/g with an initial Coulombic efficiency of 83.2%is obtained at a rate of 0.5 A/g.Even at a high rate of 3 A/g,the specific capacity is1793 m Ah/g.At a rate of 1 A/g,the Si/C anode delivers a long cycling performance over 500 cycles while maintains a capacity of 1135 mAh/g.This work provides a new strategy that combines charge transfer kinetics and interfacial chemistry design toward high energy density Si-based SSBs.展开更多
基金supported by grants from the Tianjin Health Technology Project(Grant no.2022QN106).
文摘Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations,and functional implications of RIPK family members across various cancers.Methods:We collected multi-omics data from The Cancer Genome Atlas and other public databases,including gene expression,copy number variation(CNV),mutation,methylation,tumor mutation burden(TMB),and microsatellite instability(MSI).Differential expression and survival analyses were performed using DESeq2 and Cox proportional hazards models.CNV and mutation data were analyzed with GISTIC2 and Mutect2,and methylation data with the ChAMP package.Correlations with TMB and MSI were assessed using Pearson coefficients,and gene set enrichment analysis was conducted with the MSigDB Hallmark gene sets.Results:RIPK family members show significant differential expression in various cancers,with RIPK1 and RIPK4 frequently altered.Survival analysis reveals heterogeneous impacts on overall survival.CNV and mutation analyses identify high alteration frequencies for RIPK2 and RIPK7,affecting gene expression.RIPK1 and RIPK7 are hypermethylated in several cancers,inversely correlating with RIPK3 expression.RIPK1,RIPK2,RIPK5,RIPK6,and RIPK7 correlate positively with TMB,while RIPK3 shows negative correlations in some cancers.MSI analysis indicates associations with DNA mismatch repair.G ene set enrichment analysis highlights immune-related pathway enrichment for RIPK1,RIPK2,RIPK3,and RIPK6,and cell proliferation and DNA repair pathways for RIPK4 and RIPK5.RIPK family members showed heterogeneous alterations across cancers:for example,RIPK7 was mutated in up to~15%of u terine c orpus e ndometrial c arcinoma and l ung s quamous c ell c arcinoma cases,and RIPK1 and RIPK7 exhibited frequent promoter hypermethylation in multiple tumor types.Several genes displayed context-dependent associations with overall survival and with TMB/MSI.Conclusion:This pan-cancer analysis of the RIPK family reveals their diverse roles and potential as biomarkers and therapeutic targets.The findings emphasize the importance of RIPK genes in tumorigenesis and suggest context-dependent functions across cancer types.Further studies are needed to explore their mechanisms in cancer development and clinical applications.
基金supported by the National Natural Science Foundation of China(Nos.12575124,12175071,12205103)the National Key R&D Program of China(No.2024YFE0109803)the Fundamental Research Funds for the Central Universities。
文摘We investigate the effects of temperature on the structural evolution and clustering in the hypernucleus,taking_(Λ)^(21)Ne as an example,in the framework of deformed finite-temperature Skyrme-Hartree-Fock.The SkI4 Skyrme force is employed for nucleon-nucleon interaction,while the NSC97f force is used for the hyperon-nucleon interaction.It is found that the system exhibits a strongly deformed ground state with pronouncedα-cluster correlations and localized density distributions at low temperatures.As temperature increases,nuclear deformation weakens,the nuclear density spreads over the surface,and clustering gradually diminishes and vanishes entirely at T≈2.8 MeV.This is because that the thermal excitations lower the Fermi surface and enhance single-particle level splitting.In particular,owing to the lower excitation threshold of hyperons in the hypernuclear system,the hyperon radii exhibit a stronger temperature dependence than the nucleons.We further analyze the temperature-dependent changes in deformation,single-Λbinding energy,and entropy,providing new insights into the thermal evolution of the hypernuclear structure.
基金the Shanghai Leading Talents Award,Shanghai Municipal Health Commission(No.LJ2016-01)the Clinical Research Plan of Shanghai Hospital Development Center(No.SHDC2022CRW004)。
文摘Polymyxin B,which is a last-line antibiotic for extensively drug-resistant Gram-negative bacterial infections,became available in China in Dec.2017.As dose adjustments are based solely on clinical experience of risk toxicity,treatment failure,and emergence of resistance,there is an urgent clinical need to perform therapeutic drug monitoring(TDM)to optimize the use of polymyxin B.It is thus necessary to standardize operating procedures to ensure the accuracy of TDM and provide evidence for their rational use.We report a consensus on TDM guidelines for polymyxin B,as endorsed by the Infection and Chemotherapy Committee of the Shanghai Medical Association and the Therapeutic Drug Monitoring Committee of the Chinese Pharmacological Society.The consensus panel was composed of clinicians,pharmacists,and microbiologists from different provinces in China and Australia who made recommendations regarding target concentrations,sample collection,reporting,and explanation of TDM results.The guidelines provide the first-ever consensus on conducting TDM of polymyxin B,and are intended to guide optimal clinical use.
基金supported by the National Natural Science Foundation of China(No.U21A20290)Guangdong Basic and Applied Basic Research Foundation(No.2022A1515011656)+2 种基金the Projects of Talents Recruitment of GDUPT(No.2023rcyj1003)the 2022“Sail Plan”Project of Maoming Green Chemical Industry Research Institute(No.MMGCIRI2022YFJH-Y-024)Maoming Science and Technology Project(No.2023382).
文摘The presence of aluminum(Al^(3+))and fluoride(F^(−))ions in the environment can be harmful to ecosystems and human health,highlighting the need for accurate and efficient monitoring.In this paper,an innovative approach is presented that leverages the power of machine learning to enhance the accuracy and efficiency of fluorescence-based detection for sequential quantitative analysis of aluminum(Al^(3+))and fluoride(F^(−))ions in aqueous solutions.The proposed method involves the synthesis of sulfur-functionalized carbon dots(C-dots)as fluorescence probes,with fluorescence enhancement upon interaction with Al^(3+)ions,achieving a detection limit of 4.2 nmol/L.Subsequently,in the presence of F^(−)ions,fluorescence is quenched,with a detection limit of 47.6 nmol/L.The fingerprints of fluorescence images are extracted using a cross-platform computer vision library in Python,followed by data preprocessing.Subsequently,the fingerprint data is subjected to cluster analysis using the K-means model from machine learning,and the average Silhouette Coefficient indicates excellent model performance.Finally,a regression analysis based on the principal component analysis method is employed to achieve more precise quantitative analysis of aluminum and fluoride ions.The results demonstrate that the developed model excels in terms of accuracy and sensitivity.This groundbreaking model not only showcases exceptional performance but also addresses the urgent need for effective environmental monitoring and risk assessment,making it a valuable tool for safeguarding our ecosystems and public health.
基金supported by the NSFC Distinguished Young Scholars Fund(82325010)the National Natural Science Foundation of China(82370874)+4 种基金the Innovative Research Team of High-Level Local Universities in Shanghai(SHSMU-ZDCX20212700)the Major Natural Science Project of the Scientific Research and Innovation Plan of Shanghai Municipal Commission of Education(2023ZKZD17)the Shanghai Research Center for Endocrine and Metabolic Diseases(2022ZZ01002)the Shanghai Key Discipline of Public Health Grants Award(GWVI-11.1-20)the Basic Scientific Research Project(General Cultivation Program)of Shanghai Sixth People’s Hospital(ynms202203).
文摘Background:Acute liver injury(ALI)requires rapid hepatic regeneration to avert fatal liver failure.As key mechanisms,systemic metabolic remodeling and inter-organ crosstalk are critical for this regenerative process.Skeletal muscle,as a major metabolic organ system,undergoes significant remodeling during ALI.However,its specific regulatory contributions remain largely uncharacterized.Methods:Partial(2/3)hepatectomy and acetaminophen were used to induce ALI in male mice.RNA-sequencing(RNA-seq),assay for transposase-accessible chromatin by sequencing(ATAC-seq),chromatin immunoprecipitation,luciferase assay,Western blotting,TUNEL assay,immunohistochemistry,and phase separation assays were performed to reveal the transcriptional axis involved.Serum fibroblast growth factor binding protein 1(FGFBP1)protein levels in ALI patients were assessed via enzyme-linked immunosorbent assay.Results:Integrated analysis of RNA-seq and ATAC-seq following ALI identifies glucocorticoid(GC)signaling-mediated regulation of fibroblast growth factor 6(FGF6)in skeletal muscle metabolism.Muscle-specific knockdown of GC receptor(GR)exacerbates ALI and suppresses liver regeneration.Fgf6-knockout mice exhibited improved ALI and enhanced liver regeneration,with intramuscular injection of FGF6-neutralizing antibody rescuing the detrimental effects induced by GR knockdown.Further analysis of the FGF6 downstream target revealed that FGF6 regulates FGFBP1 expression through extracellular signal regulated kinase-activating transcription factor 3 signaling.Moreover,FGF6 regulates the heparin-dependent release kinetics of FGFBP1 by perturbing its liquid-liquid phase separation(LLPS)-driven condensate dynamics at the plasma membrane.Circulating FGFBP1 subsequently interacts with hepatic FGF5 through LLPS mechanisms to regulate liver regeneration.Conclusion:Our results demonstrate a molecular mechanism by which muscle-liver crosstalk can initiate and sustain liver regeneration via the FGF6-FGFBP1/FGF5 axis,providing a potential therapeutic target and treatment strategy for ALI.
基金supported by the Fund of University of South China(201RGC013 and 200XQD052)the Youth Science Fund Project of Hunan Provincial Natural Science Foundation(2224SZ048)。
文摘The practical application of energy-dense lithium(Li)metal batteries is severely hindered by the lack of suitable electrolytes.Weakening solvent coordination to enhance Li+kinetics has become a critical principle in electrolyte design.Here,we propose an electrolyte design strategy that weakens Li^(+)-solvent coordination through the synergistic drag effects of dual diluents.Specifically,the-CF_(2)H group in ethyl 1,1,2,2-tetrafluoroethyl ether(ETE)forms hydrogen bonds with the oxygen atom in 1,2-dimethoxyethane(DME),while the electron-donating-N=and C_(2)H_(5)O-groups in ethoxy(pentafluoro)cyclotriphosphazene(PFPN)coordinate synergistically with Li^(+).The combined effects of hydrogen bonding between ETE and DME,along with the coordination of PFPN with Li^(+),weaken the Li^(+)-DME interaction and promote anion-enriched solvation structure,thereby facilitating Li^(+)desolvation process and forming an inorganic-rich solid-electrolyte interphase.In a Li metal battery with a 30μm ultrathin Li anode and high-loading LiNi_(0.5)Co_(0.2)Mn_(0.3)O_(2)cathode(23.5 mg cm^(-2)),80% of capacity was achieved after 430 cycles at 4.3 V and 84% after 310 cycles at 4.5 V.Furthermore,a 331 mAh pouch cell achieved 148 cycles with 94.9% of capacity retention.
基金supported by the grants of Innovation and Entrepreneurship Investment Project in Hunan(2017GK5009)Postgraduate Scientific Research and Innovation Project of Hunan(CX20190500)+1 种基金the Hunan Collaborative Innovation Center of Animal Production Safety,Laboratory of Animal Clinical Toxicology at The Department of Veterinary,Hunan Agriculture UniversityAnimal Health Care Engineering Technology Research Center of Hunan Agricultural University。
文摘A simulate daily oriental dietary pattern(a blend of lard and soybean oil)was performed in this research to investigate influence on liver and kidney function.Sixty mice were randomly divided into 6 groups with diets of different fat added oils respectively for 12 weeks.Malondialdehyde and uric acid contents in mice fed with blended oil were significantly lower than in those fed only with soybean oil and lard due to the improved activities of antioxidant enzymes.Daily use of a blend of lard with soybean oil significantly increased antioxidant capacity,reduced lipid peroxidation of liver and serum uric acid production,thus protected liver and renal function.It also suggests that the oriental dietary pattern might reduce the risk of gout.
基金supported by the National Natural Science Foundation of China(22265021)the Aeronautical Science Foundation of China(2020Z056056003)Jiangxi Provincial Natural Science Foundation(20232BAB212004).
文摘Atomic-scale doping strategies and structure design play pivotal roles in tailoring the electronic structure and physicochemical property of electromagnetic wave absorption(EMWA)materials.However,the relationship between configuration and electromagnetic(EM)loss mechanism has remained elusive.Herein,drawing inspiration from the DNA transcription process,we report the successful synthesis of novel in situ Mn/N co-doped helical carbon nanotubes with ultrabroad EMWA capability.Theoretical calculation and EM simulation confirm that the orbital coupling and spin polarization of the Mn–N4–C configuration,along with cross polarization generated by the helical structure,endow the helical converters with enhanced EM loss.As a result,HMC-8 demonstrates outstanding EMWA performance,achieving a minimum reflection loss of−63.13 dB at an ultralow thickness of 1.29 mm.Through precise tuning of the graphite domain size,HMC-7 achieves an effective absorption bandwidth(EAB)of 6.08 GHz at 2.02 mm thickness.Furthermore,constructing macroscale gradient metamaterials enables an ultrabroadband EAB of 12.16 GHz at a thickness of only 5.00 mm,with the maximum radar cross section reduction value reaching 36.4 dB m2.This innovative approach not only advances the understanding of metal–nonmetal co-doping but also realizes broadband EMWA,thus contributing to the development of EMWA mechanisms and applications.
文摘Vortex levitation attains non-contact handling by injecting air through a tangential nozzle into a cylindrical cup generating the swirling flow. The precessing of the swirling flow causes pressure fluctuation. This phenomenon becomes apparent as the gap between the cup and workpiece increases, which significantly disturbs the stability of conveyance. In this paper, suppression of pressure fluctuation by a cylindrical column that stabilizes the vortex levitation is described and its mechanism is mentioned. According to the experimental set up, the pressure was measured at the center of the workpiece and the wall of the cup;velocity field under the work piece was visualized by PIV. The result suggested that the larger diameter column denoted the effect on suppression of the fluctuation because the precessing of the swirling flow became stable. On the other hand, variation of the column thickness had insignificant effect on suppressing the fluctuation, but sucking force became weakened since the swirling velocity decreased.
基金supported by the China Agriculture Research System of Ministry of Finance of the People’s Republic of China(MOF)Ministry of Agriculture+1 种基金Rural Affairs of the People’s Republic of China(MARA)(CARS-38)S&T Program of Hebei(215A7101D).
文摘Microbial growth causes lamb spoilage.This study explored the spoilage ability of Latilactobacillus sakei,Serratia proteamaculans and Hafnia proteus in vacuum-packed raw lamb,including growth ability,degradation of protein and lipid,and change of volatile organic compounds(VOCs)profile,meanwhile screened the key VOCs produced by the targeted strains with meat background excluding,finally confirmed the volatile spoilage marker of vacuum-packaged lamb by comparing with our previous work.The results showed that L.sakei,S.proteamaculans and H.proteus had excellent growth ability.L.sakei inoculated group significantly reduced the pH value,showed higher trichloroacetic acid-soluble peptides content,and excellently degraded sarcoplasmic and myofibrillar proteins.About free amino acids,L.sakei significantly degraded serine,arginine and aspartic acid,while S.proteamaculans and H.proteus significantly degraded serine and lysine.In addition,L.sakei had the strongest effect on promoting free fatty acid production,followed by S.proteamaculans and finally H.proteus.Evaluating from various indicators,the co-culture of the three strains did not have any effect.The key volatiles produced by L.sakei were 1-hexanol,acetic acid and hexanoic acid,S.proteamaculans produced 1-hexanol and acetoin,and H.proteus produced 1-hexanol,acetic acid and acetoin.In the end,1-hexanol,hexanoic acid and acetoin were proven to be spoilage markers for vacuum-packaged and chilled lamb.This study can provide fundamental information for inhibiting and rapid identification of spoilage in vacuum-packaged lamb.
基金the financial supports from the National Natural Science Foundation of China(52004096)Natural Science Foundation of Hebei Province(E2024209101)+2 种基金Hebei Province Science and Technology R&D Platform Construction Project(23560301D)Tangshan Science and Technology Bureau Project(23130202E)Graduate Student Innovation Fund of North China University of Science and Technology(CXZZBS2025150).
文摘In the traditional blast furnace(BF)ironmaking process in China,a notable deviation exists between the theoretical and actual yield of hot metal,leading to unexpected iron loss and restricting the improvement of production capacity,which cannot adapt to the increasingly intensified smelting rhythm.Focusing on a BF in a Chinese steel enterprise,a deep neural network algorithm was designed to model the impact of multiple parameters on actual yield of hot metal in a single BF smelting cycle,successfully accomplishing the theoretical computation and real-time prediction of yield of hot metal for subsequent,unknown BF smelting cycle.Test results show that the proposed algorithm demonstrates an impressive prediction accuracy of 86.7% within an error range of±10 t and can swiftly complete the training and convergence process in 32.5 s.By integrating prediction results with Nomogram,a regulatory mechanism was engineered to minimize the deviation between theoretical and actual yield of hot metal.This mechanism ensures the yield enhancement of hot metal through dynamic adjustments of BF operational parameters.Industrial-scale application experiments confirmed that the intelligent operation and optimization system,developed in the laboratory,can maintain the yield deviation of hot metal within a stable range of 30 t,achieving a maximum reduction in iron loss rate of 17.65%compared to that before system operation.The findings provide robust support for the yield increase and efficiency improvement of the experimental BF.
基金financially supported by the National Natural Science Foundation of China(No.52102062)the Xi’an Science and Technology Plan Project(No.23LLRH0004)the Key Research and Development Project of Shaanxi Province of China(2024GX-YBXM-352)。
文摘Vat photopolymerization(VPP)3D printing is an optimized technology for complex-shaped ceramic cores,in which the solid loading of ceramic slurries greatly infiuences the microstructure and property of the final ceramic parts.However,the high solid loading of slurries is highly limited by the high viscosity.In this study,silica-based ceramic core slurries with solid loading up to 68vol.%were achieved by the composition design to optimize the performance,considering the curing,rheological,and double bond conversion rate.The slurries demonstrate superior curing and rheological performance with mass ratio of monomers being 3:2 and mass fraction of BYK111 being 4wt.%.Afterwards,the impact of solid loading on the morphology and mechanical properties was investigated.As the solid loading increases,the microstructure becomes gradually dense,leading to an improved flexural strength of 19.5 MPa.Additionally,the sintering shrinkage becomes more uniform,satisfying the casting requirements effectively.This work serves as a guide for the preparation of ceramic slurries with a high solid loading.
基金supported by the National Natural Science Foundation of China(No.62101587)the National Funded Postdoctoral Researcher Program of China(No.GZC20233578)。
文摘Micro-nano Earth Observation Satellite(MEOS)constellation has the advantages of low construction cost,short revisit cycle,and high functional density,which is considered a promising solution for serving rapidly growing observation demands.The observation Scheduling Problem in the MEOS constellation(MEOSSP)is a challenging issue due to the large number of satellites and tasks,as well as complex observation constraints.To address the large-scale and complicated MEOSSP,we develop a Two-Stage Scheduling Algorithm based on the Pointer Network with Attention mechanism(TSSA-PNA).In TSSA-PNA,the MEOS observation scheduling is decomposed into a task allocation stage and a single-MEOS scheduling stage.In the task allocation stage,an adaptive task allocation algorithm with four problem-specific allocation operators is proposed to reallocate the unscheduled tasks to new MEOSs.Regarding the single-MEOS scheduling stage,we design a pointer network based on the encoder-decoder architecture to learn the optimal singleMEOS scheduling solution and introduce the attention mechanism into the encoder to improve the learning efficiency.The Pointer Network with Attention mechanism(PNA)can generate the single-MEOS scheduling solution quickly in an end-to-end manner.These two decomposed stages are performed iteratively to search for the solution with high profit.A greedy local search algorithm is developed to improve the profits further.The performance of the PNA and TSSA-PNA on singleMEOS and multi-MEOS scheduling problems are evaluated in the experiments.The experimental results demonstrate that PNA can obtain the approximate solution for the single-MEOS scheduling problem in a short time.Besides,the TSSA-PNA can achieve higher observation profits than the existing scheduling algorithms within the acceptable computational time for the large-scale MEOS scheduling problem.
文摘BACKGROUND The clinical metastasis rate of lung cancer is tremendously low in gastrointestinal tract.Individuals enduring small intestine metastasis of lung cancer are normally featured by less desirable prognosis and shorter survival than those with me-tastasis in other parts of the body.As a consequence,it holds crucial significance to conduct early diagnosis and development of systematic treatment for patients with gastrointestinal metastasis in lung cancer.In this case,a 59-year-old female patient,diagnosed with lung adenocarcinoma,experienced intestinal obstruction attributable to subsequent small intestinal metastasis.Imaging confirmed the metastasis to the small intestine after the adenocarcinoma diagnosis,ultimately giving rise to advanced-stage intestinal obstruction.Conservative treatment proved ineffective,progressing to intestinal perforation in the later stages.This resulted in peritonitis and infectious toxic shock and other serious clinical manifestations.Aggressive surgical resection mitigated the risk of disease progression and even fatality,which tremendously ameliorated the patient’s prognosis and prolonged her survival.CONCLUSION Patients enduring lung cancer who exhibit acute abdominal symptoms should be mindful of the potential for small intestinal metastasis.Intestinal perforation typically occurs in advanced stages of the disease.Moreover,and aggressive surgical treatment can mitigate the risk of multifarious complications such as peritonitis,infectious toxic shock,and even fatality.
基金the National Natural Science Foundation of China(Nos.21801063,22305070 and U20041101)the Top-Notch Talents Program of Henan Agricultural University(Nos.30501049 and 30501032)for financial support。
文摘Herein,a ternary supramolecular assembly(BPP-BQ?CB[8]-SCD)is successfully constructed by a bromophenylpyridine-tethered-bromoisoquinoline(BPP-BQ),cucurbit[8]uril(CB[8])and sulfonatedβ-cyclodextrin(SCD)via successive assembling way,exhibiting progressively enhanced green roomtemperature phosphorescence(RTP).The self-aggregates of BPP-BQ?CB[8]-SCD accommodate an energy acceptor rhodamine B(Rh B)to form a light-harvesting system(BPP-BQ?CB[8]-SCD@Rh B)with further enhanced yellow long-lifetime luminescence with large Stokes shift based on triplet-singlet F?rster resonance energy transfer(TS-FRET).Crucially,the introduction of a photoactive diarylethene achieves the long-lived photoluminescence of BPP-BQ?CB[8]-SCD@Rh B to be switched with the efficiency of up to98%through logically ordered lowering/enhancing RTP performance of the energy donor and intercepting/restoring TS-FRET pathway,when stimulated by host-vip competition and light illumination in sequence.Moreover,BPP-BQ?CB[8]-SCD@Rh B is evenly doped into polyvinyl alcohol or polyacrylamide to obtain high-performance luminescent films with long afterglow.The abovementioned logically ordered stimulus-switched long-lived emission enables the light-harvesting system in both solution and solid state to be applied in high-security-level information encryption and transformation,and anticounterfeiting.
基金supported by the National Natural Science Foundation of China(Grant Nos.62473374,62403487 and U2441243).
文摘For the longitudinal midcourse guidance problem of a cruise-glide integrated hypersonic vehicle(CGHV),an analytical method based on optimal control theory is proposed.This method constructs a guidance dynamics model for such vehicles,using aerodynamic load as the control variable,and introduces a framework for solving the guidance laws.This framework unifies the design process of guidance laws for both the glide and cruise phases.By decomposing the longitudinal guidance task into position control and velocity control,and minimizing energy consumption as the objective function,the method provides an analytical solution for velocity control load through the calculation of costate variables.This approach requires only the current state and terminal state parameters to determine the guidance law solution.Furthermore,by transforming path constraints into aerodynamic load constraints and solving backwards to obtain the angle of attack,bank angle,and throttle setting,this method ensures a smooth transition from the glide phase to the cruise phase,guaranteeing the successful completion of the guidance task.Finally,the effectiveness and practicality of the proposed method are validated through case simulations and analysis.
基金supported by the National Natural Science Foundation of China(32072655 and 32272792)。
文摘Cover cropping is a diversifying agricultural practice that can improve soil structure and function by altering the underground litter diversity and soil microbial communities.Here,we tested how a wheat cover crop alters the decomposition of cucumber root litter.A three-year greenhouse litterbag decomposition experiment showed that a wheat cover crop accelerates the decomposition of cucumber root litter.A microcosm litterbag experiment further showed that wheat litter and the soil microbial community could improve cucumber root litter decomposition.Moreover,the wheat cover crop altered the abundances and diversities of soil bacterial and fungal communities,and enriched several putative keystone operational taxonomic units(OTUs),such as Bacillus sp.OTU1837 and Mortierella sp.OTU1236,that were positively related to the mass loss of cucumber root litter.The representative bacterial and fungal strains B186 and M3 were isolated and cultured.In vitro decomposition tests demonstrated that both B186 and M3 had cucumber root litter decomposition activity and a stronger effect was found when they were co-incubated.Overall,a wheat cover crop accelerated cucumber root litter decomposition by altering the soil microbial communities,particularly by stimulating certain putative keystone taxa,which provides a theoretical basis for using cover crops to promote sustainable agricultural development.
基金financially supported by the Natural Science Foundation of Fujian Province(No.2021J01333)the funding from the Fujian Education Department of China(No.JAT210582)。
文摘Solid-state batteries(SSBs)with high-capacity Si anodes have been regarded as one of the most promising candidates to meet the large scale energy storage and electrical vehicles due to its intrinsic safety and potential high energy density.However,Si suffers from poor electrical conductivity and huge volume change and particles fracture during lithiaiotn and delithiation,which induces low practical energy density.In addition,the SSBs are often operated at high temperature due to the poor physical contact and huge resistance between Si and solid-state electrolyte(SSE).To improve the bulk electronic/ionic conductivity of Si and its interfacial compatibility with SSE,herein,a binder free and self-supporting Si/C film was developed.The monolithic carbon not only enhance the electric conductivity but also release huge stress during lithiation and delithiation.In addition,paired with the flexible and soft poly(vinylidene fluoride)-co-hexafluoropropylene(PVDF-HFP)and Li_(1.3)A_(l0.3)Ti_(1.7)(PO_(4))_(3)(LATP)solid-state electrolyte,a LiF-rich and electrochemical stable solid-electrolyte interphase(SEI)layer is in-situ engineered.The fast bulk and interfacial ionic transportation as well as the mechanical integrity of MSi enable high performance SSBs at room temperature.As a result,high specific capacity of 2137 m Ah/g with an initial Coulombic efficiency of 83.2%is obtained at a rate of 0.5 A/g.Even at a high rate of 3 A/g,the specific capacity is1793 m Ah/g.At a rate of 1 A/g,the Si/C anode delivers a long cycling performance over 500 cycles while maintains a capacity of 1135 mAh/g.This work provides a new strategy that combines charge transfer kinetics and interfacial chemistry design toward high energy density Si-based SSBs.
