Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations...Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations,and functional implications of RIPK family members across various cancers.Methods:We collected multi-omics data from The Cancer Genome Atlas and other public databases,including gene expression,copy number variation(CNV),mutation,methylation,tumor mutation burden(TMB),and microsatellite instability(MSI).Differential expression and survival analyses were performed using DESeq2 and Cox proportional hazards models.CNV and mutation data were analyzed with GISTIC2 and Mutect2,and methylation data with the ChAMP package.Correlations with TMB and MSI were assessed using Pearson coefficients,and gene set enrichment analysis was conducted with the MSigDB Hallmark gene sets.Results:RIPK family members show significant differential expression in various cancers,with RIPK1 and RIPK4 frequently altered.Survival analysis reveals heterogeneous impacts on overall survival.CNV and mutation analyses identify high alteration frequencies for RIPK2 and RIPK7,affecting gene expression.RIPK1 and RIPK7 are hypermethylated in several cancers,inversely correlating with RIPK3 expression.RIPK1,RIPK2,RIPK5,RIPK6,and RIPK7 correlate positively with TMB,while RIPK3 shows negative correlations in some cancers.MSI analysis indicates associations with DNA mismatch repair.G ene set enrichment analysis highlights immune-related pathway enrichment for RIPK1,RIPK2,RIPK3,and RIPK6,and cell proliferation and DNA repair pathways for RIPK4 and RIPK5.RIPK family members showed heterogeneous alterations across cancers:for example,RIPK7 was mutated in up to~15%of u terine c orpus e ndometrial c arcinoma and l ung s quamous c ell c arcinoma cases,and RIPK1 and RIPK7 exhibited frequent promoter hypermethylation in multiple tumor types.Several genes displayed context-dependent associations with overall survival and with TMB/MSI.Conclusion:This pan-cancer analysis of the RIPK family reveals their diverse roles and potential as biomarkers and therapeutic targets.The findings emphasize the importance of RIPK genes in tumorigenesis and suggest context-dependent functions across cancer types.Further studies are needed to explore their mechanisms in cancer development and clinical applications.展开更多
Polymyxin B,which is a last-line antibiotic for extensively drug-resistant Gram-negative bacterial infections,became available in China in Dec.2017.As dose adjustments are based solely on clinical experience of risk t...Polymyxin B,which is a last-line antibiotic for extensively drug-resistant Gram-negative bacterial infections,became available in China in Dec.2017.As dose adjustments are based solely on clinical experience of risk toxicity,treatment failure,and emergence of resistance,there is an urgent clinical need to perform therapeutic drug monitoring(TDM)to optimize the use of polymyxin B.It is thus necessary to standardize operating procedures to ensure the accuracy of TDM and provide evidence for their rational use.We report a consensus on TDM guidelines for polymyxin B,as endorsed by the Infection and Chemotherapy Committee of the Shanghai Medical Association and the Therapeutic Drug Monitoring Committee of the Chinese Pharmacological Society.The consensus panel was composed of clinicians,pharmacists,and microbiologists from different provinces in China and Australia who made recommendations regarding target concentrations,sample collection,reporting,and explanation of TDM results.The guidelines provide the first-ever consensus on conducting TDM of polymyxin B,and are intended to guide optimal clinical use.展开更多
The presence of aluminum(Al^(3+))and fluoride(F^(−))ions in the environment can be harmful to ecosystems and human health,highlighting the need for accurate and efficient monitoring.In this paper,an innovative approac...The presence of aluminum(Al^(3+))and fluoride(F^(−))ions in the environment can be harmful to ecosystems and human health,highlighting the need for accurate and efficient monitoring.In this paper,an innovative approach is presented that leverages the power of machine learning to enhance the accuracy and efficiency of fluorescence-based detection for sequential quantitative analysis of aluminum(Al^(3+))and fluoride(F^(−))ions in aqueous solutions.The proposed method involves the synthesis of sulfur-functionalized carbon dots(C-dots)as fluorescence probes,with fluorescence enhancement upon interaction with Al^(3+)ions,achieving a detection limit of 4.2 nmol/L.Subsequently,in the presence of F^(−)ions,fluorescence is quenched,with a detection limit of 47.6 nmol/L.The fingerprints of fluorescence images are extracted using a cross-platform computer vision library in Python,followed by data preprocessing.Subsequently,the fingerprint data is subjected to cluster analysis using the K-means model from machine learning,and the average Silhouette Coefficient indicates excellent model performance.Finally,a regression analysis based on the principal component analysis method is employed to achieve more precise quantitative analysis of aluminum and fluoride ions.The results demonstrate that the developed model excels in terms of accuracy and sensitivity.This groundbreaking model not only showcases exceptional performance but also addresses the urgent need for effective environmental monitoring and risk assessment,making it a valuable tool for safeguarding our ecosystems and public health.展开更多
A simulate daily oriental dietary pattern(a blend of lard and soybean oil)was performed in this research to investigate influence on liver and kidney function.Sixty mice were randomly divided into 6 groups with diets ...A simulate daily oriental dietary pattern(a blend of lard and soybean oil)was performed in this research to investigate influence on liver and kidney function.Sixty mice were randomly divided into 6 groups with diets of different fat added oils respectively for 12 weeks.Malondialdehyde and uric acid contents in mice fed with blended oil were significantly lower than in those fed only with soybean oil and lard due to the improved activities of antioxidant enzymes.Daily use of a blend of lard with soybean oil significantly increased antioxidant capacity,reduced lipid peroxidation of liver and serum uric acid production,thus protected liver and renal function.It also suggests that the oriental dietary pattern might reduce the risk of gout.展开更多
Atomic-scale doping strategies and structure design play pivotal roles in tailoring the electronic structure and physicochemical property of electromagnetic wave absorption(EMWA)materials.However,the relationship betw...Atomic-scale doping strategies and structure design play pivotal roles in tailoring the electronic structure and physicochemical property of electromagnetic wave absorption(EMWA)materials.However,the relationship between configuration and electromagnetic(EM)loss mechanism has remained elusive.Herein,drawing inspiration from the DNA transcription process,we report the successful synthesis of novel in situ Mn/N co-doped helical carbon nanotubes with ultrabroad EMWA capability.Theoretical calculation and EM simulation confirm that the orbital coupling and spin polarization of the Mn–N4–C configuration,along with cross polarization generated by the helical structure,endow the helical converters with enhanced EM loss.As a result,HMC-8 demonstrates outstanding EMWA performance,achieving a minimum reflection loss of−63.13 dB at an ultralow thickness of 1.29 mm.Through precise tuning of the graphite domain size,HMC-7 achieves an effective absorption bandwidth(EAB)of 6.08 GHz at 2.02 mm thickness.Furthermore,constructing macroscale gradient metamaterials enables an ultrabroadband EAB of 12.16 GHz at a thickness of only 5.00 mm,with the maximum radar cross section reduction value reaching 36.4 dB m2.This innovative approach not only advances the understanding of metal–nonmetal co-doping but also realizes broadband EMWA,thus contributing to the development of EMWA mechanisms and applications.展开更多
Vortex levitation attains non-contact handling by injecting air through a tangential nozzle into a cylindrical cup generating the swirling flow. The precessing of the swirling flow causes pressure fluctuation. This ph...Vortex levitation attains non-contact handling by injecting air through a tangential nozzle into a cylindrical cup generating the swirling flow. The precessing of the swirling flow causes pressure fluctuation. This phenomenon becomes apparent as the gap between the cup and workpiece increases, which significantly disturbs the stability of conveyance. In this paper, suppression of pressure fluctuation by a cylindrical column that stabilizes the vortex levitation is described and its mechanism is mentioned. According to the experimental set up, the pressure was measured at the center of the workpiece and the wall of the cup;velocity field under the work piece was visualized by PIV. The result suggested that the larger diameter column denoted the effect on suppression of the fluctuation because the precessing of the swirling flow became stable. On the other hand, variation of the column thickness had insignificant effect on suppressing the fluctuation, but sucking force became weakened since the swirling velocity decreased.展开更多
Microbial growth causes lamb spoilage.This study explored the spoilage ability of Latilactobacillus sakei,Serratia proteamaculans and Hafnia proteus in vacuum-packed raw lamb,including growth ability,degradation of pr...Microbial growth causes lamb spoilage.This study explored the spoilage ability of Latilactobacillus sakei,Serratia proteamaculans and Hafnia proteus in vacuum-packed raw lamb,including growth ability,degradation of protein and lipid,and change of volatile organic compounds(VOCs)profile,meanwhile screened the key VOCs produced by the targeted strains with meat background excluding,finally confirmed the volatile spoilage marker of vacuum-packaged lamb by comparing with our previous work.The results showed that L.sakei,S.proteamaculans and H.proteus had excellent growth ability.L.sakei inoculated group significantly reduced the pH value,showed higher trichloroacetic acid-soluble peptides content,and excellently degraded sarcoplasmic and myofibrillar proteins.About free amino acids,L.sakei significantly degraded serine,arginine and aspartic acid,while S.proteamaculans and H.proteus significantly degraded serine and lysine.In addition,L.sakei had the strongest effect on promoting free fatty acid production,followed by S.proteamaculans and finally H.proteus.Evaluating from various indicators,the co-culture of the three strains did not have any effect.The key volatiles produced by L.sakei were 1-hexanol,acetic acid and hexanoic acid,S.proteamaculans produced 1-hexanol and acetoin,and H.proteus produced 1-hexanol,acetic acid and acetoin.In the end,1-hexanol,hexanoic acid and acetoin were proven to be spoilage markers for vacuum-packaged and chilled lamb.This study can provide fundamental information for inhibiting and rapid identification of spoilage in vacuum-packaged lamb.展开更多
Vat photopolymerization(VPP)3D printing is an optimized technology for complex-shaped ceramic cores,in which the solid loading of ceramic slurries greatly infiuences the microstructure and property of the final cerami...Vat photopolymerization(VPP)3D printing is an optimized technology for complex-shaped ceramic cores,in which the solid loading of ceramic slurries greatly infiuences the microstructure and property of the final ceramic parts.However,the high solid loading of slurries is highly limited by the high viscosity.In this study,silica-based ceramic core slurries with solid loading up to 68vol.%were achieved by the composition design to optimize the performance,considering the curing,rheological,and double bond conversion rate.The slurries demonstrate superior curing and rheological performance with mass ratio of monomers being 3:2 and mass fraction of BYK111 being 4wt.%.Afterwards,the impact of solid loading on the morphology and mechanical properties was investigated.As the solid loading increases,the microstructure becomes gradually dense,leading to an improved flexural strength of 19.5 MPa.Additionally,the sintering shrinkage becomes more uniform,satisfying the casting requirements effectively.This work serves as a guide for the preparation of ceramic slurries with a high solid loading.展开更多
Micro-nano Earth Observation Satellite(MEOS)constellation has the advantages of low construction cost,short revisit cycle,and high functional density,which is considered a promising solution for serving rapidly growin...Micro-nano Earth Observation Satellite(MEOS)constellation has the advantages of low construction cost,short revisit cycle,and high functional density,which is considered a promising solution for serving rapidly growing observation demands.The observation Scheduling Problem in the MEOS constellation(MEOSSP)is a challenging issue due to the large number of satellites and tasks,as well as complex observation constraints.To address the large-scale and complicated MEOSSP,we develop a Two-Stage Scheduling Algorithm based on the Pointer Network with Attention mechanism(TSSA-PNA).In TSSA-PNA,the MEOS observation scheduling is decomposed into a task allocation stage and a single-MEOS scheduling stage.In the task allocation stage,an adaptive task allocation algorithm with four problem-specific allocation operators is proposed to reallocate the unscheduled tasks to new MEOSs.Regarding the single-MEOS scheduling stage,we design a pointer network based on the encoder-decoder architecture to learn the optimal singleMEOS scheduling solution and introduce the attention mechanism into the encoder to improve the learning efficiency.The Pointer Network with Attention mechanism(PNA)can generate the single-MEOS scheduling solution quickly in an end-to-end manner.These two decomposed stages are performed iteratively to search for the solution with high profit.A greedy local search algorithm is developed to improve the profits further.The performance of the PNA and TSSA-PNA on singleMEOS and multi-MEOS scheduling problems are evaluated in the experiments.The experimental results demonstrate that PNA can obtain the approximate solution for the single-MEOS scheduling problem in a short time.Besides,the TSSA-PNA can achieve higher observation profits than the existing scheduling algorithms within the acceptable computational time for the large-scale MEOS scheduling problem.展开更多
BACKGROUND The clinical metastasis rate of lung cancer is tremendously low in gastrointestinal tract.Individuals enduring small intestine metastasis of lung cancer are normally featured by less desirable prognosis and...BACKGROUND The clinical metastasis rate of lung cancer is tremendously low in gastrointestinal tract.Individuals enduring small intestine metastasis of lung cancer are normally featured by less desirable prognosis and shorter survival than those with me-tastasis in other parts of the body.As a consequence,it holds crucial significance to conduct early diagnosis and development of systematic treatment for patients with gastrointestinal metastasis in lung cancer.In this case,a 59-year-old female patient,diagnosed with lung adenocarcinoma,experienced intestinal obstruction attributable to subsequent small intestinal metastasis.Imaging confirmed the metastasis to the small intestine after the adenocarcinoma diagnosis,ultimately giving rise to advanced-stage intestinal obstruction.Conservative treatment proved ineffective,progressing to intestinal perforation in the later stages.This resulted in peritonitis and infectious toxic shock and other serious clinical manifestations.Aggressive surgical resection mitigated the risk of disease progression and even fatality,which tremendously ameliorated the patient’s prognosis and prolonged her survival.CONCLUSION Patients enduring lung cancer who exhibit acute abdominal symptoms should be mindful of the potential for small intestinal metastasis.Intestinal perforation typically occurs in advanced stages of the disease.Moreover,and aggressive surgical treatment can mitigate the risk of multifarious complications such as peritonitis,infectious toxic shock,and even fatality.展开更多
Herein,a ternary supramolecular assembly(BPP-BQ?CB[8]-SCD)is successfully constructed by a bromophenylpyridine-tethered-bromoisoquinoline(BPP-BQ),cucurbit[8]uril(CB[8])and sulfonatedβ-cyclodextrin(SCD)via successive ...Herein,a ternary supramolecular assembly(BPP-BQ?CB[8]-SCD)is successfully constructed by a bromophenylpyridine-tethered-bromoisoquinoline(BPP-BQ),cucurbit[8]uril(CB[8])and sulfonatedβ-cyclodextrin(SCD)via successive assembling way,exhibiting progressively enhanced green roomtemperature phosphorescence(RTP).The self-aggregates of BPP-BQ?CB[8]-SCD accommodate an energy acceptor rhodamine B(Rh B)to form a light-harvesting system(BPP-BQ?CB[8]-SCD@Rh B)with further enhanced yellow long-lifetime luminescence with large Stokes shift based on triplet-singlet F?rster resonance energy transfer(TS-FRET).Crucially,the introduction of a photoactive diarylethene achieves the long-lived photoluminescence of BPP-BQ?CB[8]-SCD@Rh B to be switched with the efficiency of up to98%through logically ordered lowering/enhancing RTP performance of the energy donor and intercepting/restoring TS-FRET pathway,when stimulated by host-vip competition and light illumination in sequence.Moreover,BPP-BQ?CB[8]-SCD@Rh B is evenly doped into polyvinyl alcohol or polyacrylamide to obtain high-performance luminescent films with long afterglow.The abovementioned logically ordered stimulus-switched long-lived emission enables the light-harvesting system in both solution and solid state to be applied in high-security-level information encryption and transformation,and anticounterfeiting.展开更多
For the longitudinal midcourse guidance problem of a cruise-glide integrated hypersonic vehicle(CGHV),an analytical method based on optimal control theory is proposed.This method constructs a guidance dynamics model f...For the longitudinal midcourse guidance problem of a cruise-glide integrated hypersonic vehicle(CGHV),an analytical method based on optimal control theory is proposed.This method constructs a guidance dynamics model for such vehicles,using aerodynamic load as the control variable,and introduces a framework for solving the guidance laws.This framework unifies the design process of guidance laws for both the glide and cruise phases.By decomposing the longitudinal guidance task into position control and velocity control,and minimizing energy consumption as the objective function,the method provides an analytical solution for velocity control load through the calculation of costate variables.This approach requires only the current state and terminal state parameters to determine the guidance law solution.Furthermore,by transforming path constraints into aerodynamic load constraints and solving backwards to obtain the angle of attack,bank angle,and throttle setting,this method ensures a smooth transition from the glide phase to the cruise phase,guaranteeing the successful completion of the guidance task.Finally,the effectiveness and practicality of the proposed method are validated through case simulations and analysis.展开更多
Cover cropping is a diversifying agricultural practice that can improve soil structure and function by altering the underground litter diversity and soil microbial communities.Here,we tested how a wheat cover crop alt...Cover cropping is a diversifying agricultural practice that can improve soil structure and function by altering the underground litter diversity and soil microbial communities.Here,we tested how a wheat cover crop alters the decomposition of cucumber root litter.A three-year greenhouse litterbag decomposition experiment showed that a wheat cover crop accelerates the decomposition of cucumber root litter.A microcosm litterbag experiment further showed that wheat litter and the soil microbial community could improve cucumber root litter decomposition.Moreover,the wheat cover crop altered the abundances and diversities of soil bacterial and fungal communities,and enriched several putative keystone operational taxonomic units(OTUs),such as Bacillus sp.OTU1837 and Mortierella sp.OTU1236,that were positively related to the mass loss of cucumber root litter.The representative bacterial and fungal strains B186 and M3 were isolated and cultured.In vitro decomposition tests demonstrated that both B186 and M3 had cucumber root litter decomposition activity and a stronger effect was found when they were co-incubated.Overall,a wheat cover crop accelerated cucumber root litter decomposition by altering the soil microbial communities,particularly by stimulating certain putative keystone taxa,which provides a theoretical basis for using cover crops to promote sustainable agricultural development.展开更多
Solid-state batteries(SSBs)with high-capacity Si anodes have been regarded as one of the most promising candidates to meet the large scale energy storage and electrical vehicles due to its intrinsic safety and potenti...Solid-state batteries(SSBs)with high-capacity Si anodes have been regarded as one of the most promising candidates to meet the large scale energy storage and electrical vehicles due to its intrinsic safety and potential high energy density.However,Si suffers from poor electrical conductivity and huge volume change and particles fracture during lithiaiotn and delithiation,which induces low practical energy density.In addition,the SSBs are often operated at high temperature due to the poor physical contact and huge resistance between Si and solid-state electrolyte(SSE).To improve the bulk electronic/ionic conductivity of Si and its interfacial compatibility with SSE,herein,a binder free and self-supporting Si/C film was developed.The monolithic carbon not only enhance the electric conductivity but also release huge stress during lithiation and delithiation.In addition,paired with the flexible and soft poly(vinylidene fluoride)-co-hexafluoropropylene(PVDF-HFP)and Li_(1.3)A_(l0.3)Ti_(1.7)(PO_(4))_(3)(LATP)solid-state electrolyte,a LiF-rich and electrochemical stable solid-electrolyte interphase(SEI)layer is in-situ engineered.The fast bulk and interfacial ionic transportation as well as the mechanical integrity of MSi enable high performance SSBs at room temperature.As a result,high specific capacity of 2137 m Ah/g with an initial Coulombic efficiency of 83.2%is obtained at a rate of 0.5 A/g.Even at a high rate of 3 A/g,the specific capacity is1793 m Ah/g.At a rate of 1 A/g,the Si/C anode delivers a long cycling performance over 500 cycles while maintains a capacity of 1135 mAh/g.This work provides a new strategy that combines charge transfer kinetics and interfacial chemistry design toward high energy density Si-based SSBs.展开更多
Ni-rich cathode materials have become the mainstream choice in the mileage electric vehicle sector due to their high specific capacity and safety factor.However,the volume changes occurring during charging and dischar...Ni-rich cathode materials have become the mainstream choice in the mileage electric vehicle sector due to their high specific capacity and safety factor.However,the volume changes occurring during charging and discharging lead to microcracking and surface remodeling,posing challenges to achieving such as high specific capacity and long cycle stability.This paper reviews existing modification strategies for Ni-rich layered oxide cathode materials.Unlike previous reviews and related papers,we comprehensively discuss a variety of modification strategies and deeply discuss the synergistic modification effect of surface coating and bulk doping,which is how to improve the cycling stability of the Ni-rich cathode.In addition,based on recent research advances,the prospects and challenges of modifying Ni-rich layered cathodes for cycle stability upgrading of the lithium-ion battery,as well as the potential application prospects in the field of power automobiles,are comprehensively analyzed.展开更多
Combining solar-driven H_(2) evolution with the selective conversion of the biomass platform compound 5-hydroxymethylfurfural(HMF)into high-value-added chemicals is promising.However,the development of this approach i...Combining solar-driven H_(2) evolution with the selective conversion of the biomass platform compound 5-hydroxymethylfurfural(HMF)into high-value-added chemicals is promising.However,the development of this approach is impeded by slow electron-hole separation and uncontrollable HMF conversion.In this study,we present a novel S-scheme sp^(2)-carbon COF(TFPD)/CdS heterojunction bifunctional photo-catalyst for the highly selective oxidation of HMF or C-C coupling,integrated with H_(2) production.The TFPD/CdS heterojunction forms an intrinsic electric field that facilitates efficient charge separation and migration during the photocatalytic process.Additionally,theoretical calculations and in situ diffuse re-flectance infrared Fourier transform spectroscopy(DRIFTS)reveal that the adsorption and desorption of(CHOH)C4 H_(2)(CHO)·radical on the catalyst surface are critical for the selective conversion of HMF.Con-sequently,depending on the reaction atmosphere,this photocatalyst selectively oxidizes HMF to 2,5-diformylfuran(DFF)with over 90%selectivity,or to 2,5-furandicarboxylic acid(FDCA)with approximately 80%selectivity.Notably,by controlling the solvent to promote the desorption of the(CHOH)C4 H_(2)(CHO)·radical,this system also produces HMF dimers with about 89%selectivity,alongside simultaneous H_(2) generation.This work pioneers the photocatalytic oxidation of HMF to C-C coupling products,providing insights into guiding radical reaction pathways for the selective photocatalytic conversion of HMF.展开更多
The management of nitrogenous waste emissions presents significant environmental and health challenges.Efficient and sustainable upcycling strategies are needed to convert waste nitrogen compounds into valuable resour...The management of nitrogenous waste emissions presents significant environmental and health challenges.Efficient and sustainable upcycling strategies are needed to convert waste nitrogen compounds into valuable resources.Electrocatalysis has emerged as a promising solution for waste management,but several challenges remain,including the identification of suitable electrocatalysts and understanding the complex reaction mechanisms.In this review,we focus on the progress in electrocatalytic oxidized nitrogen waste upgrading and utilization,highlighting the application of advanced in situ/operando characterization techniques,including X-ray spectroscopy,scanning electrochemical microscopy and others.These techniques provide valuable insights into the structural and chemical properties of electrocatalysts as well as intermediates during electrochemical reactions,enabling a better understanding of reaction mechanisms and optimization of reaction conditions.The review explores the mechanisms of electrocatalytic upcycling of nitrogenous waste,including nitrate/nitrite reduction,nitric oxide reduction,and carbon dioxide and nitrate co-reduction reactions.Additionally,future research directions and development trends are discussed,offering a relevant guide for the development of sustainable electrocatalytic technologies for waste management and resource recovery.展开更多
This paper investigated and analyzed the conservation and utilization of four local livestock breeds in Binzhou City:Wadi Sheep,Bohai Black Cattle,Wudi Donkey,and Lubei White Goat.Shortcomings in the protection and ut...This paper investigated and analyzed the conservation and utilization of four local livestock breeds in Binzhou City:Wadi Sheep,Bohai Black Cattle,Wudi Donkey,and Lubei White Goat.Shortcomings in the protection and utilization of local germplasm resources were pointed out,and strategies and recommendations were proposed to promote high-quality development of livestock and poultry genetic resources in Binzhou,including building a solid germplasm foundation,standardizing production,and driving innovation.This paper provides references for the conservation,development,and utilization of local genetic resources in Binzhou City.展开更多
As battlefield scale enlarges,cross-platform collaborative combat provides an appealing paradigm for modern warfare.Complicated constraints and vast solution space pose great challenge for reasonable and efficient mis...As battlefield scale enlarges,cross-platform collaborative combat provides an appealing paradigm for modern warfare.Complicated constraints and vast solution space pose great challenge for reasonable and efficient mission planning,where path planning and target assignment are tightly coupled.In this paper,we focus on UAV mission planning under carrier delivery mode(e.g.,by aircraft carrier,ground vehicle,or transport aircraft) and design a three-layer hierarchical solution framework.In the first layer,we simultaneously determine delivery points and target set division by clustering.To address the safety concerns of radar risk and UAV endurance,an improved density peak clustering algorithm is developed by constraint fusio n.In the second layer,mission planning within each cluster is viewed as a coope rative multiple-task assignment problem.A hybrid heuristic algorithm that integrates a voting-based heuristic solution generation strategy(VHSG) and a stochastic variable neighborhood search(SVNS),called VHSG-SVNS,is proposed for rapid solution.Based on the results of the first two layers,the third layer transforms carrier path planning into a multiple-vehicle routing problem with time window.The cost between any two nodes is calculated by the A~* algorithm,and the genetic algorithm is then implemented to determine the global route.Finally,a practical mission scenario containing 200 targets is used to validate the effectiveness of the designed framework,where three layers cooperate well with each other to generate satisfactory combat scheduling.Comparisons are made in each layer to highlight optimum-seeking capability and efficiency of the proposed algorithms.Works done in this paper provide a simple but efficient solution framework for cross-platform cooperative mission planning problems,and can be potentially extended to other applications such as post-disaster search and rescue,forest surveillance and firefighting,logistics pick and delivery,etc.展开更多
This paper systematically analyzed the development status of sheep industry in Lubei region,and comprehensively expounded the scale and distribution of key industries,breed resources and genetic characteristics,feedin...This paper systematically analyzed the development status of sheep industry in Lubei region,and comprehensively expounded the scale and distribution of key industries,breed resources and genetic characteristics,feeding management status,disease prevention and control and veterinary services,and sheep product processing and sales.The research shows that the sheep industry in Lubei region has formed a certain scale,but there are some problems such as intensified resource and environmental constraints,unreasonable industrial structure,insufficient scientific and technological innovation capacity and market competitiveness to be improved.In view of these problems,this paper put forward some countermeasures and suggestions to promote the high-quality development of the industry,including establishing forage and feed system,promoting the adjustment and optimization of industrial structure,strengthening scientific and technological innovation and talent cultivation and introduction,and enhancing brand influence and market competitiveness,providing useful reference for the sustainable development of sheep industry in Lubei region.展开更多
基金supported by grants from the Tianjin Health Technology Project(Grant no.2022QN106).
文摘Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations,and functional implications of RIPK family members across various cancers.Methods:We collected multi-omics data from The Cancer Genome Atlas and other public databases,including gene expression,copy number variation(CNV),mutation,methylation,tumor mutation burden(TMB),and microsatellite instability(MSI).Differential expression and survival analyses were performed using DESeq2 and Cox proportional hazards models.CNV and mutation data were analyzed with GISTIC2 and Mutect2,and methylation data with the ChAMP package.Correlations with TMB and MSI were assessed using Pearson coefficients,and gene set enrichment analysis was conducted with the MSigDB Hallmark gene sets.Results:RIPK family members show significant differential expression in various cancers,with RIPK1 and RIPK4 frequently altered.Survival analysis reveals heterogeneous impacts on overall survival.CNV and mutation analyses identify high alteration frequencies for RIPK2 and RIPK7,affecting gene expression.RIPK1 and RIPK7 are hypermethylated in several cancers,inversely correlating with RIPK3 expression.RIPK1,RIPK2,RIPK5,RIPK6,and RIPK7 correlate positively with TMB,while RIPK3 shows negative correlations in some cancers.MSI analysis indicates associations with DNA mismatch repair.G ene set enrichment analysis highlights immune-related pathway enrichment for RIPK1,RIPK2,RIPK3,and RIPK6,and cell proliferation and DNA repair pathways for RIPK4 and RIPK5.RIPK family members showed heterogeneous alterations across cancers:for example,RIPK7 was mutated in up to~15%of u terine c orpus e ndometrial c arcinoma and l ung s quamous c ell c arcinoma cases,and RIPK1 and RIPK7 exhibited frequent promoter hypermethylation in multiple tumor types.Several genes displayed context-dependent associations with overall survival and with TMB/MSI.Conclusion:This pan-cancer analysis of the RIPK family reveals their diverse roles and potential as biomarkers and therapeutic targets.The findings emphasize the importance of RIPK genes in tumorigenesis and suggest context-dependent functions across cancer types.Further studies are needed to explore their mechanisms in cancer development and clinical applications.
基金the Shanghai Leading Talents Award,Shanghai Municipal Health Commission(No.LJ2016-01)the Clinical Research Plan of Shanghai Hospital Development Center(No.SHDC2022CRW004)。
文摘Polymyxin B,which is a last-line antibiotic for extensively drug-resistant Gram-negative bacterial infections,became available in China in Dec.2017.As dose adjustments are based solely on clinical experience of risk toxicity,treatment failure,and emergence of resistance,there is an urgent clinical need to perform therapeutic drug monitoring(TDM)to optimize the use of polymyxin B.It is thus necessary to standardize operating procedures to ensure the accuracy of TDM and provide evidence for their rational use.We report a consensus on TDM guidelines for polymyxin B,as endorsed by the Infection and Chemotherapy Committee of the Shanghai Medical Association and the Therapeutic Drug Monitoring Committee of the Chinese Pharmacological Society.The consensus panel was composed of clinicians,pharmacists,and microbiologists from different provinces in China and Australia who made recommendations regarding target concentrations,sample collection,reporting,and explanation of TDM results.The guidelines provide the first-ever consensus on conducting TDM of polymyxin B,and are intended to guide optimal clinical use.
基金supported by the National Natural Science Foundation of China(No.U21A20290)Guangdong Basic and Applied Basic Research Foundation(No.2022A1515011656)+2 种基金the Projects of Talents Recruitment of GDUPT(No.2023rcyj1003)the 2022“Sail Plan”Project of Maoming Green Chemical Industry Research Institute(No.MMGCIRI2022YFJH-Y-024)Maoming Science and Technology Project(No.2023382).
文摘The presence of aluminum(Al^(3+))and fluoride(F^(−))ions in the environment can be harmful to ecosystems and human health,highlighting the need for accurate and efficient monitoring.In this paper,an innovative approach is presented that leverages the power of machine learning to enhance the accuracy and efficiency of fluorescence-based detection for sequential quantitative analysis of aluminum(Al^(3+))and fluoride(F^(−))ions in aqueous solutions.The proposed method involves the synthesis of sulfur-functionalized carbon dots(C-dots)as fluorescence probes,with fluorescence enhancement upon interaction with Al^(3+)ions,achieving a detection limit of 4.2 nmol/L.Subsequently,in the presence of F^(−)ions,fluorescence is quenched,with a detection limit of 47.6 nmol/L.The fingerprints of fluorescence images are extracted using a cross-platform computer vision library in Python,followed by data preprocessing.Subsequently,the fingerprint data is subjected to cluster analysis using the K-means model from machine learning,and the average Silhouette Coefficient indicates excellent model performance.Finally,a regression analysis based on the principal component analysis method is employed to achieve more precise quantitative analysis of aluminum and fluoride ions.The results demonstrate that the developed model excels in terms of accuracy and sensitivity.This groundbreaking model not only showcases exceptional performance but also addresses the urgent need for effective environmental monitoring and risk assessment,making it a valuable tool for safeguarding our ecosystems and public health.
基金supported by the grants of Innovation and Entrepreneurship Investment Project in Hunan(2017GK5009)Postgraduate Scientific Research and Innovation Project of Hunan(CX20190500)+1 种基金the Hunan Collaborative Innovation Center of Animal Production Safety,Laboratory of Animal Clinical Toxicology at The Department of Veterinary,Hunan Agriculture UniversityAnimal Health Care Engineering Technology Research Center of Hunan Agricultural University。
文摘A simulate daily oriental dietary pattern(a blend of lard and soybean oil)was performed in this research to investigate influence on liver and kidney function.Sixty mice were randomly divided into 6 groups with diets of different fat added oils respectively for 12 weeks.Malondialdehyde and uric acid contents in mice fed with blended oil were significantly lower than in those fed only with soybean oil and lard due to the improved activities of antioxidant enzymes.Daily use of a blend of lard with soybean oil significantly increased antioxidant capacity,reduced lipid peroxidation of liver and serum uric acid production,thus protected liver and renal function.It also suggests that the oriental dietary pattern might reduce the risk of gout.
基金supported by the National Natural Science Foundation of China(22265021)the Aeronautical Science Foundation of China(2020Z056056003)Jiangxi Provincial Natural Science Foundation(20232BAB212004).
文摘Atomic-scale doping strategies and structure design play pivotal roles in tailoring the electronic structure and physicochemical property of electromagnetic wave absorption(EMWA)materials.However,the relationship between configuration and electromagnetic(EM)loss mechanism has remained elusive.Herein,drawing inspiration from the DNA transcription process,we report the successful synthesis of novel in situ Mn/N co-doped helical carbon nanotubes with ultrabroad EMWA capability.Theoretical calculation and EM simulation confirm that the orbital coupling and spin polarization of the Mn–N4–C configuration,along with cross polarization generated by the helical structure,endow the helical converters with enhanced EM loss.As a result,HMC-8 demonstrates outstanding EMWA performance,achieving a minimum reflection loss of−63.13 dB at an ultralow thickness of 1.29 mm.Through precise tuning of the graphite domain size,HMC-7 achieves an effective absorption bandwidth(EAB)of 6.08 GHz at 2.02 mm thickness.Furthermore,constructing macroscale gradient metamaterials enables an ultrabroadband EAB of 12.16 GHz at a thickness of only 5.00 mm,with the maximum radar cross section reduction value reaching 36.4 dB m2.This innovative approach not only advances the understanding of metal–nonmetal co-doping but also realizes broadband EMWA,thus contributing to the development of EMWA mechanisms and applications.
文摘Vortex levitation attains non-contact handling by injecting air through a tangential nozzle into a cylindrical cup generating the swirling flow. The precessing of the swirling flow causes pressure fluctuation. This phenomenon becomes apparent as the gap between the cup and workpiece increases, which significantly disturbs the stability of conveyance. In this paper, suppression of pressure fluctuation by a cylindrical column that stabilizes the vortex levitation is described and its mechanism is mentioned. According to the experimental set up, the pressure was measured at the center of the workpiece and the wall of the cup;velocity field under the work piece was visualized by PIV. The result suggested that the larger diameter column denoted the effect on suppression of the fluctuation because the precessing of the swirling flow became stable. On the other hand, variation of the column thickness had insignificant effect on suppressing the fluctuation, but sucking force became weakened since the swirling velocity decreased.
基金supported by the China Agriculture Research System of Ministry of Finance of the People’s Republic of China(MOF)Ministry of Agriculture+1 种基金Rural Affairs of the People’s Republic of China(MARA)(CARS-38)S&T Program of Hebei(215A7101D).
文摘Microbial growth causes lamb spoilage.This study explored the spoilage ability of Latilactobacillus sakei,Serratia proteamaculans and Hafnia proteus in vacuum-packed raw lamb,including growth ability,degradation of protein and lipid,and change of volatile organic compounds(VOCs)profile,meanwhile screened the key VOCs produced by the targeted strains with meat background excluding,finally confirmed the volatile spoilage marker of vacuum-packaged lamb by comparing with our previous work.The results showed that L.sakei,S.proteamaculans and H.proteus had excellent growth ability.L.sakei inoculated group significantly reduced the pH value,showed higher trichloroacetic acid-soluble peptides content,and excellently degraded sarcoplasmic and myofibrillar proteins.About free amino acids,L.sakei significantly degraded serine,arginine and aspartic acid,while S.proteamaculans and H.proteus significantly degraded serine and lysine.In addition,L.sakei had the strongest effect on promoting free fatty acid production,followed by S.proteamaculans and finally H.proteus.Evaluating from various indicators,the co-culture of the three strains did not have any effect.The key volatiles produced by L.sakei were 1-hexanol,acetic acid and hexanoic acid,S.proteamaculans produced 1-hexanol and acetoin,and H.proteus produced 1-hexanol,acetic acid and acetoin.In the end,1-hexanol,hexanoic acid and acetoin were proven to be spoilage markers for vacuum-packaged and chilled lamb.This study can provide fundamental information for inhibiting and rapid identification of spoilage in vacuum-packaged lamb.
基金financially supported by the National Natural Science Foundation of China(No.52102062)the Xi’an Science and Technology Plan Project(No.23LLRH0004)the Key Research and Development Project of Shaanxi Province of China(2024GX-YBXM-352)。
文摘Vat photopolymerization(VPP)3D printing is an optimized technology for complex-shaped ceramic cores,in which the solid loading of ceramic slurries greatly infiuences the microstructure and property of the final ceramic parts.However,the high solid loading of slurries is highly limited by the high viscosity.In this study,silica-based ceramic core slurries with solid loading up to 68vol.%were achieved by the composition design to optimize the performance,considering the curing,rheological,and double bond conversion rate.The slurries demonstrate superior curing and rheological performance with mass ratio of monomers being 3:2 and mass fraction of BYK111 being 4wt.%.Afterwards,the impact of solid loading on the morphology and mechanical properties was investigated.As the solid loading increases,the microstructure becomes gradually dense,leading to an improved flexural strength of 19.5 MPa.Additionally,the sintering shrinkage becomes more uniform,satisfying the casting requirements effectively.This work serves as a guide for the preparation of ceramic slurries with a high solid loading.
基金supported by the National Natural Science Foundation of China(No.62101587)the National Funded Postdoctoral Researcher Program of China(No.GZC20233578)。
文摘Micro-nano Earth Observation Satellite(MEOS)constellation has the advantages of low construction cost,short revisit cycle,and high functional density,which is considered a promising solution for serving rapidly growing observation demands.The observation Scheduling Problem in the MEOS constellation(MEOSSP)is a challenging issue due to the large number of satellites and tasks,as well as complex observation constraints.To address the large-scale and complicated MEOSSP,we develop a Two-Stage Scheduling Algorithm based on the Pointer Network with Attention mechanism(TSSA-PNA).In TSSA-PNA,the MEOS observation scheduling is decomposed into a task allocation stage and a single-MEOS scheduling stage.In the task allocation stage,an adaptive task allocation algorithm with four problem-specific allocation operators is proposed to reallocate the unscheduled tasks to new MEOSs.Regarding the single-MEOS scheduling stage,we design a pointer network based on the encoder-decoder architecture to learn the optimal singleMEOS scheduling solution and introduce the attention mechanism into the encoder to improve the learning efficiency.The Pointer Network with Attention mechanism(PNA)can generate the single-MEOS scheduling solution quickly in an end-to-end manner.These two decomposed stages are performed iteratively to search for the solution with high profit.A greedy local search algorithm is developed to improve the profits further.The performance of the PNA and TSSA-PNA on singleMEOS and multi-MEOS scheduling problems are evaluated in the experiments.The experimental results demonstrate that PNA can obtain the approximate solution for the single-MEOS scheduling problem in a short time.Besides,the TSSA-PNA can achieve higher observation profits than the existing scheduling algorithms within the acceptable computational time for the large-scale MEOS scheduling problem.
文摘BACKGROUND The clinical metastasis rate of lung cancer is tremendously low in gastrointestinal tract.Individuals enduring small intestine metastasis of lung cancer are normally featured by less desirable prognosis and shorter survival than those with me-tastasis in other parts of the body.As a consequence,it holds crucial significance to conduct early diagnosis and development of systematic treatment for patients with gastrointestinal metastasis in lung cancer.In this case,a 59-year-old female patient,diagnosed with lung adenocarcinoma,experienced intestinal obstruction attributable to subsequent small intestinal metastasis.Imaging confirmed the metastasis to the small intestine after the adenocarcinoma diagnosis,ultimately giving rise to advanced-stage intestinal obstruction.Conservative treatment proved ineffective,progressing to intestinal perforation in the later stages.This resulted in peritonitis and infectious toxic shock and other serious clinical manifestations.Aggressive surgical resection mitigated the risk of disease progression and even fatality,which tremendously ameliorated the patient’s prognosis and prolonged her survival.CONCLUSION Patients enduring lung cancer who exhibit acute abdominal symptoms should be mindful of the potential for small intestinal metastasis.Intestinal perforation typically occurs in advanced stages of the disease.Moreover,and aggressive surgical treatment can mitigate the risk of multifarious complications such as peritonitis,infectious toxic shock,and even fatality.
基金the National Natural Science Foundation of China(Nos.21801063,22305070 and U20041101)the Top-Notch Talents Program of Henan Agricultural University(Nos.30501049 and 30501032)for financial support。
文摘Herein,a ternary supramolecular assembly(BPP-BQ?CB[8]-SCD)is successfully constructed by a bromophenylpyridine-tethered-bromoisoquinoline(BPP-BQ),cucurbit[8]uril(CB[8])and sulfonatedβ-cyclodextrin(SCD)via successive assembling way,exhibiting progressively enhanced green roomtemperature phosphorescence(RTP).The self-aggregates of BPP-BQ?CB[8]-SCD accommodate an energy acceptor rhodamine B(Rh B)to form a light-harvesting system(BPP-BQ?CB[8]-SCD@Rh B)with further enhanced yellow long-lifetime luminescence with large Stokes shift based on triplet-singlet F?rster resonance energy transfer(TS-FRET).Crucially,the introduction of a photoactive diarylethene achieves the long-lived photoluminescence of BPP-BQ?CB[8]-SCD@Rh B to be switched with the efficiency of up to98%through logically ordered lowering/enhancing RTP performance of the energy donor and intercepting/restoring TS-FRET pathway,when stimulated by host-vip competition and light illumination in sequence.Moreover,BPP-BQ?CB[8]-SCD@Rh B is evenly doped into polyvinyl alcohol or polyacrylamide to obtain high-performance luminescent films with long afterglow.The abovementioned logically ordered stimulus-switched long-lived emission enables the light-harvesting system in both solution and solid state to be applied in high-security-level information encryption and transformation,and anticounterfeiting.
基金supported by the National Natural Science Foundation of China(Grant Nos.62473374,62403487 and U2441243).
文摘For the longitudinal midcourse guidance problem of a cruise-glide integrated hypersonic vehicle(CGHV),an analytical method based on optimal control theory is proposed.This method constructs a guidance dynamics model for such vehicles,using aerodynamic load as the control variable,and introduces a framework for solving the guidance laws.This framework unifies the design process of guidance laws for both the glide and cruise phases.By decomposing the longitudinal guidance task into position control and velocity control,and minimizing energy consumption as the objective function,the method provides an analytical solution for velocity control load through the calculation of costate variables.This approach requires only the current state and terminal state parameters to determine the guidance law solution.Furthermore,by transforming path constraints into aerodynamic load constraints and solving backwards to obtain the angle of attack,bank angle,and throttle setting,this method ensures a smooth transition from the glide phase to the cruise phase,guaranteeing the successful completion of the guidance task.Finally,the effectiveness and practicality of the proposed method are validated through case simulations and analysis.
基金supported by the National Natural Science Foundation of China(32072655 and 32272792)。
文摘Cover cropping is a diversifying agricultural practice that can improve soil structure and function by altering the underground litter diversity and soil microbial communities.Here,we tested how a wheat cover crop alters the decomposition of cucumber root litter.A three-year greenhouse litterbag decomposition experiment showed that a wheat cover crop accelerates the decomposition of cucumber root litter.A microcosm litterbag experiment further showed that wheat litter and the soil microbial community could improve cucumber root litter decomposition.Moreover,the wheat cover crop altered the abundances and diversities of soil bacterial and fungal communities,and enriched several putative keystone operational taxonomic units(OTUs),such as Bacillus sp.OTU1837 and Mortierella sp.OTU1236,that were positively related to the mass loss of cucumber root litter.The representative bacterial and fungal strains B186 and M3 were isolated and cultured.In vitro decomposition tests demonstrated that both B186 and M3 had cucumber root litter decomposition activity and a stronger effect was found when they were co-incubated.Overall,a wheat cover crop accelerated cucumber root litter decomposition by altering the soil microbial communities,particularly by stimulating certain putative keystone taxa,which provides a theoretical basis for using cover crops to promote sustainable agricultural development.
基金financially supported by the Natural Science Foundation of Fujian Province(No.2021J01333)the funding from the Fujian Education Department of China(No.JAT210582)。
文摘Solid-state batteries(SSBs)with high-capacity Si anodes have been regarded as one of the most promising candidates to meet the large scale energy storage and electrical vehicles due to its intrinsic safety and potential high energy density.However,Si suffers from poor electrical conductivity and huge volume change and particles fracture during lithiaiotn and delithiation,which induces low practical energy density.In addition,the SSBs are often operated at high temperature due to the poor physical contact and huge resistance between Si and solid-state electrolyte(SSE).To improve the bulk electronic/ionic conductivity of Si and its interfacial compatibility with SSE,herein,a binder free and self-supporting Si/C film was developed.The monolithic carbon not only enhance the electric conductivity but also release huge stress during lithiation and delithiation.In addition,paired with the flexible and soft poly(vinylidene fluoride)-co-hexafluoropropylene(PVDF-HFP)and Li_(1.3)A_(l0.3)Ti_(1.7)(PO_(4))_(3)(LATP)solid-state electrolyte,a LiF-rich and electrochemical stable solid-electrolyte interphase(SEI)layer is in-situ engineered.The fast bulk and interfacial ionic transportation as well as the mechanical integrity of MSi enable high performance SSBs at room temperature.As a result,high specific capacity of 2137 m Ah/g with an initial Coulombic efficiency of 83.2%is obtained at a rate of 0.5 A/g.Even at a high rate of 3 A/g,the specific capacity is1793 m Ah/g.At a rate of 1 A/g,the Si/C anode delivers a long cycling performance over 500 cycles while maintains a capacity of 1135 mAh/g.This work provides a new strategy that combines charge transfer kinetics and interfacial chemistry design toward high energy density Si-based SSBs.
基金supported by the Science and Technology Research Project of Changchun City(24GXYSZZ01)the Natural Science Foundation of Jilin Province(NO.20220101036JC)。
文摘Ni-rich cathode materials have become the mainstream choice in the mileage electric vehicle sector due to their high specific capacity and safety factor.However,the volume changes occurring during charging and discharging lead to microcracking and surface remodeling,posing challenges to achieving such as high specific capacity and long cycle stability.This paper reviews existing modification strategies for Ni-rich layered oxide cathode materials.Unlike previous reviews and related papers,we comprehensively discuss a variety of modification strategies and deeply discuss the synergistic modification effect of surface coating and bulk doping,which is how to improve the cycling stability of the Ni-rich cathode.In addition,based on recent research advances,the prospects and challenges of modifying Ni-rich layered cathodes for cycle stability upgrading of the lithium-ion battery,as well as the potential application prospects in the field of power automobiles,are comprehensively analyzed.
基金X.Li thanks the National Natural Science Foundation of China(Nos.22378148,and 21975084)the Natural Science Founda-tion of Guangdong Province(No.2024A1515012433)for their sup-port.R.Shen thanks the National Natural Science Foundation of China(No.2230082074).
文摘Combining solar-driven H_(2) evolution with the selective conversion of the biomass platform compound 5-hydroxymethylfurfural(HMF)into high-value-added chemicals is promising.However,the development of this approach is impeded by slow electron-hole separation and uncontrollable HMF conversion.In this study,we present a novel S-scheme sp^(2)-carbon COF(TFPD)/CdS heterojunction bifunctional photo-catalyst for the highly selective oxidation of HMF or C-C coupling,integrated with H_(2) production.The TFPD/CdS heterojunction forms an intrinsic electric field that facilitates efficient charge separation and migration during the photocatalytic process.Additionally,theoretical calculations and in situ diffuse re-flectance infrared Fourier transform spectroscopy(DRIFTS)reveal that the adsorption and desorption of(CHOH)C4 H_(2)(CHO)·radical on the catalyst surface are critical for the selective conversion of HMF.Con-sequently,depending on the reaction atmosphere,this photocatalyst selectively oxidizes HMF to 2,5-diformylfuran(DFF)with over 90%selectivity,or to 2,5-furandicarboxylic acid(FDCA)with approximately 80%selectivity.Notably,by controlling the solvent to promote the desorption of the(CHOH)C4 H_(2)(CHO)·radical,this system also produces HMF dimers with about 89%selectivity,alongside simultaneous H_(2) generation.This work pioneers the photocatalytic oxidation of HMF to C-C coupling products,providing insights into guiding radical reaction pathways for the selective photocatalytic conversion of HMF.
基金supported by the National Key Research and Development Project(No.2022YFA1505300)National Nature Science Foundation of China(Nos.52202372 and 22304021)Sichuan Science and Technology Program(Nos.2023NSFSC0089 and 2023NSFSC0436).
文摘The management of nitrogenous waste emissions presents significant environmental and health challenges.Efficient and sustainable upcycling strategies are needed to convert waste nitrogen compounds into valuable resources.Electrocatalysis has emerged as a promising solution for waste management,but several challenges remain,including the identification of suitable electrocatalysts and understanding the complex reaction mechanisms.In this review,we focus on the progress in electrocatalytic oxidized nitrogen waste upgrading and utilization,highlighting the application of advanced in situ/operando characterization techniques,including X-ray spectroscopy,scanning electrochemical microscopy and others.These techniques provide valuable insights into the structural and chemical properties of electrocatalysts as well as intermediates during electrochemical reactions,enabling a better understanding of reaction mechanisms and optimization of reaction conditions.The review explores the mechanisms of electrocatalytic upcycling of nitrogenous waste,including nitrate/nitrite reduction,nitric oxide reduction,and carbon dioxide and nitrate co-reduction reactions.Additionally,future research directions and development trends are discussed,offering a relevant guide for the development of sustainable electrocatalytic technologies for waste management and resource recovery.
基金Supported by Binzhou Social Sciences Planning Project in 2024(24-SKGH-051)Binzhou Comprehensive Experimental Station Project of Shandong Provincial Forage Industry Technology System(SDAIT-23-10).
文摘This paper investigated and analyzed the conservation and utilization of four local livestock breeds in Binzhou City:Wadi Sheep,Bohai Black Cattle,Wudi Donkey,and Lubei White Goat.Shortcomings in the protection and utilization of local germplasm resources were pointed out,and strategies and recommendations were proposed to promote high-quality development of livestock and poultry genetic resources in Binzhou,including building a solid germplasm foundation,standardizing production,and driving innovation.This paper provides references for the conservation,development,and utilization of local genetic resources in Binzhou City.
文摘As battlefield scale enlarges,cross-platform collaborative combat provides an appealing paradigm for modern warfare.Complicated constraints and vast solution space pose great challenge for reasonable and efficient mission planning,where path planning and target assignment are tightly coupled.In this paper,we focus on UAV mission planning under carrier delivery mode(e.g.,by aircraft carrier,ground vehicle,or transport aircraft) and design a three-layer hierarchical solution framework.In the first layer,we simultaneously determine delivery points and target set division by clustering.To address the safety concerns of radar risk and UAV endurance,an improved density peak clustering algorithm is developed by constraint fusio n.In the second layer,mission planning within each cluster is viewed as a coope rative multiple-task assignment problem.A hybrid heuristic algorithm that integrates a voting-based heuristic solution generation strategy(VHSG) and a stochastic variable neighborhood search(SVNS),called VHSG-SVNS,is proposed for rapid solution.Based on the results of the first two layers,the third layer transforms carrier path planning into a multiple-vehicle routing problem with time window.The cost between any two nodes is calculated by the A~* algorithm,and the genetic algorithm is then implemented to determine the global route.Finally,a practical mission scenario containing 200 targets is used to validate the effectiveness of the designed framework,where three layers cooperate well with each other to generate satisfactory combat scheduling.Comparisons are made in each layer to highlight optimum-seeking capability and efficiency of the proposed algorithms.Works done in this paper provide a simple but efficient solution framework for cross-platform cooperative mission planning problems,and can be potentially extended to other applications such as post-disaster search and rescue,forest surveillance and firefighting,logistics pick and delivery,etc.
基金Supported by Binzhou Social Science Planning Project(25-SKGH-063)Shandong Agricultural Innovation Team Project(SDAIT-10-06,SDAIT-23-10).
文摘This paper systematically analyzed the development status of sheep industry in Lubei region,and comprehensively expounded the scale and distribution of key industries,breed resources and genetic characteristics,feeding management status,disease prevention and control and veterinary services,and sheep product processing and sales.The research shows that the sheep industry in Lubei region has formed a certain scale,but there are some problems such as intensified resource and environmental constraints,unreasonable industrial structure,insufficient scientific and technological innovation capacity and market competitiveness to be improved.In view of these problems,this paper put forward some countermeasures and suggestions to promote the high-quality development of the industry,including establishing forage and feed system,promoting the adjustment and optimization of industrial structure,strengthening scientific and technological innovation and talent cultivation and introduction,and enhancing brand influence and market competitiveness,providing useful reference for the sustainable development of sheep industry in Lubei region.
