In order to understand the change characteristics of ecological landscape pattern of desert sewage discharge area in the desert-oasis ecotone on the southern edge of Junggar Basin,Xinjiang,based on the remote sensing ...In order to understand the change characteristics of ecological landscape pattern of desert sewage discharge area in the desert-oasis ecotone on the southern edge of Junggar Basin,Xinjiang,based on the remote sensing images of 13 scenes GF1 and GF2 from 2013 to 2019,through image preprocessing,classification interpretation,GIS spatial analysis and landscape pattern index,the conclusions were as follows.From 2013 to 2019,the landscape area of sparse shrub forest land,grassland and saline alkali land increased,while the area of sandy bare land and pond surface increased.The mutual transformation among various types of landscapes was more active,among which the mutual transfer between sandy bare land and sparse shrub forest land was the most frequent.Various landscape dynamics changed significantly with time.All kinds of landscapes and the overall landscape showed the trend of fragmentation,discretization and complexity,and the overall landscape showed the trend of balanced distribution.The above results hoped to provide basic data and technical basis for eco-environmental protection,restoration and treatmen on the southern edge of Junggar Basin,and fill the current research gap.展开更多
Rod-shaped gold nanomaterials,known as gold nanorods(GNRs),may undergo specific surface modification,because of their straightforward surface chemistry.This feature makes them appropriate for use as functional and bio...Rod-shaped gold nanomaterials,known as gold nanorods(GNRs),may undergo specific surface modification,because of their straightforward surface chemistry.This feature makes them appropriate for use as functional and biocompatible nano-formulations.By optimizing the absorption of longitudinally localized surface plasmon resonance in the near-infrared region,which corresponds to the near-infrared bio-tissue window,GNRs with appropriate modifications may improve the results of photothermal treatment(PTT).In dermatology,potential noninvasive uses of GNRs to enhance wound healing,manage infections,combat cutaneous malignancies,and remodel skin tissues via PTT have attracted research attention in recent years.The review discussed the basic properties of GNRs,such as their shape,size,optical performance,photothermal efficiency,and metabolism.Then,the disadvantages of using these particles in photodynamic therapy are highlighted.Next,biological applications of GNRs-based PTT are explored in detail.Finally,the limitations and future perspectives of this research are addressed,providing a comprehensive perspective on the potential GNRs with PTT.展开更多
Cornus officinalis,a medicinal and edible plant known for its liver-nourishing properties,has shown promise in inhibiting the activation of hepatic stellate cells(HSCs),crucial indicators of hepatic fibrosis,especiall...Cornus officinalis,a medicinal and edible plant known for its liver-nourishing properties,has shown promise in inhibiting the activation of hepatic stellate cells(HSCs),crucial indicators of hepatic fibrosis,especially when processed by high pressure wine steaming(HPWS).Herein,this study aims to investigate the regulatory effects of cornus officinalis,both in its raw and HPWS forms,on inflammation and apoptosis in liver fibrosis and their underlying mechanisms.In vivo liver fibrosis models were established by subcutaneous injection of CCl4,while in vitro HSCs were exposed to transforming growth factor-b(TGF-b).These findings demonstrated that cornus officinalis with HPWS conspicuously ameliorated histopathological injury,reduced the release of proinflammatory factors,and decreased collagen deposition in CCl4-induced rats compared to its raw form.Utilizing ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometer(UHPLC-QTOF-MS)combined with network analysis,we identified that the pharmacological effects of the changed components of cornus officinalis before and after HPWS,primarily centered on the adenosine phosphate(AMP)-activated protein kinase(AMPK)pathway.Of note,cornus officinalis activated AMPK and sirtuin 3(SIRT3),promoting the apoptosis of activated HSCs through the caspase cascade by regulating caspase3,caspase6 and caspase9.small interfering RNA(siRNA)experiments showed that cornus officinalis could regulate AMPK activity and its mediated-apoptosis through SIRT3.In conclusion,cornus officinalis exhibited the ability to reduce inflammation and apoptosis,with the SIRT3-AMPK signaling pathway identified as a potential mechanism underlying the synergistic effect of cornus officinalis with HPWS on anti-liver fibrosis.展开更多
To understand the mechanical response pattern of the existing structure and ground due to the construction of metro tunnels underneath,the finite difference method is adopted to study the torsional deformation and str...To understand the mechanical response pattern of the existing structure and ground due to the construction of metro tunnels underneath,the finite difference method is adopted to study the torsional deformation and stress variation of the existing structure and the effect of underground carriageway structures on the surface subsidence.The curves of the maximum differential subsidence,torsion angle,and distortion of the cross-section of the existing structure show two peaks in succession during traversing of two metro tunnels beneath it.The torsion angle of the existing structure changes when the two tunnels traverse beneath it in opposite directions.The first traversing of the shield tunnel mainly induces the magnitude variation in torsional deformation of the existing structure,but the second traversing of the subsurface tunnel may cause a dynamic change in the magnitude and form of torsional deformation in the existing structure.The shielding effect can reduce the surface subsidence caused by metro tunnel excavation to a certain extent,and the development trend of subsidence becomes slower as the excavation continues.展开更多
In recent years,the protection of PSESP has gradually become a hot issue in biodiversity research.Through the investigation and analysis of PSESP in Xinjiang,it is shown that:①there are 75 species of PSESP in Xinjian...In recent years,the protection of PSESP has gradually become a hot issue in biodiversity research.Through the investigation and analysis of PSESP in Xinjiang,it is shown that:①there are 75 species of PSESP in Xinjiang,including 22 species of trees,18 species of shrubs and 35 species of herbs.The habitats are mainly in extremely cold,extremely dry or extremely narrow conditions such as snow line,desert,mountain,wetland and so on.②53 species(70.67%)are listed as national or autonomous region protected plants,and 22 species of PSESP are not listed in the protection;there are 70 species of PSESP listed in the red list,accounting for 93.33%.③The PSESP in Xinjiang are mainly distributed in the Altai Mountains,western Tianshan Mountains,Pamir Plateau and Karakoram Mountains;they are distributed in all kinds of nature reserves,forest parks,wetland parks and other natural ecological protection areas in Xinjiang.Ammopiptanthus nanus(M.Pop.)Cheng F.,Cistanche tubulosa(Schenk)Wight,Calligonum roborovskii A.Los.and Prunus cerasifera Ehrhart have not been found in the literature,indicating that they are distributed in protected areas.In order to provide a theoretical basis for the conservation of biodiversity in Xinjiang,this paper puts forward some suggestions on the protection of PSESP.展开更多
BACKGROUND Esophageal cancer is the sixth most common cancer worldwide,with a high mortality rate.Early prognosis of esophageal abnormalities can improve patient survival rates.The progression of esophageal cancer fol...BACKGROUND Esophageal cancer is the sixth most common cancer worldwide,with a high mortality rate.Early prognosis of esophageal abnormalities can improve patient survival rates.The progression of esophageal cancer follows a sequence from esophagitis to non-dysplastic Barrett’s esophagus,dysplastic Barrett’s esophagus,and eventually esophageal adenocarcinoma(EAC).This study explored the application of deep learning technology in the precise diagnosis of pathological classification and staging of EAC to enhance diagnostic accuracy and efficiency.AIM To explore the application of deep learning models,particularly Wave-Vision Transformer(Wave-ViT),in the pathological classification and staging of esophageal cancer to enhance diagnostic accuracy and efficiency.METHODS We applied several deep learning models,including multi-layer perceptron,residual network,transformer,and Wave-ViT,to a dataset of clinically validated esophageal pathology images.The models were trained to identify pathological features and assist in the classification and staging of different stages of esophageal cancer.The models were compared based on accuracy,computational complexity,and efficiency.RESULTS The Wave-ViT model demonstrated the highest accuracy at 88.97%,surpassing the transformer(87.65%),residual network(85.44%),and multi-layer perceptron(81.17%).Additionally,Wave-ViT exhibited low computational complexity with significantly reduced parameter size,making it highly efficient for real-time clinical applications.CONCLUSION Deep learning technology,particularly the Frequency-Domain Transformer model,shows promise in improving the precision of pathological classification and staging of EAC.The application of the Frequency-Domain Transformer model enhances the automation of the diagnostic process and may support early detection and treatment of EAC.Future research may further explore the potential of this model in broader medical image analysis applications,particularly in the field of precision medicine.展开更多
BACKGROUND: The increasing morbidity of liver cancer has led to a growing demand for transplantation. Split liver transplantation(SLT) is a promising way to ameliorate organ shortages. However, the safety and efficacy...BACKGROUND: The increasing morbidity of liver cancer has led to a growing demand for transplantation. Split liver transplantation(SLT) is a promising way to ameliorate organ shortages. However, the safety and efficacy of SLT are still controversial. The aim of this study was to assess the clinical outcome of SLT in liver cancer patients at our center. METHODS: A total of 74 patients who received liver transplantation at a tertiary hospital from March 2019 to July 2023 were retrospectively studied, of whom 37 recipients underwent SLT and 37 recipients underwent whole-graft liver transplantation(WGLT). Clinical data were analyzed and compared between patients who underwent SLT and WGLT.RESULTS: SLT and WGLT were successfully performed, with no intraoperative transplantrelated mortality. Postoperatively, no significant differences in total bilirubin(TB, P=0.266), alanine transaminase(ALT, P=0.403) and aspartate transaminase(AST, P=0.160) levels within 30 d were detected between the two groups. The transplant-related mortality rates were 8.1% in the SLT group and 5.4% in the WGLT group within 30 d of surgery(P=1.000), and 10.8% and 8.1%, respectively, at 90 d after surgery(P=1.000). There were no significant differences in overall survival(OS) and progress-free survival(PFS) between the SLT and WGLT groups(P=0.910, P=0.190). CONCLUSION: Our results show that SLT does not imply additional risks in treating liver cancer compared with WGLT.展开更多
Research on detonation has traditionally focused on forward solutions,with limited attention to inverse design methods,which has significantly hindered the development of detonation engines.In this paper,the Method of...Research on detonation has traditionally focused on forward solutions,with limited attention to inverse design methods,which has significantly hindered the development of detonation engines.In this paper,the Method of characteristics for Curved-Detonation(MOCD)is proposed to enable the inverse design of detonation waves.MOCD is based on the Method of Curved-shock Characteristics(MOCC)and integrates higher-order aerodynamic parameters from Curved Detonation Equations(CDE),allowing the calculation of the wedge angle given specific wave angle.The effectiveness of MOCD is validated using both oblique and curved detonation waves with single-step and detailed chemical reactions.Various applications demonstrate the ability to meet the inverse design requirements of detonation engines.For example,inverse design for given wave angles can optimize engine thrust and prevent Mach reflections.Additionally,inverse design schemes tailored to incoming flow conditions,such as varying Mach numbers and equivalence ratios,enhance the feasibility of detonation engines.Applying the method to given post-wave aerodynamic parameters enables more precise engine design,which is crucial for improving propulsion performance and effective thermal protection.In summary,the advantages of MOCD include not only performing a fast solution of the detonation flow field,but also allowing the inverse design of the detonation wave.展开更多
Cancer is characterized by abnormal cell proliferation.Cyclins and cyclin-dependent kinases(CDKs)have been recognized as essential regulators of the intricate cell cycle,orchestrating DNA replication and transcription...Cancer is characterized by abnormal cell proliferation.Cyclins and cyclin-dependent kinases(CDKs)have been recognized as essential regulators of the intricate cell cycle,orchestrating DNA replication and transcription,RNA splicing,and protein synthesis.Dysregulation of the CDK pathway is prevalent in the development and progression of human cancers,rendering cyclins and CDKs attractive therapeutic targets.Several CDK4/6 inhibitors have demonstrated promising anti-cancer efficacy and have been successfully translated into clinical use,fueling the development of CDK-targeted therapies.With this enthusiasm for finding novel CDK-targeting anti-cancer agents,there have also been exciting advances in the field of targeted protein degradation through innovative strategies,such as using proteolysis-targeting chimera,heat shock protein 90(HSP90)-mediated targeting chimera,hydrophobic tag-based protein degradation,and molecular glue.With a focus on the translational potential of cyclin-and CDK-targeting strategies in cancer,this review presents the fundamental roles of cyclins and CDKs in cancer.Furthermore,it summarizes current strategies for the proteasome-dependent targeted degradation of cyclins and CDKs,detailing the underlying mechanisms of action for each approach.A comprehensive overview of the structure and activity of existing CDK degraders is also provided.By examining the structure‒activity relationships,target profiles,and biological effects of reported cyclin/CDK degraders,this review provides a valuable reference for both CDK pathway-targeted biomedical research and cancer therapeutics.展开更多
The van der Waals cluster magnet Nb_(3)Cl_(8)has recently been shown to possibly host a quantum-spin-liquid ground state.The Nb ions in this compound form a breathing kagome structure,where the magnetic moment comes f...The van der Waals cluster magnet Nb_(3)Cl_(8)has recently been shown to possibly host a quantum-spin-liquid ground state.The Nb ions in this compound form a breathing kagome structure,where the magnetic moment comes from three nearest Nb ions forming a molecular cluster with spin 1/2.Previous bulk measurements including magnetic susceptibility and specific heat suggested the existence of spinon Fermi surfaces.Here we further probe the spin system by nuclear magnetic resonance(NMR)and muon spin rotation and relaxation(μSR)techniques.We confirm that there is no magnetic long-range order and the dynamical spin fluctuations persist down to 0.075 K.These results provide further evidence that Nb_(3)Cl_(8)may host a quantum spin liquid.展开更多
AIM: To detect the expression of sal-like protein 4 (SALL4) and to explore its relationship with clinicopathological characteristics and prognosis of hepatocellular carcinoma (HCC).METHODS: One hundred and twenty-six ...AIM: To detect the expression of sal-like protein 4 (SALL4) and to explore its relationship with clinicopathological characteristics and prognosis of hepatocellular carcinoma (HCC).METHODS: One hundred and twenty-six samples of HCC tissue, 44 of adjacent noncancerous cirrhotic tissue and 10 of liver hemangioma tissue, were obtained from patients who underwent hepatectomy for HCC at the Fourth Hospital of Hebei Medical University. None of the patients had received any form of treatment before the operation. After resection, all the tissues were fixed in 10% neutral formaldehyde and embedded in paraffin. Expression of SALL4 was detected by immunohistochemistry. Patients were followed up for postoperative survival until February 2014. The relationships between SALL4 expression level and clinicopathological data and prognosis of HCC were analyzed.RESULTS: SALL4 expression was negative in the 10 samples of tissue from liver hemangioma, was weakly positive in the two samples from adjacent noncancerous cirrhotic tissue, and positive in 58 samples of HCC tissues. The differences were statistically significant (P < 0.05). Expression of SALL4 was higher in patients with higher α-fetoprotein (AFP) levels, portal vein tumor thrombus, and later clinical stage based on the Barcelona Clinic Liver Cancer classification (P < 0.05). Among patients with negative expression, weakly positive expression, positive expression, and strongly positive expression of SALL4, the median survival time was 39, 25, 23, and 9 mo, respectively (P < 0.001). When both AFP and SALL4 were detected, patients who were negative for both AFP and SALL4, SALL4-positive only, AFP-positive only, and positive for both AFP and SALL4, had a median survival time of 41, 38, 31, and 12 mo, respectively (P < 0.001).CONCLUSION: Expression of SALL4 is relevant to the prognosis of HCC patients. Patients with higher expression levels of SALL4 and AFP have worse prognosis.展开更多
A controller which is locally optimal near the origin and globally inverse optimal for the nonlinear system is proposed for path following of over actuated marine crafts with actuator dynamics. The motivation is the e...A controller which is locally optimal near the origin and globally inverse optimal for the nonlinear system is proposed for path following of over actuated marine crafts with actuator dynamics. The motivation is the existence of undesired signals sent to the actuators, which can result in bad behavior in path following. To attenuate the oscillation of the control signal and obtain smooth thrust outputs, the actuator dynamics are added into the ship maneuvering model. Instead of modifying the Line-of-Sight (LOS) guidance law, this proposed controller can easily adjust the vessel speed to minimize the large cross-track error caused by the high vessel speed when it is turning. Numerical simulations demonstrate the validity of this proposed controller.展开更多
基金Supported by Special Project for the Construction of Innovation Environment(Talent and Base)in Xinjiang Uygur Autonomous Region in 2020:Construction of Scientific and Technological Innovation Base(Construction of Resource Sharing Platform)(PT2034)Innovation Fund of Xinjiang Academy of Environmental Protection Science(202002).
文摘In order to understand the change characteristics of ecological landscape pattern of desert sewage discharge area in the desert-oasis ecotone on the southern edge of Junggar Basin,Xinjiang,based on the remote sensing images of 13 scenes GF1 and GF2 from 2013 to 2019,through image preprocessing,classification interpretation,GIS spatial analysis and landscape pattern index,the conclusions were as follows.From 2013 to 2019,the landscape area of sparse shrub forest land,grassland and saline alkali land increased,while the area of sandy bare land and pond surface increased.The mutual transformation among various types of landscapes was more active,among which the mutual transfer between sandy bare land and sparse shrub forest land was the most frequent.Various landscape dynamics changed significantly with time.All kinds of landscapes and the overall landscape showed the trend of fragmentation,discretization and complexity,and the overall landscape showed the trend of balanced distribution.The above results hoped to provide basic data and technical basis for eco-environmental protection,restoration and treatmen on the southern edge of Junggar Basin,and fill the current research gap.
基金supported by the National Natural Science Foundation of China(Grant Nos.82073439 and 82373475)。
文摘Rod-shaped gold nanomaterials,known as gold nanorods(GNRs),may undergo specific surface modification,because of their straightforward surface chemistry.This feature makes them appropriate for use as functional and biocompatible nano-formulations.By optimizing the absorption of longitudinally localized surface plasmon resonance in the near-infrared region,which corresponds to the near-infrared bio-tissue window,GNRs with appropriate modifications may improve the results of photothermal treatment(PTT).In dermatology,potential noninvasive uses of GNRs to enhance wound healing,manage infections,combat cutaneous malignancies,and remodel skin tissues via PTT have attracted research attention in recent years.The review discussed the basic properties of GNRs,such as their shape,size,optical performance,photothermal efficiency,and metabolism.Then,the disadvantages of using these particles in photodynamic therapy are highlighted.Next,biological applications of GNRs-based PTT are explored in detail.Finally,the limitations and future perspectives of this research are addressed,providing a comprehensive perspective on the potential GNRs with PTT.
基金supported by the National Natural Science Foundation of China(Grant Nos.:82104394 and 81973481)the Natural Science Foundation of Zhejiang Province(Grant Nos.:LY23H280008 and LQ23H280004)+2 种基金Zhejiang Province Traditional Chinese Medicine Science and Technology Project(Grant No.:2022ZQ033)Zhejiang Chinese Medicine University UniversityLevel Talent Special Project(Grant No.:2021ZR06)Zhejiang Province Postdoctoral Research Project(Grant No.:ZJ2022057).
文摘Cornus officinalis,a medicinal and edible plant known for its liver-nourishing properties,has shown promise in inhibiting the activation of hepatic stellate cells(HSCs),crucial indicators of hepatic fibrosis,especially when processed by high pressure wine steaming(HPWS).Herein,this study aims to investigate the regulatory effects of cornus officinalis,both in its raw and HPWS forms,on inflammation and apoptosis in liver fibrosis and their underlying mechanisms.In vivo liver fibrosis models were established by subcutaneous injection of CCl4,while in vitro HSCs were exposed to transforming growth factor-b(TGF-b).These findings demonstrated that cornus officinalis with HPWS conspicuously ameliorated histopathological injury,reduced the release of proinflammatory factors,and decreased collagen deposition in CCl4-induced rats compared to its raw form.Utilizing ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometer(UHPLC-QTOF-MS)combined with network analysis,we identified that the pharmacological effects of the changed components of cornus officinalis before and after HPWS,primarily centered on the adenosine phosphate(AMP)-activated protein kinase(AMPK)pathway.Of note,cornus officinalis activated AMPK and sirtuin 3(SIRT3),promoting the apoptosis of activated HSCs through the caspase cascade by regulating caspase3,caspase6 and caspase9.small interfering RNA(siRNA)experiments showed that cornus officinalis could regulate AMPK activity and its mediated-apoptosis through SIRT3.In conclusion,cornus officinalis exhibited the ability to reduce inflammation and apoptosis,with the SIRT3-AMPK signaling pathway identified as a potential mechanism underlying the synergistic effect of cornus officinalis with HPWS on anti-liver fibrosis.
基金National Natural Science Foundation of China,Grant/Award Numbers:51878060,52078046。
文摘To understand the mechanical response pattern of the existing structure and ground due to the construction of metro tunnels underneath,the finite difference method is adopted to study the torsional deformation and stress variation of the existing structure and the effect of underground carriageway structures on the surface subsidence.The curves of the maximum differential subsidence,torsion angle,and distortion of the cross-section of the existing structure show two peaks in succession during traversing of two metro tunnels beneath it.The torsion angle of the existing structure changes when the two tunnels traverse beneath it in opposite directions.The first traversing of the shield tunnel mainly induces the magnitude variation in torsional deformation of the existing structure,but the second traversing of the subsurface tunnel may cause a dynamic change in the magnitude and form of torsional deformation in the existing structure.The shielding effect can reduce the surface subsidence caused by metro tunnel excavation to a certain extent,and the development trend of subsidence becomes slower as the excavation continues.
基金Supported by Basic Scientific Research Business Funds of Public Welfare Scientific Research Institutes of the Autonomous Region in 2022 (kyys202201)
文摘In recent years,the protection of PSESP has gradually become a hot issue in biodiversity research.Through the investigation and analysis of PSESP in Xinjiang,it is shown that:①there are 75 species of PSESP in Xinjiang,including 22 species of trees,18 species of shrubs and 35 species of herbs.The habitats are mainly in extremely cold,extremely dry or extremely narrow conditions such as snow line,desert,mountain,wetland and so on.②53 species(70.67%)are listed as national or autonomous region protected plants,and 22 species of PSESP are not listed in the protection;there are 70 species of PSESP listed in the red list,accounting for 93.33%.③The PSESP in Xinjiang are mainly distributed in the Altai Mountains,western Tianshan Mountains,Pamir Plateau and Karakoram Mountains;they are distributed in all kinds of nature reserves,forest parks,wetland parks and other natural ecological protection areas in Xinjiang.Ammopiptanthus nanus(M.Pop.)Cheng F.,Cistanche tubulosa(Schenk)Wight,Calligonum roborovskii A.Los.and Prunus cerasifera Ehrhart have not been found in the literature,indicating that they are distributed in protected areas.In order to provide a theoretical basis for the conservation of biodiversity in Xinjiang,this paper puts forward some suggestions on the protection of PSESP.
文摘BACKGROUND Esophageal cancer is the sixth most common cancer worldwide,with a high mortality rate.Early prognosis of esophageal abnormalities can improve patient survival rates.The progression of esophageal cancer follows a sequence from esophagitis to non-dysplastic Barrett’s esophagus,dysplastic Barrett’s esophagus,and eventually esophageal adenocarcinoma(EAC).This study explored the application of deep learning technology in the precise diagnosis of pathological classification and staging of EAC to enhance diagnostic accuracy and efficiency.AIM To explore the application of deep learning models,particularly Wave-Vision Transformer(Wave-ViT),in the pathological classification and staging of esophageal cancer to enhance diagnostic accuracy and efficiency.METHODS We applied several deep learning models,including multi-layer perceptron,residual network,transformer,and Wave-ViT,to a dataset of clinically validated esophageal pathology images.The models were trained to identify pathological features and assist in the classification and staging of different stages of esophageal cancer.The models were compared based on accuracy,computational complexity,and efficiency.RESULTS The Wave-ViT model demonstrated the highest accuracy at 88.97%,surpassing the transformer(87.65%),residual network(85.44%),and multi-layer perceptron(81.17%).Additionally,Wave-ViT exhibited low computational complexity with significantly reduced parameter size,making it highly efficient for real-time clinical applications.CONCLUSION Deep learning technology,particularly the Frequency-Domain Transformer model,shows promise in improving the precision of pathological classification and staging of EAC.The application of the Frequency-Domain Transformer model enhances the automation of the diagnostic process and may support early detection and treatment of EAC.Future research may further explore the potential of this model in broader medical image analysis applications,particularly in the field of precision medicine.
基金Key Project of Traditional Chinese Medicine Science and Technology Plan of Zhejiang Province (GZY-ZJ-KJ-24077)National Natural Science Foundation of China (No. U23A202181, 8207101520, 82272860)+2 种基金Central Guidance on Local Science and Technology Development Fund of Zhejiang Province (2023ZY1017)Fundamental Research Funds for the Central Universities (No. 226-2023-00038)Special Financial Support for Zhejiang Traditional Chinese Medicine Innovation Teams。
文摘BACKGROUND: The increasing morbidity of liver cancer has led to a growing demand for transplantation. Split liver transplantation(SLT) is a promising way to ameliorate organ shortages. However, the safety and efficacy of SLT are still controversial. The aim of this study was to assess the clinical outcome of SLT in liver cancer patients at our center. METHODS: A total of 74 patients who received liver transplantation at a tertiary hospital from March 2019 to July 2023 were retrospectively studied, of whom 37 recipients underwent SLT and 37 recipients underwent whole-graft liver transplantation(WGLT). Clinical data were analyzed and compared between patients who underwent SLT and WGLT.RESULTS: SLT and WGLT were successfully performed, with no intraoperative transplantrelated mortality. Postoperatively, no significant differences in total bilirubin(TB, P=0.266), alanine transaminase(ALT, P=0.403) and aspartate transaminase(AST, P=0.160) levels within 30 d were detected between the two groups. The transplant-related mortality rates were 8.1% in the SLT group and 5.4% in the WGLT group within 30 d of surgery(P=1.000), and 10.8% and 8.1%, respectively, at 90 d after surgery(P=1.000). There were no significant differences in overall survival(OS) and progress-free survival(PFS) between the SLT and WGLT groups(P=0.910, P=0.190). CONCLUSION: Our results show that SLT does not imply additional risks in treating liver cancer compared with WGLT.
基金the support of the National Natural Science Foundation of China,China(Nos.U20A2069,U21B6003,and 12302389)the Advanced Aero-Power Innovation Workstation,China(No.HKCX2024-01-017)。
文摘Research on detonation has traditionally focused on forward solutions,with limited attention to inverse design methods,which has significantly hindered the development of detonation engines.In this paper,the Method of characteristics for Curved-Detonation(MOCD)is proposed to enable the inverse design of detonation waves.MOCD is based on the Method of Curved-shock Characteristics(MOCC)and integrates higher-order aerodynamic parameters from Curved Detonation Equations(CDE),allowing the calculation of the wedge angle given specific wave angle.The effectiveness of MOCD is validated using both oblique and curved detonation waves with single-step and detailed chemical reactions.Various applications demonstrate the ability to meet the inverse design requirements of detonation engines.For example,inverse design for given wave angles can optimize engine thrust and prevent Mach reflections.Additionally,inverse design schemes tailored to incoming flow conditions,such as varying Mach numbers and equivalence ratios,enhance the feasibility of detonation engines.Applying the method to given post-wave aerodynamic parameters enables more precise engine design,which is crucial for improving propulsion performance and effective thermal protection.In summary,the advantages of MOCD include not only performing a fast solution of the detonation flow field,but also allowing the inverse design of the detonation wave.
基金supported by the Zhejiang Provincial Nat ural Science Foundation of China(Nos.LZ23C060002 and LZ24H160004)the National Natural Science Foundation of China(Nos.32270746,82203247,82203415,82272637,82204429,and 82073332)+2 种基金the National Key Research and Development Program of China(No.2022YFE0107800)the Medical Interdisciplinary Innovation Program 2024,Zhejiang University School of Medicine,and the Fundamental Research Funds for the Central Universities(No.K20220228)It is add-itionally supported by the National Institute of Health(No.R01-CA200992-03).
文摘Cancer is characterized by abnormal cell proliferation.Cyclins and cyclin-dependent kinases(CDKs)have been recognized as essential regulators of the intricate cell cycle,orchestrating DNA replication and transcription,RNA splicing,and protein synthesis.Dysregulation of the CDK pathway is prevalent in the development and progression of human cancers,rendering cyclins and CDKs attractive therapeutic targets.Several CDK4/6 inhibitors have demonstrated promising anti-cancer efficacy and have been successfully translated into clinical use,fueling the development of CDK-targeted therapies.With this enthusiasm for finding novel CDK-targeting anti-cancer agents,there have also been exciting advances in the field of targeted protein degradation through innovative strategies,such as using proteolysis-targeting chimera,heat shock protein 90(HSP90)-mediated targeting chimera,hydrophobic tag-based protein degradation,and molecular glue.With a focus on the translational potential of cyclin-and CDK-targeting strategies in cancer,this review presents the fundamental roles of cyclins and CDKs in cancer.Furthermore,it summarizes current strategies for the proteasome-dependent targeted degradation of cyclins and CDKs,detailing the underlying mechanisms of action for each approach.A comprehensive overview of the structure and activity of existing CDK degraders is also provided.By examining the structure‒activity relationships,target profiles,and biological effects of reported cyclin/CDK degraders,this review provides a valuable reference for both CDK pathway-targeted biomedical research and cancer therapeutics.
基金supported by the National Key Research and Development Program of China(Grant Nos.2022YFA1403800,2022YFA1403400,2021YFA1400400,2023YFA1406100,and 2024YFA1409200)the National Natural Science Foundation of China(Grant Nos.12274444,12374142,and 12304170)+1 种基金the Chinese Academy of Sciences President’s International Fellowship Initiative(Grant No.2025PG0007)We thank ISIS Facility for beam time(Grant No.RB2310088).
文摘The van der Waals cluster magnet Nb_(3)Cl_(8)has recently been shown to possibly host a quantum-spin-liquid ground state.The Nb ions in this compound form a breathing kagome structure,where the magnetic moment comes from three nearest Nb ions forming a molecular cluster with spin 1/2.Previous bulk measurements including magnetic susceptibility and specific heat suggested the existence of spinon Fermi surfaces.Here we further probe the spin system by nuclear magnetic resonance(NMR)and muon spin rotation and relaxation(μSR)techniques.We confirm that there is no magnetic long-range order and the dynamical spin fluctuations persist down to 0.075 K.These results provide further evidence that Nb_(3)Cl_(8)may host a quantum spin liquid.
基金Supported by the National Natural Science Foundation of China,No.81072966/H2902the Natural Science Foundation of Hebei Province,China,No.C2011206134
文摘AIM: To detect the expression of sal-like protein 4 (SALL4) and to explore its relationship with clinicopathological characteristics and prognosis of hepatocellular carcinoma (HCC).METHODS: One hundred and twenty-six samples of HCC tissue, 44 of adjacent noncancerous cirrhotic tissue and 10 of liver hemangioma tissue, were obtained from patients who underwent hepatectomy for HCC at the Fourth Hospital of Hebei Medical University. None of the patients had received any form of treatment before the operation. After resection, all the tissues were fixed in 10% neutral formaldehyde and embedded in paraffin. Expression of SALL4 was detected by immunohistochemistry. Patients were followed up for postoperative survival until February 2014. The relationships between SALL4 expression level and clinicopathological data and prognosis of HCC were analyzed.RESULTS: SALL4 expression was negative in the 10 samples of tissue from liver hemangioma, was weakly positive in the two samples from adjacent noncancerous cirrhotic tissue, and positive in 58 samples of HCC tissues. The differences were statistically significant (P < 0.05). Expression of SALL4 was higher in patients with higher α-fetoprotein (AFP) levels, portal vein tumor thrombus, and later clinical stage based on the Barcelona Clinic Liver Cancer classification (P < 0.05). Among patients with negative expression, weakly positive expression, positive expression, and strongly positive expression of SALL4, the median survival time was 39, 25, 23, and 9 mo, respectively (P < 0.001). When both AFP and SALL4 were detected, patients who were negative for both AFP and SALL4, SALL4-positive only, AFP-positive only, and positive for both AFP and SALL4, had a median survival time of 41, 38, 31, and 12 mo, respectively (P < 0.001).CONCLUSION: Expression of SALL4 is relevant to the prognosis of HCC patients. Patients with higher expression levels of SALL4 and AFP have worse prognosis.
基金Supported by the National Natural Science Foundation of China under Grant Nos. 61301279, 51479158 and the Fundamental Research Funds for the Central Universities under Grant No. WUT: 163102006
文摘A controller which is locally optimal near the origin and globally inverse optimal for the nonlinear system is proposed for path following of over actuated marine crafts with actuator dynamics. The motivation is the existence of undesired signals sent to the actuators, which can result in bad behavior in path following. To attenuate the oscillation of the control signal and obtain smooth thrust outputs, the actuator dynamics are added into the ship maneuvering model. Instead of modifying the Line-of-Sight (LOS) guidance law, this proposed controller can easily adjust the vessel speed to minimize the large cross-track error caused by the high vessel speed when it is turning. Numerical simulations demonstrate the validity of this proposed controller.
