Unravelling lineage plasticity and cellular contribution to hepatocytes provides valuable information for understanding sources that fuel homeostatic renewal of the liver(Miyajima et al.,2014).In the adult stage,hepat...Unravelling lineage plasticity and cellular contribution to hepatocytes provides valuable information for understanding sources that fuel homeostatic renewal of the liver(Miyajima et al.,2014).In the adult stage,hepatocytes are mainly self-renewed through cell division(Schaub et al.,2014;Tarlow et al.,2014;Yanger et al.,2014).Under severe injury or when hepatocyte proliferation is significantly impaired,cholangiocytes or biliary epithelial cells contribute to hepatocytes(Raven et al.,2017;Deng et al.,2018).展开更多
Dear editor,Site specific recombinases have been widely used for genome engineering in cardiovascular research(Fu et al.,2024;Huang et al.,2023;Xue et al.,2022).In particular,Cre is the most broadly used recombinase f...Dear editor,Site specific recombinases have been widely used for genome engineering in cardiovascular research(Fu et al.,2024;Huang et al.,2023;Xue et al.,2022).In particular,Cre is the most broadly used recombinase for cell type-specific lineage tracing and gene manipulation in mammals.For smooth muscle cell(SMC)-specific targeting,several SMC promoters including Myh11(smooth muscle myosin heavy chain),Acta2(smooth muscle a-2 actin),and SM22a(Tagln)have been used to drive Cre or CreER.展开更多
基金supported by the National Key Research and Development Program of China(2018YFA0107900 and 2018YFA0108100)the National Science Foundation of China(31730112 and 31625019)the China Postdoctoral Innovative Talent Support Program。
文摘Unravelling lineage plasticity and cellular contribution to hepatocytes provides valuable information for understanding sources that fuel homeostatic renewal of the liver(Miyajima et al.,2014).In the adult stage,hepatocytes are mainly self-renewed through cell division(Schaub et al.,2014;Tarlow et al.,2014;Yanger et al.,2014).Under severe injury or when hepatocyte proliferation is significantly impaired,cholangiocytes or biliary epithelial cells contribute to hepatocytes(Raven et al.,2017;Deng et al.,2018).
基金supported by the National Natural Science Foundation of China(81970412,82270415,82088101,32050087,82300552)Shanghai Municipal Science and Technology Commission Innovation Fund(22S31904800)+3 种基金Fujian Province Health Science and Technology Fund(2021GGB030)Fujian Natural Science Foundation Fund(2022J01410826)Shanghai Municipal Health Commission(20234Z0012)the New Cornerstone Science Foundation through the New Cornerstone Investigator Program and the XPLORER PRIZE。
文摘Dear editor,Site specific recombinases have been widely used for genome engineering in cardiovascular research(Fu et al.,2024;Huang et al.,2023;Xue et al.,2022).In particular,Cre is the most broadly used recombinase for cell type-specific lineage tracing and gene manipulation in mammals.For smooth muscle cell(SMC)-specific targeting,several SMC promoters including Myh11(smooth muscle myosin heavy chain),Acta2(smooth muscle a-2 actin),and SM22a(Tagln)have been used to drive Cre or CreER.
