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Effects of doors on an open cavity flow at Mach number 6
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作者 Baoping NIE xilin hu Zhufei LI 《Chinese Journal of Aeronautics》 2025年第2期75-91,共17页
Open cavities with different door-opening angles are investigated using high-speed schlieren visualization and dynamic pressure measurements in hypersonic flow with a freestream Mach number of 6.With the help of numer... Open cavities with different door-opening angles are investigated using high-speed schlieren visualization and dynamic pressure measurements in hypersonic flow with a freestream Mach number of 6.With the help of numerical simulations,the shear layer deformation and pressure increase in the cavities due to the impingement of the door-leading-edge shocks are identified via comparison with those in the cavity without doors.As the door-opening angle decreases from 90°,the shear layer above the forepart of the cavity is gradually raised by the high pressure in the cavity.When the door-opening angle decreases to 30°and 15°,the boundary layer on the upstream flat plate of the cavity separates,and separation shock is observed.The doors enhance the instability of the cavity flow and increase the pressure fluctuations in the cavities.A new oscillation pattern,referred to as coupled oscillation,is observed in the cases with separation on the upstream flat plate,in which the separation shock oscillates at the same dominant frequency as the flow inside the cavity.Compared with the cavity without doors,this coupled oscillation causes a lower oscillation frequency and a larger overall sound pressure level.Cross-correlation analyses between pressure signals indicate that the disturbances generated at the trailing edge of the cavity can propagate to the separation on the upstream flat plate and cause coupled oscillation of the separation shock.The fundamental frequencies of the coupled oscillations can be normalized to approximately the same Strouhal number as that of the cavity without doors.These findings support that the oscillation mechanisms of hypersonic cavities without and with doors are primarily dominated by acoustic feedback. 展开更多
关键词 Hypersonic flow Cavity oscillation Doors Shear-layer deformation Pressure fluctuation Acoustic feedback
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表观遗传修饰调控微小RNA表达在肺癌中的研究进展 被引量:4
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作者 胡锡麟 田凯华 《中国肺癌杂志》 CAS CSCD 北大核心 2020年第7期582-588,共7页
肺癌是全世界癌症引起死亡中较常见的一种。近年来,参与肺癌发病的分子机制被逐步揭开,但是其发生发展的确切机制并未完全阐明。其中微小RNAs(microRNAs,miRNAs)是一种短小并且广泛存在于植物、病毒及人类等各种生物中的内源性单链的非... 肺癌是全世界癌症引起死亡中较常见的一种。近年来,参与肺癌发病的分子机制被逐步揭开,但是其发生发展的确切机制并未完全阐明。其中微小RNAs(microRNAs,miRNAs)是一种短小并且广泛存在于植物、病毒及人类等各种生物中的内源性单链的非编码RNA。miRNAs在正常肺组织中发挥着多种功能,它参与细胞生长、代谢、增殖和分化等众多生物学过程。而miRNAs的异常表达与肺肿瘤的发生、发展、侵袭、转移相关。因此,miRNAs可被视为一种新的生物标志物。与编码蛋白质的基因类似,miRNA的表达和功能受多种因素以及表观遗传网络(包括DNA甲基化和组蛋白修饰机制)的调控。此外,miRNAs本身也能调控那些表观遗传修饰的关键酶来影响表观修饰。miRNA与表观基因学之间的相互联系将有助于我们研发以miRNA为导向的肺癌诊断、治疗和预后的方案。 展开更多
关键词 肺肿瘤 MIRNA 表观遗传修饰
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