Cervical cancer stands is a formidablemalignancy that poses a significant threat towomen’s health.Calcium overload,a minimally invasive tumor treatment,aims to accumulate an excessive concentration of Ca^(2+)within m...Cervical cancer stands is a formidablemalignancy that poses a significant threat towomen’s health.Calcium overload,a minimally invasive tumor treatment,aims to accumulate an excessive concentration of Ca^(2+)within mitochondria,triggering apoptosis.Copper sulfide(CuS)represents a photothermal mediator for tumor hyperthermia.However,relying solely on thermotherapy often proves insufficient in controlling tumor growth.Curcumin(CUR),an herbal compound with anti-cancer properties,inhibits the efflux of exogenous Ca^(2+)while promoting its excretion from the endoplasmic reticulum into the cytoplasm.To harness these therapeutic modalities,we have developed a nanoplatform that incorporates hollow CuS nanoparticles(NPs)adorned with multiple CaCO_(3) particles and internally loaded with CUR.This nanocomposite exhibits high uptake and easy escape from lysosomes,along with the degradation of surrounding CaCO3,provoking the generation of abundant exogenous Ca^(2+)in situ,ultimately damaging the mitochondria of diseased cells.Impressively,under laser excitation,the CuS NPs demonstrate a photothermal effect that accelerates the degradation of CaCO_(3),synergistically enhancing the antitumor effect through photothermal therapy.Additionally,fluorescence imaging reveals the distribution of these nanovehicles in vivo,indicating their effective accumulation at the tumor site.This nanoplatform shows promising outcomes for tumor-targeting and the effective treatment in a murine model of cervical cancer,achieved through cascade enhancement of calcium overload-based dual therapy.展开更多
WO_(3-X)(W-l)was used to achieve controllable photoisomerization of linear olefins without substituents under 625 nm light irradiation.Thermodynamic and kinetic isomers were obtained by regulating the carbon chain len...WO_(3-X)(W-l)was used to achieve controllable photoisomerization of linear olefins without substituents under 625 nm light irradiation.Thermodynamic and kinetic isomers were obtained by regulating the carbon chain length of the olefins.Terminal olefins were converted into isomerized products,and the internal olefin mixtures present in petroleum derivatives were transformed into valuable pure olefin products.Oxygen vacancies(OVs)in W-1 altered the electronic structure of W-1 to improve its light-harvesting ability,which accounted for the high activity of olefin isomerization under light irradiation up to 625 nm.Additionally,OVs on the W-1 surface generated unsaturated W^(5+)sites that coordinated with olefins for the efficient adsorption and activation of olefins.Mechanistic studies reveal that the in situ formation of surface Ti-complexes and ir-allylic W intermediates originating from the coordination of coordinated unsaturated W^(5+)sites and olefins ensure high photocatalytic activity and selectivity of W-1 for the photocatalytic isomerization of olefins via a radical mechanism.展开更多
To attenuate white noise, nonstationary noise and impulse noise are important for signal processing. In this letter, we present nonlinear fusion filters (NFF) based on prediction and smoothing. By means of least squar...To attenuate white noise, nonstationary noise and impulse noise are important for signal processing. In this letter, we present nonlinear fusion filters (NFF) based on prediction and smoothing. By means of least square fitting of a polynomial, we define and give the operators of left prediction and right prediction, left smoothing and right smoothing, central smoothing and cross-validation smoothing. In simulated experiments, it is shown that the present method is an effective one.展开更多
基金This research was sponsored by the key research program of Ningbo(No.2023Z210)funded by Ningbo Natural Science Foundation(No.202003N4006)the Joint Research Funds of Department of Science&Technology of Shaanxi Province,Northwestern Polytechnical University(No.2020GXLH-Z-017).
文摘Cervical cancer stands is a formidablemalignancy that poses a significant threat towomen’s health.Calcium overload,a minimally invasive tumor treatment,aims to accumulate an excessive concentration of Ca^(2+)within mitochondria,triggering apoptosis.Copper sulfide(CuS)represents a photothermal mediator for tumor hyperthermia.However,relying solely on thermotherapy often proves insufficient in controlling tumor growth.Curcumin(CUR),an herbal compound with anti-cancer properties,inhibits the efflux of exogenous Ca^(2+)while promoting its excretion from the endoplasmic reticulum into the cytoplasm.To harness these therapeutic modalities,we have developed a nanoplatform that incorporates hollow CuS nanoparticles(NPs)adorned with multiple CaCO_(3) particles and internally loaded with CUR.This nanocomposite exhibits high uptake and easy escape from lysosomes,along with the degradation of surrounding CaCO3,provoking the generation of abundant exogenous Ca^(2+)in situ,ultimately damaging the mitochondria of diseased cells.Impressively,under laser excitation,the CuS NPs demonstrate a photothermal effect that accelerates the degradation of CaCO_(3),synergistically enhancing the antitumor effect through photothermal therapy.Additionally,fluorescence imaging reveals the distribution of these nanovehicles in vivo,indicating their effective accumulation at the tumor site.This nanoplatform shows promising outcomes for tumor-targeting and the effective treatment in a murine model of cervical cancer,achieved through cascade enhancement of calcium overload-based dual therapy.
文摘WO_(3-X)(W-l)was used to achieve controllable photoisomerization of linear olefins without substituents under 625 nm light irradiation.Thermodynamic and kinetic isomers were obtained by regulating the carbon chain length of the olefins.Terminal olefins were converted into isomerized products,and the internal olefin mixtures present in petroleum derivatives were transformed into valuable pure olefin products.Oxygen vacancies(OVs)in W-1 altered the electronic structure of W-1 to improve its light-harvesting ability,which accounted for the high activity of olefin isomerization under light irradiation up to 625 nm.Additionally,OVs on the W-1 surface generated unsaturated W^(5+)sites that coordinated with olefins for the efficient adsorption and activation of olefins.Mechanistic studies reveal that the in situ formation of surface Ti-complexes and ir-allylic W intermediates originating from the coordination of coordinated unsaturated W^(5+)sites and olefins ensure high photocatalytic activity and selectivity of W-1 for the photocatalytic isomerization of olefins via a radical mechanism.
文摘To attenuate white noise, nonstationary noise and impulse noise are important for signal processing. In this letter, we present nonlinear fusion filters (NFF) based on prediction and smoothing. By means of least square fitting of a polynomial, we define and give the operators of left prediction and right prediction, left smoothing and right smoothing, central smoothing and cross-validation smoothing. In simulated experiments, it is shown that the present method is an effective one.
