The development of rodent models that accurately reflect the pathogenesis of alcoholic liver disease(ALD)in humans is crucial for evaluating the nutritional intervention of food bioactive ingredients in ALD.Although v...The development of rodent models that accurately reflect the pathogenesis of alcoholic liver disease(ALD)in humans is crucial for evaluating the nutritional intervention of food bioactive ingredients in ALD.Although various models have been employed to establish ALD models over the past few decades,most successful cases are associated with high mortality rates,operational difficulties,and incompatibility formation mechanism compared to human ALD.However,the ALD models established by oral administration that simulate human drinking behavior often fail to induce significant liver damage.Therefore,it is imperative to explore simple and effective modes of oral administration for establishing ALD models consistent with the pathophysiological process of human ALD.Herein,we summarized the pathogenesis of ALD and discussed several issues related to construct ALD models with rodents(mainly mice and rats)by oral administration,including animal selection,animal feeding,alcohol intervention,and evaluation criteria.The purpose of this review is to provide a standardized and efficient formula for ALD modeling,so as to facilitate efficacy evaluation and mechanism analysis of food bioactive ingredients in ALD.展开更多
The next-generation energy storage systems such as fuel cells,metal-air batteries,and alkali metal(Li,Na)-chalcogen(S,Se)batteries have received increasing attention owing to their high energy density and low cost.How...The next-generation energy storage systems such as fuel cells,metal-air batteries,and alkali metal(Li,Na)-chalcogen(S,Se)batteries have received increasing attention owing to their high energy density and low cost.However,one of the main obstacles of these systems is the poor reaction kinetics in the involved chemical reactions.Therefore,it is essential to incorporate suitable and efficient catalysts into the cell.These years,single-atom catalysts(SACs)are emerging as a frontier in catalysis due to their maximum atom efficiency and unique reaction selectivity.For SACs fabrication,metal-organic frameworks(MOFs)have been confirmed as promising templates or precursors due to their high metal loadings,structural adjustability,porosity,and tailorable catalytic site.In this review,we summarize effective strategies for fabricating SACs by MOFs with corresponding advanced characterization techniques and illustrate the key role of MOFs-based SACs in these batteries by explaining their reaction mechanisms and challenges.Finally,current applications,prospects,and opportunities for MOFs-based SACs in energy storage systems are discussed.展开更多
The global water scarcity problem is becoming increasingly acute as a result of population growth and environmental changes.Water collection from air is a promising solution and is gaining popularity because it in-vol...The global water scarcity problem is becoming increasingly acute as a result of population growth and environmental changes.Water collection from air is a promising solution and is gaining popularity because it in-volves the collection of ubiquitous water vapor.The inherent structural properties of biopolymers,including abundant hydrophilic groups,naturally evolved interfaces,and hierarchical structures,provide natural sites for the trapping,transport,and storage of water.Moreover,it is a substantial source of inspiration for scientists,thereby facilitating the design and development of advanced materials for water collection from air.This re-view commences with a concise overview of the adsorption-desorption mechanism,encompassing the processes of adsorption and uptake in addition to isotherms.The subsequent sections of the paper discuss how biopolymer materials,from the macroscopic to the molecular level,can take advantage of their natural structure to establish interactions with water and realize the applications of water collection from air and point out the advantages of biopolymers for this application in terms of structural design and performance tuning.Finally,the current challenges facing biopolymer resources are summarized.The objective of this review is to establish a novel paradigm for the design of renewable biopolymer-based materials and new green water-efficient recycling technologies.展开更多
Astaxanthin(AXT)with mitochondria-targeted ability is desired for effectively preventing oxidative stress in various intestinal diseases.However,it is challenging to prepare mitochondria-targeted AXT(Mito-AXT)using tr...Astaxanthin(AXT)with mitochondria-targeted ability is desired for effectively preventing oxidative stress in various intestinal diseases.However,it is challenging to prepare mitochondria-targeted AXT(Mito-AXT)using traditional covalent bond methods due to the fragile structure of AXT and harsh reaction conditions,which result in low production yields and poor biocompatibility.Herein,we proposed a strategy to enhance the mitochondriatargeted efficiency of AXT by combining it with lipophilic cationic compounds through a non-covalent approach.Mito-AXT was synthesized through electrostatic coupling between anionic sulfonate-modified AXT(AXT-SO3)and cationic(3-carboxypropyl)triphenylphosphonium bromide(TPP).The synthetic strategy successfully preserved the inherent DPPH and hydroxyl radical trapping capacity of AXT and achieved the efficient preparation of Mito-AXT with a yield of 86.17%.The accumulation of cationic TPP in mitochondria after the disassembly of Mito-AXT surprisingly facilitated the enrichment of anionic AXT-SO3 in mitochondria.Notably,Mito-AXT regulated the redox balance,mitochondrial membrane potential,and mitophagy in IEC-6 cells under oxidative stress,thereby preventing apoptosis,compared to TPP-modified AXT molecules formed by covalent bonds.Furthermore,biosecurity analysis confirmed that Mito-AXT exhibited excellent biocompatibility.The results provided a simple,effective,and safe way to enhance the mitochondria-targeted efficiency of AXT through Mito-AXT,thereby effectively regulating the mitochondrial homeostasis in intestinal cells under oxidative stress.展开更多
基金supported by the National Natural Science Foundation of China(32430083).
文摘The development of rodent models that accurately reflect the pathogenesis of alcoholic liver disease(ALD)in humans is crucial for evaluating the nutritional intervention of food bioactive ingredients in ALD.Although various models have been employed to establish ALD models over the past few decades,most successful cases are associated with high mortality rates,operational difficulties,and incompatibility formation mechanism compared to human ALD.However,the ALD models established by oral administration that simulate human drinking behavior often fail to induce significant liver damage.Therefore,it is imperative to explore simple and effective modes of oral administration for establishing ALD models consistent with the pathophysiological process of human ALD.Herein,we summarized the pathogenesis of ALD and discussed several issues related to construct ALD models with rodents(mainly mice and rats)by oral administration,including animal selection,animal feeding,alcohol intervention,and evaluation criteria.The purpose of this review is to provide a standardized and efficient formula for ALD modeling,so as to facilitate efficacy evaluation and mechanism analysis of food bioactive ingredients in ALD.
基金Financial support was provided by the Guangdong College Students’Innovative Project(202110580014)the Guangdong “Climbing”Program for Research Items(pdjh2021b0544)。
文摘The next-generation energy storage systems such as fuel cells,metal-air batteries,and alkali metal(Li,Na)-chalcogen(S,Se)batteries have received increasing attention owing to their high energy density and low cost.However,one of the main obstacles of these systems is the poor reaction kinetics in the involved chemical reactions.Therefore,it is essential to incorporate suitable and efficient catalysts into the cell.These years,single-atom catalysts(SACs)are emerging as a frontier in catalysis due to their maximum atom efficiency and unique reaction selectivity.For SACs fabrication,metal-organic frameworks(MOFs)have been confirmed as promising templates or precursors due to their high metal loadings,structural adjustability,porosity,and tailorable catalytic site.In this review,we summarize effective strategies for fabricating SACs by MOFs with corresponding advanced characterization techniques and illustrate the key role of MOFs-based SACs in these batteries by explaining their reaction mechanisms and challenges.Finally,current applications,prospects,and opportunities for MOFs-based SACs in energy storage systems are discussed.
基金support from the National Natural Science Foundation of China(32271814)the Natural Science Foundation of Tianjin(24JCJQJC00030 and 23JCZDJC00630).
文摘The global water scarcity problem is becoming increasingly acute as a result of population growth and environmental changes.Water collection from air is a promising solution and is gaining popularity because it in-volves the collection of ubiquitous water vapor.The inherent structural properties of biopolymers,including abundant hydrophilic groups,naturally evolved interfaces,and hierarchical structures,provide natural sites for the trapping,transport,and storage of water.Moreover,it is a substantial source of inspiration for scientists,thereby facilitating the design and development of advanced materials for water collection from air.This re-view commences with a concise overview of the adsorption-desorption mechanism,encompassing the processes of adsorption and uptake in addition to isotherms.The subsequent sections of the paper discuss how biopolymer materials,from the macroscopic to the molecular level,can take advantage of their natural structure to establish interactions with water and realize the applications of water collection from air and point out the advantages of biopolymers for this application in terms of structural design and performance tuning.Finally,the current challenges facing biopolymer resources are summarized.The objective of this review is to establish a novel paradigm for the design of renewable biopolymer-based materials and new green water-efficient recycling technologies.
基金supported by the National Natural Science Foundation of China(32430083).
文摘Astaxanthin(AXT)with mitochondria-targeted ability is desired for effectively preventing oxidative stress in various intestinal diseases.However,it is challenging to prepare mitochondria-targeted AXT(Mito-AXT)using traditional covalent bond methods due to the fragile structure of AXT and harsh reaction conditions,which result in low production yields and poor biocompatibility.Herein,we proposed a strategy to enhance the mitochondriatargeted efficiency of AXT by combining it with lipophilic cationic compounds through a non-covalent approach.Mito-AXT was synthesized through electrostatic coupling between anionic sulfonate-modified AXT(AXT-SO3)and cationic(3-carboxypropyl)triphenylphosphonium bromide(TPP).The synthetic strategy successfully preserved the inherent DPPH and hydroxyl radical trapping capacity of AXT and achieved the efficient preparation of Mito-AXT with a yield of 86.17%.The accumulation of cationic TPP in mitochondria after the disassembly of Mito-AXT surprisingly facilitated the enrichment of anionic AXT-SO3 in mitochondria.Notably,Mito-AXT regulated the redox balance,mitochondrial membrane potential,and mitophagy in IEC-6 cells under oxidative stress,thereby preventing apoptosis,compared to TPP-modified AXT molecules formed by covalent bonds.Furthermore,biosecurity analysis confirmed that Mito-AXT exhibited excellent biocompatibility.The results provided a simple,effective,and safe way to enhance the mitochondria-targeted efficiency of AXT through Mito-AXT,thereby effectively regulating the mitochondrial homeostasis in intestinal cells under oxidative stress.
