The discussion on cosmetic animal testing ban started since 1990s, with the fnally implementation of full animal testing ban in both research and marketing in EU and Israel in 2013. Now it has been fully or partially ...The discussion on cosmetic animal testing ban started since 1990s, with the fnally implementation of full animal testing ban in both research and marketing in EU and Israel in 2013. Now it has been fully or partially banned by law in 33 countries or regions, with more and more countries lining up to do the same. Beyond animal welfare consideration, the need of mutual acceptance of data （MAD） and harmonization of global market have made non-animal testing an irresistible general trend for worldwide countries to made regulation and policy. Recently, China is in critical crossroad to shift the toxicity paradigm and explore a proper strategy to promote the development of cosmetic non-animal testing. 3R theory has been frstly introduced in Chinese legislation in 2006 that is an important step forward to seriously thinking of animal test. In the following 10 years, the alternative technology in China has been developed dramatically with the implementation of relevant legislations, holding various theoretical and hands-on training, exploration work on methods validation, adoption of internationally recognized methods, propagation of alternative standards and in-depth investigation in in vitro bioscience. The ultimate goal of alternative technology is the regulatory application, thus demands infrastructure constructing, technology capability building and national standard forming. However, concrete works should be carefully planned to facilitate the technology transformation and standardization. This paper will give a retrospective review on the progress in recent years and put forward a middle-out strategy to promote the development of cosmetics alternative in China.展开更多
文摘The discussion on cosmetic animal testing ban started since 1990s, with the fnally implementation of full animal testing ban in both research and marketing in EU and Israel in 2013. Now it has been fully or partially banned by law in 33 countries or regions, with more and more countries lining up to do the same. Beyond animal welfare consideration, the need of mutual acceptance of data （MAD） and harmonization of global market have made non-animal testing an irresistible general trend for worldwide countries to made regulation and policy. Recently, China is in critical crossroad to shift the toxicity paradigm and explore a proper strategy to promote the development of cosmetic non-animal testing. 3R theory has been frstly introduced in Chinese legislation in 2006 that is an important step forward to seriously thinking of animal test. In the following 10 years, the alternative technology in China has been developed dramatically with the implementation of relevant legislations, holding various theoretical and hands-on training, exploration work on methods validation, adoption of internationally recognized methods, propagation of alternative standards and in-depth investigation in in vitro bioscience. The ultimate goal of alternative technology is the regulatory application, thus demands infrastructure constructing, technology capability building and national standard forming. However, concrete works should be carefully planned to facilitate the technology transformation and standardization. This paper will give a retrospective review on the progress in recent years and put forward a middle-out strategy to promote the development of cosmetics alternative in China.
