Ferroptosis is defined as an iron-dependent,non-apoptotic cell death pathway,with specific morphological phenotypes and biochemical changes.There is a growing realization that ferroptosis has significant implications ...Ferroptosis is defined as an iron-dependent,non-apoptotic cell death pathway,with specific morphological phenotypes and biochemical changes.There is a growing realization that ferroptosis has significant implications for several neurodegenerative diseases.Even though ferroptosis is different from other forms of programmed death such as apoptosis and autophagic death,they involve a number of common protein molecules.This review focuses on current research on ferroptosis and summarizes the cross-talk among ferroptosis,apoptosis,and autophagy that are implicated in neurodegenerative diseases.We hope that this information provides new ideas for understanding the mechanisms and searching for potential therapeutic approaches and prevention of neurodegenerative diseases.展开更多
基金We gratefully acknowledge financial support from the National Natural Science Foundation of China(82071429 and 32171131)Shandong Province Natural Science Foundation(ZR2019ZD31,ZR2020MC072,and ZR2020QH125)Innovative Research Team of High-level Local Universities in Shanghai,China.
文摘Ferroptosis is defined as an iron-dependent,non-apoptotic cell death pathway,with specific morphological phenotypes and biochemical changes.There is a growing realization that ferroptosis has significant implications for several neurodegenerative diseases.Even though ferroptosis is different from other forms of programmed death such as apoptosis and autophagic death,they involve a number of common protein molecules.This review focuses on current research on ferroptosis and summarizes the cross-talk among ferroptosis,apoptosis,and autophagy that are implicated in neurodegenerative diseases.We hope that this information provides new ideas for understanding the mechanisms and searching for potential therapeutic approaches and prevention of neurodegenerative diseases.
