Highlights ZmMYC2 promoter contains favorable haplotypes selected during domestication,enhancing its expression level in modern maize.ZmMYC2 may balance the trade-off between growth and defense via jasmonate and auxin...Highlights ZmMYC2 promoter contains favorable haplotypes selected during domestication,enhancing its expression level in modern maize.ZmMYC2 may balance the trade-off between growth and defense via jasmonate and auxin signaling pathways.ZmMYC2 regulates drought-response genes(CER2 and TIP3c)to optimize drought stress resilience.展开更多
Ensemble learning,a pivotal branch of machine learning,amalgamates multiple base models to enhance the overarching performance of predictive models,capitalising on the diversity and collective wisdom of the ensemble t...Ensemble learning,a pivotal branch of machine learning,amalgamates multiple base models to enhance the overarching performance of predictive models,capitalising on the diversity and collective wisdom of the ensemble to surpass individual models and mitigate overfitting.In this review,a four-layer research framework is established for the research of ensemble learning,which can offer a comprehensive and structured review of ensemble learning from bottom to top.Firstly,this survey commences by introducing fundamental ensemble learning techniques,including bagging,boosting,and stacking,while also exploring the ensemble's diversity.Then,deep ensemble learning and semi-supervised ensemble learning are studied in detail.Furthermore,the utilisation of ensemble learning techniques to navigate challenging datasets,such as imbalanced and highdimensional data,is discussed.The application of ensemble learning techniques across various research domains,including healthcare,transportation,finance,manufacturing,and the Internet,is also examined.The survey concludes by discussing challenges intrinsic to ensemble learning.展开更多
A dilute Mg-0.7Al-0.3Ca(AX0703,wt%)alloy with high strength is developed via conventional low-temperature extrusion,with tensile yield strength of 376 MPa and elongation of 5.3%.As-extruded AX0703 sample exhibits the ...A dilute Mg-0.7Al-0.3Ca(AX0703,wt%)alloy with high strength is developed via conventional low-temperature extrusion,with tensile yield strength of 376 MPa and elongation of 5.3%.As-extruded AX0703 sample exhibits the bimodal grain structures consisting of dynamically recrystallized(DRXed)ultrafine grains and coarse non-DRXed grains with strong basal texture,which contributes to the strength.The numerous nano-Al2Ca phases were developed in non-DRXed grains during extrusion,which not only generates the remarkable precipitation hardening effect,but also favors the improved thermal stability by retarding recrystallization process.Also,it is found that co-segregations of Al-Ca solutes at DRXed grain boundaries hinder grain growth during heat treatment at 300℃,contributing to the thermal stability of as-extruded AX0703 alloy.This work provides valuable insights into the development of high-strength and low-alloyed Mg extrusions with high thermostability.展开更多
Nitrogen(N)serves as an essential nutrient for yield formation across diverse crop types.However,agricultural production encounters numerous challenges,notably high N fertilizer rates coupled with low N use efficiency...Nitrogen(N)serves as an essential nutrient for yield formation across diverse crop types.However,agricultural production encounters numerous challenges,notably high N fertilizer rates coupled with low N use efficiency and serious environmental pollution.Deep placement of nitrogen fertilizer(DPNF)is an agronomic measure that shows promise in addressing these issues.This review aims to offer a comprehensive understanding of DPNF,beginning with a succinct overview of its development and methodologies for implementation.Subsequently,the optimal fertilization depth and influencing factors for different crops are analyzed and discussed.Additionally,it investigates the regulation and mechanism underlying the DPNF on crop development,yield,N use efficiency and greenhouse gas emissions.Finally,the review delineates the limitations and challenges of this technology and provides suggestions for its improvement and application.This review provides valuable insight and reference for the promotion and adoption of DPNF in agricultural practice.展开更多
Electrochemical nitrogen looping represents a promising carbon-free and sustainable solution for the energy transition,in which electrochemical ammonia oxidation stays at the central position.However,the various nitro...Electrochemical nitrogen looping represents a promising carbon-free and sustainable solution for the energy transition,in which electrochemical ammonia oxidation stays at the central position.However,the various nitrogen-containing intermediates tend to poison and corrode the electrocatalysts,even the state-of-the-art noble-metal ones,which is worsened at a high applied potential.Herein,we present an ultrarapid laser quenching strategy for constructing a corrosion-resistant and nanostructured CuNi alloy metallic glass electrocatalyst.In this material,single-atom Cu species are firmly bonded with the surrounding Ni atoms,endowing exceptional resistance against ammonia corrosion relative of conventional CuNi alloys.Remarkably,a record-high durability for over 300 h is achieved.Ultrarapid quenching also allows a much higher Cu content than typical single-atom alloys,simultaneously yielding a high rate and selectivity for ammonia oxidation reaction(AOR).Consequently,an outstanding ammonia conversion rate of up to 95%is achieved with 91.8%selectivity toward nitrite after 8 h.Theoretical simulations reveal that the structural amorphization of CuNi alloy could effectively modify the electronic configuration and reaction pathway,generating stable singleatom Cu active sites with low kinetic barriers for AOR.This ultrarapid laser quenching strategy thus provides a new avenue for constructing metallic glasses with well-defined nanostructures,presenting feasible opportunities for performance enhancement for AOR and other electrocatalytic processes.展开更多
Mg-1.2Y-1.2Ni(at.%)alloy was extruded at 400℃with an extrusion ratio of 16:1 and different rates from 1 to 6 mm/s.The effect of extrusion rate on microstructure and mechanical properties of the Mg-1.2Y-1.2Ni alloy wa...Mg-1.2Y-1.2Ni(at.%)alloy was extruded at 400℃with an extrusion ratio of 16:1 and different rates from 1 to 6 mm/s.The effect of extrusion rate on microstructure and mechanical properties of the Mg-1.2Y-1.2Ni alloy was systematically investigated.With the increase of extrusion rate,the average recrystallized grain size of Mg-1.2Y-1.2Ni alloy and mean particle diameter of Mg2Ni phase were increased,while the density of geometrically necessary dislocation and the intensity of the basal texture were decreased.When extrusion rate increases from 1 to 6 mm/s,the tensile yield strength(TYS)of asextruded Mg-1.2Y-1.2Ni alloy decreases from 501 to 281 MPa,while the elongation to failure increases from 1.5%to 6.2%.The Mg-1.2Y-1.2Ni alloy extruded at 3 mm/s obtained TYS of 421 MPa,the ultimate tensile strength(UTS)of 440 MPa and elongation to failure of 2.6%,respectively,exhibiting comprehensive mechanical properties with relatively good plasticity and ultrahigh strength.The ultrahigh TYS of 501 and 421 MPa was mainly due to the strengthening from ultrafine recrystallized grains,high volume fraction long period stacking ordered(LPSO)phases and high density dislocations.展开更多
Background:It remains unclear whether the cardiovascular benefits of physical activity(PA)vary across populations with different predicted atherosclerotic cardiovascular disease(ASCVD)risks.This study aimed to determi...Background:It remains unclear whether the cardiovascular benefits of physical activity(PA)vary across populations with different predicted atherosclerotic cardiovascular disease(ASCVD)risks.This study aimed to determine the modification of predicted cardiovascular risk on the association between PA and ASCVD incidence.Methods:A total of 94,734 participants without ASCVD in the Prediction for Atherosclerotic Cardiovascular Disease Risk in China(China-PAR)project were included,with a median follow-up of 6.0 years.PA volume(metabolic equivalent of task(MET)-h/day)and intensity(%,percentage of moderate-to-vigorous PA(MVPA))were assessed by questionnaires.Based on the ASCVD 10-year and lifetime risk prediction scores,participants were classified into low-to-medium-risk and high-risk groups.Hazard ratios(HRs)and 95%confidence intervals(95%CIs)for ASCVD were calculated using Cox proportional hazards models.Results:During 679,438 person-years of follow-up,3470 ASCVD events occurred.Higher PA volume was associated with lower ASCVD incidence,which was more pronounced among high-predicted-risk individuals than their low-to-medium-risk counterparts,with HRs(95%CIs)of0.58(0.50-0.67)and 0.62(0.53-0.71)for the highest vs.lowest quartiles of PA volume,respectively.Additionally,analyses for PA intensity showed similar results.Compared with inactive individuals,there was a 32%(95%CI:25%-38%)and 23%(95%CI:13%-32%)risk reduction in high-and low-to-medium-risk groups,respectively,when over half of the PA volume was from MVPA.Furthermore,the additive interactions between PA and predicted risk indicated a further risk reduction by increasing PA,especially MVPA,in high-risk individuals.Conclusion:Engaging in more PA,especially MVPA,reduced the risk of ASCVD incidence,with greater benefits among high-risk individuals.These findings emphasize the imperative for personalized PA recommendations tailored to distinct risk populations—in particular,reinforcing PA guidance for high-risk individuals.展开更多
Epstein-Barr virus(EBV)infection is well-known for its association with lymphoproliferative disorders and various lymphomas,causing significant global morbidity and mortality.EBV-positive vitreoretinal lymphoma(VRL)is...Epstein-Barr virus(EBV)infection is well-known for its association with lymphoproliferative disorders and various lymphomas,causing significant global morbidity and mortality.EBV-positive vitreoretinal lymphoma(VRL)is exceedingly rare.As a result,the pathogenic role and genomic characteristics of EBV in VRL remain poorly understood.In this study,we employed droplet digital PCR(ddPCR)combined with EBV-specific immunofluorescence assay to detect EBV in the vitreous fluid of fifty-three VRL patients.We found that approximately 28%(15/53)of the patients were EBV positive.Analysis of clinical data showed that EBV-positive VRL patients had shorter progression-free survival(PFS)compared to EBV-negative patients(P=0.004).Additionally,through integration of EBV-targeted sequencing and PCR-based deep sequencing,we found that all five VRL-derived EBV genomes formed a distinct cluster within one phylogenetic branch.Meanwhile,several non-synonymous mutations were exclusively detected in the VRL group,including S229T in latent membrane protein 1(LMP1)and G2248R in the Epstein-Barr virus BamHI-PraL fragment 1(BPLF1).In conclusion,our findings suggest that EBV as a risk factor associated with poor prognosis in VRL,and we provide a genome-wide view of EBV sequence variations from VRL patients.This may offer insights into the pathogenic role of EBV in VRL and could potentially assist in the diagnosis and treatment of this disease.展开更多
Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial ...Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation.展开更多
Background:The trade-off between the benefits of regular physical activity(PA)and the potentially detrimental effects of augmented exposure to air pollution in highly polluted regions remains unclear.This study aimed ...Background:The trade-off between the benefits of regular physical activity(PA)and the potentially detrimental effects of augmented exposure to air pollution in highly polluted regions remains unclear.This study aimed to examine whether ambient fine particulate matter(PM_(2.5))exposure modified the impacts of PA volume and intensity on hypertension risk.Methods:We included 54,797 participants without hypertension at baseline in a nationwide cohort of the Prediction for Atherosclerotic Cardiovascular Disease Risk in China(China-PAR)project.PA volume and intensitywere assessed by questionnaire,and high-resolution(1 km×1 km)PM_(2.5)estimates were generated using a satellite-based model.Results:During 413,516 person-years of follow-up,12,100 incident hypertension cases were identified.PM_(2.5)significantly modified the relationship between PA and hypertension incidence(p_(interaction)<0.001).Increased PA volume was negatively associated with incident hypertension in the low PM_(2.5)stratum(<59.8μg/m^(3),ptrend<0.001),with a hazard ratio of 0.81(95%confidence interval(95%CI):0.74-0.88)when comparing the fourth with the first quartile of PA volume.However,the health benefits were not observed in the high PM_(2.5)stratum(≥59.8μg/m^(3),p_(trend)=0.370).Moreover,compared with light PA intensity,vigorous intensity was related to a 20%(95%CI:9%-29%)decreased risk of hypertension for participants exposed to low PM_(2.5),but a 17%(95%CI:4%-33%)increased risk for those with high PM_(2.5)levels.Conclusion:PA was associated with a reduced risk of hypertension only among participants with low PM_(2.5)exposure.Our findings recommended regular PA to prevent hypertension in less polluted regions and reinforced the importance of air quality improvement.展开更多
Background:Inconsistent results have been reported in developed countries for relationships between sedentary behavior and cancer incidence and mortality,and evidence from the Chinese population is scarce.This study a...Background:Inconsistent results have been reported in developed countries for relationships between sedentary behavior and cancer incidence and mortality,and evidence from the Chinese population is scarce.This study aimed to investigate such relationships in large Chinese population-based prospective cohorts and to explore the joint effect and interaction of sedentary behavior and moderate-to-vigorous physical activity(MVPA)on these relationships.Methods:We included 95,319 Chinese adults without cancer from 3 large cohorts and assessed their sedentary behavior and physical activity with a unified questionnaire.Cancer incidence and mortality were confirmed by interviewing participants or their proxies and checking hospital records and death certificates.Hazard ratios(HRs)and 95%confidence intervals(95%CIs)for cancer and mortality were estimated using Cox proportional hazards regression models.Results:During 559,002 person-years of follow-up,2388 cancer events,1571 cancer deaths,and 4562 all-cause deaths were recorded.Sedentary behavior was associated with increased risk of developing cancer and deaths in a doseresponse manner.The multivariable-adjusted HRs(95%CIs)were the following:HR=1.16,95%CI:1.01-1.33;HR=1.24,95%CI:1.04-1.48;and HR=1.15,95%CI:1.04-1.28 for cancer incidence,cancer mortality,and all-cause mortality,respectively,for those having≥10 h/day of sedentary time compared with those having<6 h/day of sedentary time.Sedentary populations(≥10 h/day)developed cancer or died 4.09 years and 2.79 years earlier,respectively,at the index age of 50 years.Failure to achieve the recommended level of MVPA may further aggravate the adverse associations,with the highest cancer and mortality risks being observed among participants with both≥10 h/day of sedentary time and<150 min/week of MVPA.Limitations of this study include the fact that physical activity information was obtained via questionnaire instead of objective measurement and that there were insufficient incident cases for the analysis of associations between sedentary behavior and site-specific cancers.Conclusion:Sedentary behavior was associated with an increased risk of cancer and all-cause mortality among Chinese adults,especially for those with≥10 h/day of sedentary time.It is necessary to reduce sedentary time,in addition to increasing MVPA levels,for the prevention of cancer and premature death.展开更多
For the simultaneous wireless information and power transfer(SWIPT), the full-duplex MIMO system can achieve simultaneous transmission of information and energy more efficiently than the half-duplex. Based on the mean...For the simultaneous wireless information and power transfer(SWIPT), the full-duplex MIMO system can achieve simultaneous transmission of information and energy more efficiently than the half-duplex. Based on the mean-square-error(MSE) criterion, the optimization problem of joint transceiver design with transmitting power constraint and energy harvesting constraint is formulated. Next, by semidefinite relaxation(SDR) and randomization method, the SDRbased scheme is proposed. In order to reduce the complexity, the closed-form scheme is presented with some simplified measures. Robust beamforming is then studied considering the practical condition. The simulation results such as MSE versus signal-noise-ratio(SNR), MSE versus the iteration number, well prove the performance of the proposed schemes for the system model.展开更多
Zinc-ion hybrid supercapacitors(ZHSCs)have garnered increasing attention as promising energy storage devices in recent years,as they combine the advantages of high-energy Zn-ion batteries and high-power supercapacitor...Zinc-ion hybrid supercapacitors(ZHSCs)have garnered increasing attention as promising energy storage devices in recent years,as they combine the advantages of high-energy Zn-ion batteries and high-power supercapacitors.However,the development of ZHSCs is still in its infancy and there are many bottlenecks to overcome.In particular,the challenge induced by the limited ion adsorption capability of carbon-positive electrodes severely restricts the energy density of ZHSCs.Therefore,it has become a key issue to design novel carbon-positive electrodes that enable high energy density yet do not deteriorate the intrinsic power capability and long-term durability.This study focuses on recent achievements in synthesis,morphology,and electrochemical performance of various carbon materials applied in ZHSCs.The modification strategies to optimize their electrochemical performance are briefly summarized.In addition,current challenges and future opportunities in this field are also outlined.This review will be beneficial to provide an organized framework for the research systems of carbon-positive electrodes and develop novel ZHSCs with high energy density.展开更多
Electrocatalytic oxygen reduction via a two-electron pathway(2e^(-)-ORR)is a promising and eco-friendly route for producing hydrogen peroxide(H_(2)O_(2)).Single-atom catalysts(SACs)typically show excellent selectivity...Electrocatalytic oxygen reduction via a two-electron pathway(2e^(-)-ORR)is a promising and eco-friendly route for producing hydrogen peroxide(H_(2)O_(2)).Single-atom catalysts(SACs)typically show excellent selectivity towards 2e^(-)-ORR due to their unique electronic structures and geometrical configurations.The very low density of single-atom active centers,however,often leads to unsatisfactory H_(2)O_(2)yield rate,significantly inhibiting their practical feasibility.Addressing this,we herein introduce fluorine as a secondary doping element into conventional SACs,which does not directly coordinate with the singleatom metal centers but synergize with them in a remote manner.This strategy effectively activates the surrounding carbon atoms and converts them into highly active sites for 2e^(-)-ORR.Consequently,a record-high H_(2)O_(2)yield rate up to 27 mol g^(-1)h^(-1)has been achieved on the Mo–F–C catalyst,with high Faradaic efficiency of 90%.Density functional theory calculations further confirm the very kinetically facile 2e^(-)-ORR over these additional active sites and the superiority of Mo as the single-atom center to others.This strategy thus not only provides a high-performance electrocatalyst for 2e^(-)-ORR but also should shed light on new strategies to significantly increase the active centers number of SACs.展开更多
The ever-growing market of wearable electronic devices has greatly stimulated the rapid development of flexible Zn-ion batteries(ZIBs).Manganese oxides are one of the most commonly used hosts for zinc ion accommodatio...The ever-growing market of wearable electronic devices has greatly stimulated the rapid development of flexible Zn-ion batteries(ZIBs).Manganese oxides are one of the most commonly used hosts for zinc ion accommodation and thus receive particular research interest for high-performance flexible ZIB constructions.In this review,a comprehensive summary of the recent development of flexible ZIBs with manganese oxides as cathode materials is presented.Apart from the brief introduction of flexible electronic devices and ZIBs,the charge storage mechanisms and crystal structures of various manganese oxides are summarized.Modifications of the cathode materials in terms of morphology,conductivity,structures,and flexibilities are illustrated in detail,together with the demonstration of structure-performance relationships and applications in flexible ZIBs.Finally,limitations to be overcome are indicated and the future work directions are proposed.展开更多
Objective： To compare the efficacy and safety of Lobaplatin plus Etoposide （EL） and Cisplatin plus Etoposide （EP） regimens in chemonaive with extensive-stage small-cell lung cancer （SCLC）. Methods： Between Jul...Objective： To compare the efficacy and safety of Lobaplatin plus Etoposide （EL） and Cisplatin plus Etoposide （EP） regimens in chemonaive with extensive-stage small-cell lung cancer （SCLC）. Methods： Between July 2010 and July 2011, a total of 62 patients with extensive-stage small-cell lung cancer who received initial treatment in our hospital and 309 hospital of PLA. 31 patients were randomly assigned to the EL Group： Lobaplatin was given intravenously at a dose of 30 mg/m2 on day 1 and Etoposide 100 mg/m2 on days 1 to 3 of 21-day cycles for a maximum of six cycles. Another 31 patients were assigned to the EP Group： Cisplatin was given intravenously at a dose of 75 mg/m2 on day 1 and Etoposide 100 mg/m2 on days 1 to 3 of 21-day cycles for a maximum of six cycles. We evaluated the efficacy, overall response rate （ORR）, disease control rate （DCR）, the progression-free survival （PFS） and toxicity between the patients of the two groups. Results： All 62 patients were eligible. In the EL group, 2 （6.5%） patients had complete response, 20 （64.5%） patients had partial response, 5 （16.1%） patients had stable disease and 4 （12.9%） patients had progress disease. In the EP group, 2 （6.5%） patients had complete response, 22 （70.9%） patients had partial response, 4 （12.9%） patients had stable disease and 3 （9.7%） patients had progress disease. The ORR of EL and EP group were 70.9% and 77.4%, respectively, showing no significant difference （P = 0.562）. The DCR of both groups were 87% and 90%, respectively, showing no significant difference （P = 0.688）. Median PFS of patients with EL and EP regimens were 5.5 months and 5 months, respectively, showing no significant difference （P = 0.637）. Adverse events were observed in all 62 patients. Grade 1 to 4 anemia was higher in the EP group than in EL group, showing significant difference （P = 0.02）. Grade 3 and 4 thrombocytopenia was seen in 4 patients （12.9%） in EL group and 1 patient （3.2%） in EP group. Although one patient had platelet transfusion owing to Grade 4 thrombocytopenia in EL group, no significant difference （P = 0.637） were shown. The incidence of nausea/vomiting was higher in the EP group than in the EL group （96.7% vs 51.6%, P = 0.00）. Conclusien： The EL regimen is an effective and low-toxicity chemotherapy and no inferior to EP regimen in treatment response, therefore, EL regimen maybe is a good choice for patients with extensive-stage SCLC.展开更多
Monitoringα-glucosidase(α-Glu)activity is of great significance for the early diagnosis of typeⅡdiabetes.Here the blue fluorescent carbon dots(CDs)were integrated with two different recognizing molecules,β-cyclode...Monitoringα-glucosidase(α-Glu)activity is of great significance for the early diagnosis of typeⅡdiabetes.Here the blue fluorescent carbon dots(CDs)were integrated with two different recognizing molecules,β-cyclodextrin and phenylboronic acid,for assembling a multifunctional CDs(mCDs)nanoplatform for sensitively analyzingα-Glu and its inhibitors.The hydrolyzed product of 4-nitrophenyl-α-D-glucopyranoside(α-Glu substrate),p-nitrophenol,could efficiently quench the fluorescence of mCDs due to its cooperative molecular recognition withβ-cyclodextrin and phenylboronic acid.The mCDs could be utilized for the detection ofα-Glu activity with the limit of detection of 0.030 U/L.Moreover,the presentα-Glu detection platform revealed a high selectivity,and other natural enzymes showed scarcely any effect on the present mCDs system.The proposed method could be facilely used to screenα-Glu inhibitors with satisfying performance.The rational mCDs is expected to supplement more comprehensive biosensing platforms for highly sensitive and specific recognition of disease-relevant biomarkers with clinical importance.展开更多
Dracomolphesin A-E(1-5),five 3,4-seco-phenylpropanoids featuring an aromatic ring opened framework,were isolated from the aerial parts of Dracocephalum moldavica.The structures with absolute configurations were determ...Dracomolphesin A-E(1-5),five 3,4-seco-phenylpropanoids featuring an aromatic ring opened framework,were isolated from the aerial parts of Dracocephalum moldavica.The structures with absolute configurations were determined by spectroscopic methods coupled with Mosher method.Notably,these compounds represented an example of aromatic ring cleavage products of phenylpropanoids.The possible biosynthetic pathway of these compounds was proposed.Compounds 1,2,4 and 5 were demonstrated to be Nrf2 pathway activators.展开更多
基金supported by the National Key Research and Development Program of China(2023YFD1200503 to Shuai Ma and 2021YFD1200700 to Tianyu Wang)。
文摘Highlights ZmMYC2 promoter contains favorable haplotypes selected during domestication,enhancing its expression level in modern maize.ZmMYC2 may balance the trade-off between growth and defense via jasmonate and auxin signaling pathways.ZmMYC2 regulates drought-response genes(CER2 and TIP3c)to optimize drought stress resilience.
基金supported in part by National Natural Science Foundation of China No.92467109,U21A20478National Key R&D Program of China 2023YFA1011601the Major Key Project of PCL(Grant PCL2024A05).
文摘Ensemble learning,a pivotal branch of machine learning,amalgamates multiple base models to enhance the overarching performance of predictive models,capitalising on the diversity and collective wisdom of the ensemble to surpass individual models and mitigate overfitting.In this review,a four-layer research framework is established for the research of ensemble learning,which can offer a comprehensive and structured review of ensemble learning from bottom to top.Firstly,this survey commences by introducing fundamental ensemble learning techniques,including bagging,boosting,and stacking,while also exploring the ensemble's diversity.Then,deep ensemble learning and semi-supervised ensemble learning are studied in detail.Furthermore,the utilisation of ensemble learning techniques to navigate challenging datasets,such as imbalanced and highdimensional data,is discussed.The application of ensemble learning techniques across various research domains,including healthcare,transportation,finance,manufacturing,and the Internet,is also examined.The survey concludes by discussing challenges intrinsic to ensemble learning.
基金support from the National Natural Science Foundation of China(Nos.52471128,5250010127 and 12164004)the Jiangxi Provincial Natural Science Foundation(Nos.20232BCJ25067,20232BAB214004 and 20242BAB25210)supported by Sinoma Institute of Materials Research(Guang Zhou)Co.,Ltd(SIMR).
文摘A dilute Mg-0.7Al-0.3Ca(AX0703,wt%)alloy with high strength is developed via conventional low-temperature extrusion,with tensile yield strength of 376 MPa and elongation of 5.3%.As-extruded AX0703 sample exhibits the bimodal grain structures consisting of dynamically recrystallized(DRXed)ultrafine grains and coarse non-DRXed grains with strong basal texture,which contributes to the strength.The numerous nano-Al2Ca phases were developed in non-DRXed grains during extrusion,which not only generates the remarkable precipitation hardening effect,but also favors the improved thermal stability by retarding recrystallization process.Also,it is found that co-segregations of Al-Ca solutes at DRXed grain boundaries hinder grain growth during heat treatment at 300℃,contributing to the thermal stability of as-extruded AX0703 alloy.This work provides valuable insights into the development of high-strength and low-alloyed Mg extrusions with high thermostability.
基金funded by grants from the National Natural Science Foundation of China(32301947,32272220 and 32172120)the China Postdoctoral Science Foundation(2023M730909).
文摘Nitrogen(N)serves as an essential nutrient for yield formation across diverse crop types.However,agricultural production encounters numerous challenges,notably high N fertilizer rates coupled with low N use efficiency and serious environmental pollution.Deep placement of nitrogen fertilizer(DPNF)is an agronomic measure that shows promise in addressing these issues.This review aims to offer a comprehensive understanding of DPNF,beginning with a succinct overview of its development and methodologies for implementation.Subsequently,the optimal fertilization depth and influencing factors for different crops are analyzed and discussed.Additionally,it investigates the regulation and mechanism underlying the DPNF on crop development,yield,N use efficiency and greenhouse gas emissions.Finally,the review delineates the limitations and challenges of this technology and provides suggestions for its improvement and application.This review provides valuable insight and reference for the promotion and adoption of DPNF in agricultural practice.
基金National Natural Science Foundation of China,Grant/Award Numbers:22179093,22379111Department of Education of Guangdong Province for Higher Educational Institution,Grant/Award Number:2022ZDZX4104Shenzhen General Project for Institutions of Higher Education,Grant/Award Number:20231127113219001。
文摘Electrochemical nitrogen looping represents a promising carbon-free and sustainable solution for the energy transition,in which electrochemical ammonia oxidation stays at the central position.However,the various nitrogen-containing intermediates tend to poison and corrode the electrocatalysts,even the state-of-the-art noble-metal ones,which is worsened at a high applied potential.Herein,we present an ultrarapid laser quenching strategy for constructing a corrosion-resistant and nanostructured CuNi alloy metallic glass electrocatalyst.In this material,single-atom Cu species are firmly bonded with the surrounding Ni atoms,endowing exceptional resistance against ammonia corrosion relative of conventional CuNi alloys.Remarkably,a record-high durability for over 300 h is achieved.Ultrarapid quenching also allows a much higher Cu content than typical single-atom alloys,simultaneously yielding a high rate and selectivity for ammonia oxidation reaction(AOR).Consequently,an outstanding ammonia conversion rate of up to 95%is achieved with 91.8%selectivity toward nitrite after 8 h.Theoretical simulations reveal that the structural amorphization of CuNi alloy could effectively modify the electronic configuration and reaction pathway,generating stable singleatom Cu active sites with low kinetic barriers for AOR.This ultrarapid laser quenching strategy thus provides a new avenue for constructing metallic glasses with well-defined nanostructures,presenting feasible opportunities for performance enhancement for AOR and other electrocatalytic processes.
基金the financial support from the National Natural Science Foundation of China(No.12164004)the Jiangxi Provincial Natural Science Foundation(Nos.20242BAB25210,20232BCJ25067,20232BAB214004 and 20224BAB204029)+2 种基金the Foundation of Education Department of Jiangxi Provincial(Nos.GJJ2201247 and GJJ211436)the Young and Middle-aged Teachers Education Scientific Research Project of Fujian Province(No.JAT231008)supported by Sinoma Institute of Materials Research(Guang Zhou)Co.,Ltd(SIMR).
文摘Mg-1.2Y-1.2Ni(at.%)alloy was extruded at 400℃with an extrusion ratio of 16:1 and different rates from 1 to 6 mm/s.The effect of extrusion rate on microstructure and mechanical properties of the Mg-1.2Y-1.2Ni alloy was systematically investigated.With the increase of extrusion rate,the average recrystallized grain size of Mg-1.2Y-1.2Ni alloy and mean particle diameter of Mg2Ni phase were increased,while the density of geometrically necessary dislocation and the intensity of the basal texture were decreased.When extrusion rate increases from 1 to 6 mm/s,the tensile yield strength(TYS)of asextruded Mg-1.2Y-1.2Ni alloy decreases from 501 to 281 MPa,while the elongation to failure increases from 1.5%to 6.2%.The Mg-1.2Y-1.2Ni alloy extruded at 3 mm/s obtained TYS of 421 MPa,the ultimate tensile strength(UTS)of 440 MPa and elongation to failure of 2.6%,respectively,exhibiting comprehensive mechanical properties with relatively good plasticity and ultrahigh strength.The ultrahigh TYS of 501 and 421 MPa was mainly due to the strengthening from ultrafine recrystallized grains,high volume fraction long period stacking ordered(LPSO)phases and high density dislocations.
基金supported by the National Natural Science Foundation of China(Grant No.:82322059(FL))Noncommunicable Chronic Diseases-National Science and Technology Major Project(Grant No.:2023ZD0503500(XFL))+1 种基金Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(Grant No.:2021-I2M-1-010(FL))National High-Level Hospital Clinical Research Funding(Grant No.:2022-GSP-GG-1(DG),2022-GSP-GG-2(XFL),and 2023GSP-RC-19(FL))。
文摘Background:It remains unclear whether the cardiovascular benefits of physical activity(PA)vary across populations with different predicted atherosclerotic cardiovascular disease(ASCVD)risks.This study aimed to determine the modification of predicted cardiovascular risk on the association between PA and ASCVD incidence.Methods:A total of 94,734 participants without ASCVD in the Prediction for Atherosclerotic Cardiovascular Disease Risk in China(China-PAR)project were included,with a median follow-up of 6.0 years.PA volume(metabolic equivalent of task(MET)-h/day)and intensity(%,percentage of moderate-to-vigorous PA(MVPA))were assessed by questionnaires.Based on the ASCVD 10-year and lifetime risk prediction scores,participants were classified into low-to-medium-risk and high-risk groups.Hazard ratios(HRs)and 95%confidence intervals(95%CIs)for ASCVD were calculated using Cox proportional hazards models.Results:During 679,438 person-years of follow-up,3470 ASCVD events occurred.Higher PA volume was associated with lower ASCVD incidence,which was more pronounced among high-predicted-risk individuals than their low-to-medium-risk counterparts,with HRs(95%CIs)of0.58(0.50-0.67)and 0.62(0.53-0.71)for the highest vs.lowest quartiles of PA volume,respectively.Additionally,analyses for PA intensity showed similar results.Compared with inactive individuals,there was a 32%(95%CI:25%-38%)and 23%(95%CI:13%-32%)risk reduction in high-and low-to-medium-risk groups,respectively,when over half of the PA volume was from MVPA.Furthermore,the additive interactions between PA and predicted risk indicated a further risk reduction by increasing PA,especially MVPA,in high-risk individuals.Conclusion:Engaging in more PA,especially MVPA,reduced the risk of ASCVD incidence,with greater benefits among high-risk individuals.These findings emphasize the imperative for personalized PA recommendations tailored to distinct risk populations—in particular,reinforcing PA guidance for high-risk individuals.
基金supported by the Basic Research Youth Talent Development Program of Huashan Hospital,Fudan University(2024JC030).
文摘Epstein-Barr virus(EBV)infection is well-known for its association with lymphoproliferative disorders and various lymphomas,causing significant global morbidity and mortality.EBV-positive vitreoretinal lymphoma(VRL)is exceedingly rare.As a result,the pathogenic role and genomic characteristics of EBV in VRL remain poorly understood.In this study,we employed droplet digital PCR(ddPCR)combined with EBV-specific immunofluorescence assay to detect EBV in the vitreous fluid of fifty-three VRL patients.We found that approximately 28%(15/53)of the patients were EBV positive.Analysis of clinical data showed that EBV-positive VRL patients had shorter progression-free survival(PFS)compared to EBV-negative patients(P=0.004).Additionally,through integration of EBV-targeted sequencing and PCR-based deep sequencing,we found that all five VRL-derived EBV genomes formed a distinct cluster within one phylogenetic branch.Meanwhile,several non-synonymous mutations were exclusively detected in the VRL group,including S229T in latent membrane protein 1(LMP1)and G2248R in the Epstein-Barr virus BamHI-PraL fragment 1(BPLF1).In conclusion,our findings suggest that EBV as a risk factor associated with poor prognosis in VRL,and we provide a genome-wide view of EBV sequence variations from VRL patients.This may offer insights into the pathogenic role of EBV in VRL and could potentially assist in the diagnosis and treatment of this disease.
基金supported by grants from Guangdong Provincial Key Lab of Translational Medicine in Lung Cancer (Grant No. 2017B030314120)General Research Project of Guangzhou Science and Technology Bureau (Grant No. 201607010391)+1 种基金National Key Research and Development Program of China (Grant No. 2016YFC1303800)Guangdong Provincial Applied S&T R&D Program (Grant No. 2016B020237006)
文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation.
基金supported by the National Key Research and Development Program of China(2018YFE0115300 and 2017YFC0211703)the National Natural Science Foundation of China(91643208,82073658,and 91843302)+3 种基金the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2021-I2M-1-010,2017-I2M-1-004,and 2019-I2M-2-003)Research Unit of Prospective Cohort of Cardiovascular Diseases and Cancers,Chinese Academy of Medical Sciences(2019RU038)the China Medical Board(15-220)supported by the National Institute of Environmental Health Sciences of the National Institutes of Health(Award#1R01ES032140).
文摘Background:The trade-off between the benefits of regular physical activity(PA)and the potentially detrimental effects of augmented exposure to air pollution in highly polluted regions remains unclear.This study aimed to examine whether ambient fine particulate matter(PM_(2.5))exposure modified the impacts of PA volume and intensity on hypertension risk.Methods:We included 54,797 participants without hypertension at baseline in a nationwide cohort of the Prediction for Atherosclerotic Cardiovascular Disease Risk in China(China-PAR)project.PA volume and intensitywere assessed by questionnaire,and high-resolution(1 km×1 km)PM_(2.5)estimates were generated using a satellite-based model.Results:During 413,516 person-years of follow-up,12,100 incident hypertension cases were identified.PM_(2.5)significantly modified the relationship between PA and hypertension incidence(p_(interaction)<0.001).Increased PA volume was negatively associated with incident hypertension in the low PM_(2.5)stratum(<59.8μg/m^(3),ptrend<0.001),with a hazard ratio of 0.81(95%confidence interval(95%CI):0.74-0.88)when comparing the fourth with the first quartile of PA volume.However,the health benefits were not observed in the high PM_(2.5)stratum(≥59.8μg/m^(3),p_(trend)=0.370).Moreover,compared with light PA intensity,vigorous intensity was related to a 20%(95%CI:9%-29%)decreased risk of hypertension for participants exposed to low PM_(2.5),but a 17%(95%CI:4%-33%)increased risk for those with high PM_(2.5)levels.Conclusion:PA was associated with a reduced risk of hypertension only among participants with low PM_(2.5)exposure.Our findings recommended regular PA to prevent hypertension in less polluted regions and reinforced the importance of air quality improvement.
基金supported by the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2019-I2M-2-003,2017-I2M-1-004)National Key R&D Program of China(2017YFC0211700,2018YFE0115300)the National Natural Science Foundation of China(91643208).
文摘Background:Inconsistent results have been reported in developed countries for relationships between sedentary behavior and cancer incidence and mortality,and evidence from the Chinese population is scarce.This study aimed to investigate such relationships in large Chinese population-based prospective cohorts and to explore the joint effect and interaction of sedentary behavior and moderate-to-vigorous physical activity(MVPA)on these relationships.Methods:We included 95,319 Chinese adults without cancer from 3 large cohorts and assessed their sedentary behavior and physical activity with a unified questionnaire.Cancer incidence and mortality were confirmed by interviewing participants or their proxies and checking hospital records and death certificates.Hazard ratios(HRs)and 95%confidence intervals(95%CIs)for cancer and mortality were estimated using Cox proportional hazards regression models.Results:During 559,002 person-years of follow-up,2388 cancer events,1571 cancer deaths,and 4562 all-cause deaths were recorded.Sedentary behavior was associated with increased risk of developing cancer and deaths in a doseresponse manner.The multivariable-adjusted HRs(95%CIs)were the following:HR=1.16,95%CI:1.01-1.33;HR=1.24,95%CI:1.04-1.48;and HR=1.15,95%CI:1.04-1.28 for cancer incidence,cancer mortality,and all-cause mortality,respectively,for those having≥10 h/day of sedentary time compared with those having<6 h/day of sedentary time.Sedentary populations(≥10 h/day)developed cancer or died 4.09 years and 2.79 years earlier,respectively,at the index age of 50 years.Failure to achieve the recommended level of MVPA may further aggravate the adverse associations,with the highest cancer and mortality risks being observed among participants with both≥10 h/day of sedentary time and<150 min/week of MVPA.Limitations of this study include the fact that physical activity information was obtained via questionnaire instead of objective measurement and that there were insufficient incident cases for the analysis of associations between sedentary behavior and site-specific cancers.Conclusion:Sedentary behavior was associated with an increased risk of cancer and all-cause mortality among Chinese adults,especially for those with≥10 h/day of sedentary time.It is necessary to reduce sedentary time,in addition to increasing MVPA levels,for the prevention of cancer and premature death.
基金supported by the National Great Science Specif ic Project (Grants No. 2014ZX03002002-004)National Natural Science Foundation of China (Grants No. NSFC-61471067)
文摘For the simultaneous wireless information and power transfer(SWIPT), the full-duplex MIMO system can achieve simultaneous transmission of information and energy more efficiently than the half-duplex. Based on the mean-square-error(MSE) criterion, the optimization problem of joint transceiver design with transmitting power constraint and energy harvesting constraint is formulated. Next, by semidefinite relaxation(SDR) and randomization method, the SDRbased scheme is proposed. In order to reduce the complexity, the closed-form scheme is presented with some simplified measures. Robust beamforming is then studied considering the practical condition. The simulation results such as MSE versus signal-noise-ratio(SNR), MSE versus the iteration number, well prove the performance of the proposed schemes for the system model.
基金The authors thank the financial support of this study received by the National Natural Science Foundation of China(21822509,U1810110,and 21802173)the Science and Technology Planning Project of Guangdong Province(2018A050506028)the Natural Science Foundation of Guangdong Province(2018A030310301).
文摘Zinc-ion hybrid supercapacitors(ZHSCs)have garnered increasing attention as promising energy storage devices in recent years,as they combine the advantages of high-energy Zn-ion batteries and high-power supercapacitors.However,the development of ZHSCs is still in its infancy and there are many bottlenecks to overcome.In particular,the challenge induced by the limited ion adsorption capability of carbon-positive electrodes severely restricts the energy density of ZHSCs.Therefore,it has become a key issue to design novel carbon-positive electrodes that enable high energy density yet do not deteriorate the intrinsic power capability and long-term durability.This study focuses on recent achievements in synthesis,morphology,and electrochemical performance of various carbon materials applied in ZHSCs.The modification strategies to optimize their electrochemical performance are briefly summarized.In addition,current challenges and future opportunities in this field are also outlined.This review will be beneficial to provide an organized framework for the research systems of carbon-positive electrodes and develop novel ZHSCs with high energy density.
基金supported by the National Natural Science Foundation of China(Nos.22179093 and 21905202)。
文摘Electrocatalytic oxygen reduction via a two-electron pathway(2e^(-)-ORR)is a promising and eco-friendly route for producing hydrogen peroxide(H_(2)O_(2)).Single-atom catalysts(SACs)typically show excellent selectivity towards 2e^(-)-ORR due to their unique electronic structures and geometrical configurations.The very low density of single-atom active centers,however,often leads to unsatisfactory H_(2)O_(2)yield rate,significantly inhibiting their practical feasibility.Addressing this,we herein introduce fluorine as a secondary doping element into conventional SACs,which does not directly coordinate with the singleatom metal centers but synergize with them in a remote manner.This strategy effectively activates the surrounding carbon atoms and converts them into highly active sites for 2e^(-)-ORR.Consequently,a record-high H_(2)O_(2)yield rate up to 27 mol g^(-1)h^(-1)has been achieved on the Mo–F–C catalyst,with high Faradaic efficiency of 90%.Density functional theory calculations further confirm the very kinetically facile 2e^(-)-ORR over these additional active sites and the superiority of Mo as the single-atom center to others.This strategy thus not only provides a high-performance electrocatalyst for 2e^(-)-ORR but also should shed light on new strategies to significantly increase the active centers number of SACs.
基金The authors thank the financial support of this study received by the National Natural Science Foundation of China(21802173,21822509,and U1810110)Science and Technology Planning Project of Guangdong Province(2018A050506028)Youth Innovation Talents Project of Guangdong Universities(natural science)(2019KQNCX098).
文摘The ever-growing market of wearable electronic devices has greatly stimulated the rapid development of flexible Zn-ion batteries(ZIBs).Manganese oxides are one of the most commonly used hosts for zinc ion accommodation and thus receive particular research interest for high-performance flexible ZIB constructions.In this review,a comprehensive summary of the recent development of flexible ZIBs with manganese oxides as cathode materials is presented.Apart from the brief introduction of flexible electronic devices and ZIBs,the charge storage mechanisms and crystal structures of various manganese oxides are summarized.Modifications of the cathode materials in terms of morphology,conductivity,structures,and flexibilities are illustrated in detail,together with the demonstration of structure-performance relationships and applications in flexible ZIBs.Finally,limitations to be overcome are indicated and the future work directions are proposed.
基金a grant of the Hainan Chang'an International Pharmaceutical Company Limited
文摘Objective： To compare the efficacy and safety of Lobaplatin plus Etoposide （EL） and Cisplatin plus Etoposide （EP） regimens in chemonaive with extensive-stage small-cell lung cancer （SCLC）. Methods： Between July 2010 and July 2011, a total of 62 patients with extensive-stage small-cell lung cancer who received initial treatment in our hospital and 309 hospital of PLA. 31 patients were randomly assigned to the EL Group： Lobaplatin was given intravenously at a dose of 30 mg/m2 on day 1 and Etoposide 100 mg/m2 on days 1 to 3 of 21-day cycles for a maximum of six cycles. Another 31 patients were assigned to the EP Group： Cisplatin was given intravenously at a dose of 75 mg/m2 on day 1 and Etoposide 100 mg/m2 on days 1 to 3 of 21-day cycles for a maximum of six cycles. We evaluated the efficacy, overall response rate （ORR）, disease control rate （DCR）, the progression-free survival （PFS） and toxicity between the patients of the two groups. Results： All 62 patients were eligible. In the EL group, 2 （6.5%） patients had complete response, 20 （64.5%） patients had partial response, 5 （16.1%） patients had stable disease and 4 （12.9%） patients had progress disease. In the EP group, 2 （6.5%） patients had complete response, 22 （70.9%） patients had partial response, 4 （12.9%） patients had stable disease and 3 （9.7%） patients had progress disease. The ORR of EL and EP group were 70.9% and 77.4%, respectively, showing no significant difference （P = 0.562）. The DCR of both groups were 87% and 90%, respectively, showing no significant difference （P = 0.688）. Median PFS of patients with EL and EP regimens were 5.5 months and 5 months, respectively, showing no significant difference （P = 0.637）. Adverse events were observed in all 62 patients. Grade 1 to 4 anemia was higher in the EP group than in EL group, showing significant difference （P = 0.02）. Grade 3 and 4 thrombocytopenia was seen in 4 patients （12.9%） in EL group and 1 patient （3.2%） in EP group. Although one patient had platelet transfusion owing to Grade 4 thrombocytopenia in EL group, no significant difference （P = 0.637） were shown. The incidence of nausea/vomiting was higher in the EP group than in the EL group （96.7% vs 51.6%, P = 0.00）. Conclusien： The EL regimen is an effective and low-toxicity chemotherapy and no inferior to EP regimen in treatment response, therefore, EL regimen maybe is a good choice for patients with extensive-stage SCLC.
基金supported by National Natural Science Foundation of China(Nos.32202171,22274121 and 22274123)。
文摘Monitoringα-glucosidase(α-Glu)activity is of great significance for the early diagnosis of typeⅡdiabetes.Here the blue fluorescent carbon dots(CDs)were integrated with two different recognizing molecules,β-cyclodextrin and phenylboronic acid,for assembling a multifunctional CDs(mCDs)nanoplatform for sensitively analyzingα-Glu and its inhibitors.The hydrolyzed product of 4-nitrophenyl-α-D-glucopyranoside(α-Glu substrate),p-nitrophenol,could efficiently quench the fluorescence of mCDs due to its cooperative molecular recognition withβ-cyclodextrin and phenylboronic acid.The mCDs could be utilized for the detection ofα-Glu activity with the limit of detection of 0.030 U/L.Moreover,the presentα-Glu detection platform revealed a high selectivity,and other natural enzymes showed scarcely any effect on the present mCDs system.The proposed method could be facilely used to screenα-Glu inhibitors with satisfying performance.The rational mCDs is expected to supplement more comprehensive biosensing platforms for highly sensitive and specific recognition of disease-relevant biomarkers with clinical importance.
基金supported by the National Natural Science Foundation of China(No.81973202)the Key Research and Development Program of Shandong Province (No. 2018GSF118085)。
文摘Dracomolphesin A-E(1-5),five 3,4-seco-phenylpropanoids featuring an aromatic ring opened framework,were isolated from the aerial parts of Dracocephalum moldavica.The structures with absolute configurations were determined by spectroscopic methods coupled with Mosher method.Notably,these compounds represented an example of aromatic ring cleavage products of phenylpropanoids.The possible biosynthetic pathway of these compounds was proposed.Compounds 1,2,4 and 5 were demonstrated to be Nrf2 pathway activators.
