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临床基因组测序解读与报告专家共识
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作者 卢宇蓝 李国壮 +31 位作者 王雅琼 徐可欣 董欣然 蔡继昊 吴冰冰 王慧君 方萍 王剑 王华 孙路明 叶勇裕 李晴 刘雅萍 刘丽 刘宁 刘嘉琦 宋昉 杨琳 邱正庆 陈泽夫 罗华夏 郭丹 郝婵娟 赵森 黄尚志 彭镜 蔡小强 睢瑞芳 李林康 吴南 周文浩 张抒扬 《遗传》 北大核心 2025年第3期314-328,共15页
基因组测序(genome sequencing,GS)是一种全面且系统地检测个体核基因组和线粒体基因组DNA序列的技术,旨在识别遗传变异并研究这些变异在人类健康和疾病发生发展中的作用。作为一种应用越来越广泛的检测技术,GS凭借高通量、高准确性和... 基因组测序(genome sequencing,GS)是一种全面且系统地检测个体核基因组和线粒体基因组DNA序列的技术,旨在识别遗传变异并研究这些变异在人类健康和疾病发生发展中的作用。作为一种应用越来越广泛的检测技术,GS凭借高通量、高准确性和全面性的优势,为临床诊断提供了重要支持。然而,其复杂的数据分析与解读对专业知识和经验提出了较高要求,也带来了诸多挑战。运用GS技术进行遗传病分子诊断会涉及临床应用的伦理与技术问题,包括知情同意、诊断性数据解读、报告范围和内容等。本专家共识总结了临床基因组测序(clinical GS,c GS)的核心流程,明确了检测范围与技术局限性,提供了数据质控、分析、注释及变异解读的关键步骤,并对报告内容和知情同意的争议性问题展开讨论。本共识旨在帮助相关从业人员正确理解和规范使用临床基因组测序技术,提升遗传病诊断的准确性,优化技术的临床效用,推动医学科学研究的进步。 展开更多
关键词 遗传罕见病 基因组测序 高通量测序数据分析 变异解读 遗传检测报告
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Exploring Polarizing Political Discourse Among U.S.Congressional Members with Large Language Models
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作者 Cheng FU Zili HUANG xiaoqiang cai 《Journal of Systems Science and Information》 2025年第1期102-115,共14页
In July 2024,a shooting incident involving President Trump drew widespread public attention,highlighting the need for a deeper understanding of political rhetoric among U.S.Congressional members.This study analyzes di... In July 2024,a shooting incident involving President Trump drew widespread public attention,highlighting the need for a deeper understanding of political rhetoric among U.S.Congressional members.This study analyzes discourse patterns on Twitter using large language models(LLMs),specifically ChatGPT and bidirectional encoder representations from transformers(BERT),to explore underlying factors that may contribute to polarizing political language.By collecting and preprocessing Twitter data,we initially labeled 20,000 tweets using ChatGPT and then utilized the BERT-large model to classify the remaining 980,000 tweets.The analysis identified party affiliation and geographic region as significant factors influencing political rhetoric.Republican lawmakers exhibited a higher prevalence of polarizing language,while New Jersey recorded the highest rate among the states.Newly elected Congressional members also tended to adopt more provocative language,potentially as a strategy to engage with their voter base or distinguish themselves in a competitive political environment.Temporal analysis revealed spikes in polarizing rhetoric corresponding to events such as discussions on the new fiscal year budget.This study offers insights into the dynamics of political discourse,providing a foundation for promoting constructive dialogue and fostering institutional resilience. 展开更多
关键词 U.S.Congressional members polarizing discourses TWITTER large language models
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OPTIMAL OPERATIONAL DECISIONS WHEN A MANUFACTURER OFFERS TRADE CREDIT TO HIS RETAILER 被引量:2
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作者 Dan SHI Yongjian LI xiaoqiang cai 《Journal of Systems Science and Systems Engineering》 SCIE EI CSCD 2012年第4期480-496,共17页
In this paper, we develop models to determine operational and financial decisions of a supply chain under the condition that the retailer faces a financial constraint and the manufacturer can offer trade credit to ass... In this paper, we develop models to determine operational and financial decisions of a supply chain under the condition that the retailer faces a financial constraint and the manufacturer can offer trade credit to assist the retailer. We first study the case where the retailer is risk-neutral, and derive the optimal ordering and financial decisions. Then, the case where the retailer is risk-averse (downside risk) is studied and-the effects of the risk on the retailer and manufacturer's operational and financial decisions are discussed. Finally, numerical examples are provided to conduct managerial analysis. 展开更多
关键词 Financial constraint trade credit downside risk supply chain operations
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CAPACITY ALLOCATION AND COORDINATION ISSUES FOR THE TIMELY PROCESSING OF OUTSOURCED OPERATIONS 被引量:1
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作者 Tolga Aydinliyim xiaoqiang cai George L.Vairaktarakis 《Journal of Systems Science and Systems Engineering》 SCIE EI CSCD 2014年第3期300-312,共13页
We consider dynamic capacity booking problems faced by multiple manufacturers each outsourcing certain operations to a common third-party firm. Each manufacturer, upon observing the current state of the third-party sc... We consider dynamic capacity booking problems faced by multiple manufacturers each outsourcing certain operations to a common third-party firm. Each manufacturer, upon observing the current state of the third-party schedule, books capacity with the objective to jointly minimize holding costs that result from early deliveries, tardiness penalties due to late deliveries, and third-party capacity booking costs. When making a reservation, each manufacturer evaluates two alternative courses of action: (i) reserving capacity not yet utilized by other manufactures who booked earlier; or (ii) forming a coalition with a subset or all of other manufacturers to achieve a schedule minimizing coalition costs, i.e., a centralized schedule for that coalition. The latter practice surely benefits the coalition as a whole; however, some manufacturers may incur higher costs if their operations are either pushed back too much, or delivered too early. For this reason, a cost allocation scheme making each manufacturer no worse than they would be when acting differently (i.e., participating in a smaller coalition or acting on their own behalf,) must accompany centralized scheduling for the coalition. We model this relationship among the manufacturers as a cooperative game with transferable utility, and present optimal and/or heuristic algorithms to attain individually and eoalitionally optimal schedules as well as a linear program formulation to find a core allocation of the manufacturers' costs. 展开更多
关键词 OUTSOURCING SCHEDULING capacity allocation cooperative games
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Cooperation and Contract Design in Project Management with Outsourcing
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作者 xiaoqiang cai Nicholas G.Hall +1 位作者 Siyi Wang Feng Zhang 《Journal of Systems Science and Systems Engineering》 SCIE EI CSCD 2023年第1期34-70,共37页
We study a project management problem where the prime contractor needs to outsource tasks to subcontractors with the required resources.Successful execution of the project requires proper coordination among the subcon... We study a project management problem where the prime contractor needs to outsource tasks to subcontractors with the required resources.Successful execution of the project requires proper coordination among the subcontractors,as well as contract design by the prime contractor to incentivize the subcontractors.By modeling the subcontractors’coordination problem as a cooperative game,we develop a profit sharing scheme to facilitate the subcontractors’cooperation.We consider two contract designs for the prime contractor:a uniform contract across all subcontractors,and a nonuniform one that customizes incentives for each subcontractor.We propose efficient algorithms to solve the implicit optimization problems for optimal contract parameters.Computational experiments show that the pooling effect of subcontractors’cooperation mitigates the negative impact of poor estimates about the crashing cost and resource availability.We observe three unexpected results through the randomized computation experiments:(i)the subcontractors’profits may decrease if they provide false information;(ii)it is safer for the prime contractor to overestimate subcontractors’crashing costs than underestimate them;and(iii)uniform contracts deliver more project profit for the subcontractors in the coalitions. 展开更多
关键词 Project management with outsourcing SUBCONTRACTING cooperative game contract design
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On the Quasi-Concavity of Equipment Sharing Games with Perishable Raw Materials
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作者 Jun Li xiaoqiang cai +1 位作者 Yinlian Zeng Hairong Feng 《Journal of Systems Science and Systems Engineering》 SCIE EI CSCD 2021年第6期649-666,共18页
We study the equipment sharing problem where a group of food&beverage companies share the same equipment of a contractor and wish to have their processing tasks coordinated such that the total cost is minimized.Th... We study the equipment sharing problem where a group of food&beverage companies share the same equipment of a contractor and wish to have their processing tasks coordinated such that the total cost is minimized.The raw materials to be processed are perishable,which incur a decay cost as time goes.One key issue of this equipment sharing problem is how to allocate the total cost among the participants.We apply cooperative game theory to tackle this issue and formulate the problem as an equipment sharing game.First,we study the 1-equipment sharing game in which all participants share one equipment.We show that the 1-equipment sharing game is quasi-concave when the fixed operation cost is larger than a certain value.We then discuss the special case where the processing time for all participants is equal.For this case,we further investigate the properties of the 1-equipment sharing game and the multi-equipment sharing game.We identify the conditions under which the Shapely value and the T-value can be easily calculated for the 1-equipment and multi-equipment sharing games. 展开更多
关键词 Equipment sharing quasi-concave games perishable raw materials decay loss
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Chemical composition and antimicrobial activity of the essential oil of Cacalia tangutica (Maxim.) Hand.-Mazz
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作者 Yang YANG Shunying ZHU +4 位作者 xiaoqiang cai Lifei TANG Deqing LIU Jinghua HUANG Guolin ZOU 《Frontiers in Biology》 CSCD 2008年第4期402-407,共6页
Essential oil of the subterranean part of Cacalia tangutica(Maxim.)Hand.-Mazz was analyzed by gas chromatography(GC)-mass spectrum(MS)technique in two different capillary columns of different polarities.Thirty-one com... Essential oil of the subterranean part of Cacalia tangutica(Maxim.)Hand.-Mazz was analyzed by gas chromatography(GC)-mass spectrum(MS)technique in two different capillary columns of different polarities.Thirty-one components were identified in the oil and the main compounds were a-zingiberene(13.49%),germacrene D(10.76%),α-pinene(8.54%),caryophyllene(Z-)(6.36%),linalool(6.16%),β-myrcene(4.89%),β-ocimene(Z-)(4.40%)and ocimenone(Z-)(3.58%).The antimicrobial activity of the oil was evaluated against 2 fungi and 12 bacteria including 6 clinically isolated strains using the agar disc diffusion and broth microdilution methods.The results show that the oil presented a broad antimicrobial spectrum and had better antimicrobial activity against yeast and gram-positive bacteria.The minimum inhibitory concentration values were 0.16–5.00 g/L and minimum bactericidal concentration values were 0.16–5.00 g/L. 展开更多
关键词 Cacalia tangutica antimicrobial activity essential oil gas chromatography(GC)-mass spectrum(MS)
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