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Characteristics of Lake Breezes and Their Impacts on Energy and Carbon Fluxes in Mountainous Areas 被引量:3
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作者 Lujun XU Huizhi LIU +4 位作者 Qun DU Yang LIU Jihua SUN Anlun XU xiaoni meng 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2021年第4期603-614,共12页
In mountainous lake areas, lake–land and mountain–valley breezes interact with each other, leading to an "extended lake breeze". These extended lake breezes can regulate and control energy and carbon cycle... In mountainous lake areas, lake–land and mountain–valley breezes interact with each other, leading to an "extended lake breeze". These extended lake breezes can regulate and control energy and carbon cycles at different scales. Based on meteorological and turbulent fluxes data from an eddy covariance observation site at Erhai Lake in the Dali Basin,southwest China, characteristics of daytime and nighttime extended lake breezes and their impacts on energy and carbon dioxide exchange in 2015 are investigated. Lake breezes dominate during the daytime while, due to different prevailing circulations at night, there are two types of nighttime breezes. The mountain breeze from the Cangshan Mountain range leads to N1 type nighttime breeze events. When a cyclonic circulation forms and maintains in the southern part of Erhai Lake at night, its northern branch contributes to the formation of N2 type nighttime breeze events. The prevailing wind directions for daytime, N1, and N2 breeze events are southeast, west, and southeast, respectively. Daytime breeze events are more intense than N1 events and weaker than N2 events. During daytime breeze events, the lake breeze decreases the sensible heat flux(Hs) and carbon dioxide flux(F_(CO_2)) and increases the latent heat flux(LE). During N1 breeze events, the mountain breeze decreases Hs and LE and increases F_(CO_2). For N2 breeze events, the southeast wind from the lake surface increases Hs and LE and decreases suppress carbon dioxide exchange. 展开更多
关键词 sensible heat flux latent heat flux carbon dioxide flux lake breeze mountain breeze
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免疫球蛋白G N-糖基化与代谢特征之间的双向因果关联--一项孟德尔随机化研究
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作者 孟晓妮 曹维杰 +6 位作者 刘迪 Isinta Maranga Elijah 邢薇佳 侯海峰 徐希柱 宋曼殳 王友信 《Engineering》 SCIE EI CAS CSCD 2023年第7期74-88,I0004,共16页
既往研究已发现免疫球蛋白G(immunoglobulin G,IgG)N-糖基化与代谢特征之间存在关联,但它们之间是否存在因果关联尚有待研究。本研究使用孟德尔随机化(Mendelian randomization,MR)研究方法整合全基因组关联研究(genome-wide associatio... 既往研究已发现免疫球蛋白G(immunoglobulin G,IgG)N-糖基化与代谢特征之间存在关联,但它们之间是否存在因果关联尚有待研究。本研究使用孟德尔随机化(Mendelian randomization,MR)研究方法整合全基因组关联研究(genome-wide association studies,GWAS)和数量性状基因座(quantitative trait loci,QTL)数据探究IgG N-糖基化与代谢特征之间的双向因果关联。在正向MR分析中,通过整合IgG N-糖基-QTL遗传变异与GWAS数据和代谢特征进行分析,分别发现59个包括影响体质指数(body mass index,BMI)的9个IgG N-糖基(glycan peaks,GP)(GP1和GP6等)和影响空腹血糖(fasting plasma glucose,FPG)的7个IgG N-糖基(GP1和GP5等)以及15个[包括影响BMI的5个IgG N-糖基(GP2和GP11等)和影响FPG的4个IgG N-糖基(GP1和GP10等)]由遗传决定的IgG N-糖基在单样本和两样本MR研究中与代谢特征存在因果关联(全部P<0.05)。相应地,对整合代谢特征-QTL-遗传变异与GWAS结果和IgG N-糖基进行MR分析的结果显示,在单样本和两样本MR研究中,分别发现72个包括影响GP1的1个因果代谢特征[高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)]和影响GP2的5个因果代谢特征[FPG、收缩压(systolic blood pressure,SBP)等]和4个[包括影响GP3的1个因果代谢特征(HDL-C)和影响GP9的1个代谢特征(HDL-C)]由遗传决定的代谢特征与IgG N-糖基之间存在因果关联(全部P<0.05)。值得注意的是,在单样本和两样本的MR分析中均发现了遗传决定的高水平的GP11与BMI水平增高存在因果关联[固定效应模型-Beta(SE):0.106(0.034)和0.010(0.005)]和高水平的HDL-C与GP9水平降低存在因果关联[-0.071(0.022)和-0.306(0.151)],且这一结果在单样本和两样本的meta汇总分析中得到了进一步验证[固定效应模型-Beta(95%置信区间)分别为:0.0109(0.0012,0.0207)和-0.0759(-0.1186,-0.0332)]。综上所述,本研究全面的双向MR分析提供了IgG N-糖基化与代谢特征之间双向因果关联的证据,在一定程度上揭示了IgG N-糖基化与代谢特征之间的生物学机制。 展开更多
关键词 Mendelian randomization study Immunoglobulin G N-glycosylation Metabolic traits Quantitative trait loci Bidirectional causality
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