Tow different computer calculation methods for distortion of the wide-band diode bridge track and hold amplifier (THA) are presented based on a high frequency Schottky diode model. One of the computer programs calcula...Tow different computer calculation methods for distortion of the wide-band diode bridge track and hold amplifier (THA) are presented based on a high frequency Schottky diode model. One of the computer programs calculates the distortion of weekly nonlinear THA based on the KCL and the nonlinear-current method. The other calculates the weekly nonlinear distortion by using a Volterra series method and a nodal formulation. Comparative calculation results for the diode bridge THA have shown good agreement with these two computer program calculation methods, whereas the overall computational efficiency of the nonlinear-current method is better than that of the nodal formulation method in a special evaluation.展开更多
A high power buck-boost switch-mode LED driver delivering a constant 350 mA with a power efficient current sensing scheme is presented in this paper. The LED current is extracted by differentiating the output capacito...A high power buck-boost switch-mode LED driver delivering a constant 350 mA with a power efficient current sensing scheme is presented in this paper. The LED current is extracted by differentiating the output capacitor voltage and maintained by a feedback. The circuit has been fabricated in a standard 0.35 μm AMS CMOS process. Measurement results demonstrated a power-conversion efficiency over 90% with a line regulation of 8%/V for input voltage of 3.3 V and current output between 200 mA and 350 mA.展开更多
Pancreatic cancer(PaCa)is one of the most aggressive and lethal malignancies with rapid progression and poor prognosis with the 5-year survival rate remaining less than 5%because approximately 80%of PaCa patients are ...Pancreatic cancer(PaCa)is one of the most aggressive and lethal malignancies with rapid progression and poor prognosis with the 5-year survival rate remaining less than 5%because approximately 80%of PaCa patients are diagnosed at an advanced stage and lose the chance of curative resection.1 Accumulated evidence has revealed that noncoding RNAs(ncRNAs)are involved in the pathogenesis of PaCa and serve as potential biomarkers for PaCa.2,3 Exosomal lncRNAs also play a vital role in tumorigenesis and some exosomal lncRNAs have been reported to accelerate tumor progression.4 In this study,we first employed RNA-seq of PaCa plasma samples to identify significantly differentially expressed lncRNAs in PaCa patients and revealed that LINC01268 was up-regulated in PaCa tumor tissues and plasma.LINC01268 is an emerging lncRNA associated with glioma malignancy grade.5 Thus.we further analyzed the malignant biological behaviors of this lncRNA in PaCa and found that LINC01268 promoted cell proliferation,migration,and invasion as an oncogene,which promoted epithelial–mesenchymal transition(EMT)in PaCa via the miR-217-KIF2A-PI3K/AKT axis.展开更多
The electrochemical reduction of carbon dioxide(CO_(2)RR)stands as an enticing approach for the production of essential chemicals and feedstocks,storing clean electric energy and mitigating greenhouse gas emissions.Re...The electrochemical reduction of carbon dioxide(CO_(2)RR)stands as an enticing approach for the production of essential chemicals and feedstocks,storing clean electric energy and mitigating greenhouse gas emissions.Recent years have witnessed remarkable breakthroughs in CO_(2)RR,enhancing its performance and transitioning related research from laboratory settings toward industrial realization.However,the journey of CO_(2)RR development is not devoid of challenges,including issues like mass transfer limitation,salt accumulation,and flooding phenomena.Remarkably,recent studies have unveiled a promising avenue by conducting CO_(2)RR in an acidic environment,effectively circumventing these challenges and presenting novel opportunities.In this review,we embark on a reassessment of H-cells and flow cells,delving into their opportunities,challenges,strengths,and weaknesses.Additionally,we compile recent advancements in CO_(2)RR under acidic conditions,elucidating the performance metrics and strategies embraced by pertinent research.Subsequently,we propose three pivotal concerns in acidic CO_(2)RR:①balancing the competition between CO_(2)RR and hydrogen evolution reaction(HER),②enhancing the selectivity,and③exploring industrial applications.And finally,we delve into the core factors influencing the performance of CO_(2)RR in acid:local pH,cation effects,and catalyst design.Building upon these strategies,challenges,and insights,prospects are proposed for the future trajectory of CO_(2)RR development.展开更多
文摘Tow different computer calculation methods for distortion of the wide-band diode bridge track and hold amplifier (THA) are presented based on a high frequency Schottky diode model. One of the computer programs calculates the distortion of weekly nonlinear THA based on the KCL and the nonlinear-current method. The other calculates the weekly nonlinear distortion by using a Volterra series method and a nodal formulation. Comparative calculation results for the diode bridge THA have shown good agreement with these two computer program calculation methods, whereas the overall computational efficiency of the nonlinear-current method is better than that of the nodal formulation method in a special evaluation.
文摘A high power buck-boost switch-mode LED driver delivering a constant 350 mA with a power efficient current sensing scheme is presented in this paper. The LED current is extracted by differentiating the output capacitor voltage and maintained by a feedback. The circuit has been fabricated in a standard 0.35 μm AMS CMOS process. Measurement results demonstrated a power-conversion efficiency over 90% with a line regulation of 8%/V for input voltage of 3.3 V and current output between 200 mA and 350 mA.
基金supported by the National Natural Science Foundation of China(No.81672383)the Science and Technology Commission of Shanghai,China(No.20Y11900700)+1 种基金the Special Research Fund of Youan Medical Alliance for the Liver and Infectious Diseases(China)(No.LM202020)the Shanghai Public Health Clinical Center,Shanghai,China(No.KY-GW-2020-09 to X.He).
文摘Pancreatic cancer(PaCa)is one of the most aggressive and lethal malignancies with rapid progression and poor prognosis with the 5-year survival rate remaining less than 5%because approximately 80%of PaCa patients are diagnosed at an advanced stage and lose the chance of curative resection.1 Accumulated evidence has revealed that noncoding RNAs(ncRNAs)are involved in the pathogenesis of PaCa and serve as potential biomarkers for PaCa.2,3 Exosomal lncRNAs also play a vital role in tumorigenesis and some exosomal lncRNAs have been reported to accelerate tumor progression.4 In this study,we first employed RNA-seq of PaCa plasma samples to identify significantly differentially expressed lncRNAs in PaCa patients and revealed that LINC01268 was up-regulated in PaCa tumor tissues and plasma.LINC01268 is an emerging lncRNA associated with glioma malignancy grade.5 Thus.we further analyzed the malignant biological behaviors of this lncRNA in PaCa and found that LINC01268 promoted cell proliferation,migration,and invasion as an oncogene,which promoted epithelial–mesenchymal transition(EMT)in PaCa via the miR-217-KIF2A-PI3K/AKT axis.
基金financial support by the International Cooperation Program of Science and Technology Commission of Shanghai Municipality(No.22160712100)the National Natural Science Foundation of China(No.22178274)National Key R&D Program of China(No.2022YFE0102900).
文摘The electrochemical reduction of carbon dioxide(CO_(2)RR)stands as an enticing approach for the production of essential chemicals and feedstocks,storing clean electric energy and mitigating greenhouse gas emissions.Recent years have witnessed remarkable breakthroughs in CO_(2)RR,enhancing its performance and transitioning related research from laboratory settings toward industrial realization.However,the journey of CO_(2)RR development is not devoid of challenges,including issues like mass transfer limitation,salt accumulation,and flooding phenomena.Remarkably,recent studies have unveiled a promising avenue by conducting CO_(2)RR in an acidic environment,effectively circumventing these challenges and presenting novel opportunities.In this review,we embark on a reassessment of H-cells and flow cells,delving into their opportunities,challenges,strengths,and weaknesses.Additionally,we compile recent advancements in CO_(2)RR under acidic conditions,elucidating the performance metrics and strategies embraced by pertinent research.Subsequently,we propose three pivotal concerns in acidic CO_(2)RR:①balancing the competition between CO_(2)RR and hydrogen evolution reaction(HER),②enhancing the selectivity,and③exploring industrial applications.And finally,we delve into the core factors influencing the performance of CO_(2)RR in acid:local pH,cation effects,and catalyst design.Building upon these strategies,challenges,and insights,prospects are proposed for the future trajectory of CO_(2)RR development.
