The prognosis of drug-induced acute liver failure(ALF)is poor,with a survival rate of 27.1%without liver transplantation.Liver transplantation significantly improved survival rates to 66.2%.[1]The shortage of availabl...The prognosis of drug-induced acute liver failure(ALF)is poor,with a survival rate of 27.1%without liver transplantation.Liver transplantation significantly improved survival rates to 66.2%.[1]The shortage of available grafts can be addressed by living donor liver transplantation(LDLT),an effective and safe method that expands the donor pool,enhances timely transplantation,and improves patient survival.展开更多
We present a comprehensive investigation of the vibrational spectra and conformational distribution of neutral and cationic monoethanolamine(MEA)in the gas phase.Using infrared-vacuum ultraviolet non-resonant ionizati...We present a comprehensive investigation of the vibrational spectra and conformational distribution of neutral and cationic monoethanolamine(MEA)in the gas phase.Using infrared-vacuum ultraviolet non-resonant ionization fragmentation detected IR spectroscopy(NRIFD-IR),we obtained vibrational spectra in the 2500-3800 cm^(−1)range for both neutral and cationic MEA.Density functional theory(DFT)calculations at the B3LYPD3(BJ)/def2-TZVPP level were employed to elucidate the molecular structures and vibrational modes.Our analysis revealed twelve distinct conformers for neutral MEA,with N1gʹGgʹbeing the most stable,while cationic MEA exhibited four conformers,among which C1gʹGt conformer was found to be the primary contributor to the observed spectra.The experimental spectra were interpreted through comparison with anharmonic calculations,allowing for detailed assignment of vibrational modes.Notably,we observed significant differences in the OH stretch region between neutral and cationic species,reflecting changes in intramolecular hydrogen bonding upon ionization.Furthermore,our study highlights the necessity for distinct scaling factors when calculating harmonic frequencies for neutral and cationic substances.展开更多
The intramolecular O−H…πhydrogen bond has garnered significant research interest in recent decades.In this work,we utilized the infrared(IR)-vacuum-ultraviolet(VUV)nonresonant ionization detected IR spectroscopy(NRI...The intramolecular O−H…πhydrogen bond has garnered significant research interest in recent decades.In this work,we utilized the infrared(IR)-vacuum-ultraviolet(VUV)nonresonant ionization detected IR spectroscopy(NRID-IR)method to study the molecular structure of neutral and cationic 2-methylallyl alcohol(MAA,CH_(2)=C(CH_(3))−CH_(2)−OH).Density functional theory calculations revealed five stable neutral and three stable cationic MAA conformers,respectively.Two neutral MAA conformers are expected to have an O−H…πintramolecular hydrogen bond interaction,based on the structural characterization that the OH group is directed toward the C=C double bond.The IR spectra of both neutral(2700−3700 cm^(−1))and cationic MAA(2500−7200 cm^(−1))were measured,and the anharmonic IR spectra were calculated at the B3LYP-D3(BJ)/def2-TZVPP level.The OH stretching vibration frequency of neutral MAA was observed at 3656 cm−1,slightly lower than those of methanol and ethanol.In contrast,the OH stretching vibration of cationic MAA was red-shifted by about 140 cm^(−1)compared to neutral MAA.The interaction region indicator and natural bond orbital analysis suggest that the O−H…πinteraction in neutral MAA is weak,and may not play a major role in stabilizing the neutral MAA.展开更多
In cerebrovascular interventional surgery,spatial position prediction navigation(SPPN)provides 3D spatial information of the vascular lumen,reducing the spatial dimension loss from digital subtraction angiography(DSA)...In cerebrovascular interventional surgery,spatial position prediction navigation(SPPN)provides 3D spatial information of the vascular lumen,reducing the spatial dimension loss from digital subtraction angiography(DSA)and improving surgical precision.However,it is limited in its adaptability to complex vascular environments and prone to error accumulation.To address these issues,we propose spatial position prediction-based multimodal navigation(SPPMN),integrating minimal intraoperative X-ray images to enhance SPPN accuracy.In the first phase,a feature-weighted dynamic time warping(FDTW)-based branch matching algorithm is introduced for 3D topological positioning under non-registered conditions,with a dynamic location repositioning module for real-time corrections.In the second phase,an occlusion correction module,based on the elastic potential energy of the instrument tip,dynamically adjusts the tip's angle to achieve low-projection occlusion control.Experimental validation using a high-precision electromagnetic tracking system(EMTS)on a 3D vascular model shows that the proposed method achieves an average 3D positioning accuracy of 9.36 mm in intracranial vascular regions,with a 78%reduction in radiation exposure,significantly enhancing both precision and safety in interventional surgeries.展开更多
We discuss the problem of accountability when multiple parties cooperate towards an end result,such as multiple companies in a supply chain or departments of a government service under different authorities.In cases w...We discuss the problem of accountability when multiple parties cooperate towards an end result,such as multiple companies in a supply chain or departments of a government service under different authorities.In cases where a fully trusted central point does not exist,it is difficult to obtain a trusted audit trail of a workflow when each individual participant is unaccountable to all others.We propose AudiWFlow,an auditing architecture that makes participants accountable for their contributions in a distributed workflow.Our scheme provides confidentiality in most cases,collusion detection,and availability of evidence after the workflow terminates.AudiWFlow is based on verifiable secret sharing and real-time peer-to-peer verification of records;it further supports multiple levels of assurance to meet a desired trade-off between the availability of evidence and the overhead resulting from the auditing approach.We propose and evaluate two implementation approaches for AudiWFlow.The first one is fully distributed except for a central auxiliary point that,nevertheless,needs only a low level of trust.The second one is based on smart contracts running on a public blockchain,which is able to remove the need for any central point but requires integration with a blockchain.展开更多
基金approved by the Ethics Committee of the Second Affiliated Hospital,Zhejiang University School of Medicine(2024-0690).
文摘The prognosis of drug-induced acute liver failure(ALF)is poor,with a survival rate of 27.1%without liver transplantation.Liver transplantation significantly improved survival rates to 66.2%.[1]The shortage of available grafts can be addressed by living donor liver transplantation(LDLT),an effective and safe method that expands the donor pool,enhances timely transplantation,and improves patient survival.
基金the Dalian Coherent Light Source (DCLS) for support and assistancesurported by the National Natural Science Foundation of China (No.22288201)+1 种基金the Chinese Academy of Sciences (GJJSTD20220001)the Innovation Program for Quantum Science and Technology (No.2021ZD0303305)。
文摘We present a comprehensive investigation of the vibrational spectra and conformational distribution of neutral and cationic monoethanolamine(MEA)in the gas phase.Using infrared-vacuum ultraviolet non-resonant ionization fragmentation detected IR spectroscopy(NRIFD-IR),we obtained vibrational spectra in the 2500-3800 cm^(−1)range for both neutral and cationic MEA.Density functional theory(DFT)calculations at the B3LYPD3(BJ)/def2-TZVPP level were employed to elucidate the molecular structures and vibrational modes.Our analysis revealed twelve distinct conformers for neutral MEA,with N1gʹGgʹbeing the most stable,while cationic MEA exhibited four conformers,among which C1gʹGt conformer was found to be the primary contributor to the observed spectra.The experimental spectra were interpreted through comparison with anharmonic calculations,allowing for detailed assignment of vibrational modes.Notably,we observed significant differences in the OH stretch region between neutral and cationic species,reflecting changes in intramolecular hydrogen bonding upon ionization.Furthermore,our study highlights the necessity for distinct scaling factors when calculating harmonic frequencies for neutral and cationic substances.
基金gratefully acknowledge the Dalian Coherent Light Source(DCLS)for support and assistanceThis work was supported by the National Natural Science Foundation of China(No.22288201)+1 种基金the Chinese Academy of Sciences(GJJSTD20220001)the Innovation Program for Quantum Science and Technology(No.2021ZD0303305).
文摘The intramolecular O−H…πhydrogen bond has garnered significant research interest in recent decades.In this work,we utilized the infrared(IR)-vacuum-ultraviolet(VUV)nonresonant ionization detected IR spectroscopy(NRID-IR)method to study the molecular structure of neutral and cationic 2-methylallyl alcohol(MAA,CH_(2)=C(CH_(3))−CH_(2)−OH).Density functional theory calculations revealed five stable neutral and three stable cationic MAA conformers,respectively.Two neutral MAA conformers are expected to have an O−H…πintramolecular hydrogen bond interaction,based on the structural characterization that the OH group is directed toward the C=C double bond.The IR spectra of both neutral(2700−3700 cm^(−1))and cationic MAA(2500−7200 cm^(−1))were measured,and the anharmonic IR spectra were calculated at the B3LYP-D3(BJ)/def2-TZVPP level.The OH stretching vibration frequency of neutral MAA was observed at 3656 cm−1,slightly lower than those of methanol and ethanol.In contrast,the OH stretching vibration of cationic MAA was red-shifted by about 140 cm^(−1)compared to neutral MAA.The interaction region indicator and natural bond orbital analysis suggest that the O−H…πinteraction in neutral MAA is weak,and may not play a major role in stabilizing the neutral MAA.
基金supported in part by the National Key Research and Development Program of China(2024YFF1206902)in part by the National Natural Science Foundation of China(62303463)+1 种基金in part by the Beijing Natural Science Foundation,China(L232137,L246047)in part by the National High Level Hospital Clinical Research Funding(2022-PUMCH-B-125).
文摘In cerebrovascular interventional surgery,spatial position prediction navigation(SPPN)provides 3D spatial information of the vascular lumen,reducing the spatial dimension loss from digital subtraction angiography(DSA)and improving surgical precision.However,it is limited in its adaptability to complex vascular environments and prone to error accumulation.To address these issues,we propose spatial position prediction-based multimodal navigation(SPPMN),integrating minimal intraoperative X-ray images to enhance SPPN accuracy.In the first phase,a feature-weighted dynamic time warping(FDTW)-based branch matching algorithm is introduced for 3D topological positioning under non-registered conditions,with a dynamic location repositioning module for real-time corrections.In the second phase,an occlusion correction module,based on the elastic potential energy of the instrument tip,dynamically adjusts the tip's angle to achieve low-projection occlusion control.Experimental validation using a high-precision electromagnetic tracking system(EMTS)on a 3D vascular model shows that the proposed method achieves an average 3D positioning accuracy of 9.36 mm in intracranial vascular regions,with a 78%reduction in radiation exposure,significantly enhancing both precision and safety in interventional surgeries.
文摘We discuss the problem of accountability when multiple parties cooperate towards an end result,such as multiple companies in a supply chain or departments of a government service under different authorities.In cases where a fully trusted central point does not exist,it is difficult to obtain a trusted audit trail of a workflow when each individual participant is unaccountable to all others.We propose AudiWFlow,an auditing architecture that makes participants accountable for their contributions in a distributed workflow.Our scheme provides confidentiality in most cases,collusion detection,and availability of evidence after the workflow terminates.AudiWFlow is based on verifiable secret sharing and real-time peer-to-peer verification of records;it further supports multiple levels of assurance to meet a desired trade-off between the availability of evidence and the overhead resulting from the auditing approach.We propose and evaluate two implementation approaches for AudiWFlow.The first one is fully distributed except for a central auxiliary point that,nevertheless,needs only a low level of trust.The second one is based on smart contracts running on a public blockchain,which is able to remove the need for any central point but requires integration with a blockchain.
