L-malate is an intermediate of the tricarboxylic acid cycle which is naturally occurred in various microorganisms,and it has been widely applied in polymer,beverage and food,textile,agricultural and pharmaceutical ind...L-malate is an intermediate of the tricarboxylic acid cycle which is naturally occurred in various microorganisms,and it has been widely applied in polymer,beverage and food,textile,agricultural and pharmaceutical industries.Driven by the pursuit of a sustainable economy,microbial production of L-malate has received much attention in last decades.In this review,we focus on the utilization of wastes and/or byproducts as feedstocks for the microbial production of L-malate.Firstly,we present the recent developments on the natural or engineered metabolic pathways that dedicate to the biosynthesis of L-malate,and also provide a comprehensive discussions on developing high-efficient producers.Then,the recent achievements in microbial production of L-malate from various carbon sources were concluded and discussed.Furthermore,some abundant non-food feedstocks which have been used for microbial production of other chemicals were reviewed,as they may be potential candidate feedstock for L-malate production in future.Finally,we outlined the major challenges and proposed further improvements for the production of L-malate.展开更多
To the Editor:The treatment principle for pediatric spinal deformity is not only to control the spinal deformity but also to maintain the development of the spine and the chest and the mobility of the spine.To achieve...To the Editor:The treatment principle for pediatric spinal deformity is not only to control the spinal deformity but also to maintain the development of the spine and the chest and the mobility of the spine.To achieve this goal,various kinds of growth-friendly implants have been introduced over the last two decades,which can be divided into three categories,including distraction-based,compression-based,and guided growth systems.The aim of this article is to comprehensively review the currently available growth-friendly implants for pediatric spinal deformity,especially the advancements made in recent decades,to provide reference for clinical treatment and implant design.展开更多
Fluorescence active fused-triazole was developed as a ligand in gold(I) cation coordination. The coordination ability was evaluated using NMR and fluorescence emission. Our previously reported N-2-aryl-triazoles, thou...Fluorescence active fused-triazole was developed as a ligand in gold(I) cation coordination. The coordination ability was evaluated using NMR and fluorescence emission. Our previously reported N-2-aryl-triazoles, though gave good emission, could not form stable complexes with gold cations. A new N-fused-triazole(NFT) derivative was prepared and the ligand indicated good fluorescence emission, and formed strong coordination with gold cations. Both ligand and complex were characterized by X-ray crystallography. Fluorescence properties of various gold complexes(with different primary ligands) were evaluated, which suggested the feasibility of using fluorescence emission as potential tools for future mechanistic investigation.展开更多
基金This work was supported by the National Key R&D Program of China(2018YFA0901500)the National Natural Science Foundation of China(21706124,21727818)+1 种基金the Key Science and Technology Project of Jiangsu Province(BE2016389)the Jiangsu Synergetic Innovation Center for Advanced Bio-Manufacture of China.
文摘L-malate is an intermediate of the tricarboxylic acid cycle which is naturally occurred in various microorganisms,and it has been widely applied in polymer,beverage and food,textile,agricultural and pharmaceutical industries.Driven by the pursuit of a sustainable economy,microbial production of L-malate has received much attention in last decades.In this review,we focus on the utilization of wastes and/or byproducts as feedstocks for the microbial production of L-malate.Firstly,we present the recent developments on the natural or engineered metabolic pathways that dedicate to the biosynthesis of L-malate,and also provide a comprehensive discussions on developing high-efficient producers.Then,the recent achievements in microbial production of L-malate from various carbon sources were concluded and discussed.Furthermore,some abundant non-food feedstocks which have been used for microbial production of other chemicals were reviewed,as they may be potential candidate feedstock for L-malate production in future.Finally,we outlined the major challenges and proposed further improvements for the production of L-malate.
基金supported by the National Natural Science Foundation of China(No.82172382)Beijing Municipal Natural Science Foundation(Nos.7222133 and L222096)National High Level Hospital Clinical Research Funding(Nos.2022-PUMCH-B-122 and 2022-PUMCH-A-045).
文摘To the Editor:The treatment principle for pediatric spinal deformity is not only to control the spinal deformity but also to maintain the development of the spine and the chest and the mobility of the spine.To achieve this goal,various kinds of growth-friendly implants have been introduced over the last two decades,which can be divided into three categories,including distraction-based,compression-based,and guided growth systems.The aim of this article is to comprehensively review the currently available growth-friendly implants for pediatric spinal deformity,especially the advancements made in recent decades,to provide reference for clinical treatment and implant design.
基金supported by the Natural Science Foundation of the United States(CHE-1362057,CHE-1336071)the National Natural Science Foundation of China(21228204)
文摘Fluorescence active fused-triazole was developed as a ligand in gold(I) cation coordination. The coordination ability was evaluated using NMR and fluorescence emission. Our previously reported N-2-aryl-triazoles, though gave good emission, could not form stable complexes with gold cations. A new N-fused-triazole(NFT) derivative was prepared and the ligand indicated good fluorescence emission, and formed strong coordination with gold cations. Both ligand and complex were characterized by X-ray crystallography. Fluorescence properties of various gold complexes(with different primary ligands) were evaluated, which suggested the feasibility of using fluorescence emission as potential tools for future mechanistic investigation.
