Satellite constellations are promising in enabling the global Internet.However,the increasing constellation size also complicates tracking,telemetry and command(TT&C)systems.Traditional groundbased and space-based...Satellite constellations are promising in enabling the global Internet.However,the increasing constellation size also complicates tracking,telemetry and command(TT&C)systems.Traditional groundbased and space-based approaches have encountered significant obstacles due to,e.g.,the limited satellite visible arc and long transmission delay.Considering the fast development of intersatellite communications,synergy among multiple connected satellites can be exploited to facilitate TT&C system designs.This leads to networked TT&C,which requires much less predeployed infrastructures and even performs better than traditional TT&C systems.In this paper,we elaborate system characteristics of networked TT&C compared with traditional ground-based and spacebased TT&C,and propose the unique security challenges and opportunities for networked TT&C,which includes secure routing and trust mechanisms.Furthermore,since networked TT&C is a novel scenario with few relevant researches,we first investigate the current researches on secure routing and trust mechanisms for traditional terrestrial and satellite networks,and then accordingly deliver our security perspectives considering the system characteristics and security requirements of networked TT&C.展开更多
The safety of submerged buoy is higher than traditional buoy. The most important problem for submerged buoy is that signal will be attenuated greatly due to ocean wave fluctuation and seawater. On the basis of ocean w...The safety of submerged buoy is higher than traditional buoy. The most important problem for submerged buoy is that signal will be attenuated greatly due to ocean wave fluctuation and seawater. On the basis of ocean wave model, propagation characteristics of electromagnetic wave in seawater channel for submerged buoy is analyzed in this letter. It includes the propagation properties of electromagnetic wave in seawater and across the air-sea interface. The results show that the VHF frequency band, first order sea level and water depth of less than 10 cm are acceptable for submerged buoy.展开更多
Host-microbiome interactions are crucial for physiological homeostasis and disease progression.While traditional microbiome research provided foundational insights,multi-omics approaches enable a more comprehensive an...Host-microbiome interactions are crucial for physiological homeostasis and disease progression.While traditional microbiome research provided foundational insights,multi-omics approaches enable a more comprehensive and systems-level understanding.However,integrating multi-omics data presents significant methodological challenges,including inconsistent sample coverage,heterogeneous data formats,and complex analytical workflows,which collectively impair reproducibility and reliability.To address these critical challenges,we developed the EasyMultiProfiler(EMP),a streamlined and efficient analytical workflow.EMP utilizes SummarizedExperiment and MultiAssayExperiment classes to establish a unified multi-omics data storage and analysis framework.Its architecture comprises five interconnected functional modules:data extraction,preparation,support,analysis,and visualization,integrated into a user-friendly and natural language-style workflow.This design offers an efficient and standardized solution,directly resolving data integration issues,workflow standardization,and result reproducibility.EMP provides researchers and clinicians with a robust and flexible platform to systematically extract biologically relevant insights from complex multi-omics datasets,overcoming key barriers in contemporary microbiome research.展开更多
Skeletal muscle plays a significant role in both local and systemic energy metabolism.The current investigation aims to explore the role of the Bambi gene in skeletal muscle,focusing on its implications for muscle hyp...Skeletal muscle plays a significant role in both local and systemic energy metabolism.The current investigation aims to explore the role of the Bambi gene in skeletal muscle,focusing on its implications for muscle hypertrophy and systemic metabolism.We hypothesize that skeletal muscle-specific deletion of Bambi induces muscle hypertrophy,improves metabolic performance,and activates thermogenic adipocytes via the reprogramming of progenitor of iWAT,offering potential therapeutic strategies for metabolic syndromes.Leveraging the Chromatin immunoprecipitation(ChIP)-seq and bioinformatics analysis,Bambi gene is shown to be a direct target of HIF2α,which is further confirmed by ChIP-qPCR and promoter luciferase assay.Skeletal muscle-specific Bambi deletion led to significant muscle hypertrophy and improved metabolic parameters,even under high-fat diet conditions.This deletion induced metabolic reprogramming of stromal vascular fractions(SVFs)into thermogenic adipocytes,contributing to systemic metabolic improvements,potentially through the secretory factor.Notably,mice with skeletal muscle-specific Bambi deletion demonstrate resistance to high-fat diet-induced metabolic disorders,highlighting a potential therapeutic pathway for metabolic syndrome management.Thus,skeletal muscle-specific deletion of Bambi triggers muscle growth,enhances metabolic performance,and activates thermogenic adipocytes.These findings suggest Bambi as a novel therapeutic target for metabolic syndromes,providing new insights into the interaction between muscle hypertrophy and systemic metabolic improvement.The study underscores the potential of manipulating muscle physiology to regulate whole-body metabolism,offering a novel perspective on treating metabolic disorders.展开更多
基金supported by the National Natural Science Foundation of China under Grant 61971261/62131012Technology Project of the State Grid Corporation of China under Grant 5400202255158A-1-1-ZN。
文摘Satellite constellations are promising in enabling the global Internet.However,the increasing constellation size also complicates tracking,telemetry and command(TT&C)systems.Traditional groundbased and space-based approaches have encountered significant obstacles due to,e.g.,the limited satellite visible arc and long transmission delay.Considering the fast development of intersatellite communications,synergy among multiple connected satellites can be exploited to facilitate TT&C system designs.This leads to networked TT&C,which requires much less predeployed infrastructures and even performs better than traditional TT&C systems.In this paper,we elaborate system characteristics of networked TT&C compared with traditional ground-based and spacebased TT&C,and propose the unique security challenges and opportunities for networked TT&C,which includes secure routing and trust mechanisms.Furthermore,since networked TT&C is a novel scenario with few relevant researches,we first investigate the current researches on secure routing and trust mechanisms for traditional terrestrial and satellite networks,and then accordingly deliver our security perspectives considering the system characteristics and security requirements of networked TT&C.
文摘The safety of submerged buoy is higher than traditional buoy. The most important problem for submerged buoy is that signal will be attenuated greatly due to ocean wave fluctuation and seawater. On the basis of ocean wave model, propagation characteristics of electromagnetic wave in seawater channel for submerged buoy is analyzed in this letter. It includes the propagation properties of electromagnetic wave in seawater and across the air-sea interface. The results show that the VHF frequency band, first order sea level and water depth of less than 10 cm are acceptable for submerged buoy.
基金supported by the National Natural Science Foundation of China(32170013)the CAMS Initiative for Innovative Medicine(2021-I2M-1-031)+1 种基金the Science and Technology Project of Xizang Autonomous Region(XZ202402ZD0002)Science and Technology Program of Inner Mongolia Autonomous Region(2023YFDZ0076).
文摘Host-microbiome interactions are crucial for physiological homeostasis and disease progression.While traditional microbiome research provided foundational insights,multi-omics approaches enable a more comprehensive and systems-level understanding.However,integrating multi-omics data presents significant methodological challenges,including inconsistent sample coverage,heterogeneous data formats,and complex analytical workflows,which collectively impair reproducibility and reliability.To address these critical challenges,we developed the EasyMultiProfiler(EMP),a streamlined and efficient analytical workflow.EMP utilizes SummarizedExperiment and MultiAssayExperiment classes to establish a unified multi-omics data storage and analysis framework.Its architecture comprises five interconnected functional modules:data extraction,preparation,support,analysis,and visualization,integrated into a user-friendly and natural language-style workflow.This design offers an efficient and standardized solution,directly resolving data integration issues,workflow standardization,and result reproducibility.EMP provides researchers and clinicians with a robust and flexible platform to systematically extract biologically relevant insights from complex multi-omics datasets,overcoming key barriers in contemporary microbiome research.
基金supported by National Natural Science Foundation of China(82072436)Guangdong Basic and Applied Basic Research Foundation(2020B1515020046)‘GDAS’Project of Science and Technology Development(2021GDASYL-20210102003,2018GDASCX-0102)。
文摘Skeletal muscle plays a significant role in both local and systemic energy metabolism.The current investigation aims to explore the role of the Bambi gene in skeletal muscle,focusing on its implications for muscle hypertrophy and systemic metabolism.We hypothesize that skeletal muscle-specific deletion of Bambi induces muscle hypertrophy,improves metabolic performance,and activates thermogenic adipocytes via the reprogramming of progenitor of iWAT,offering potential therapeutic strategies for metabolic syndromes.Leveraging the Chromatin immunoprecipitation(ChIP)-seq and bioinformatics analysis,Bambi gene is shown to be a direct target of HIF2α,which is further confirmed by ChIP-qPCR and promoter luciferase assay.Skeletal muscle-specific Bambi deletion led to significant muscle hypertrophy and improved metabolic parameters,even under high-fat diet conditions.This deletion induced metabolic reprogramming of stromal vascular fractions(SVFs)into thermogenic adipocytes,contributing to systemic metabolic improvements,potentially through the secretory factor.Notably,mice with skeletal muscle-specific Bambi deletion demonstrate resistance to high-fat diet-induced metabolic disorders,highlighting a potential therapeutic pathway for metabolic syndrome management.Thus,skeletal muscle-specific deletion of Bambi triggers muscle growth,enhances metabolic performance,and activates thermogenic adipocytes.These findings suggest Bambi as a novel therapeutic target for metabolic syndromes,providing new insights into the interaction between muscle hypertrophy and systemic metabolic improvement.The study underscores the potential of manipulating muscle physiology to regulate whole-body metabolism,offering a novel perspective on treating metabolic disorders.
