The microstructural evolution of a cold-rolled and intercritical annealed medium-Mn steel(Fe-0.10C-5Mn)was investigated during uniaxial tensile testing.In-situ observations under scanning electron microscopy,transmiss...The microstructural evolution of a cold-rolled and intercritical annealed medium-Mn steel(Fe-0.10C-5Mn)was investigated during uniaxial tensile testing.In-situ observations under scanning electron microscopy,transmission electron microscopy,and X-ray diffraction analysis were conducted to characterize the progressive transformation-induced plasticity process and associated fracture initiation mechanisms.These findings were discussed with the local strain measurements via digital image correlation.The results indicated that Lüders band formation in the steel was limited to 1.5%strain,which was mainly due to the early-stage martensitic phase transformation of a very small amount of the less stable large-sized retained austenite(RA),which led to localized stress concentrations and strain hardening and further retardation of yielding.The small-sized RA exhibited high stability and progressively transformed into martensite and contributed to a stably extended Portevin-Le Chatelier effect.The volume fraction of RA gradually decreased from 26.8%to 8.2%prior to fracture.In the late deformation stage,fracture initiation primarily occurred at the austenite/martensite and ferrite/martensite interfaces and the ferrite phase.展开更多
In the non-uniform stress field, the surrounding rock plastic zone of the circular roadway shows different shapes under the different confining pressure conditions. Based on the boundary shape characteristics of the p...In the non-uniform stress field, the surrounding rock plastic zone of the circular roadway shows different shapes under the different confining pressure conditions. Based on the boundary shape characteristics of the plastic zone, the characteristic radii of the plastic zone were proposed, namely the horizontal,longitudinal and medial axis radii, which could reflect the plastic zone shapes characteristics and classify the sizes of the key parts. On the theoretical basis of elastic-plastic mechanics, analytical solutions for the characteristic radii were obtained by theoretical deduction, and the relationships between the characteristic radii and key influencing factors were analyzed. Finally, the evaluation criterion of the circular roadway surrounding rock plastic zone shapes, evaluation criterion of the location of potential hazards caused by the roadway surrounding rock and evaluation critical points of roadway dynamic disasters based on characteristic radii were proposed. This work could provide a theoretical basis for stability analysis of the surrounding rock, support design, and guide the prevention and control of dynamic roadway disasters.展开更多
The Ailaoshan-Red River（ASRR） shear zone in SW China represents an important discontinuity believed to have accommodated eastward extrusion of the Tibetan Plateau in response to the collision of the Indian and Euras...The Ailaoshan-Red River（ASRR） shear zone in SW China represents an important discontinuity believed to have accommodated eastward extrusion of the Tibetan Plateau in response to the collision of the Indian and Eurasian plates. The onset timing and duration of the ASRR sinistral strike-slip shearing have been hotly disputed. In this paper we present new zircon LA-ICP-MS U-Pb geochronological data from six syntectonic granitic mylonite and leucosomes samples from the ASRR shear zone. Our data reveal a metamorphic age of ~40 Ma, most likely suggesting the maximum age of the shearing initiation. Rocks showing syn-kinematic signatures yield crystallization ages of 38–22 Ma, with inherited components ranging from 716 to 108 Ma. These results, together with existing geological and geochronological data, indicate that the sinistral shearing along the ASRR zone probably began at 40 Ma, mainly activated at 29–22 Ma and lasted at least to ~22 Ma. Our data suggest a continuous extrusion between the Indochina and South China blocks during ~35–17 Ma. The ASRR sinistral shearing has accommodated large scale eastward displacement of the southeastern Tibetan syntaxis, and is likely responsible for the opening of the South China Sea.展开更多
The assessment of the spatiotemporal evolution of habitat quality caused by land use changes can provide a scientifc basis for the ecological protection and green development of mining cities.Taking Yanshan County as ...The assessment of the spatiotemporal evolution of habitat quality caused by land use changes can provide a scientifc basis for the ecological protection and green development of mining cities.Taking Yanshan County as an example of a typical mining city,this article discussed the spatial pattern and evolution characteristics of habitat quality in 2000 and 2018 based on the ArcGIS platform and the InVEST model.The conclusions are as below:from 2000 to 2018,the area of farmland and construction land changed the most in the study area.Among them,the area of farmland decreased by 3.48%,and the area of industrial and mining land and construction land increased by 53.25%.Areas of low,relatively low and high habitat quality expanded,and areas of medium and relatively high habitat quality shrank,which is closely related to the distribution of land use.The areas with high habitat degradation degrees appear around cities,mining areas and watersheds,while the areas with low habitat degradation degrees are mainly distributed in the southern woodland.The distribution of cold and hot spots in the habitat quality distribution of Yanshan County presents a pattern of“hot in the south and cold in the north”.The results are of great signifcance to the precise implementation of ecosystem management decisions in mining cities and the creation of a landscape pattern of“beautiful countrysides,green cities,and green mines”.展开更多
The rockburst dynamic disasters in the process of deep coal mining become more and more serious.Taking the rockburst occurred in the 23130 working face of Yuejin Coal Mine as the engineering background,we study the ch...The rockburst dynamic disasters in the process of deep coal mining become more and more serious.Taking the rockburst occurred in the 23130 working face of Yuejin Coal Mine as the engineering background,we study the characteristics of mining stress feld around roadway,the plastic failure morphological characteristics of surrounding rock and the accumulation/release law of elastic energy before and after burst.An analysis model quantitatively describing the physical process of rockburst in the mining roadway is established,and the calculation method of dynamic release of elastic energy in the physical process of rockburst is educed.The mechanism of rockburst in mining roadway is revealed.The results show that an“L-shaped”stress concentration zone is formed within 100 m of the 23130 working face,and the principal stress ratio of the surrounding rock of the transportation roadway is 2.59–4.26.The change of the direction of the maximum principal stress has a signifcant efect on the burst appearance characteristics.The failure strength of diferent sections of the mining roadway is characterized by the elastic energy release value.With the increase of the working face distance,the elastic energy released by burst failure and the expansion variation of failure boundary radius show a nonlinear variation law that tends to decrease steadily after sharp fuctuation.The closer to the working face,the higher the burst risk.At a distance of 10 m from the working surface,the maximum principal stress reaches its maximum value.The butterfy-shaped failure system generated by the surrounding rock of the roadway has energy self-sustainability,and the elastic energy released by the sudden expansion of the butterfy leaf is enough to cause a burst damage of 1.9 magnitude.This work could provide theoretical support for the prediction and prevention of rockburst.展开更多
The influences of hydrogen on the mechanical properties and the fracture behaviour of Fe-22Mn-0.6C twinning induced plasticity steel have been investigated by slow strain rate tests and fractographic analysis.The stee...The influences of hydrogen on the mechanical properties and the fracture behaviour of Fe-22Mn-0.6C twinning induced plasticity steel have been investigated by slow strain rate tests and fractographic analysis.The steel showed high susceptibility to hydrogen embrittlement,which led to 62.9%and 74.2%reduction in engineering strain with 3.1 and 14.4 ppm diffusive hydrogen,respectively.The fracture surfaces revealed a transition from ductile to brittle dominated fracture modes with the rising hydrogen contents.The underlying deformation and fracture mechanisms were further exploited by examining the hydrogen effects on the dislocation substructure,stacking fault probability,and twinning behaviour in pre-strained slow strain rate test specimens and notched tensile specimens using coupled electron channelling contrast imaging and electron backscatter diffraction techniques.The results reveal that the addition of hydrogen promotes planar dislocation structures,earlier nucleation of stacking faults,and deformation twinning within those grains which have tensile axis orientations close to<111>//rolling direction and<112>//rolling direction.The developed twin lamellae result in strain localization and micro-voids at grain boundaries and eventually lead to grain boundary decohesion.展开更多
Shuozhou is a typical coal mining city,and the Pingshuo Antaibao open-pit coal mine in its area is one of the largest open-pit coal mines in China.The mining of coal resources is an important part of ensuring national...Shuozhou is a typical coal mining city,and the Pingshuo Antaibao open-pit coal mine in its area is one of the largest open-pit coal mines in China.The mining of coal resources is an important part of ensuring national energy security,and at the same time,it inevitably has a certain impact on the ecology,such as coal dust generated by open-pit mining will affect air quality,soil,water and vegetation.It is of great significance to explore the temporal and spatial variation of ecological environment quality in coal mining cities for ecological protection and sustainable social and economic development.Based on the Google Earth Engine(GEE)platform,this paper combines the index-based coal dust index(ICDI)and Remote Sensing Ecological Index(RSEI)models to construct an improved RSEI(IRSEI)that can reflect coal mining cities.This paper explores the spatial-temporal evolution characteristics and spatial correlation of ecological environment quality in Shuozhou from 2000 to 2020.The results showed that the average value of IRSEI in Shuozhou was between 0.262 and 0.418,and the overall change showed an upward trend.The growth areas of ecological environment quality are mainly located in the eastern and southwestern areas with good vegetation growth,and these regions have vigorously implemented the Northern Shelter Forest Project,afforestation and greening projects,implemented the forest resource management and protection responsibility system,promoted the construction of ecological civilization,and significantly improved the ecological environment.While the declining areas are mainly located in the central and southern regions where mining activities and human activities are more intensive.The IRSEI in the study area showed a significant spatial positive correlation,and the agglomeration types of the spatial pattern were mainly high-high and low-low agglomeration types,with the high-high agglomeration types mainly distributed in the eastern and southwestern regions,and the low-low agglomeration types distributed in the northern and south-central regions of the study area.The trend of low and low agglomeration has decreased,which further proves that the ecological restoration measures taken by the government,such as returning farmland to forests,integrating protection and restoration of mountains,waters,forests,fields,lakes,grasslands,and sands,controlling soil erosion,and stage wise reclamation of coal mining subsidence areas,have improved the ecological environment quality of Shuozhou.This study provides a reference for understanding the spatiotemporal changes of the ecological environment of coal mining cities,and is conducive to formulating appropriate ecological protection strategies.展开更多
In this study,the effect of hydrogen on dislocation and twinning behavior along various grain boundaries in a high-manganese twinning-induced plasticity steel was investigated using an in situ micropillar compression ...In this study,the effect of hydrogen on dislocation and twinning behavior along various grain boundaries in a high-manganese twinning-induced plasticity steel was investigated using an in situ micropillar compression test.The compressive stress in both elastic and plastic regimes was increased with the presence of hydrogen.Further investigation by transmission electron backscatter diffraction and scanning transmission electron microscope demonstrated that hydrogen promoted both dislocation multiplication and twin formation,which resulted in higher stress concentration at twin-twin and twin-grain boundary intersections.展开更多
The associations of individual amino acid with non-alcoholic fatty liver disease(NAFLD)risk remained unclear.The present study aimed to investigate the associations between the two in the Chinese elderly.Methods:A com...The associations of individual amino acid with non-alcoholic fatty liver disease(NAFLD)risk remained unclear.The present study aimed to investigate the associations between the two in the Chinese elderly.Methods:A community-based health check-up program was conducted in Qingdao,China.NAFLD was diagnosed by ultrasonography accompanied by epidemiological investigation.The dietary intakes of amino acids were investigated with 3-day,24-h dietary records and calculated by Nutrition Calculator software.Restricted cubic spline model was used to evaluate a nonlinear relationship between amino acid intake and NAFLD risk.Results:400 NAFLD subjects were identified,and 400 participants were randomly selected as controls and matched by gender and age(±3 years)Dose-response analysis showed that 1000 mg increment of aromatic amino acids(AAAs)was associated with reduced 16%risk of NAFLD.Dietary increments of 750 mg/d threonine,950 mg/d valine,or 1700 mg/d lysine were associated with a 20%reduction in the NAFLD risk(all P for linearity<0.05).Conclusion:The present study demonstrated that the dietary increases in milk,eggs and deep-sea fish,which are rich in the amino acids,might contribute to protecting against NAFLD in the elderly.展开更多
Background:Cardiomyocytes derived from human embryonic stem cells(hESCs)are regulated by complex and stringent gene networks during differentiation.Long non-coding RNAs(lncRNAs)exert critical epigenetic regulatory fun...Background:Cardiomyocytes derived from human embryonic stem cells(hESCs)are regulated by complex and stringent gene networks during differentiation.Long non-coding RNAs(lncRNAs)exert critical epigenetic regulatory functions in multiple differentiation processes.However,the involvement of lncRNAs in the differentiation of hESCs into cardiomyocytes has not yet been fully elucidated.Here,we identified the key roles of ZFAS1(lncRNA zinc finger antisense 1)in the differentiation of cardiomyocytes from hESCs.Methods:A model of cardiomyocyte differentiation from stem cells was established using the monolayer differentiation method,and the number of beating hESCs-derived cardiomyocytes was calculated.Gene expression was analyzed by quantitative real-time PCR(qRTPCR).Immunofluorescence assays were performed to assess the expression of cardiac troponin T(cTnT)andα-actinin protein in cardiomyocytes.Results:qRT-PCR showed that ZFAS1 expression in the mesoderm was significantly higher than that in embryonic stem cells,cardiac progenitor cells,and cardiomyocytes.Knockdown of ZFAS1 inhibited cardiomyocyte differentiation from hESCs,which was characterized by reduced expression of the cardiac-specific markers cTnT,α-actinin,myosin heavy chain 6(MYH6),and myosin heavy chain 7(MYH7).In contrast,ZFAS1 overexpression remarkably increased the percentage of spontaneously beating cardiomyocytes.In terms of the mechanism,we found that ZFAS1 is an antisense lncRNA at the 5′end of the protein-coding gene ZNFX1.Knockdown of ZFAS1 could increase the mRNA expression level of ZNFX1.Furthermore,qRT-PCR demonstrated that the silencing of ZNFX1 led to an increase in cardiac-specific markers that predicted the promotion of cardiomyocyte differentiation.Conclusion:Altogether,these data suggest that lncRNA-ZFAS1 is required for cardiac differentiation by functionally inhibiting the expression of ZNFX1,which may provide a reference for the treatment of heart disease to a certain extent.展开更多
In order to evaluate the accumulation characteristics of heavy metals in the cultivars of Agaricus bisporus in Shanxi Province and to select the varieties with high resistances to heavy metal pollution, atomic absorpt...In order to evaluate the accumulation characteristics of heavy metals in the cultivars of Agaricus bisporus in Shanxi Province and to select the varieties with high resistances to heavy metal pollution, atomic absorption spectrophotometer and the atomic fluorescence spectrophotometer were used as the determination methods to compare the heavy metal contents and accumulation characteristics of 6 different varieties. The results showed that 3 heavy metal elements （lead, chromium and cadmium） were tested in the 6 varieties of A. bisporus , all of which were contaminated by heavy metals, but basically no beyond the national standards for food safety. In general, these varieties had less quality risk and could be eaten safely. The accumulation characteristics of heavy metals in these varieties were analyzed, and the varieties were screened according to the resistance to heavy metals pollution. The results showed that variety No. 1 and No. 6 were the varieties with strong comprehensive resistance to the 3 types of heavy metal pollution, and variety No. 3 was a species with weak comprehensive ability in resisting heavy metal pollution.展开更多
Cardiac fibrosis is characterized by an elevated amount of extracellular matrix(ECM)within the heart.However,the persistence of cardiac fibrosis ultimately diminishes contractility and precipitates cardiac dysfunction...Cardiac fibrosis is characterized by an elevated amount of extracellular matrix(ECM)within the heart.However,the persistence of cardiac fibrosis ultimately diminishes contractility and precipitates cardiac dysfunction.Circular RNAs(circRNAs)are emerging as important regulators of cardiac fibrosis.Here,we elucidate the functional role of a specific circular RNA CELF1 in cardiac fibrosis and delineate a novel feedback loop mechanism.Functionally,circ-CELF1 was involved in enhancing fibrosis-related markers'expression and promoting the proliferation of cardiac fibroblasts(CFs),thereby exacerbating cardiac fibrosis.Mechanistically,circ-CELF1 reduced the ubiquitination-degradation rate of BRPF3,leading to an elevation of BRPF3 protein levels.Additionally,BRPF3 acted as a modular scaffold for the recruitment of histone acetyltransferase KAT7 to facilitate the induction of H3K14 acetylation within the promoters of the Celf1 gene.Thus,the transcription of Celf1 was dramatically activated,thereby inhibiting the subsequent response of their downstream target gene Smad7 expression to promote cardiac fibrosis.Moreover,Celf1 further promoted Celf1 pre-mRNA transcription and back-splicing,thereby establishing a feedback loop for circ-CELF1 production.Consequently,a novel feedback loop involving CELF1/circ-CELF1/BRPF3/KAT7 was established,suggesting that circ-CELF1 may serve as a potential novel therapeutic target for cardiac fibrosis.展开更多
Robo-pigeons,a novel class of hybrid robotic systems developed using brain–computer interface technology,hold marked promise for search and rescue missions due to their superior load-bearing capacity and sustained fl...Robo-pigeons,a novel class of hybrid robotic systems developed using brain–computer interface technology,hold marked promise for search and rescue missions due to their superior load-bearing capacity and sustained flight performance.However,current research remains largely confined to laboratory environments,and precise control of their flight behavior,especially flight altitude regulation,in a large-scale spatial range outdoors continues to pose a challenge.Herein,we focus on overcoming this limitation by using electrical stimulation of the locus coeruleus(LoC)nucleus to regulate outdoor flight altitude.We investigated the effects of varying stimulation parameters,including stimulation frequency(SF),interstimulus interval(ISI),and stimulation cycles(SC),on the flight altitude of robo-pigeons.The findings indicate that SF functions as a pivotal switch controlling the ascending and descending flight modes of the robo-pigeons.Specifically,60 Hz stimulation effectively induced an average ascending flight of 12.241 m with an 87.72% success rate,while 80 Hz resulted in an average descending flight of 15.655 m with a 90.52% success rate.SF below 40 Hz did not affect flight altitude change,whereas over 100 Hz caused unstable flights.The number of SC was directly correlated with the magnitude of altitude change,enabling quantitative control of flight behavior.Importantly,electrical stimulation of the LoC nucleus had no significant effects on flight direction.This study is the first to establish that targeted variation of electrical stimulation parameters within the LoC nucleus can achieve precise altitude control in robo-pigeons,providing new insights for advancing the control of flight animal–robot systems in real-world applications.展开更多
The evolution law of mechanical properties and damage characteristics of early-age flexible formwork filling concrete have a decisive influence on the stability control of surrounding rock of large deformation roadway...The evolution law of mechanical properties and damage characteristics of early-age flexible formwork filling concrete have a decisive influence on the stability control of surrounding rock of large deformation roadway. This study obtained the mechanical evolution characteristics of flexible formwork concrete filling body by using the standard ratio of engineering site and laboratory system test, clarified the time-space coupling mechanism of acoustic emission characteristic parameters and stress field evolution in the process of damage accumulation, and established a multi-parameter damage constitutive model of early-age concrete considering aging characteristics in combining with the theory of damage mechanics. The results show that:(1) Under the same curing age, the compressive strength of the filling body is significantly negatively correlated with the water-cement ratio, and the correlation decreases with the increase of the curing age, showing obvious strain softening behavior in the post-peak stage;(2) During the loading process, the concrete filling body presents a typical' three-stage' acoustic emission response characteristics, that is, the rising period of the initial micro-fracture accumulation, the active period of the main fracture development and the attenuation period after the failure;(3) At a certain curing age, with the increase of water-cement ratio, the total number of acoustic emission b-value signal points generated by the specimen during the test gradually decreases, and the b-value curve changes, and the minimum value appears near the peak stress point;and(4) The pre-peak and post-peak complete damage constitutive equations are established, which can accurately predict the mechanical response of concrete backfill under different curing times and water-cement ratios. The research results provide a basis for selecting the support time and support parameters for large deformation roadway.展开更多
In the sentence beginning'and more irreversible hydrogentrapping sites….'in this article,the value'0.38×10^(25) cm^(-3)'should have read'0.68×10^(20) cm^(-3)'.These corrections do no...In the sentence beginning'and more irreversible hydrogentrapping sites….'in this article,the value'0.38×10^(25) cm^(-3)'should have read'0.68×10^(20) cm^(-3)'.These corrections do not alter the primary conclusion that the irreversible hydrogen trap density in 42CrNiMoV steel is nearly twice that of 40CrNiMo steel.展开更多
Hydrogen embrittlement(HE)remains a critical challenge for high-strength steels.This study comparatively investigates the HE behavior and hydrogen diffusion characteristics of a vanadium-micro-alloyed 42CrNiMoV steel ...Hydrogen embrittlement(HE)remains a critical challenge for high-strength steels.This study comparatively investigates the HE behavior and hydrogen diffusion characteristics of a vanadium-micro-alloyed 42CrNiMoV steel against conventional 40CrNiMo steel through slow strain rate testing(SSRT),hydrogen thermal desorption,and hydrogen permeation measurements.The 42CrNiMoV steel demonstrated better mechanical properties and improved HE resistance under SSRT with both hydrogen pre-charged and in situ charging conditions.Microstructural analysis revealed that vanadium micro-alloying leads to grain refinement and reduces hydrogen diffusivity through vanadium carbides.Fractographic investigations revealed the environment-dependent fracture mechanisms,transitioning from ductile-to brittle-dominated failure modes under different hydrogen-charging conditions.These findings validate that vanadium micro-alloying represents a promising,cost-effective strategy for developing hydrogen-resistant high-strength steels,while emphasizing the crucial need for rigorous hydrogen ingress control in practical applications.展开更多
S-Nitros(yl)ation is a ubiquitous redox-based post-translational modification of protein cysteine thiols by nitric oxide or its derivatives,which transduces the bioactivity of nitric oxide(NO)by regulation of protein ...S-Nitros(yl)ation is a ubiquitous redox-based post-translational modification of protein cysteine thiols by nitric oxide or its derivatives,which transduces the bioactivity of nitric oxide(NO)by regulation of protein conformation,activity,stability,localization and pro-tein-protein interactions.These years,more and more S-nitrosated proteins were identified in physiological and pathological processes and the number is still growing.Here we developed a database named SNO-base(http://www.nitrosation.org),which collected S-nitrosation targets extracted from literatures up to June 1st,2012.SNObase contained 2561 instances,and provided information about S-nitrosation targets,sites,biological model,related diseases,trends of S-nitrosation level and effects of S-nitrosation on protein function.With SNObase,we did functional analysis for all the SNO targets:In the gene ontology(GO)biological process category,some processes were discovered to be related to S-nitrosation(“response to drug”,“regulation of cell motion”)besides the previously reported related processes.In the GO cellular component category,cytosol and mitochondrion were both enriched.From the KEGG pathway enrichment results,we found SNO targets were enriched in different diseases,which suggests possible significant roles of S-nitrosation in the progress of these diseases.This SNObase means to be a database with precise,comprehensive and easily accessible information,an environment to help researchers integrate data with comparison and relevancy analysis between different groups or works,and also an SNO knowledgebase offering feasibility for systemic and global analysis of S-nitrosation in interdisciplinary studies.展开更多
The N^(6)-methyladenosine(m^(6)A)modification is the most prevalent modification of eukaryotic mRNAs and plays a crucial role in various physiological processes by regulating the stability or function of target mRNAs....The N^(6)-methyladenosine(m^(6)A)modification is the most prevalent modification of eukaryotic mRNAs and plays a crucial role in various physiological processes by regulating the stability or function of target mRNAs.Accumulating evidence has suggested that m6A methylation may be involved in the pathological process of major depressive disorder(MDD),a common neuropsychiatric disorder with an unclear aetiology.Here,we found that the levels of the circular RNA HECW2(circHECW2)were significantly increased in the plasma of both MDD patients and the chronic unpredictable stress(CUS)mouse model.Notably,the downregulation of circHECW2 attenuated astrocyte dysfunction and depression-like behaviors induced by CUS.Furthermore,we demonstrated that the downregulation of circHECW2 increased the expression of the methylase WTAP,leading to an increase in Gng4 expression via m^(6)A modifications.Our findings provide functional insight into the correlation between circHECW2 and m^(6)A methylation,suggesting that circHECW2 may represent a potential target for MDD treatment.展开更多
Some mathematical models in geophysics and graphic processing need to compute integrals with scattered data on the sphere.Thus cubature formula plays an important role in computing these spherical integrals.This paper...Some mathematical models in geophysics and graphic processing need to compute integrals with scattered data on the sphere.Thus cubature formula plays an important role in computing these spherical integrals.This paper is devoted to establishing an exact positive cubature formula for spherical basis function networks.The authors give an existence proof of the exact positive cubature formula for spherical basis function networks,and prove that the cubature points needed in the cubature formula are not larger than the number of the scattered data.展开更多
Science is principally driven by the efforts of a small fraction of researchers publishing the m ajority of scientific research and garnering the m ajority of citations.The quantitative analysis of outstanding scienti...Science is principally driven by the efforts of a small fraction of researchers publishing the m ajority of scientific research and garnering the m ajority of citations.The quantitative analysis of outstanding scientists’publication and citation patterns provides a new perspective fo r understanding of scientific talents.The study of outstanding scientists can enhance our understanding of the publication and citation patterns and their scientific careers more generally.Based on 35,315 research papers from the biomedical field,we analyzed the academic productivity and influence characteristics of 244 outstanding scientists in biomedical field.Several interesting patterns are observed as follows:as outstanding scientists’career age increased,(1)their scientific output shows a trend of decreasing after increasing,(2)their academic influence shows a trend of continuous growth,(3)their number of the co-authors in their scientific career first increases and then remains stable,and(4)the number of their research areas first decreases and then increases.展开更多
基金supported by the National Key R&D Program of China(No.2017YFB0304402)。
文摘The microstructural evolution of a cold-rolled and intercritical annealed medium-Mn steel(Fe-0.10C-5Mn)was investigated during uniaxial tensile testing.In-situ observations under scanning electron microscopy,transmission electron microscopy,and X-ray diffraction analysis were conducted to characterize the progressive transformation-induced plasticity process and associated fracture initiation mechanisms.These findings were discussed with the local strain measurements via digital image correlation.The results indicated that Lüders band formation in the steel was limited to 1.5%strain,which was mainly due to the early-stage martensitic phase transformation of a very small amount of the less stable large-sized retained austenite(RA),which led to localized stress concentrations and strain hardening and further retardation of yielding.The small-sized RA exhibited high stability and progressively transformed into martensite and contributed to a stably extended Portevin-Le Chatelier effect.The volume fraction of RA gradually decreased from 26.8%to 8.2%prior to fracture.In the late deformation stage,fracture initiation primarily occurred at the austenite/martensite and ferrite/martensite interfaces and the ferrite phase.
基金supported by the National Natural Science Foundation of China (Grant No. 51234006)the National Key Research and Development Program of China (Grant No. 2016YFC0600708)
文摘In the non-uniform stress field, the surrounding rock plastic zone of the circular roadway shows different shapes under the different confining pressure conditions. Based on the boundary shape characteristics of the plastic zone, the characteristic radii of the plastic zone were proposed, namely the horizontal,longitudinal and medial axis radii, which could reflect the plastic zone shapes characteristics and classify the sizes of the key parts. On the theoretical basis of elastic-plastic mechanics, analytical solutions for the characteristic radii were obtained by theoretical deduction, and the relationships between the characteristic radii and key influencing factors were analyzed. Finally, the evaluation criterion of the circular roadway surrounding rock plastic zone shapes, evaluation criterion of the location of potential hazards caused by the roadway surrounding rock and evaluation critical points of roadway dynamic disasters based on characteristic radii were proposed. This work could provide a theoretical basis for stability analysis of the surrounding rock, support design, and guide the prevention and control of dynamic roadway disasters.
基金Supported by the National Basic Research Program of China(No.2014CB440901)the China National Natural Science Foundation(No.41190073)the Fundamental Research Funds for the Central Universities to SYSU
文摘The Ailaoshan-Red River（ASRR） shear zone in SW China represents an important discontinuity believed to have accommodated eastward extrusion of the Tibetan Plateau in response to the collision of the Indian and Eurasian plates. The onset timing and duration of the ASRR sinistral strike-slip shearing have been hotly disputed. In this paper we present new zircon LA-ICP-MS U-Pb geochronological data from six syntectonic granitic mylonite and leucosomes samples from the ASRR shear zone. Our data reveal a metamorphic age of ~40 Ma, most likely suggesting the maximum age of the shearing initiation. Rocks showing syn-kinematic signatures yield crystallization ages of 38–22 Ma, with inherited components ranging from 716 to 108 Ma. These results, together with existing geological and geochronological data, indicate that the sinistral shearing along the ASRR zone probably began at 40 Ma, mainly activated at 29–22 Ma and lasted at least to ~22 Ma. Our data suggest a continuous extrusion between the Indochina and South China blocks during ~35–17 Ma. The ASRR sinistral shearing has accommodated large scale eastward displacement of the southeastern Tibetan syntaxis, and is likely responsible for the opening of the South China Sea.
基金was funded by the Jiangxi Provincial Social Science Foundation“the 14th Five-Year Plan”(2021)regional project(21DQ44)Science and Technology Research Project of Jiangxi Provincial Department of Education(GJJ210723)+1 种基金the Doctoral Research Initiation fund of East China University of Technology(DHBK2019184)the Graduate Innovation Fund of East China University of Technology(DHYC-202123).
文摘The assessment of the spatiotemporal evolution of habitat quality caused by land use changes can provide a scientifc basis for the ecological protection and green development of mining cities.Taking Yanshan County as an example of a typical mining city,this article discussed the spatial pattern and evolution characteristics of habitat quality in 2000 and 2018 based on the ArcGIS platform and the InVEST model.The conclusions are as below:from 2000 to 2018,the area of farmland and construction land changed the most in the study area.Among them,the area of farmland decreased by 3.48%,and the area of industrial and mining land and construction land increased by 53.25%.Areas of low,relatively low and high habitat quality expanded,and areas of medium and relatively high habitat quality shrank,which is closely related to the distribution of land use.The areas with high habitat degradation degrees appear around cities,mining areas and watersheds,while the areas with low habitat degradation degrees are mainly distributed in the southern woodland.The distribution of cold and hot spots in the habitat quality distribution of Yanshan County presents a pattern of“hot in the south and cold in the north”.The results are of great signifcance to the precise implementation of ecosystem management decisions in mining cities and the creation of a landscape pattern of“beautiful countrysides,green cities,and green mines”.
基金supported by the National Natural Science Foundation of China(52004291,52130409,51874314)the Research Fund of State and Local Joint Engineering Laboratory for Gas Drainage&Ground Control of Deep Mines(Henan Polytechnic University)(SJF202003)+1 种基金the Fundamental Research Funds for the Central Universities(2022XJAQ02)the Innovative Training Program for College Students(C202112035,C202112003).
文摘The rockburst dynamic disasters in the process of deep coal mining become more and more serious.Taking the rockburst occurred in the 23130 working face of Yuejin Coal Mine as the engineering background,we study the characteristics of mining stress feld around roadway,the plastic failure morphological characteristics of surrounding rock and the accumulation/release law of elastic energy before and after burst.An analysis model quantitatively describing the physical process of rockburst in the mining roadway is established,and the calculation method of dynamic release of elastic energy in the physical process of rockburst is educed.The mechanism of rockburst in mining roadway is revealed.The results show that an“L-shaped”stress concentration zone is formed within 100 m of the 23130 working face,and the principal stress ratio of the surrounding rock of the transportation roadway is 2.59–4.26.The change of the direction of the maximum principal stress has a signifcant efect on the burst appearance characteristics.The failure strength of diferent sections of the mining roadway is characterized by the elastic energy release value.With the increase of the working face distance,the elastic energy released by burst failure and the expansion variation of failure boundary radius show a nonlinear variation law that tends to decrease steadily after sharp fuctuation.The closer to the working face,the higher the burst risk.At a distance of 10 m from the working surface,the maximum principal stress reaches its maximum value.The butterfy-shaped failure system generated by the surrounding rock of the roadway has energy self-sustainability,and the elastic energy released by the sudden expansion of the butterfy leaf is enough to cause a burst damage of 1.9 magnitude.This work could provide theoretical support for the prediction and prevention of rockburst.
文摘The influences of hydrogen on the mechanical properties and the fracture behaviour of Fe-22Mn-0.6C twinning induced plasticity steel have been investigated by slow strain rate tests and fractographic analysis.The steel showed high susceptibility to hydrogen embrittlement,which led to 62.9%and 74.2%reduction in engineering strain with 3.1 and 14.4 ppm diffusive hydrogen,respectively.The fracture surfaces revealed a transition from ductile to brittle dominated fracture modes with the rising hydrogen contents.The underlying deformation and fracture mechanisms were further exploited by examining the hydrogen effects on the dislocation substructure,stacking fault probability,and twinning behaviour in pre-strained slow strain rate test specimens and notched tensile specimens using coupled electron channelling contrast imaging and electron backscatter diffraction techniques.The results reveal that the addition of hydrogen promotes planar dislocation structures,earlier nucleation of stacking faults,and deformation twinning within those grains which have tensile axis orientations close to<111>//rolling direction and<112>//rolling direction.The developed twin lamellae result in strain localization and micro-voids at grain boundaries and eventually lead to grain boundary decohesion.
基金This research was funded by the National Natural Science Foundation of China(42377472,42174055)Jiangxi Provincial Social Science Foundation Project(23GL34)+4 种基金Humanities and social science research project of universities in Jiangxi Province(GL22228)Open Fund of Key Laboratory of Mine Environmental Monitoring and Improving around Poyang Lake of the Ministry of Natural Resources(MEMI-2021-2022-28)Science and Technology Research Project of Jiangxi Provincial Department of Education(GJJ2200741)the Graduate Innovation Fund of Jiangxi(YC2023-S557)the Doctoral Research Initiation fund of East China University of Technology(DHBK2019184).
文摘Shuozhou is a typical coal mining city,and the Pingshuo Antaibao open-pit coal mine in its area is one of the largest open-pit coal mines in China.The mining of coal resources is an important part of ensuring national energy security,and at the same time,it inevitably has a certain impact on the ecology,such as coal dust generated by open-pit mining will affect air quality,soil,water and vegetation.It is of great significance to explore the temporal and spatial variation of ecological environment quality in coal mining cities for ecological protection and sustainable social and economic development.Based on the Google Earth Engine(GEE)platform,this paper combines the index-based coal dust index(ICDI)and Remote Sensing Ecological Index(RSEI)models to construct an improved RSEI(IRSEI)that can reflect coal mining cities.This paper explores the spatial-temporal evolution characteristics and spatial correlation of ecological environment quality in Shuozhou from 2000 to 2020.The results showed that the average value of IRSEI in Shuozhou was between 0.262 and 0.418,and the overall change showed an upward trend.The growth areas of ecological environment quality are mainly located in the eastern and southwestern areas with good vegetation growth,and these regions have vigorously implemented the Northern Shelter Forest Project,afforestation and greening projects,implemented the forest resource management and protection responsibility system,promoted the construction of ecological civilization,and significantly improved the ecological environment.While the declining areas are mainly located in the central and southern regions where mining activities and human activities are more intensive.The IRSEI in the study area showed a significant spatial positive correlation,and the agglomeration types of the spatial pattern were mainly high-high and low-low agglomeration types,with the high-high agglomeration types mainly distributed in the eastern and southwestern regions,and the low-low agglomeration types distributed in the northern and south-central regions of the study area.The trend of low and low agglomeration has decreased,which further proves that the ecological restoration measures taken by the government,such as returning farmland to forests,integrating protection and restoration of mountains,waters,forests,fields,lakes,grasslands,and sands,controlling soil erosion,and stage wise reclamation of coal mining subsidence areas,have improved the ecological environment quality of Shuozhou.This study provides a reference for understanding the spatiotemporal changes of the ecological environment of coal mining cities,and is conducive to formulating appropriate ecological protection strategies.
基金X.Lu and D.Wang acknowledge the financial support from the Research Council of Norway through the project MHEAT(294689)and HyLINE(294739)。
文摘In this study,the effect of hydrogen on dislocation and twinning behavior along various grain boundaries in a high-manganese twinning-induced plasticity steel was investigated using an in situ micropillar compression test.The compressive stress in both elastic and plastic regimes was increased with the presence of hydrogen.Further investigation by transmission electron backscatter diffraction and scanning transmission electron microscope demonstrated that hydrogen promoted both dislocation multiplication and twin formation,which resulted in higher stress concentration at twin-twin and twin-grain boundary intersections.
基金supported by National Natural Science Foundation of China(NSFC:82073538 and 81773433)by the 2018 Chinese Nutrition Society(CNS)Nutrition Research Foundation-DSM Research Fund(CNS-DSM2018A30)。
文摘The associations of individual amino acid with non-alcoholic fatty liver disease(NAFLD)risk remained unclear.The present study aimed to investigate the associations between the two in the Chinese elderly.Methods:A community-based health check-up program was conducted in Qingdao,China.NAFLD was diagnosed by ultrasonography accompanied by epidemiological investigation.The dietary intakes of amino acids were investigated with 3-day,24-h dietary records and calculated by Nutrition Calculator software.Restricted cubic spline model was used to evaluate a nonlinear relationship between amino acid intake and NAFLD risk.Results:400 NAFLD subjects were identified,and 400 participants were randomly selected as controls and matched by gender and age(±3 years)Dose-response analysis showed that 1000 mg increment of aromatic amino acids(AAAs)was associated with reduced 16%risk of NAFLD.Dietary increments of 750 mg/d threonine,950 mg/d valine,or 1700 mg/d lysine were associated with a 20%reduction in the NAFLD risk(all P for linearity<0.05).Conclusion:The present study demonstrated that the dietary increases in milk,eggs and deep-sea fish,which are rich in the amino acids,might contribute to protecting against NAFLD in the elderly.
基金the National Natural Science Foundation of China[81573434 to BZC]Heilongjiang Touyan Innovation Team Program[BZC],HMU Marshal Initiative Funding(HMUMIF-21018 to BZC)National Nature Science Youth Foudation of China[82000226 to XFG].
文摘Background:Cardiomyocytes derived from human embryonic stem cells(hESCs)are regulated by complex and stringent gene networks during differentiation.Long non-coding RNAs(lncRNAs)exert critical epigenetic regulatory functions in multiple differentiation processes.However,the involvement of lncRNAs in the differentiation of hESCs into cardiomyocytes has not yet been fully elucidated.Here,we identified the key roles of ZFAS1(lncRNA zinc finger antisense 1)in the differentiation of cardiomyocytes from hESCs.Methods:A model of cardiomyocyte differentiation from stem cells was established using the monolayer differentiation method,and the number of beating hESCs-derived cardiomyocytes was calculated.Gene expression was analyzed by quantitative real-time PCR(qRTPCR).Immunofluorescence assays were performed to assess the expression of cardiac troponin T(cTnT)andα-actinin protein in cardiomyocytes.Results:qRT-PCR showed that ZFAS1 expression in the mesoderm was significantly higher than that in embryonic stem cells,cardiac progenitor cells,and cardiomyocytes.Knockdown of ZFAS1 inhibited cardiomyocyte differentiation from hESCs,which was characterized by reduced expression of the cardiac-specific markers cTnT,α-actinin,myosin heavy chain 6(MYH6),and myosin heavy chain 7(MYH7).In contrast,ZFAS1 overexpression remarkably increased the percentage of spontaneously beating cardiomyocytes.In terms of the mechanism,we found that ZFAS1 is an antisense lncRNA at the 5′end of the protein-coding gene ZNFX1.Knockdown of ZFAS1 could increase the mRNA expression level of ZNFX1.Furthermore,qRT-PCR demonstrated that the silencing of ZNFX1 led to an increase in cardiac-specific markers that predicted the promotion of cardiomyocyte differentiation.Conclusion:Altogether,these data suggest that lncRNA-ZFAS1 is required for cardiac differentiation by functionally inhibiting the expression of ZNFX1,which may provide a reference for the treatment of heart disease to a certain extent.
基金Supported by the Science and Technology Infrastructure Platform of Shanxi Province(201705D121012)the Technology Independent Innovation Capability Upgrading Project(2017zzcx-20)the Doctoral Fund Project of Shanxi Academy of Agricultural Sciences(YBSJJ1616)
文摘In order to evaluate the accumulation characteristics of heavy metals in the cultivars of Agaricus bisporus in Shanxi Province and to select the varieties with high resistances to heavy metal pollution, atomic absorption spectrophotometer and the atomic fluorescence spectrophotometer were used as the determination methods to compare the heavy metal contents and accumulation characteristics of 6 different varieties. The results showed that 3 heavy metal elements （lead, chromium and cadmium） were tested in the 6 varieties of A. bisporus , all of which were contaminated by heavy metals, but basically no beyond the national standards for food safety. In general, these varieties had less quality risk and could be eaten safely. The accumulation characteristics of heavy metals in these varieties were analyzed, and the varieties were screened according to the resistance to heavy metals pollution. The results showed that variety No. 1 and No. 6 were the varieties with strong comprehensive resistance to the 3 types of heavy metal pollution, and variety No. 3 was a species with weak comprehensive ability in resisting heavy metal pollution.
基金supported by research grants from the Noncommunicable Chronic Diseases-National Science and Technology Major Project(Nos.2024ZD0521500 and 2024ZD0521501,China)the National Natural Science Foundation of China(82270246,82070240,82470280 and 82300493)+1 种基金the Natural Science Foundation of Heilongjiang Province of China(JJ2024LH2446)China Postdoctoral Science Foundation(2023MD734169,China).
文摘Cardiac fibrosis is characterized by an elevated amount of extracellular matrix(ECM)within the heart.However,the persistence of cardiac fibrosis ultimately diminishes contractility and precipitates cardiac dysfunction.Circular RNAs(circRNAs)are emerging as important regulators of cardiac fibrosis.Here,we elucidate the functional role of a specific circular RNA CELF1 in cardiac fibrosis and delineate a novel feedback loop mechanism.Functionally,circ-CELF1 was involved in enhancing fibrosis-related markers'expression and promoting the proliferation of cardiac fibroblasts(CFs),thereby exacerbating cardiac fibrosis.Mechanistically,circ-CELF1 reduced the ubiquitination-degradation rate of BRPF3,leading to an elevation of BRPF3 protein levels.Additionally,BRPF3 acted as a modular scaffold for the recruitment of histone acetyltransferase KAT7 to facilitate the induction of H3K14 acetylation within the promoters of the Celf1 gene.Thus,the transcription of Celf1 was dramatically activated,thereby inhibiting the subsequent response of their downstream target gene Smad7 expression to promote cardiac fibrosis.Moreover,Celf1 further promoted Celf1 pre-mRNA transcription and back-splicing,thereby establishing a feedback loop for circ-CELF1 production.Consequently,a novel feedback loop involving CELF1/circ-CELF1/BRPF3/KAT7 was established,suggesting that circ-CELF1 may serve as a potential novel therapeutic target for cardiac fibrosis.
基金supported by the Research Fund of State Key Laboratory of Mechanics and Control for Aerospace Structures(grant no.1005-IZD2300225)the Scientific Research Starting Foundation of Chinese Academy of Sciences(no.E3J1230201)+1 种基金the National Key Research and Development Program of China(no.2020YFB1313504)the Science and Technology Cooperation Project of the China Electronics Technology Group Corporation.
文摘Robo-pigeons,a novel class of hybrid robotic systems developed using brain–computer interface technology,hold marked promise for search and rescue missions due to their superior load-bearing capacity and sustained flight performance.However,current research remains largely confined to laboratory environments,and precise control of their flight behavior,especially flight altitude regulation,in a large-scale spatial range outdoors continues to pose a challenge.Herein,we focus on overcoming this limitation by using electrical stimulation of the locus coeruleus(LoC)nucleus to regulate outdoor flight altitude.We investigated the effects of varying stimulation parameters,including stimulation frequency(SF),interstimulus interval(ISI),and stimulation cycles(SC),on the flight altitude of robo-pigeons.The findings indicate that SF functions as a pivotal switch controlling the ascending and descending flight modes of the robo-pigeons.Specifically,60 Hz stimulation effectively induced an average ascending flight of 12.241 m with an 87.72% success rate,while 80 Hz resulted in an average descending flight of 15.655 m with a 90.52% success rate.SF below 40 Hz did not affect flight altitude change,whereas over 100 Hz caused unstable flights.The number of SC was directly correlated with the magnitude of altitude change,enabling quantitative control of flight behavior.Importantly,electrical stimulation of the LoC nucleus had no significant effects on flight direction.This study is the first to establish that targeted variation of electrical stimulation parameters within the LoC nucleus can achieve precise altitude control in robo-pigeons,providing new insights for advancing the control of flight animal–robot systems in real-world applications.
基金supported by the National Natural Science Foundation of China (Nos. 52004289 and U22A20165)the fundamental Research Funds for the Central Universities (Nos. 2022XJNY01 and BBJ2024001)。
文摘The evolution law of mechanical properties and damage characteristics of early-age flexible formwork filling concrete have a decisive influence on the stability control of surrounding rock of large deformation roadway. This study obtained the mechanical evolution characteristics of flexible formwork concrete filling body by using the standard ratio of engineering site and laboratory system test, clarified the time-space coupling mechanism of acoustic emission characteristic parameters and stress field evolution in the process of damage accumulation, and established a multi-parameter damage constitutive model of early-age concrete considering aging characteristics in combining with the theory of damage mechanics. The results show that:(1) Under the same curing age, the compressive strength of the filling body is significantly negatively correlated with the water-cement ratio, and the correlation decreases with the increase of the curing age, showing obvious strain softening behavior in the post-peak stage;(2) During the loading process, the concrete filling body presents a typical' three-stage' acoustic emission response characteristics, that is, the rising period of the initial micro-fracture accumulation, the active period of the main fracture development and the attenuation period after the failure;(3) At a certain curing age, with the increase of water-cement ratio, the total number of acoustic emission b-value signal points generated by the specimen during the test gradually decreases, and the b-value curve changes, and the minimum value appears near the peak stress point;and(4) The pre-peak and post-peak complete damage constitutive equations are established, which can accurately predict the mechanical response of concrete backfill under different curing times and water-cement ratios. The research results provide a basis for selecting the support time and support parameters for large deformation roadway.
文摘In the sentence beginning'and more irreversible hydrogentrapping sites….'in this article,the value'0.38×10^(25) cm^(-3)'should have read'0.68×10^(20) cm^(-3)'.These corrections do not alter the primary conclusion that the irreversible hydrogen trap density in 42CrNiMoV steel is nearly twice that of 40CrNiMo steel.
基金supported by the Natural Science Foundation of Shanghai(No.23ZR1421700).
文摘Hydrogen embrittlement(HE)remains a critical challenge for high-strength steels.This study comparatively investigates the HE behavior and hydrogen diffusion characteristics of a vanadium-micro-alloyed 42CrNiMoV steel against conventional 40CrNiMo steel through slow strain rate testing(SSRT),hydrogen thermal desorption,and hydrogen permeation measurements.The 42CrNiMoV steel demonstrated better mechanical properties and improved HE resistance under SSRT with both hydrogen pre-charged and in situ charging conditions.Microstructural analysis revealed that vanadium micro-alloying leads to grain refinement and reduces hydrogen diffusivity through vanadium carbides.Fractographic investigations revealed the environment-dependent fracture mechanisms,transitioning from ductile-to brittle-dominated failure modes under different hydrogen-charging conditions.These findings validate that vanadium micro-alloying represents a promising,cost-effective strategy for developing hydrogen-resistant high-strength steels,while emphasizing the crucial need for rigorous hydrogen ingress control in practical applications.
基金supported by the National Basic Research Program of China(973 Program)(Nos.2011CB910900,2012CB911000,2011CB503900)the National Natural Sciences Foundation of China(Grant No.31030023)the Knowledge Innovation Program of the Chinese Academy of Sciences.
文摘S-Nitros(yl)ation is a ubiquitous redox-based post-translational modification of protein cysteine thiols by nitric oxide or its derivatives,which transduces the bioactivity of nitric oxide(NO)by regulation of protein conformation,activity,stability,localization and pro-tein-protein interactions.These years,more and more S-nitrosated proteins were identified in physiological and pathological processes and the number is still growing.Here we developed a database named SNO-base(http://www.nitrosation.org),which collected S-nitrosation targets extracted from literatures up to June 1st,2012.SNObase contained 2561 instances,and provided information about S-nitrosation targets,sites,biological model,related diseases,trends of S-nitrosation level and effects of S-nitrosation on protein function.With SNObase,we did functional analysis for all the SNO targets:In the gene ontology(GO)biological process category,some processes were discovered to be related to S-nitrosation(“response to drug”,“regulation of cell motion”)besides the previously reported related processes.In the GO cellular component category,cytosol and mitochondrion were both enriched.From the KEGG pathway enrichment results,we found SNO targets were enriched in different diseases,which suggests possible significant roles of S-nitrosation in the progress of these diseases.This SNObase means to be a database with precise,comprehensive and easily accessible information,an environment to help researchers integrate data with comparison and relevancy analysis between different groups or works,and also an SNO knowledgebase offering feasibility for systemic and global analysis of S-nitrosation in interdisciplinary studies.
基金This work was supported by grants from the Science and Technology Innovation 2030-Major Project of the Ministry of Science and Technology of China(2021ZD0202904/2021ZD0202900)the National Science Fund Distinguished Young Scholars(82025033,China)+4 种基金the National Natural Science Foundation of China(82230115,82273914,81903591,82372024,82003733)the Natural Science Foundation of Jiangsu Province(BK20200358,China)ZhiShan Scholar Program of Southeast University(2242022R40059 and 2242021R40023,China)the Jiangsu Provincial Key Laboratory of Critical Care Medicine(JSKLCCM-2022-02-008,China)the Open Project Program of the Key Laboratory of Developmental Genes and Human Diseases of the Ministry of Education(LDGHD202304,China).
文摘The N^(6)-methyladenosine(m^(6)A)modification is the most prevalent modification of eukaryotic mRNAs and plays a crucial role in various physiological processes by regulating the stability or function of target mRNAs.Accumulating evidence has suggested that m6A methylation may be involved in the pathological process of major depressive disorder(MDD),a common neuropsychiatric disorder with an unclear aetiology.Here,we found that the levels of the circular RNA HECW2(circHECW2)were significantly increased in the plasma of both MDD patients and the chronic unpredictable stress(CUS)mouse model.Notably,the downregulation of circHECW2 attenuated astrocyte dysfunction and depression-like behaviors induced by CUS.Furthermore,we demonstrated that the downregulation of circHECW2 increased the expression of the methylase WTAP,leading to an increase in Gng4 expression via m^(6)A modifications.Our findings provide functional insight into the correlation between circHECW2 and m^(6)A methylation,suggesting that circHECW2 may represent a potential target for MDD treatment.
基金Project supported by the Key Program of the National Natural Science Foundation of China(No.11131006)the National Natural Science Foundation of China(Nos.61075054,90818020,60873206)
文摘Some mathematical models in geophysics and graphic processing need to compute integrals with scattered data on the sphere.Thus cubature formula plays an important role in computing these spherical integrals.This paper is devoted to establishing an exact positive cubature formula for spherical basis function networks.The authors give an existence proof of the exact positive cubature formula for spherical basis function networks,and prove that the cubature points needed in the cubature formula are not larger than the number of the scattered data.
基金supported partially by the National Natural Science Foundation of China(Grant Nos.72174016)。
文摘Science is principally driven by the efforts of a small fraction of researchers publishing the m ajority of scientific research and garnering the m ajority of citations.The quantitative analysis of outstanding scientists’publication and citation patterns provides a new perspective fo r understanding of scientific talents.The study of outstanding scientists can enhance our understanding of the publication and citation patterns and their scientific careers more generally.Based on 35,315 research papers from the biomedical field,we analyzed the academic productivity and influence characteristics of 244 outstanding scientists in biomedical field.Several interesting patterns are observed as follows:as outstanding scientists’career age increased,(1)their scientific output shows a trend of decreasing after increasing,(2)their academic influence shows a trend of continuous growth,(3)their number of the co-authors in their scientific career first increases and then remains stable,and(4)the number of their research areas first decreases and then increases.
