We sought to determine risk factors associated with fetal macrosomia and to explore the long-term consequence of infant macrosomia at the age of 7 years.A prospective population based cohort study was designed to exam...We sought to determine risk factors associated with fetal macrosomia and to explore the long-term consequence of infant macrosomia at the age of 7 years.A prospective population based cohort study was designed to examine the associations between maternal and perinatal characteristics and the risk of macrosomia.A nested case-control study was conducted to explore the long-term health consequence of infant macrosomia.The mean maternal age of the macrosomia group was 24.74±3.32 years,which is slightly older than that in the control group（24.35±3.14 years,P = 0.000）.The mean maternal body mass index（BMI） at early pregnancy was 22.75±2.81 kg/m 2,which was also higher than that in the control group（21.76±2.59 kg/m 2,P = 0.000）.About 64.6% of macrosomic neonates were males,compared with 51.0% in the control group（P = 0.000）.Compared with women with normal weight（BMI：18.5-23.9 kg/m 2）,women who were overweight（BMI：24-27.9 kg/m 2） or obese（BMI ≥ 28 kg/m 2）,respectively,had a 1.69-fold（P = 0.000） and a 1.49-fold（P = 0.000） increased risks of having a neonate with macrosomia,while light weight（BMI〈18.5 kg/m 2） women had an approximately 50% reduction of the risk.Furthermore,macrosomia infant had a 1.52-fold and 1.50-fold risk,respectively,of developing overweight or obesity at the age of 7 years（P = 0.001 and P = 0.000）.Older maternal age,higher maternal BMI at early pregnancy and male gender were independent risk factors of macrosomia.Macrosomic infant was associated with an increased predisposition to develop overweight or obesity at the beginning of their childhood.展开更多
Diabetic nephropathy(DN)is one of the major microvascular complications of diabetes mellitus and a major cause of end-stage renal disease(ESRD).The pathogenesis of DN is unknown,but it is closely related to disorders ...Diabetic nephropathy(DN)is one of the major microvascular complications of diabetes mellitus and a major cause of end-stage renal disease(ESRD).The pathogenesis of DN is unknown,but it is closely related to disorders of glucolipid metabolism,abnormal hemodynamics,chronic inflammatory response,oxidative stress,and genetics.Once DN develops into ESRD,it is often more difficult to treat than ESRD caused by other kidney diseases.Therefore,a deeper knowledge of the pathophysiological mechanisms of DN and the discovery of candidate markers for early diagnosis are mandatory.Exosomes secreted by renal cells can regulate a series of pathophysiological processes such as translation and transcription by releasing miRNAs or proteins,thereby regulating the biological functions and phenotype of recipient kidney cells.It has been found that miRNA secreted by urinary exosomes in patients with DN is involved in the occurrence and development of DN and may become biological markers.1 However,studies on exosome proteins are relatively few and lack validation in humans.In the present study,we identified an altered pathway in urinary exosomes from DN patients for the first time.Notably,the altered ferroptosis-related proteins may represent novel candidate markers for early progression of disease and/or early treatment effects.展开更多
基金supported by grants from the Jiangsu Birth Defects Intervention Program(No.JS200302)the Natural Science Foundation of Jiangsu Province(No.BK2008501)
文摘We sought to determine risk factors associated with fetal macrosomia and to explore the long-term consequence of infant macrosomia at the age of 7 years.A prospective population based cohort study was designed to examine the associations between maternal and perinatal characteristics and the risk of macrosomia.A nested case-control study was conducted to explore the long-term health consequence of infant macrosomia.The mean maternal age of the macrosomia group was 24.74±3.32 years,which is slightly older than that in the control group（24.35±3.14 years,P = 0.000）.The mean maternal body mass index（BMI） at early pregnancy was 22.75±2.81 kg/m 2,which was also higher than that in the control group（21.76±2.59 kg/m 2,P = 0.000）.About 64.6% of macrosomic neonates were males,compared with 51.0% in the control group（P = 0.000）.Compared with women with normal weight（BMI：18.5-23.9 kg/m 2）,women who were overweight（BMI：24-27.9 kg/m 2） or obese（BMI ≥ 28 kg/m 2）,respectively,had a 1.69-fold（P = 0.000） and a 1.49-fold（P = 0.000） increased risks of having a neonate with macrosomia,while light weight（BMI〈18.5 kg/m 2） women had an approximately 50% reduction of the risk.Furthermore,macrosomia infant had a 1.52-fold and 1.50-fold risk,respectively,of developing overweight or obesity at the age of 7 years（P = 0.001 and P = 0.000）.Older maternal age,higher maternal BMI at early pregnancy and male gender were independent risk factors of macrosomia.Macrosomic infant was associated with an increased predisposition to develop overweight or obesity at the beginning of their childhood.
基金the Shanghai Municipal Health Commission health Industry clinical research special project(No.20214Y0353)Excellent young cultivation plan of Shanghai Pudong New Area Health System(No.PWRq2021-27)+1 种基金Top-100 Talent Cultivation Plan of Shanghai University of Medicine and Health Sciences(No.A3-0200-22-311007)The second round of medical discipline construction project of Pudong New Area-clinical characteristic discipline(No.PWYts2021-09).
文摘Diabetic nephropathy(DN)is one of the major microvascular complications of diabetes mellitus and a major cause of end-stage renal disease(ESRD).The pathogenesis of DN is unknown,but it is closely related to disorders of glucolipid metabolism,abnormal hemodynamics,chronic inflammatory response,oxidative stress,and genetics.Once DN develops into ESRD,it is often more difficult to treat than ESRD caused by other kidney diseases.Therefore,a deeper knowledge of the pathophysiological mechanisms of DN and the discovery of candidate markers for early diagnosis are mandatory.Exosomes secreted by renal cells can regulate a series of pathophysiological processes such as translation and transcription by releasing miRNAs or proteins,thereby regulating the biological functions and phenotype of recipient kidney cells.It has been found that miRNA secreted by urinary exosomes in patients with DN is involved in the occurrence and development of DN and may become biological markers.1 However,studies on exosome proteins are relatively few and lack validation in humans.In the present study,we identified an altered pathway in urinary exosomes from DN patients for the first time.Notably,the altered ferroptosis-related proteins may represent novel candidate markers for early progression of disease and/or early treatment effects.
