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Effects of oatβ-glucan-based prebiotic blended formulas on defecation and gut microbiota in Chinese adults:a randomized clinical trial
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作者 Aiqi Li Lei Jin +13 位作者 Hui Xia Meiyuan Feng Xirui Zhou Yifang Chu Feng Liu Lanxing Jia Ximin Chen Dengfeng xu Shanjie Ma xiaofan xu Xinyu Wang Xiaoqing Li Guiju Sun Liegang Liu 《Food Science and Human Wellness》 2025年第6期2126-2135,共10页
Digestive health is important for overall well-being,but gut health problems are common in the Chinese population.The objective of this study was to investigate the effects of oatβ-glucan-based prebiotic blended form... Digestive health is important for overall well-being,but gut health problems are common in the Chinese population.The objective of this study was to investigate the effects of oatβ-glucan-based prebiotic blended formulas in humans on digestive health by assessing defecation frequency,defecation symptoms,stool quality,self-reported digestive feelings,defecation satisfaction,and gut bacteria.A parallel,randomized,double-blind,controlled trial was conducted in 168 eligible adults randomized to 3 groups for 14 days:Intervention groups A and B received 2 different doses of oatβ-glucan-based prebiotic blended formulas and a Control group received oatβ-glucan mixed with hydroxypropylmethyl-cellulose and microcrystalline cellulose.Participants completed a defecation diary and Bristol stool chart daily and digestive system questionnaires weekly.Fecal samples were collected on day 0 and day 14 to evaluate gut bacteria using 16S rDNA analysis.Both formulas improved defecation frequency,stool quality,defecation symptoms,defecation satisfaction,and on digestive health of human,compared with baseline(P<0.05).Both formulas led to increased quantities of Bifidobacterium and Akkermansia bacteria,compared to control,on day 14.This study therefore demonstrated the beneficial effects of oatβ-glucan-based prebiotic blended formulas on gut health in generally healthy Chinese adults.These formulas are a feasible nutritional strategy for digestive health. 展开更多
关键词 OAT Β-GLUCAN Prebiotic Defecation frequency Stool quality Digestive health Gut microbiota
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<i>Cedecea lapagei</i>in a Patient with Multiple Injuries: Report of a Rare Case
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作者 xiaofan xu Kaiyue Chang +9 位作者 Dongxue Song Guangtong Tian Xiaohang Hu Liqing Jiang Bin Zhang Qingli Bie Shuhua Lu Xiaozhe Li Haixin Dong Chengqiang Jin 《Journal of Biosciences and Medicines》 2021年第11期1-5,共5页
<em>Cedecea lapagei </em>(<em>C. lapagei</em>) is an opportunistic pathogen in old patients with many comorbid diseases and the immunosuppressed. It is a gram-negative, facultative anaerobe bac... <em>Cedecea lapagei </em>(<em>C. lapagei</em>) is an opportunistic pathogen in old patients with many comorbid diseases and the immunosuppressed. It is a gram-negative, facultative anaerobe bacterium of the <em>Enterobacteriaceae</em> family. We present a rare case of a patient with multiple injuries, <em>C. lapagei</em> was found from the exudate of the wound, what’s more, the <em>Proteus vulgaris</em> was also found in blood culture medium at the same time. According to the available literature, this is the first case of simultaneous infection of two bacteria including <em>C. lapagei </em>and <em>Proteus vulgaris</em> from the exudate of the traumatic wound. 展开更多
关键词 C. lapagei Cedecea Proteus vulgaris EXUDATE
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瘤内微生物与肿瘤免疫治疗的研究进展 被引量:3
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作者 徐晓帆 陈长仁 +4 位作者 胡雯蕾 吴学婷 周韧超 汪飞宇 吕巧莉 《中国肿瘤临床》 CAS CSCD 北大核心 2024年第12期622-627,共6页
随着对肿瘤免疫应答机制的深入探索,研究揭示了肿瘤微环境内微生物群落对于肿瘤进展及其与宿主免疫系统相互作用的重要性。这些位于肿瘤内部的微生物能够对肿瘤微环境施加影响,从而促进或抑制肿瘤的生长与发展。尽管如此,肿瘤内微生物... 随着对肿瘤免疫应答机制的深入探索,研究揭示了肿瘤微环境内微生物群落对于肿瘤进展及其与宿主免疫系统相互作用的重要性。这些位于肿瘤内部的微生物能够对肿瘤微环境施加影响,从而促进或抑制肿瘤的生长与发展。尽管如此,肿瘤内微生物群对于肿瘤免疫治疗效应的具体作用仍有待深入研究。对肿瘤特异性微生物群特征及其生物学功能的深入了解,预示着针对肿瘤治疗可能迎来新的革命。本文综述了肿瘤内微生物的发现和来源,讨论了肿瘤组织的特征及瘤内微生物的组成;同时简要回顾肿瘤免疫治疗的历史发展,特别是聚焦于瘤内微生物对肿瘤免疫治疗影响的研究进展,并探讨了结合瘤内微生物靶向疗法与免疫治疗可能提升免疫疗效、抑制肿瘤发展并提高治愈率的新兴策略并展望了该策略作为提高治疗成效和前景的新方向。 展开更多
关键词 瘤内微生物 免疫治疗 靶向治疗
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Tunable Emissions in Zero-Dimensional(C_(6)H_(5)CH_(2)NH_(3))_(3)InBr_(6)Enabled by Controlled Structural Amorphization
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作者 Qian Li Bin xu +2 位作者 xiaofan xu Yayun Wang Zewei Quan 《Aggregate》 2025年第5期252-259,共8页
Zero-dimensional(0D)hybrid metal halides(HMHs)hold great promise as multifunctional emitters.However,precise functionalization of organic moieties and controlled modulation of self-trapped exciton(STE)emission from in... Zero-dimensional(0D)hybrid metal halides(HMHs)hold great promise as multifunctional emitters.However,precise functionalization of organic moieties and controlled modulation of self-trapped exciton(STE)emission from inorganic polyhedra remain challenging.This study introduces 0D(PMA)_(3)InBr_(6)(PMA+=C_(6)H_(5)CH_(2)NH_(3)^(+))as a multifunctional emitter,leveraging pressure-induced structural regulation to control photoluminescence properties.Increasing pressure leads to simultaneous contraction and distortion of InBr63−octahedra,shifting the STE emission color from orange to green.At high compression,structural amorphization quenches STE emission,but upon pressure release,a bright cyan emission from the PMA^(+)cation emerges,with intensity approximately 21 times stronger than that of the initial STE emission.The enhanced emission is attributed to altered molecular configurations,disrupted intermolecular contacts,and reduced lattice vibrations,collectively suppressing excimeric coupling and minimizing nonradiative losses in the recovered amorphous phase.Furthermore,emission conversion is also achieved via laser-induced structural amorphization,expanding the potential of(PMA)_(3)InBr_(6)for direct laser writing and sensitive laser detection applications. 展开更多
关键词 high pressure PHOTOLUMINESCENCE self-trapped exciton emission structural amorphization zero-dimensional metal halide
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关于本原射影Reed-Solomon码的深洞 被引量:2
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作者 徐小凡 洪绍方 许永超 《中国科学:数学》 CSCD 北大核心 2018年第8期1087-1094,共8页
本原射影Reed-Solomon码是数字通信领域中的一类重要的极大距离可分码.在本原射影ReedSolomon码的译码过程中,人们通常采用极大似然译码算法.对于一个收到的向量u∈F_q^n,极大似然译码算法关键在于确定向量u关于码C的错误距离d(u,C).熟... 本原射影Reed-Solomon码是数字通信领域中的一类重要的极大距离可分码.在本原射影ReedSolomon码的译码过程中,人们通常采用极大似然译码算法.对于一个收到的向量u∈F_q^n,极大似然译码算法关键在于确定向量u关于码C的错误距离d(u,C).熟知d(u,C)≤ρ(C),其中ρ(C)为码C的覆盖半径.若d(u,C)=ρ(C),则称u为码C的深洞.本文得到了本原射影Reed-Solomon码PPRS_q(F_q~*,k)的一类深洞.实际上,利用有限域F_q上极大距离可分码的生成矩阵,本文证明如下结果成立:如果q≥4,整数k满足2≤k≤q-2,收到的向量u的前q-1个分量的Lagrange插值多项式为u(x)=λx^(q-2)+f≤k-2(x),其中λ∈F_q~*,f≤k-2(x)为F_q上次数不超过k-2的多项式,并且u的第q个分量为0,那么u是本原射影Reed-Solomon码PPRSq(F_q~*,k)的一个深洞. 展开更多
关键词 本原射影Reed-Solomon码 MDS(maximum distance separable)码 深洞
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On Ordinary Words of Standard Reed-Solomon Codes over Finite Fields
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作者 xiaofan xu Shaofang Hong 《Algebra Colloquium》 SCIE CSCD 2021年第4期569-580,共12页
Reed-Solomon codes are widely used to establish a reliable channel to transmit information in digital communication which has a strong error correction capability and a variety of efficient decoding algorithm.Usually ... Reed-Solomon codes are widely used to establish a reliable channel to transmit information in digital communication which has a strong error correction capability and a variety of efficient decoding algorithm.Usually we use the maximum likelihood decoding(MLD)algorithm in the decoding process of Reed-Solomon codes.MLD algorithm relies on determining the error distance of received word.Dür,Guruswami,Wan,Li,Hong,Wu,Yue and Zhu et al.got some results on the error distance.For the Reed-Solomon code C,the received word u is called an ordinary word of C if the error distance d(u,C)=n-deg u(x)with u(x)being the Lagrange interpolation polynomial of u.We introduce a new method of studying the ordinary words.In fact,we make use of the result obtained by Y.C.Xu and S.F.Hong on the decomposition of certain polynomials over the finite field to determine all the ordinary words of the standard Reed-Solomon codes over the finite field of q elements.This completely answers an open problem raised by Li and Wan in[On the subset sum problem over finite fields,Finite Fields Appl.14(2008)911-929]. 展开更多
关键词 Reed-Solomon code ordinary word Lagrange interpolation polynomial finite field
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基于孟德尔随机化分析欧洲人群ω-3脂肪酸与近视风险之间的因果关系
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作者 陈智豪 安新哲 +1 位作者 徐小凡 蓝卫忠 《中华眼视光学与视觉科学杂志》 CAS CSCD 北大核心 2024年第7期522-530,共9页
目的:应用孟德尔随机化(MR)分析方法,探讨欧洲人群ω-3脂肪酸与近视风险之间的因果关系,并评估脂联素在ω-3脂肪酸与近视之间的潜在介导作用。方法:于2024年2—4月,利用大规模全基因组关联研究的汇总数据,选择特定单核苷酸多态性(SNPs)... 目的:应用孟德尔随机化(MR)分析方法,探讨欧洲人群ω-3脂肪酸与近视风险之间的因果关系,并评估脂联素在ω-3脂肪酸与近视之间的潜在介导作用。方法:于2024年2—4月,利用大规模全基因组关联研究的汇总数据,选择特定单核苷酸多态性(SNPs)作为ω-3脂肪酸和脂联素水平的遗传工具变量,使用逆方差加权法(IVW)、MR-Egger回归、加权中位数法这3种MR分析方法进行分析。为保证结果稳健性,进一步运用Cochran Q检验、Radial-MR径向回归和MR多态性残差和离群值(MR-PRESSO)法、MR-Egger截距检验、"留一法"分析以及构建可视化漏斗图等方法对遗传工具变量的异质性、水平多效性进行评估。结果:IVW分析表明血清ω-3脂肪酸水平与近视风险呈明显的负相关性(OR=0.99,95%CI:0.99~1.00,P<0.001);血清ω-3脂肪酸水平与脂联素水平呈明显的正相关性(OR=1.07,95%CI:1.00~1.15,P=0.041);脂联素水平与近视呈明显的负相关性(OR=0.99,95%CI:0.98~0.99,P<0.001)。Cochran Q检验、Radial-MR径向回归和MR-PRESSO法、MR-Egger截距检验、"留一法"分析以及漏斗图均验证了以上结果的稳健性。介导效应分析结果显示,脂联素在ω-3脂肪酸与近视风险的因果关系中起部分介导作用(7%)。结论:MR分析方法表明,ω-3脂肪酸水平升高会降低近视风险,脂联素在这一因果联系中存在部分介导作用。 展开更多
关键词 近视 Ω-3脂肪酸 脂联素 因果关系 孟德尔随机化
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