Magnesium alloys have shown great potential for their use in the medical device field, due to the promising biodegradability. However, it remains a challenge to characterize the degradation behavior of the Mg alloys i...Magnesium alloys have shown great potential for their use in the medical device field, due to the promising biodegradability. However, it remains a challenge to characterize the degradation behavior of the Mg alloys in a quantitative manner. As such, controlling the degradation rate of the Mg alloys as per our needs is still hard, which greatly limits the practical application of the Mg alloys as a degradable biomaterial.This paper discussed a numerical model developed based on the diffusion theory, which can capture the experimental degradation behavior of the Mg alloys precisely. The numerical model is then implemented into a finite element scheme, where the model is calibrated with the data from our previous studies on the corrosion of the as-cast Mg-1 Ca and the as-rolled Mg-3 Ge binary alloys. The degradation behavior of a pin implant is predicted using the calibrated model to demonstrate the model’s capability. A standard flow is provided in a practical framework for obtaining the degradation behavior of any biomedical Mg alloys. This methodology was further verified via the comparison with enormous available experimental results. Lastly, the material parameters defined in this model were provided as a new kind of material property.展开更多
Endovascular repair of the thoracic aorta with self-expanding stent-grafts has been emerging as a less invasive alternative treatment compared with conventional open surgeries.Despite the promising efficacy and safety...Endovascular repair of the thoracic aorta with self-expanding stent-grafts has been emerging as a less invasive alternative treatment compared with conventional open surgeries.Despite the promising efficacy and safety of endovascular stent grafting,the stent-graft failure remains a major concern in terms of stent migration,device fatigue,and the risk of endoleaks.Challenges associated with the stent-grafts involve optimized geometrical structure,lifetime fatigue resistance,and adequate radial support.In this work,a novel endovascular stent-graft system is developed specially for the treatment of Stanford type B thoracic aortic dissections(TAD).Numerical study with finite element analysis(FEA)was utilized to evaluate the mechanical behaviors of the individual stent component.Results of the simulation were validated by experimental tests.Based on the systematic analysis of the parametric variations,a final stent-graft system was developed by the selection and arrangement of the individual stent components,targeting an optimal performance for treatment of TAD.The optimized solution of the stent-graft system was tested in clinical trials,showing advantageous therapeutic efficacy.展开更多
Tea plants are subjected to multiple stresses during growth,development,and postharvest processing,which affects levels of secondary metabolites in leaves and influences tea functional properties and quality.Most stud...Tea plants are subjected to multiple stresses during growth,development,and postharvest processing,which affects levels of secondary metabolites in leaves and influences tea functional properties and quality.Most studies on secondary metabolism in tea have focused on gene,protein,and metabolite levels,whereas upstream regulatory mechanisms remain unclear.In this review,we exemplify DNA methylation and histone acetylation,summarize the important regulatory effects that epigenetic modifications have on plant secondary metabolism,and discuss feasible research strategies to elucidate the underlying specific epigenetic mechanisms of secondary metabolism regulation in tea.This information will help researchers investigate the epigenetic regulation of secondary metabolism in tea,providing key epigenetic data that can be used for future tea genetic breeding.展开更多
In this article, a novel BiVO4@fibers composite photocatalyst was prepared by a process that monoclinic scheelite BiVO4 nano/micro particles were in situ formated onto fiber materials. The structure, morphology and ph...In this article, a novel BiVO4@fibers composite photocatalyst was prepared by a process that monoclinic scheelite BiVO4 nano/micro particles were in situ formated onto fiber materials. The structure, morphology and photophysical properties of the composite materials were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), and UV-Vis diffuse reflectance spectroscopy, respectively. The immobilization of BiVO4 photocatalyst on fibers reduced the particle size of the photoactive phase, and a few visible-light absorption abilities. The decomposition of a non-biodegradable dye Red FN-3G was selected to examine the photocatalytic activity of the composite photocatalyst. It was found that the formation of composite materials of BiVO4 with fibers didn’t decrease the photocatalytic activity with comparison to that of pure BiVO4. Moreover, it demonstrated that when adjusting the dye solution into about pH = 3, the highest efficiency of dye degradation over the fiber composite material can be obtained.展开更多
Plant volatile compounds have important physiological and ecological functions.Phenylacetaldehyde(PAld),a volatile phenylpropanoid/benzenoid,accumulates in the leaves of tea(Camellia sinensis)plants grown under contin...Plant volatile compounds have important physiological and ecological functions.Phenylacetaldehyde(PAld),a volatile phenylpropanoid/benzenoid,accumulates in the leaves of tea(Camellia sinensis)plants grown under continuous shading.This study was conducted to determine whether PAld production is correlated with light and to elucidate the physiological functions of PAld in tea plants.Specifically,the upstream mechanism modulating PAld biosynthesis in tea plants under different light conditions as well as the effects of PAld on chloroplast/chlorophyll were investigated.The biosynthesis of PAld was inhibited under light,whereas it was induced in darkness.The structural gene encoding aromatic amino acid aminotransferase 1(CsAAAT1)was expressed at a high level in darkness,consistent with its importance for PAld accumulation.Additionally,the results of a transcriptional activation assay and an electrophoretic mobility shift assay indicated CsAAAT1 expression was slightly activated by phytochrome-interacting factor 3-2(CsPIF3-2),which is a light-responsive transcription factor.Furthermore,PAld might promote the excitation of chlorophyll in dark-treated chloroplasts and mediate electron energy transfer in cells.However,the accumulated PAld can degrade chloroplasts and chlorophyll,with potentially detrimental effects on photosynthesis.Moreover,PAld biosynthesis is inhibited in tea leaves by red and blue light,thereby decreasing the adverse effects of PAld on chloroplasts during daytime.In conclusion,the regulated biosynthesis of PAld in tea plants under light and in darkness leads to chloroplast modifications.The results of this study have expanded our understanding of the biosynthesis and functions of volatile phenylpropanoids/benzenoids in tea leaves.展开更多
Aroma is an important quality-related trait of oolong tea.The compounds contributing to oolong tea aromas are mainly produced in response to stress during the enzyme-active stage of the tea manufacturing process.Epige...Aroma is an important quality-related trait of oolong tea.The compounds contributing to oolong tea aromas are mainly produced in response to stress during the enzyme-active stage of the tea manufacturing process.Epigenetic regulation affects stress-induced secondary metabolite production;however,the mechanisms regulating oolong tea aroma compound formation are unclear.In this study,the effect of histone acetylation on indole formation,an important aroma of oolong tea,was revealed and CsHDA8 was identified as a candidate regulator.Additionally,CsHDA8,which was localized in the nucleus and cytoplasm,may function as a histone deacetylase.Moreover,the binding of CsHDA8 to CsTSB2 promoter related to indole decreased during a wounding treatment,which resulted in increased histone acetylation and gene expression.The study results may clarify the regulatory effects of histone acetylation on the formation of tea secondary metabolites,with potential implications for studies on the epigenetic regulation in other non-model horticulture plants.展开更多
In this paper,we propose and implement a systematic pipeline for the automatic classification of AI-related documents extracted from large-scale literature databases.This process results in the creation of an AI-relat...In this paper,we propose and implement a systematic pipeline for the automatic classification of AI-related documents extracted from large-scale literature databases.This process results in the creation of an AI-related literature dataset named DeepDiveAI.The dataset construction pipeline integrates expert knowledge with the capabilities of advanced models,structured into two primary stages.In the first stage,expert-curated classification datasets are used to train a Long Short-Term Memory(LSTM)model,which performs coarse-grained classification of AI-related records from large-scale datasets.In the second stage,a large language model,specifically Qwen2.5 Plus,is employed to annotate a random 10%of the initially coarse set of classified AI-related records.These annotated records are subsequently used to train a Bidirectional Encoder Representations from Transformers(BERT)based binary classifier,further refining the coarse set to produce the final DeepDiveAI dataset.Evaluation results indicate that the proposed pipeline achieves both accuracy and efficiency in identifying AI-related literature from large-scale datasets.展开更多
基金supported by National Key Research and Development Program of China (Grant No. 2016YFC1102402)National Natural Science Foundation of China (Grant No. 51431002 and 51871004)+1 种基金NSFC/RGC Joint Research Scheme (Grant No. 51661165014)Peking University Medicine Seed Fund for Interdisciplinary Research (Grant No. BMU2018ME005)
文摘Magnesium alloys have shown great potential for their use in the medical device field, due to the promising biodegradability. However, it remains a challenge to characterize the degradation behavior of the Mg alloys in a quantitative manner. As such, controlling the degradation rate of the Mg alloys as per our needs is still hard, which greatly limits the practical application of the Mg alloys as a degradable biomaterial.This paper discussed a numerical model developed based on the diffusion theory, which can capture the experimental degradation behavior of the Mg alloys precisely. The numerical model is then implemented into a finite element scheme, where the model is calibrated with the data from our previous studies on the corrosion of the as-cast Mg-1 Ca and the as-rolled Mg-3 Ge binary alloys. The degradation behavior of a pin implant is predicted using the calibrated model to demonstrate the model’s capability. A standard flow is provided in a practical framework for obtaining the degradation behavior of any biomedical Mg alloys. This methodology was further verified via the comparison with enormous available experimental results. Lastly, the material parameters defined in this model were provided as a new kind of material property.
基金jointly supported by the National Key R&D Program of China (No.2018YFC1106600)
文摘Endovascular repair of the thoracic aorta with self-expanding stent-grafts has been emerging as a less invasive alternative treatment compared with conventional open surgeries.Despite the promising efficacy and safety of endovascular stent grafting,the stent-graft failure remains a major concern in terms of stent migration,device fatigue,and the risk of endoleaks.Challenges associated with the stent-grafts involve optimized geometrical structure,lifetime fatigue resistance,and adequate radial support.In this work,a novel endovascular stent-graft system is developed specially for the treatment of Stanford type B thoracic aortic dissections(TAD).Numerical study with finite element analysis(FEA)was utilized to evaluate the mechanical behaviors of the individual stent component.Results of the simulation were validated by experimental tests.Based on the systematic analysis of the parametric variations,a final stent-graft system was developed by the selection and arrangement of the individual stent components,targeting an optimal performance for treatment of TAD.The optimized solution of the stent-graft system was tested in clinical trials,showing advantageous therapeutic efficacy.
基金Some of the research performed by the authors is supported by financial support from the National Natural Science Foundation of China(31870684,31902073,and 31922077)the Basic Frontier Science Research Program of the Chinese Academy of Sciences(ZDBS-LY-SM032)+4 种基金the Guangdong Basic and Applied Basic Research Foundation(2020A1515010007)the Regional Key Project of Science and Technology Service Network Plan of Chinese Academy of Sciences(KFJ-STS-QYZX-093)the National Key Research and Development Program of China(2018YFD1000601)the Hangzhou Qianjiang Special Experts Project,the Guangdong Provincial Special Fund For Modern Agriculture Industry Technology Innovation Teams(2020KJ120)the Foundation of Science and Technology Program of Guangzhou(201804010097).
文摘Tea plants are subjected to multiple stresses during growth,development,and postharvest processing,which affects levels of secondary metabolites in leaves and influences tea functional properties and quality.Most studies on secondary metabolism in tea have focused on gene,protein,and metabolite levels,whereas upstream regulatory mechanisms remain unclear.In this review,we exemplify DNA methylation and histone acetylation,summarize the important regulatory effects that epigenetic modifications have on plant secondary metabolism,and discuss feasible research strategies to elucidate the underlying specific epigenetic mechanisms of secondary metabolism regulation in tea.This information will help researchers investigate the epigenetic regulation of secondary metabolism in tea,providing key epigenetic data that can be used for future tea genetic breeding.
文摘In this article, a novel BiVO4@fibers composite photocatalyst was prepared by a process that monoclinic scheelite BiVO4 nano/micro particles were in situ formated onto fiber materials. The structure, morphology and photophysical properties of the composite materials were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), and UV-Vis diffuse reflectance spectroscopy, respectively. The immobilization of BiVO4 photocatalyst on fibers reduced the particle size of the photoactive phase, and a few visible-light absorption abilities. The decomposition of a non-biodegradable dye Red FN-3G was selected to examine the photocatalytic activity of the composite photocatalyst. It was found that the formation of composite materials of BiVO4 with fibers didn’t decrease the photocatalytic activity with comparison to that of pure BiVO4. Moreover, it demonstrated that when adjusting the dye solution into about pH = 3, the highest efficiency of dye degradation over the fiber composite material can be obtained.
基金supported by grants from the National Natural Science Foundation of China(31902074)the Guangdong Basic and Applied Basic Research Foundation(2020A1515010539)+4 种基金the Young Elite Scientists Sponsorship Program by China Association for Science and Technology(2020QNRC001)the Youth Innovation Promotion Association of Chinese Academy of Sciences(2022351)the Basic Frontier Science Research Program of Chinese Academy of Sciences(ZDBS-LY-SM032)the Guangdong Provincial Special Fund for Modern Agriculture Industry Technology Innovation Teams(2023KJ120)Guangdong Provincial Department of Science and Technology Rural Science and Technology Commissioner Project(KTP20210351).
文摘Plant volatile compounds have important physiological and ecological functions.Phenylacetaldehyde(PAld),a volatile phenylpropanoid/benzenoid,accumulates in the leaves of tea(Camellia sinensis)plants grown under continuous shading.This study was conducted to determine whether PAld production is correlated with light and to elucidate the physiological functions of PAld in tea plants.Specifically,the upstream mechanism modulating PAld biosynthesis in tea plants under different light conditions as well as the effects of PAld on chloroplast/chlorophyll were investigated.The biosynthesis of PAld was inhibited under light,whereas it was induced in darkness.The structural gene encoding aromatic amino acid aminotransferase 1(CsAAAT1)was expressed at a high level in darkness,consistent with its importance for PAld accumulation.Additionally,the results of a transcriptional activation assay and an electrophoretic mobility shift assay indicated CsAAAT1 expression was slightly activated by phytochrome-interacting factor 3-2(CsPIF3-2),which is a light-responsive transcription factor.Furthermore,PAld might promote the excitation of chlorophyll in dark-treated chloroplasts and mediate electron energy transfer in cells.However,the accumulated PAld can degrade chloroplasts and chlorophyll,with potentially detrimental effects on photosynthesis.Moreover,PAld biosynthesis is inhibited in tea leaves by red and blue light,thereby decreasing the adverse effects of PAld on chloroplasts during daytime.In conclusion,the regulated biosynthesis of PAld in tea plants under light and in darkness leads to chloroplast modifications.The results of this study have expanded our understanding of the biosynthesis and functions of volatile phenylpropanoids/benzenoids in tea leaves.
基金the financial support from the National Natural Science Foundation of China(31870684)the Foundation of Science and Technology Program of Guangzhou(202102020806)+2 种基金the Key Project of Universities in Guangdong Province(2021ZDZX4066)the Young Elite Scientists Sponsorship Program by China Association for Science and Technology(2020QNRC001)the Guangdong Provincial Special Fund For Modern Agriculture Industry Technology Innovation Teams(2022KJ120).
文摘Aroma is an important quality-related trait of oolong tea.The compounds contributing to oolong tea aromas are mainly produced in response to stress during the enzyme-active stage of the tea manufacturing process.Epigenetic regulation affects stress-induced secondary metabolite production;however,the mechanisms regulating oolong tea aroma compound formation are unclear.In this study,the effect of histone acetylation on indole formation,an important aroma of oolong tea,was revealed and CsHDA8 was identified as a candidate regulator.Additionally,CsHDA8,which was localized in the nucleus and cytoplasm,may function as a histone deacetylase.Moreover,the binding of CsHDA8 to CsTSB2 promoter related to indole decreased during a wounding treatment,which resulted in increased histone acetylation and gene expression.The study results may clarify the regulatory effects of histone acetylation on the formation of tea secondary metabolites,with potential implications for studies on the epigenetic regulation in other non-model horticulture plants.
基金supported by the National Key R&D Program of China(No.2022ZD0116205).
文摘In this paper,we propose and implement a systematic pipeline for the automatic classification of AI-related documents extracted from large-scale literature databases.This process results in the creation of an AI-related literature dataset named DeepDiveAI.The dataset construction pipeline integrates expert knowledge with the capabilities of advanced models,structured into two primary stages.In the first stage,expert-curated classification datasets are used to train a Long Short-Term Memory(LSTM)model,which performs coarse-grained classification of AI-related records from large-scale datasets.In the second stage,a large language model,specifically Qwen2.5 Plus,is employed to annotate a random 10%of the initially coarse set of classified AI-related records.These annotated records are subsequently used to train a Bidirectional Encoder Representations from Transformers(BERT)based binary classifier,further refining the coarse set to produce the final DeepDiveAI dataset.Evaluation results indicate that the proposed pipeline achieves both accuracy and efficiency in identifying AI-related literature from large-scale datasets.
