Sensory processing is strongly modulated by different brain and behavioral states,and this is based on the top-down modulation.In the olfactory system,local neural circuits in the olfactory bulb(OB)are innervated by c...Sensory processing is strongly modulated by different brain and behavioral states,and this is based on the top-down modulation.In the olfactory system,local neural circuits in the olfactory bulb(OB)are innervated by centrifugal afferents in order to regulate the processing of olfactory information in the OB under different behavioral states.The purpose of the present study was to explore the organization of neural networks in olfactory-related cortices and modulatory nuclei that give rise to direct and indirect innervations to the glomerular layer(GL)of the OB at the whole-brain scale.Injection of different recombinant attenuated neurotropic viruses into the GL showed that it received direct inputs from each layer in the OB,centrifugal inputs from the ipsilateralanterior olfactory nucleus(AON),anterior piriform cortex(Pir),and horizontal limb of diagonal band of Broca(HDB),and various indirect inputs from bilateral cortical neurons in the AON,Pir,amygdala,entorhinal cortex,hippocampus,HDB,dorsal raphe,median raphe and locus coeruleus.These results provide a circuitry basis that will help further understand the mechanism by which olfactory informationprocessing in the OB is regulated.展开更多
Efficient viral vectors for mapping and manipulating long-projection neuronal circuits are crucial in structural and functional studies of the brain. The SAD strain rabies virus with the glycoprotein gene deleted pseu...Efficient viral vectors for mapping and manipulating long-projection neuronal circuits are crucial in structural and functional studies of the brain. The SAD strain rabies virus with the glycoprotein gene deleted pseudotyped with the N2 C glycoprotein(SAD-RV(DG)-N2 C(G)) shows strong neuro-tropism in cell culture, but its in vivo efficiency for retrograde gene transduction and neuro-tropism have not been systematically characterized.We compared these features in different mouse brain regions for SAD-RV-N2 C(G) and two other widely-used retrograde tracers, SAD-RV(DG)-B19(G) and r AAV2-retro. We found that SAD-RV(DG)-N2 C(G) enhanced the infection efficiency of long-projecting neurons by^10 times but with very similar neuro-tropism, compared with SAD-RV(DG)-B19(G). On the other hand, SAD-RV(DG)-N2 C(G) had an infection efficiency comparable with r AAV2-retro, but a more restricted diffusion range, and broader tropism to different types and regions of longprojecting neuronal populations. These results demonstrate that SAD-RV(DG)-N2 C(G) can serve as an effective retrograde vector for studying neuronal circuits.展开更多
Acid rain(AR),which occurs frequently in southern China,negatively affects the growth of subtropical tree species.Arbuscular mycorrhizal fungi(AMF)mitigate the detrimental effects induced by AR.However,the mechanisms ...Acid rain(AR),which occurs frequently in southern China,negatively affects the growth of subtropical tree species.Arbuscular mycorrhizal fungi(AMF)mitigate the detrimental effects induced by AR.However,the mechanisms by which AMF protect Zelkova serrata,an economically important tree species in southern China,from AR stress remain unclear.We conducted a greenhouse experiment in which Z.serrata plants were inoculated with AMF species Rhizophagus intraradices and Diversispora versiformis,either alone or as a mixed culture,or with a sterilized inoculum(negative control).The plants were subjected to three levels of simulated sulfuric AR and nitric AR(pH 2.5,4.0 and 5.6)to examine any interactive effects on growth,photosynthetic capabilities,antioxidant enzymes,osmotic adjustment and soil enzymes.AR significantly decreased dry weight,chlorophyll content,net photosynthetic rate and soluble protein(SP)of non-mycorrhizal plants.Mycorrhizal inoculation,especially a combination of R.intraradices and D.versiformis,notably improved dry weight,photosynthetic capabilities,catalase,peroxidase,superoxide dismutase,SP and root acid phosphatase activity of Z.serrata under harsh AR stress.Moreover,the benefits from AMF symbionts depended on the identity of AM fungal species and the gradient of AR stress.Our results indicate that AM fungi protect z.serrata against AR stress by synchronously activating photosynthetic ability,antioxidant enzymes and osmolyte accumulation.These findings suggest that a combination of R.intraradices and D.versiformis may be a preferable choice for culturing Z.serratain southern China.展开更多
With the continuous improvement of supercomputer performance and the integration of artificial intelligence with traditional scientific computing,the scale of applications is gradually increasing,from millions to tens...With the continuous improvement of supercomputer performance and the integration of artificial intelligence with traditional scientific computing,the scale of applications is gradually increasing,from millions to tens of millions of computing cores,which raises great challenges to achieve high scalability and efficiency of parallel applications on super-large-scale systems.Taking the Sunway exascale prototype system as an example,in this paper we first analyze the challenges of high scalability and high efficiency for parallel applications in the exascale era.To overcome these challenges,the optimization technologies used in the parallel supporting environment software on the Sunway exascale prototype system are highlighted,including the parallel operating system,input/output(I/O)optimization technology,ultra-large-scale parallel debugging technology,10-million-core parallel algorithm,and mixed-precision method.Parallel operating systems and I/O optimization technology mainly support largescale system scaling,while the ultra-large-scale parallel debugging technology,10-million-core parallel algorithm,and mixed-precision method mainly enhance the efficiency of large-scale applications.Finally,the contributions to various applications running on the Sunway exascale prototype system are introduced,verifying the effectiveness of the parallel supporting environment design.展开更多
High-entropy oxides(HEOs)composed of multiple metal elements have garnered significant attention as anode materials for lithium-ion batteries(LIBs),owing to their synergistic effects between constituent metal oxides a...High-entropy oxides(HEOs)composed of multiple metal elements have garnered significant attention as anode materials for lithium-ion batteries(LIBs),owing to their synergistic effects between constituent metal oxides and broad material design flexibility.However,the advancement of HEOs in LIBs has been hindered by time-consuming synthesis methods,complex fabrication procedures,and an insufficient understanding of their lithium storage mechanisms.In this study,a rock-salt structure HEO Fe_(0.2)Co_(0.2)Ni_(0.2)Cu_(_(0.2))Zn_(0.2)O was ultrafast synthesized by the Joule heating technique within 3 s and was applied to LIBs for the first time as a conversion-type anode material.The material exhibits not only excellent capacity retention but also remarkable structural reversibility.Specifically,the reversible capacity is determined to be 1310 mAh/g for 200 cycles at 0.1 A/g,and 705 mAh/g for 3000 cycles at 5 A/g.Detailed mechanistic investigations reveal that ZnO serves as an electrochemically inactive structural stabilizer that maintains the rock-salt framework,while Cu^(2+)is difficult to oxidize back to its original state once reduced to Cu^(0).This study provides critical insights into the composition-structure-property relationships of HEOs,offering valuable guidance for designing high-performance LIBs anode materials through entropy engineering.展开更多
As a promising renewable energy source,it is a challenging task to obtain blue energy,which is irregular and has an ultralow frequency,due to the limitation of technology.Herein,a nonresonant hybridized electromagneti...As a promising renewable energy source,it is a challenging task to obtain blue energy,which is irregular and has an ultralow frequency,due to the limitation of technology.Herein,a nonresonant hybridized electromagnetic-triboelectric nanogenerator was presented to efficiently obtain the ultralow frequency energy.The instrument adopted the flexible pendulum structure with a precise design and combined the working principle of electromagnetism and triboelectricity to realize the all-directional vibration energy acquisition successfully.The results confirmed that the triboelectric nanogenerator(TENG)had the potential to deliver the maximum power point of about 470μW while the electromagnetic nanogenerator(EMG)can provide 523 mW at most.The conversion efficiency of energy of the system reached 48.48%,which exhibited a remarkable improvement by about 2.96 times,due to the elastic buffering effect of the TENG with the double helix structure.Furthermore,its ability to collect low frequency wave energy was successfully proven by a buoy in Jialing River.This woke provides an effective candidate to harvest irregular and ultralow frequency blue energy on a large scale.展开更多
This paper proposes a property transformation perspective to examine the mechanisms of wealth accumulation and wealth inequality creation during China kpost-1978 transformation. It examines how enterprise ownership re...This paper proposes a property transformation perspective to examine the mechanisms of wealth accumulation and wealth inequality creation during China kpost-1978 transformation. It examines how enterprise ownership restructuring, marketization and state politics have resulted in greater wealth inequality between cadres and ordinary workers, between public＂ sectors^organizations and private sectors^organizations. Mainly drawing on data from the Chinese Household Income Project condueted in 1995 and 2002, we find that the property transformation process has created greater wealth disparity among different occupational groups and among those working in different work organ＆ations since the mid-1990s. However, it is inconclusive whether non-housing wealth or total household wealth are increasing at the same pace across different occupations and work organizations with the growing market penetration and the spread of privatization,展开更多
This article reviews advanced process and electron device technology of integrated circuits,including recent featuring progress and potential solutions for future development.In 5 years,for pushing the performance of ...This article reviews advanced process and electron device technology of integrated circuits,including recent featuring progress and potential solutions for future development.In 5 years,for pushing the performance of fin field-effect transistors(FinFET)to its limitations,several processes and device boosters are provided.Then,the three-dimensional(3 D)integration schemes with alternative materials and device architectures will pave paths for future technology evolution.Finally,it could be concluded that Moore’s law will undoubtedly continue in the next 15 years.展开更多
基金supported by grants from the National Natural Science Foundation of China (31400946, 31671120, 31771197, 31329001, 31771156, 91632303, and 81661148053/H09)the Strategic Priority Research Program of Chinese Academy of Science (XDB32030200)the National Basic Research Development Program (973 Program) of China (2015CB755600)
文摘Sensory processing is strongly modulated by different brain and behavioral states,and this is based on the top-down modulation.In the olfactory system,local neural circuits in the olfactory bulb(OB)are innervated by centrifugal afferents in order to regulate the processing of olfactory information in the OB under different behavioral states.The purpose of the present study was to explore the organization of neural networks in olfactory-related cortices and modulatory nuclei that give rise to direct and indirect innervations to the glomerular layer(GL)of the OB at the whole-brain scale.Injection of different recombinant attenuated neurotropic viruses into the GL showed that it received direct inputs from each layer in the OB,centrifugal inputs from the ipsilateralanterior olfactory nucleus(AON),anterior piriform cortex(Pir),and horizontal limb of diagonal band of Broca(HDB),and various indirect inputs from bilateral cortical neurons in the AON,Pir,amygdala,entorhinal cortex,hippocampus,HDB,dorsal raphe,median raphe and locus coeruleus.These results provide a circuitry basis that will help further understand the mechanism by which olfactory informationprocessing in the OB is regulated.
基金the National Basic Research Program(973 Program)of China(2015CB755601)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32030200)+1 种基金the National Natural Science Foundation of China(31771156,81661148053,91632303,31800885,31500868,31671120 and 91732304)the China Postdoctoral Science Foundation(2019M653118 and 2018M632946).
文摘Efficient viral vectors for mapping and manipulating long-projection neuronal circuits are crucial in structural and functional studies of the brain. The SAD strain rabies virus with the glycoprotein gene deleted pseudotyped with the N2 C glycoprotein(SAD-RV(DG)-N2 C(G)) shows strong neuro-tropism in cell culture, but its in vivo efficiency for retrograde gene transduction and neuro-tropism have not been systematically characterized.We compared these features in different mouse brain regions for SAD-RV-N2 C(G) and two other widely-used retrograde tracers, SAD-RV(DG)-B19(G) and r AAV2-retro. We found that SAD-RV(DG)-N2 C(G) enhanced the infection efficiency of long-projecting neurons by^10 times but with very similar neuro-tropism, compared with SAD-RV(DG)-B19(G). On the other hand, SAD-RV(DG)-N2 C(G) had an infection efficiency comparable with r AAV2-retro, but a more restricted diffusion range, and broader tropism to different types and regions of longprojecting neuronal populations. These results demonstrate that SAD-RV(DG)-N2 C(G) can serve as an effective retrograde vector for studying neuronal circuits.
基金the National Natural ScienceFoundationofChina(32071644and 31400366)the Joint Funds of the Zhejiang Provincial Natural Science Foundation of China(LTY22C030003)+2 种基金the Strategic Priority Research Program of Chinese Academy of Sciences(XDB 31030000)the Special Foundation for National Science and Technology Basic Research Program of China(2019FY102000)the Key Research and Development Plan of Zhejiang Province(2017C02028).
文摘Acid rain(AR),which occurs frequently in southern China,negatively affects the growth of subtropical tree species.Arbuscular mycorrhizal fungi(AMF)mitigate the detrimental effects induced by AR.However,the mechanisms by which AMF protect Zelkova serrata,an economically important tree species in southern China,from AR stress remain unclear.We conducted a greenhouse experiment in which Z.serrata plants were inoculated with AMF species Rhizophagus intraradices and Diversispora versiformis,either alone or as a mixed culture,or with a sterilized inoculum(negative control).The plants were subjected to three levels of simulated sulfuric AR and nitric AR(pH 2.5,4.0 and 5.6)to examine any interactive effects on growth,photosynthetic capabilities,antioxidant enzymes,osmotic adjustment and soil enzymes.AR significantly decreased dry weight,chlorophyll content,net photosynthetic rate and soluble protein(SP)of non-mycorrhizal plants.Mycorrhizal inoculation,especially a combination of R.intraradices and D.versiformis,notably improved dry weight,photosynthetic capabilities,catalase,peroxidase,superoxide dismutase,SP and root acid phosphatase activity of Z.serrata under harsh AR stress.Moreover,the benefits from AMF symbionts depended on the identity of AM fungal species and the gradient of AR stress.Our results indicate that AM fungi protect z.serrata against AR stress by synchronously activating photosynthetic ability,antioxidant enzymes and osmolyte accumulation.These findings suggest that a combination of R.intraradices and D.versiformis may be a preferable choice for culturing Z.serratain southern China.
基金Project supported by the Key R&D Program of Zhejiang Province,China(No.2022C01250)the National Key R&D Program of China(No.2019YFA0709402)。
文摘With the continuous improvement of supercomputer performance and the integration of artificial intelligence with traditional scientific computing,the scale of applications is gradually increasing,from millions to tens of millions of computing cores,which raises great challenges to achieve high scalability and efficiency of parallel applications on super-large-scale systems.Taking the Sunway exascale prototype system as an example,in this paper we first analyze the challenges of high scalability and high efficiency for parallel applications in the exascale era.To overcome these challenges,the optimization technologies used in the parallel supporting environment software on the Sunway exascale prototype system are highlighted,including the parallel operating system,input/output(I/O)optimization technology,ultra-large-scale parallel debugging technology,10-million-core parallel algorithm,and mixed-precision method.Parallel operating systems and I/O optimization technology mainly support largescale system scaling,while the ultra-large-scale parallel debugging technology,10-million-core parallel algorithm,and mixed-precision method mainly enhance the efficiency of large-scale applications.Finally,the contributions to various applications running on the Sunway exascale prototype system are introduced,verifying the effectiveness of the parallel supporting environment design.
基金supported by the National Key R&D Program of China(No.2021YFA1202300)This work was also supported by the National Natural Science Foundation of China(No.52372221)+1 种基金WenZhou-2024R3001GuangDong Basic and Applied Basic Research Foundation(No.2023B1515120095).
文摘High-entropy oxides(HEOs)composed of multiple metal elements have garnered significant attention as anode materials for lithium-ion batteries(LIBs),owing to their synergistic effects between constituent metal oxides and broad material design flexibility.However,the advancement of HEOs in LIBs has been hindered by time-consuming synthesis methods,complex fabrication procedures,and an insufficient understanding of their lithium storage mechanisms.In this study,a rock-salt structure HEO Fe_(0.2)Co_(0.2)Ni_(0.2)Cu_(_(0.2))Zn_(0.2)O was ultrafast synthesized by the Joule heating technique within 3 s and was applied to LIBs for the first time as a conversion-type anode material.The material exhibits not only excellent capacity retention but also remarkable structural reversibility.Specifically,the reversible capacity is determined to be 1310 mAh/g for 200 cycles at 0.1 A/g,and 705 mAh/g for 3000 cycles at 5 A/g.Detailed mechanistic investigations reveal that ZnO serves as an electrochemically inactive structural stabilizer that maintains the rock-salt framework,while Cu^(2+)is difficult to oxidize back to its original state once reduced to Cu^(0).This study provides critical insights into the composition-structure-property relationships of HEOs,offering valuable guidance for designing high-performance LIBs anode materials through entropy engineering.
基金support of the National Key Research and Development Program of China(Grant No.2019YFB2004800)the General Program of the National Natural Science Foundation of China(NSFC,No.52075061)+5 种基金the Fund for Cultivating Talent of Chongqing University(CQU2019HBRC1A04)the Research Funds from Shanghai Institute of Space Power-Source(YF07050118F5655)the National Key R&D Project from Minister of Science and Technology in China(No.2016YFA0202701)the National Natural Science Foundation of China(No.52072041)the University of Chinese Academy of Sciences(Grant No.Y8540XX2D2)The project was supported by the Graduate Scientific Research and Innovation Foundation of Chongqing(Grant No.GDYKC202004).
文摘As a promising renewable energy source,it is a challenging task to obtain blue energy,which is irregular and has an ultralow frequency,due to the limitation of technology.Herein,a nonresonant hybridized electromagnetic-triboelectric nanogenerator was presented to efficiently obtain the ultralow frequency energy.The instrument adopted the flexible pendulum structure with a precise design and combined the working principle of electromagnetism and triboelectricity to realize the all-directional vibration energy acquisition successfully.The results confirmed that the triboelectric nanogenerator(TENG)had the potential to deliver the maximum power point of about 470μW while the electromagnetic nanogenerator(EMG)can provide 523 mW at most.The conversion efficiency of energy of the system reached 48.48%,which exhibited a remarkable improvement by about 2.96 times,due to the elastic buffering effect of the TENG with the double helix structure.Furthermore,its ability to collect low frequency wave energy was successfully proven by a buoy in Jialing River.This woke provides an effective candidate to harvest irregular and ultralow frequency blue energy on a large scale.
基金funded by the Ministry of Education of China,Humanities and Social Sciences Youth Fund(Project No.12YJC790073)PhD Program Fund(Project No.20110142120087)
文摘This paper proposes a property transformation perspective to examine the mechanisms of wealth accumulation and wealth inequality creation during China kpost-1978 transformation. It examines how enterprise ownership restructuring, marketization and state politics have resulted in greater wealth inequality between cadres and ordinary workers, between public＂ sectors^organizations and private sectors^organizations. Mainly drawing on data from the Chinese Household Income Project condueted in 1995 and 2002, we find that the property transformation process has created greater wealth disparity among different occupational groups and among those working in different work organ＆ations since the mid-1990s. However, it is inconclusive whether non-housing wealth or total household wealth are increasing at the same pace across different occupations and work organizations with the growing market penetration and the spread of privatization,
基金the support from the members of Integrated Circuit Advanced Process R&D Center,Institute of Microelectronics,Chinese Academy of Sciencessupported in part by the National Key Project of Science and Technology of China(No.2017ZX02315001-002)。
文摘This article reviews advanced process and electron device technology of integrated circuits,including recent featuring progress and potential solutions for future development.In 5 years,for pushing the performance of fin field-effect transistors(FinFET)to its limitations,several processes and device boosters are provided.Then,the three-dimensional(3 D)integration schemes with alternative materials and device architectures will pave paths for future technology evolution.Finally,it could be concluded that Moore’s law will undoubtedly continue in the next 15 years.
