RNA molecules play diverse and essential roles in cellular processes beyond their wellknown functions in gene expression and regulation.While ribosomal RNAs(rRNAs)have long been recognized as structural components of ...RNA molecules play diverse and essential roles in cellular processes beyond their wellknown functions in gene expression and regulation.While ribosomal RNAs(rRNAs)have long been recognized as structural components of ribosomes,recent research has highlighted the importance of a distinct group of RNAs which directly compose the structures or organelles in mammalian cells.We refer to these as‘organelle formation RNAs’.Specifically,the discovery of tubulin-associated lncRNA(TubAR),the first identified cytoskeleton-forming RNA,has expanded our understanding of RNA functionality;we now recognize‘organelle formation RNAs’not only as regulatory molecules but also as direct structural components within cellular subunits.Other‘organelle formation RNAs’include paraspeckle-forming RNAs,nuclear speckle-forming RNAs,and nucleolus-forming RNAs.Various RNAs contribute to the formation of distinct cellular structures,while also participating in intricate intermolecular interactions.Understanding these molecules not only uncovers their fundamental roles in cellular physiology but also suggests potential applications in the treatment of related diseases.By examining the latest advancements and methodologies in organelle formation RNA research,this review provides a comprehensive overview of the intricate mechanisms of these RNAs and future directions in the field.展开更多
MIMO technique can provide higher information throughput and transmission reliability for the PLC system.However,the MIMO-PLC system based on three-conductor cable has a high correlation among its sub-channels.Spatial...MIMO technique can provide higher information throughput and transmission reliability for the PLC system.However,the MIMO-PLC system based on three-conductor cable has a high correlation among its sub-channels.Spatial multiplexing technology will be affected by the spatial correlation between MIMO-PLC sub-channels.To reduce the system bit error rate caused by MIMO-PLC correlation among sub-channels,this paper proposed a phase rotation precoding scheme for the 2×2 closed-loop MIMO-PLC system.According to the channel transfer function of high correlation MIMO-PLC system,the phase rotation precoding matrix F is calculated,and the transmission signal matrix S is modulated with the F,the code distance at the receiving point with smallest code distance is increased by phase rotation.Simulation results show that the scheme can effectively reduce the bit error rate of the 2×2 MIMO-PLC system based on ML detection,and significantly improve the system performance.展开更多
In this paper, a three-dimensional(3D) geometry- based stochastic scattering model(GBSSM) for wideband multi-input multi-output(MIMO) vehicle-to-vehicle(V2V) relay-based cooperative fading channel based on geometrical...In this paper, a three-dimensional(3D) geometry- based stochastic scattering model(GBSSM) for wideband multi-input multi-output(MIMO) vehicle-to-vehicle(V2V) relay-based cooperative fading channel based on geometrical three-cylinder is proposed. Non-line-of-sight(NLOS) propagation condition is assumed in amplify-and-forward(AF) cooperative networks from the source mobile station(S) to the destination mobile station(D) via the mobile relay station(R). We extend the proposed narrowband model to wideband and also introduce the carrier frequency and bandwidth into the model. To avoid complicated procedure in deriving the analytical expressions of the channel parameters and functions, the channel is realized first. By using the realized channel matrix, the channel properties are further investigated.展开更多
1|CURRENT UNDERSTANDING OF LNCRNAS Long non-coding RNAs(lncRNAs)are a class of regulatory RNA molecules that have captured the attention of researchers in recent years due to their diverse roles in development,physiol...1|CURRENT UNDERSTANDING OF LNCRNAS Long non-coding RNAs(lncRNAs)are a class of regulatory RNA molecules that have captured the attention of researchers in recent years due to their diverse roles in development,physiological and pathological processes.展开更多
Alternative splicing is a key regulatory mechanism that generates transcriptomic diversity by selectively splicing pre-RNA molecules in different ways,leading to the production of multiple RNA isoforms from a single g...Alternative splicing is a key regulatory mechanism that generates transcriptomic diversity by selectively splicing pre-RNA molecules in different ways,leading to the production of multiple RNA isoforms from a single gene.This process is crucial for the fine-tuning of gene expression and is tightly regulated during various biological processes.Recent studies have highlighted how alternative splicing contributes to stem cells self-renewal and differentiation,as well as how dysregulation of splicing factors can impact stem cells behavior and lead to developmental abnormalities or diseases.This review summarizes the current understanding of alternative splicing in stem cells and development,focusing on the molecular mechanisms that govern alternative splicing regulation,the role of splicing factors,and the impact of splicing isoforms on stem cell fate determination and developmental processes.We also discuss emerging technologies,such as CRISPR/Cas-based tools,single-cell long-read RNA sequencing,imaging technologies and 3D culture systems,which are advancing our ability to study alternative splicing in vitro and in vivo.Overall,this field is rapidly evolving,revealing new insights into how alternative splicing shapes the molecular landscape and functions of stem cells and developmental processes.展开更多
Recently,there has been increased attention toward 3D imaging using single-pixel single-photon detection(also known as temporal data)due to its potential advantages in terms of cost and power efficiency.However,to eli...Recently,there has been increased attention toward 3D imaging using single-pixel single-photon detection(also known as temporal data)due to its potential advantages in terms of cost and power efficiency.However,to eliminate the symmetry blur in the reconstructed images,a fixed background is required.This paper proposes a fusion-data-based 3D imaging method that utilizes a single-pixel single-photon detector and millimeter-wave radar to capture temporal histograms of a scene from multiple perspectives.Subsequently,the 3D information can be reconstructed from the one-dimensional fusion temporal data by using an artificial neural network.Both the simulation and experimental results demonstrate that our fusion method effectively eliminates symmetry blur and improves the quality of the reconstructed images.展开更多
基金supported by National Natural Science Foundation of China(32400436 to XLL and 32170557 to XW)Anhui Provincial Key Research and Development Project(2022e07020020 to XW)+1 种基金Research Funds of Centre for Leading Medicine and Advanced Technologies of IHM(2023IHM01034 to XW)Anhui Postdoctoral Scientific Research Program Foundation(2024C879 to XLL).
文摘RNA molecules play diverse and essential roles in cellular processes beyond their wellknown functions in gene expression and regulation.While ribosomal RNAs(rRNAs)have long been recognized as structural components of ribosomes,recent research has highlighted the importance of a distinct group of RNAs which directly compose the structures or organelles in mammalian cells.We refer to these as‘organelle formation RNAs’.Specifically,the discovery of tubulin-associated lncRNA(TubAR),the first identified cytoskeleton-forming RNA,has expanded our understanding of RNA functionality;we now recognize‘organelle formation RNAs’not only as regulatory molecules but also as direct structural components within cellular subunits.Other‘organelle formation RNAs’include paraspeckle-forming RNAs,nuclear speckle-forming RNAs,and nucleolus-forming RNAs.Various RNAs contribute to the formation of distinct cellular structures,while also participating in intricate intermolecular interactions.Understanding these molecules not only uncovers their fundamental roles in cellular physiology but also suggests potential applications in the treatment of related diseases.By examining the latest advancements and methodologies in organelle formation RNA research,this review provides a comprehensive overview of the intricate mechanisms of these RNAs and future directions in the field.
基金supported by the National Natural Science Foundation of China (No.62001166)supported by the Natural Science Foundation of Hebei Province of China (E2019502186,F2019201362)supported by the Fundamental Research Funds for the Central Universities (2021MS073)。
文摘MIMO technique can provide higher information throughput and transmission reliability for the PLC system.However,the MIMO-PLC system based on three-conductor cable has a high correlation among its sub-channels.Spatial multiplexing technology will be affected by the spatial correlation between MIMO-PLC sub-channels.To reduce the system bit error rate caused by MIMO-PLC correlation among sub-channels,this paper proposed a phase rotation precoding scheme for the 2×2 closed-loop MIMO-PLC system.According to the channel transfer function of high correlation MIMO-PLC system,the phase rotation precoding matrix F is calculated,and the transmission signal matrix S is modulated with the F,the code distance at the receiving point with smallest code distance is increased by phase rotation.Simulation results show that the scheme can effectively reduce the bit error rate of the 2×2 MIMO-PLC system based on ML detection,and significantly improve the system performance.
基金supported by the open research fund of National Mobile Communications Research Laboratory, Southeast University (No. 2016D09)National Nature Science Foundation of China (NSFC) under grant No. 61372051
文摘In this paper, a three-dimensional(3D) geometry- based stochastic scattering model(GBSSM) for wideband multi-input multi-output(MIMO) vehicle-to-vehicle(V2V) relay-based cooperative fading channel based on geometrical three-cylinder is proposed. Non-line-of-sight(NLOS) propagation condition is assumed in amplify-and-forward(AF) cooperative networks from the source mobile station(S) to the destination mobile station(D) via the mobile relay station(R). We extend the proposed narrowband model to wideband and also introduce the carrier frequency and bandwidth into the model. To avoid complicated procedure in deriving the analytical expressions of the channel parameters and functions, the channel is realized first. By using the realized channel matrix, the channel properties are further investigated.
基金National Natural Science Foundation of ChinaGrant/Award Number:31970598 and 32170557+3 种基金Anhui Provincial Key Research and Development ProjectGrant/Award Number:2022e07020020Research Funds of Centre for Leading Medicine and Advanced Technologies of IHMGrant/Award Number:2023IHM01030。
文摘1|CURRENT UNDERSTANDING OF LNCRNAS Long non-coding RNAs(lncRNAs)are a class of regulatory RNA molecules that have captured the attention of researchers in recent years due to their diverse roles in development,physiological and pathological processes.
基金supported by USTC Research Funds of the Double First-Class Initiative(Grant No.YD9110002078 to Y.J.)National Natural Science Foundation of China(Grant No.32170557 to X.W.and 32400436 to X.L.)+1 种基金Research Funds of Centre for Leading Medicine and Advanced Technologies of IHM(Grant No.2023IHM01034 to X.W.)Anhui Postdoctoral Scientific Research Program Foundation(Grant No.2024C879 to X.L.).
文摘Alternative splicing is a key regulatory mechanism that generates transcriptomic diversity by selectively splicing pre-RNA molecules in different ways,leading to the production of multiple RNA isoforms from a single gene.This process is crucial for the fine-tuning of gene expression and is tightly regulated during various biological processes.Recent studies have highlighted how alternative splicing contributes to stem cells self-renewal and differentiation,as well as how dysregulation of splicing factors can impact stem cells behavior and lead to developmental abnormalities or diseases.This review summarizes the current understanding of alternative splicing in stem cells and development,focusing on the molecular mechanisms that govern alternative splicing regulation,the role of splicing factors,and the impact of splicing isoforms on stem cell fate determination and developmental processes.We also discuss emerging technologies,such as CRISPR/Cas-based tools,single-cell long-read RNA sequencing,imaging technologies and 3D culture systems,which are advancing our ability to study alternative splicing in vitro and in vivo.Overall,this field is rapidly evolving,revealing new insights into how alternative splicing shapes the molecular landscape and functions of stem cells and developmental processes.
基金supported by the Shenzhen Science and Technology Program(Nos.JCYJ2022081 and 8102014029)the National Natural Science Foundation of China(No.62171458)the National Key Research and Development Program of China(No.2021YFB2802004)。
文摘Recently,there has been increased attention toward 3D imaging using single-pixel single-photon detection(also known as temporal data)due to its potential advantages in terms of cost and power efficiency.However,to eliminate the symmetry blur in the reconstructed images,a fixed background is required.This paper proposes a fusion-data-based 3D imaging method that utilizes a single-pixel single-photon detector and millimeter-wave radar to capture temporal histograms of a scene from multiple perspectives.Subsequently,the 3D information can be reconstructed from the one-dimensional fusion temporal data by using an artificial neural network.Both the simulation and experimental results demonstrate that our fusion method effectively eliminates symmetry blur and improves the quality of the reconstructed images.
