目的:研究1~6岁早产儿近视患者屈光参数的变化,探讨早产儿近视发生发展与屈光参数的关系。方法:收集2016-01/2018-12在湖南省儿童医院眼科门诊随诊的1~6岁早产儿近视者158例316眼作为早产儿近视组,选取同期随诊的早产儿非近视者164例32...目的:研究1~6岁早产儿近视患者屈光参数的变化,探讨早产儿近视发生发展与屈光参数的关系。方法:收集2016-01/2018-12在湖南省儿童医院眼科门诊随诊的1~6岁早产儿近视者158例316眼作为早产儿近视组,选取同期随诊的早产儿非近视者164例328眼作为早产儿非近视组。检测并分析两组受检者角膜曲率(CR)、前房深度(ACD)、玻璃体腔深度(VITR)、眼轴长度(AL)、晶状体厚度(LT)等屈光参数。结果:1~3岁受检者中,早产儿近视组较早产儿非近视组CR陡(44.47±1.14D vs 43.38±1.22D),AL延长(21.89±0.71mm vs 21.24±0.56mm)(均P<0.05),而ACD、VITR及LT值无明显差异(均P>0.05);4~6岁受检者中,早产儿近视组较早产儿非近视组AL延长(22.49±1.32mm vs21.43±0.72mm,P<0.05),而CR、ACD、VITR及AT值无明显差异(均P>0.05)。1~3岁早产儿高度近视患者较低、中度近视患者CR陡、AL长,4~6岁早产儿高度近视患者较低、中度近视患者VITR深、AL长。结论:屈光参数发育不匹配可能是早产儿近视发生的原因之一,其中眼轴长度变化起主要作用,而角膜曲率陡是低龄(≤3岁)早产儿近视发展的重要因素之一。展开更多
Acupuncture at acupoints Baihui(GV20)and Dazhui(GV14)has been shown to promote functional recovery after stroke.However,the contribution of the contralateral primary sensory cortex(S1)to recovery remains unclear.In th...Acupuncture at acupoints Baihui(GV20)and Dazhui(GV14)has been shown to promote functional recovery after stroke.However,the contribution of the contralateral primary sensory cortex(S1)to recovery remains unclear.In this study,unilateral local ischemic infarction of the primary motor cortex(M1)was induced by photothrombosis in a mouse model.Electroacupuncture(EA)was subsequently performed at acupoints GV20 and GV14 and neuronal activity and functional connectivity of contralateral S1 and M1 were detected using in vivo and in vitro electrophysiological recording techniques.Our results showed that blood perfusion and neuronal interaction between contralateral M1 and S1 is impaired after unilateral M1 infarction.Intrinsic neuronal excitability and activity were also disturbed,which was rescued by EA.Furthermore,the effectiveness of EA treatment was inhibited after virus-mediated neuronal ablation of the contralateral S1.We conclude that neuronal activity of the contralateral S1 is important for EA-mediated recovery after focal M1 infarction.Our study provides insight into how the S1-M1 circuit might be involved in the mechanism of EA treatment of unilateral cerebral infarction.The animal experiments were approved by the Committee for Care and Use of Research Animals of Guangzhou University of Chinese Medicine(approval No.20200407009)April 7,2020.展开更多
文摘目的:研究1~6岁早产儿近视患者屈光参数的变化,探讨早产儿近视发生发展与屈光参数的关系。方法:收集2016-01/2018-12在湖南省儿童医院眼科门诊随诊的1~6岁早产儿近视者158例316眼作为早产儿近视组,选取同期随诊的早产儿非近视者164例328眼作为早产儿非近视组。检测并分析两组受检者角膜曲率(CR)、前房深度(ACD)、玻璃体腔深度(VITR)、眼轴长度(AL)、晶状体厚度(LT)等屈光参数。结果:1~3岁受检者中,早产儿近视组较早产儿非近视组CR陡(44.47±1.14D vs 43.38±1.22D),AL延长(21.89±0.71mm vs 21.24±0.56mm)(均P<0.05),而ACD、VITR及LT值无明显差异(均P>0.05);4~6岁受检者中,早产儿近视组较早产儿非近视组AL延长(22.49±1.32mm vs21.43±0.72mm,P<0.05),而CR、ACD、VITR及AT值无明显差异(均P>0.05)。1~3岁早产儿高度近视患者较低、中度近视患者CR陡、AL长,4~6岁早产儿高度近视患者较低、中度近视患者VITR深、AL长。结论:屈光参数发育不匹配可能是早产儿近视发生的原因之一,其中眼轴长度变化起主要作用,而角膜曲率陡是低龄(≤3岁)早产儿近视发展的重要因素之一。
基金Guangzhou University of Chinese Medicine and by grants from General Program of the National Natural Science Foundation of China(No.81774406,to NGX)Youth Program of the National Natural Science Foundation of China(No.82004469,to LLY)+1 种基金Fellowship of China postdoctoral Science Foundation(No.2020M672601,to LLY)Opening Operation Program of Key Laboratory of Acupuncture and Moxibustion of Traditional Chinese Medicine in Guangdong(No.2017B030314143,to NGX).
文摘Acupuncture at acupoints Baihui(GV20)and Dazhui(GV14)has been shown to promote functional recovery after stroke.However,the contribution of the contralateral primary sensory cortex(S1)to recovery remains unclear.In this study,unilateral local ischemic infarction of the primary motor cortex(M1)was induced by photothrombosis in a mouse model.Electroacupuncture(EA)was subsequently performed at acupoints GV20 and GV14 and neuronal activity and functional connectivity of contralateral S1 and M1 were detected using in vivo and in vitro electrophysiological recording techniques.Our results showed that blood perfusion and neuronal interaction between contralateral M1 and S1 is impaired after unilateral M1 infarction.Intrinsic neuronal excitability and activity were also disturbed,which was rescued by EA.Furthermore,the effectiveness of EA treatment was inhibited after virus-mediated neuronal ablation of the contralateral S1.We conclude that neuronal activity of the contralateral S1 is important for EA-mediated recovery after focal M1 infarction.Our study provides insight into how the S1-M1 circuit might be involved in the mechanism of EA treatment of unilateral cerebral infarction.The animal experiments were approved by the Committee for Care and Use of Research Animals of Guangzhou University of Chinese Medicine(approval No.20200407009)April 7,2020.
