BACKGROUND Pancreatic cancer has an extremely poor prognosis.Although surgery is the firstline treatment for pancreatic cancer,its role is ultimately limited because patients often present too late for resection.Thus,...BACKGROUND Pancreatic cancer has an extremely poor prognosis.Although surgery is the firstline treatment for pancreatic cancer,its role is ultimately limited because patients often present too late for resection.Thus,multidisciplinary treatment approaches are needed.In particular,chemotherapy,targeted therapy,and immunotherapy can be ineffective for locally advanced pancreatic cancer(LAPC)because of its resistance to these modalities,but cryoablation has shown significant promise for treating this entity and prolonging survival.AIM To investigate the safety and efficacy of cryoablation for LAPC.METHODS Clinical and laboratory data,including surgical procedure,postoperative complications,immunobiochemical markers(e.g.,carbohydrate antigen 19-9),and followup visits,of 24 LAPC patients treated with cryoablation at the department of hepatobiliary and pancreatic surgery of our hospital from January 2023 to December 2024 were retrospectively analyzed.RESULTS Surgery was smooth in all patients,with no perioperative deaths.Postoperative pancreatic fistulas occurred in 18 patients(75.0%),including biochemical leak in 14 cases and grade B(fistula)in 4 cases.Three patients(12.5%)had delayed gastric emptying.The carbohydrate antigen 19-9 level remained low on postoperative day 30(P<0.05).Immune markers(natural killer cells and tumor necrosis factor-alpha)significantly increased on days 7 and 30(P<0.01 or P<0.05),whereas cluster of differentiation CD4+T cells levels on day 30 significantly differed from baseline.Day 30 pain scores were significantly lower than preoperative ones(P<0.01).Tumor volume was reduced on postoperative computed tomography.Survival was prolonged.The overall survival time of LAPC patients treated with cryoablation was 16.8 months.CONCLUSION Cryoablation can directly inactivate LAPC and boost immunity,thus delaying tumor progression,alleviating pain,improving quality of life,and prolonging survivals.Therefore,it is a safe and effective treatment option for LAPC.展开更多
The Shimensi deposit is a recently discovered W-Cu-Mo polymetallic deposit located in the Jiangnan porphyry-skarn W belt in South China.The deposit has a resource of 0.74×10^(6)t of WO_(3)accompanied by 0.4×...The Shimensi deposit is a recently discovered W-Cu-Mo polymetallic deposit located in the Jiangnan porphyry-skarn W belt in South China.The deposit has a resource of 0.74×10^(6)t of WO_(3)accompanied by 0.4×10^(6)t Cu and 28000 t Mo and other useful components like Ga,making it one of the largest W deposits in the world.This paper is aimed to reveal the ore-controlling mechanisms of the Shimensi deposit,involving the role of the ore-related granites,the tectonic background for its formation,and the metallogenesis model.The systematic geological survey suggests multi-types of alteration are developed in the deposit,mainly including greisenization,potassic-alteration,sericitization,chloritization,and silicification.Drilling engineering data and mining works indicate that the Shimensi deposit consists of two main orebodies of I and II.Therein,the W resource has reached a supergiant scale,and the accompanied Cu,Mo,Au,Bi,Ga,and some other useful components are also of economic significance.The main ore-minerals consist of scheelite,wolframite and chalcopyrite.Disseminated mineralization is the dominant type of the W-Cu-Mo polymetallic orebodies,and mainly distributes in the inner and external contact zone that between the Neoproterozoic biotite granodiorite and the Yanshanian granites.The main orebody occurs at the external contact zone,and the pegmatoid crust near the inner contact zone is an important prospecting marker of the W mineralization.Of them,the disseminated W ores within the wall rock of the Neoproterozoic biotite granodiorite is a new mineralization type identified in this paper.Combining previous geochronological and isotopic data,we propose that the mineralization of the Shimensi deposit is closely related to the intruding of the Yanshanian porphyritic biotite granite and granite porphyry.Geochemical data suggest that the biotite granodiorite is rich in Ca and had provided a large amount of Ca for the precipitation of scheelite in this area.Thus,it is a favorable wall rock type for W mineralization.The Shimensi deposit belongs to granitic-type W polymetallic deposit related to post-magmatic hydrothermal,and the ore-forming fluid was initially derived from the Yanshanian magmas.展开更多
The conjugate addition of in-situ generated(aza-)quinone methides(QMs)and indole imine methides(IIMs)emerged as a powerful protocol to access densely functionalized benzenes and indoles.Hydroxybenzyl alcohols,aminoben...The conjugate addition of in-situ generated(aza-)quinone methides(QMs)and indole imine methides(IIMs)emerged as a powerful protocol to access densely functionalized benzenes and indoles.Hydroxybenzyl alcohols,aminobenzhydryl alcohols,and varied indolylmethanols served as most effective precursors for the in-situ generation of such reactive species under acid conditions.The relevant propargylic alcohol has proven to be an elegant precursor to generate the propargylic-QMs and-IIMs via the acid promoted dehydration process,thus enabling diverse challenging remote activation to proceed conjugate1,6-and 1,8-additions.Moreover,the heteroarene has proven to be workable to transfer the LUMO of the p-QMs and 2-IIMs,thus inducing the remote nucleophilic dearomative additions.The conjugate additions of(aza-)p-QMs and varied IIMs has made significant contribution in the field of remote activation chemistry in past decade.This review summarizes the latest advances of the remote conjugate additions of the in-situ generated QMs and IIMs.展开更多
Magnetic fields are significant in the structure and evolution of stars. We present a comprehensive catalog of 1784known magnetic stars, detailing their identifications, HD numbers, precise locations, spectral types a...Magnetic fields are significant in the structure and evolution of stars. We present a comprehensive catalog of 1784known magnetic stars, detailing their identifications, HD numbers, precise locations, spectral types and averaged quadratic effective magnetic fields among other important information. The group comprises 177 O-type stars, 551B-type stars, 520 A-type stars, 91 F-type stars, 53 G-type stars, 61 K-type stars, 31 M-type stars and an additional300 stars whose spectral classification remains indeterminate. Our analysis examines the statistical properties of these magnetic stars. The relative integrated distribution function and number distribution function for all magnetic stars of the same spectral type can be effectively approximated using an exponential function of the averaged quadratic effective magnetic field. The analysis further reveals that A and B-type stars possess the strongest mean magnetic fields, indicating an easier detection of their magnetic fields.展开更多
In this paper, saponins were extracted from Northern Shaanxi＇ s big jujubes using organic solvent method and also the oxidation resistance of the extractives was analyzed. In the experiment, the crude extractives of ...In this paper, saponins were extracted from Northern Shaanxi＇ s big jujubes using organic solvent method and also the oxidation resistance of the extractives was analyzed. In the experiment, the crude extractives of the saponins from jujubes were obtained using ethyl alcohol soaking method and Soxhlet extraction method and also qualitatively tested using 3 color reactions, and the test result was positive; the oxidation resistance of jujube saponins was analyzed through DPPH, hydroxyl radical scavenging experiment and reducibility measurement, and the results showed that the capability of jujube saponins in DPPH free radical scavenging was enhanced along with the improvement of the to- be-test material concentration, so saponins played a significant role on hydroxyl radical scavenging and possessed certain reducibility. Northern Shaanxi＇ s big jujubes are rich in saponins and possess excellent antioxidant ability that will be enhanced along with the increase of saponins content. Thus, a basis is provided for the effective extension of the jujube industry chain.展开更多
文摘BACKGROUND Pancreatic cancer has an extremely poor prognosis.Although surgery is the firstline treatment for pancreatic cancer,its role is ultimately limited because patients often present too late for resection.Thus,multidisciplinary treatment approaches are needed.In particular,chemotherapy,targeted therapy,and immunotherapy can be ineffective for locally advanced pancreatic cancer(LAPC)because of its resistance to these modalities,but cryoablation has shown significant promise for treating this entity and prolonging survival.AIM To investigate the safety and efficacy of cryoablation for LAPC.METHODS Clinical and laboratory data,including surgical procedure,postoperative complications,immunobiochemical markers(e.g.,carbohydrate antigen 19-9),and followup visits,of 24 LAPC patients treated with cryoablation at the department of hepatobiliary and pancreatic surgery of our hospital from January 2023 to December 2024 were retrospectively analyzed.RESULTS Surgery was smooth in all patients,with no perioperative deaths.Postoperative pancreatic fistulas occurred in 18 patients(75.0%),including biochemical leak in 14 cases and grade B(fistula)in 4 cases.Three patients(12.5%)had delayed gastric emptying.The carbohydrate antigen 19-9 level remained low on postoperative day 30(P<0.05).Immune markers(natural killer cells and tumor necrosis factor-alpha)significantly increased on days 7 and 30(P<0.01 or P<0.05),whereas cluster of differentiation CD4+T cells levels on day 30 significantly differed from baseline.Day 30 pain scores were significantly lower than preoperative ones(P<0.01).Tumor volume was reduced on postoperative computed tomography.Survival was prolonged.The overall survival time of LAPC patients treated with cryoablation was 16.8 months.CONCLUSION Cryoablation can directly inactivate LAPC and boost immunity,thus delaying tumor progression,alleviating pain,improving quality of life,and prolonging survivals.Therefore,it is a safe and effective treatment option for LAPC.
基金supported financially by the National Natural Science Foundation of China(No.41772069)projects of the China Geological Survey(1212011220737,121201004000150015,DD20190570).
文摘The Shimensi deposit is a recently discovered W-Cu-Mo polymetallic deposit located in the Jiangnan porphyry-skarn W belt in South China.The deposit has a resource of 0.74×10^(6)t of WO_(3)accompanied by 0.4×10^(6)t Cu and 28000 t Mo and other useful components like Ga,making it one of the largest W deposits in the world.This paper is aimed to reveal the ore-controlling mechanisms of the Shimensi deposit,involving the role of the ore-related granites,the tectonic background for its formation,and the metallogenesis model.The systematic geological survey suggests multi-types of alteration are developed in the deposit,mainly including greisenization,potassic-alteration,sericitization,chloritization,and silicification.Drilling engineering data and mining works indicate that the Shimensi deposit consists of two main orebodies of I and II.Therein,the W resource has reached a supergiant scale,and the accompanied Cu,Mo,Au,Bi,Ga,and some other useful components are also of economic significance.The main ore-minerals consist of scheelite,wolframite and chalcopyrite.Disseminated mineralization is the dominant type of the W-Cu-Mo polymetallic orebodies,and mainly distributes in the inner and external contact zone that between the Neoproterozoic biotite granodiorite and the Yanshanian granites.The main orebody occurs at the external contact zone,and the pegmatoid crust near the inner contact zone is an important prospecting marker of the W mineralization.Of them,the disseminated W ores within the wall rock of the Neoproterozoic biotite granodiorite is a new mineralization type identified in this paper.Combining previous geochronological and isotopic data,we propose that the mineralization of the Shimensi deposit is closely related to the intruding of the Yanshanian porphyritic biotite granite and granite porphyry.Geochemical data suggest that the biotite granodiorite is rich in Ca and had provided a large amount of Ca for the precipitation of scheelite in this area.Thus,it is a favorable wall rock type for W mineralization.The Shimensi deposit belongs to granitic-type W polymetallic deposit related to post-magmatic hydrothermal,and the ore-forming fluid was initially derived from the Yanshanian magmas.
基金the financial support from the National Natural Science Foundation of China(No.22001216)the Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province(No.CSPC202315)+2 种基金the Science and Technology Department of Sichuan Province,China(No.2022NSFSC1203)the Higher Education Institution Key Research Project Plan of Henan Province(No.24B150031)the Program for Youth Backbone Teacher Training in University of Henan Province(No.2021GGJS163)。
文摘The conjugate addition of in-situ generated(aza-)quinone methides(QMs)and indole imine methides(IIMs)emerged as a powerful protocol to access densely functionalized benzenes and indoles.Hydroxybenzyl alcohols,aminobenzhydryl alcohols,and varied indolylmethanols served as most effective precursors for the in-situ generation of such reactive species under acid conditions.The relevant propargylic alcohol has proven to be an elegant precursor to generate the propargylic-QMs and-IIMs via the acid promoted dehydration process,thus enabling diverse challenging remote activation to proceed conjugate1,6-and 1,8-additions.Moreover,the heteroarene has proven to be workable to transfer the LUMO of the p-QMs and 2-IIMs,thus inducing the remote nucleophilic dearomative additions.The conjugate additions of(aza-)p-QMs and varied IIMs has made significant contribution in the field of remote activation chemistry in past decade.This review summarizes the latest advances of the remote conjugate additions of the in-situ generated QMs and IIMs.
基金the generous support of the National Natural Science Foundation of China(NSFC,Grant Nos.U2031204,12163005 and 12288102)the Natural Science Foundation of Xinjiang Nos.2021D01C075,2022D01D85,2022TSYCLJ0006 and 2022D01E86+1 种基金the science research grants from the China Manned Space Project with Nos.CMSCSST-2021-A10 and CMS-CSST-2021-A08the Chinese Academy of Sciences(CAS)“Light of West China”Program,No.2022-XBQNXZ-013。
文摘Magnetic fields are significant in the structure and evolution of stars. We present a comprehensive catalog of 1784known magnetic stars, detailing their identifications, HD numbers, precise locations, spectral types and averaged quadratic effective magnetic fields among other important information. The group comprises 177 O-type stars, 551B-type stars, 520 A-type stars, 91 F-type stars, 53 G-type stars, 61 K-type stars, 31 M-type stars and an additional300 stars whose spectral classification remains indeterminate. Our analysis examines the statistical properties of these magnetic stars. The relative integrated distribution function and number distribution function for all magnetic stars of the same spectral type can be effectively approximated using an exponential function of the averaged quadratic effective magnetic field. The analysis further reveals that A and B-type stars possess the strongest mean magnetic fields, indicating an easier detection of their magnetic fields.
文摘In this paper, saponins were extracted from Northern Shaanxi＇ s big jujubes using organic solvent method and also the oxidation resistance of the extractives was analyzed. In the experiment, the crude extractives of the saponins from jujubes were obtained using ethyl alcohol soaking method and Soxhlet extraction method and also qualitatively tested using 3 color reactions, and the test result was positive; the oxidation resistance of jujube saponins was analyzed through DPPH, hydroxyl radical scavenging experiment and reducibility measurement, and the results showed that the capability of jujube saponins in DPPH free radical scavenging was enhanced along with the improvement of the to- be-test material concentration, so saponins played a significant role on hydroxyl radical scavenging and possessed certain reducibility. Northern Shaanxi＇ s big jujubes are rich in saponins and possess excellent antioxidant ability that will be enhanced along with the increase of saponins content. Thus, a basis is provided for the effective extension of the jujube industry chain.
