本研究系统探究了不同复水方式对干银耳复水后品质特性及内部水分迁移规律的影响。以干银耳为原料,采用70、100℃热水复水(hot water rehydration,HWR)及70、100℃超声联合热水复水(ultrasound-hot water rehydration,US-HWR)4种方式,...本研究系统探究了不同复水方式对干银耳复水后品质特性及内部水分迁移规律的影响。以干银耳为原料,采用70、100℃热水复水(hot water rehydration,HWR)及70、100℃超声联合热水复水(ultrasound-hot water rehydration,US-HWR)4种方式,分别处理3、4、5 min。通过测定复水比、色泽、质构特性(硬度、黏稠度)、多糖含量及感官评分进行综合品质评价,并利用低场核磁共振(low-field nuclear magnetic resonance,LF-NMR)技术分析复水过程中的水分迁移状态。结果表明,US-HWR能显著提高银耳的吸水率,加速水分迁移,但同时也导致硬度下降、黏稠度升高及多糖溶出损失。综合各项指标,100℃超声联合热水复水3 min(USHWR-100℃3 min)为最优工艺。该条件下,银耳的复水比为12.79±0.78,硬度为(69.36±3.13)g,黏稠度为(0.030±0.002)g·s,感官评分达到最高值(82.50±2.55)。LF-NMR分析显示,复水银耳中的水分主要由T_(2b)、T_(21)、T_(22)和T_(234)个组分构成,且复水时间延长与超声处理均能显著提高银耳内部水分的自由度,促进水分迁移。综上,US-HWR-100℃3 min是一种高效、优质的银耳复水技术,能在最短时间内获得感官与理化品质俱佳的产品,是凉拌银耳预制菜工业化生产的理想复水方式。展开更多
Multi-label feature selection(MFS)is a crucial dimensionality reduction technique aimed at identifying informative features associated with multiple labels.However,traditional centralized methods face significant chal...Multi-label feature selection(MFS)is a crucial dimensionality reduction technique aimed at identifying informative features associated with multiple labels.However,traditional centralized methods face significant challenges in privacy-sensitive and distributed settings,often neglecting label dependencies and suffering from low computational efficiency.To address these issues,we introduce a novel framework,Fed-MFSDHBCPSO—federated MFS via dual-layer hybrid breeding cooperative particle swarm optimization algorithm with manifold and sparsity regularization(DHBCPSO-MSR).Leveraging the federated learning paradigm,Fed-MFSDHBCPSO allows clients to perform local feature selection(FS)using DHBCPSO-MSR.Locally selected feature subsets are encrypted with differential privacy(DP)and transmitted to a central server,where they are securely aggregated and refined through secure multi-party computation(SMPC)until global convergence is achieved.Within each client,DHBCPSO-MSR employs a dual-layer FS strategy.The inner layer constructs sample and label similarity graphs,generates Laplacian matrices to capture the manifold structure between samples and labels,and applies L2,1-norm regularization to sparsify the feature subset,yielding an optimized feature weight matrix.The outer layer uses a hybrid breeding cooperative particle swarm optimization algorithm to further refine the feature weight matrix and identify the optimal feature subset.The updated weight matrix is then fed back to the inner layer for further optimization.Comprehensive experiments on multiple real-world multi-label datasets demonstrate that Fed-MFSDHBCPSO consistently outperforms both centralized and federated baseline methods across several key evaluation metrics.展开更多
Huperzine A(HupA) is a highly selective, reversible acetylcholinesterase(AChE) inhibitor that exhibits neuroprotective effects and is clinically used to manage benign memory decline.However, the specific relationship ...Huperzine A(HupA) is a highly selective, reversible acetylcholinesterase(AChE) inhibitor that exhibits neuroprotective effects and is clinically used to manage benign memory decline.However, the specific relationship between the pharmacokinetic(PK) profile of HupA and cerebral acetylcholine(ACh) dynamics remains poorly characterized. Here, we characterize the PK-pharmacodynamic(PD) properties of HupA in rats under both physiological and pathological conditions. Following a single intramuscular injection, HupA exhibits a short halflife but rapid brain penetration, while multiple dosing significantly enhances its brain exposure. In a middle cerebral artery occlusion(MCAO) rat model, HupA demonstrates increased brain distribution. Furthermore, HupA elevates ACh concentrations across multiple brain regions, concurrently modulating several monoamine neurotransmitters. Using a minimal physiologically based pharmacokinetic-pharmacodynamic(mPBPK-PD) modeling approach,cerebral ACh dynamics were accurately predicted based on the pharmacokinetics of HupA in systemic circulation. The developed mPBPK-PD model exhibits robust predictive performance and holds potential for guiding the optimization of clinical dosing regimens and improving the therapeutic efficacy of HupA.展开更多
The role of ore metals in magmatic fluids during the magmatic-hydrothermal transition in porphyry systems remains unclear,and their contributions to porphyry ore genesis are unclear.This study offers fresh perspective...The role of ore metals in magmatic fluids during the magmatic-hydrothermal transition in porphyry systems remains unclear,and their contributions to porphyry ore genesis are unclear.This study offers fresh perspectives on the ore-forming process during this critical transition,focusing on the Hongyuan porphyry Mo(Cu) deposit(PMCD) in West Junggar,China.We find that sulfide-quartz-rich miarolitic cavities(MCs),characterized by micrographic quartz and feldspar,indicate the formation of initial mineralizing fluids from magmatic fluids.This conclusion is supported by three key observations: the simultaneous formation of feldspar and sulfides in the micrographic zones of MCs,the high formation temperatures(approaching 750 ℃) suggested by the sectorzoned bright CL cores of quartz phenocrysts,and the magmatic sulfur source indicated by the narrow sulfur isotopic composition ranges(+0.18‰ to +4.63‰).LA-ICP-MS analyses reveal distinct trace element distribution patterns between the early magmatic and transition stages and the later hydrothermal stage.Chalcopyrite from the early stages has higher Cd and lower Zn contents,while molybdenite has higher Re contents,and pyrite has higher Co and Ni contents than its counterparts in the hydrothermal stage.The decrease in sulfur concentrations at sulfide saturation from granite porphyry to micrographic quartz-feldspar melts(from 200 ppm to 100 ppm) suggests that nearly half of the sulfur was exsolved during the formation of feldspar and quartz intergrowths from fractionated granitic magma.These findings indicate that the initial mineralizing fluids of the porphyry deposit were high-temperature,melt-bearing,and ore-rich and originated from magma.The transition from initial melt-bearing,metal-rich fluids to hydrothermal ore-forming fluids is marked by decreasing temperatures and logf_(S2) values,underscoring the critical role of sulfide formation during the magmatic-hydrothermal transition in the development of porphyry deposits.展开更多
文摘本研究系统探究了不同复水方式对干银耳复水后品质特性及内部水分迁移规律的影响。以干银耳为原料,采用70、100℃热水复水(hot water rehydration,HWR)及70、100℃超声联合热水复水(ultrasound-hot water rehydration,US-HWR)4种方式,分别处理3、4、5 min。通过测定复水比、色泽、质构特性(硬度、黏稠度)、多糖含量及感官评分进行综合品质评价,并利用低场核磁共振(low-field nuclear magnetic resonance,LF-NMR)技术分析复水过程中的水分迁移状态。结果表明,US-HWR能显著提高银耳的吸水率,加速水分迁移,但同时也导致硬度下降、黏稠度升高及多糖溶出损失。综合各项指标,100℃超声联合热水复水3 min(USHWR-100℃3 min)为最优工艺。该条件下,银耳的复水比为12.79±0.78,硬度为(69.36±3.13)g,黏稠度为(0.030±0.002)g·s,感官评分达到最高值(82.50±2.55)。LF-NMR分析显示,复水银耳中的水分主要由T_(2b)、T_(21)、T_(22)和T_(234)个组分构成,且复水时间延长与超声处理均能显著提高银耳内部水分的自由度,促进水分迁移。综上,US-HWR-100℃3 min是一种高效、优质的银耳复水技术,能在最短时间内获得感官与理化品质俱佳的产品,是凉拌银耳预制菜工业化生产的理想复水方式。
文摘Multi-label feature selection(MFS)is a crucial dimensionality reduction technique aimed at identifying informative features associated with multiple labels.However,traditional centralized methods face significant challenges in privacy-sensitive and distributed settings,often neglecting label dependencies and suffering from low computational efficiency.To address these issues,we introduce a novel framework,Fed-MFSDHBCPSO—federated MFS via dual-layer hybrid breeding cooperative particle swarm optimization algorithm with manifold and sparsity regularization(DHBCPSO-MSR).Leveraging the federated learning paradigm,Fed-MFSDHBCPSO allows clients to perform local feature selection(FS)using DHBCPSO-MSR.Locally selected feature subsets are encrypted with differential privacy(DP)and transmitted to a central server,where they are securely aggregated and refined through secure multi-party computation(SMPC)until global convergence is achieved.Within each client,DHBCPSO-MSR employs a dual-layer FS strategy.The inner layer constructs sample and label similarity graphs,generates Laplacian matrices to capture the manifold structure between samples and labels,and applies L2,1-norm regularization to sparsify the feature subset,yielding an optimized feature weight matrix.The outer layer uses a hybrid breeding cooperative particle swarm optimization algorithm to further refine the feature weight matrix and identify the optimal feature subset.The updated weight matrix is then fed back to the inner layer for further optimization.Comprehensive experiments on multiple real-world multi-label datasets demonstrate that Fed-MFSDHBCPSO consistently outperforms both centralized and federated baseline methods across several key evaluation metrics.
基金supported by the National Key Research and Development Program of China (No. 2024YFA1308200)the National Natural Science Foundation of China (Nos. 82274009 and81973556)。
文摘Huperzine A(HupA) is a highly selective, reversible acetylcholinesterase(AChE) inhibitor that exhibits neuroprotective effects and is clinically used to manage benign memory decline.However, the specific relationship between the pharmacokinetic(PK) profile of HupA and cerebral acetylcholine(ACh) dynamics remains poorly characterized. Here, we characterize the PK-pharmacodynamic(PD) properties of HupA in rats under both physiological and pathological conditions. Following a single intramuscular injection, HupA exhibits a short halflife but rapid brain penetration, while multiple dosing significantly enhances its brain exposure. In a middle cerebral artery occlusion(MCAO) rat model, HupA demonstrates increased brain distribution. Furthermore, HupA elevates ACh concentrations across multiple brain regions, concurrently modulating several monoamine neurotransmitters. Using a minimal physiologically based pharmacokinetic-pharmacodynamic(mPBPK-PD) modeling approach,cerebral ACh dynamics were accurately predicted based on the pharmacokinetics of HupA in systemic circulation. The developed mPBPK-PD model exhibits robust predictive performance and holds potential for guiding the optimization of clinical dosing regimens and improving the therapeutic efficacy of HupA.
基金jointly supported by the National Natural Science Foundation of China (Nos.42272075,42302083,and 92162323)Guangdong Province Introduced Innovative R&D Team of Big Data-Mathematical Earth Sciences and Extreme Geological Events Team (No.2021ZT09H399)+1 种基金the National Key R&D Program of China (Nos.2017YFC0601201,2018YFC0604002)the Fundamental Research Funds for the Central Universities,Sun Yat-sen University (No.22qntd2101)。
文摘The role of ore metals in magmatic fluids during the magmatic-hydrothermal transition in porphyry systems remains unclear,and their contributions to porphyry ore genesis are unclear.This study offers fresh perspectives on the ore-forming process during this critical transition,focusing on the Hongyuan porphyry Mo(Cu) deposit(PMCD) in West Junggar,China.We find that sulfide-quartz-rich miarolitic cavities(MCs),characterized by micrographic quartz and feldspar,indicate the formation of initial mineralizing fluids from magmatic fluids.This conclusion is supported by three key observations: the simultaneous formation of feldspar and sulfides in the micrographic zones of MCs,the high formation temperatures(approaching 750 ℃) suggested by the sectorzoned bright CL cores of quartz phenocrysts,and the magmatic sulfur source indicated by the narrow sulfur isotopic composition ranges(+0.18‰ to +4.63‰).LA-ICP-MS analyses reveal distinct trace element distribution patterns between the early magmatic and transition stages and the later hydrothermal stage.Chalcopyrite from the early stages has higher Cd and lower Zn contents,while molybdenite has higher Re contents,and pyrite has higher Co and Ni contents than its counterparts in the hydrothermal stage.The decrease in sulfur concentrations at sulfide saturation from granite porphyry to micrographic quartz-feldspar melts(from 200 ppm to 100 ppm) suggests that nearly half of the sulfur was exsolved during the formation of feldspar and quartz intergrowths from fractionated granitic magma.These findings indicate that the initial mineralizing fluids of the porphyry deposit were high-temperature,melt-bearing,and ore-rich and originated from magma.The transition from initial melt-bearing,metal-rich fluids to hydrothermal ore-forming fluids is marked by decreasing temperatures and logf_(S2) values,underscoring the critical role of sulfide formation during the magmatic-hydrothermal transition in the development of porphyry deposits.
