Mitochondrial dysfunction has emerged as a critical factor in the etiology of various neurodevelopmental disorders, including autism spectrum disorders, attention-deficit/hyperactivity disorder, and Rett syndrome. Alt...Mitochondrial dysfunction has emerged as a critical factor in the etiology of various neurodevelopmental disorders, including autism spectrum disorders, attention-deficit/hyperactivity disorder, and Rett syndrome. Although these conditions differ in clinical presentation, they share fundamental pathological features that may stem from abnormal mitochondrial dynamics and impaired autophagic clearance, which contribute to redox imbalance and oxidative stress in neurons. This review aimed to elucidate the relationship between mitochondrial dynamics dysfunction and neurodevelopmental disorders. Mitochondria are highly dynamic organelles that undergo continuous fusion and fission to meet the substantial energy demands of neural cells. Dysregulation of these processes, as observed in certain neurodevelopmental disorders, causes accumulation of damaged mitochondria, exacerbating oxidative damage and impairing neuronal function. The phosphatase and tensin homolog-induced putative kinase 1/E3 ubiquitin-protein ligase pathway is crucial for mitophagy, the process of selectively removing malfunctioning mitochondria. Mutations in genes encoding mitochondrial fusion proteins have been identified in autism spectrum disorders, linking disruptions in the fusion-fission equilibrium to neurodevelopmental impairments. Additionally, animal models of Rett syndrome have shown pronounced defects in mitophagy, reinforcing the notion that mitochondrial quality control is indispensable for neuronal health. Clinical studies have highlighted the importance of mitochondrial disturbances in neurodevelopmental disorders. In autism spectrum disorders, elevated oxidative stress markers and mitochondrial DNA deletions indicate compromised mitochondrial function. Attention-deficit/hyperactivity disorder has also been associated with cognitive deficits linked to mitochondrial dysfunction and oxidative stress. Moreover, induced pluripotent stem cell models derived from patients with Rett syndrome have shown impaired mitochondrial dynamics and heightened vulnerability to oxidative injury, suggesting the role of defective mitochondrial homeostasis in these disorders. From a translational standpoint, multiple therapeutic approaches targeting mitochondrial pathways show promise. Interventions aimed at preserving normal fusion-fission cycles or enhancing mitophagy can reduce oxidative damage by limiting the accumulation of defective mitochondria. Pharmacological modulation of mitochondrial permeability and upregulation of peroxisome proliferator-activated receptor gamma coactivator 1-alpha, an essential regulator of mitochondrial biogenesis, may also ameliorate cellular energy deficits. Identifying early biomarkers of mitochondrial impairment is crucial for precision medicine, since it can help clinicians tailor interventions to individual patient profiles and improve prognoses. Furthermore, integrating mitochondria-focused strategies with established therapies, such as antioxidants or behavioral interventions, may enhance treatment efficacy and yield better clinical outcomes. Leveraging these pathways could open avenues for regenerative strategies, given the influence of mitochondria on neuronal repair and plasticity. In conclusion, this review indicates mitochondrial homeostasis as a unifying therapeutic axis within neurodevelopmental pathophysiology. Disruptions in mitochondrial dynamics and autophagic clearance converge on oxidative stress, and researchers should prioritize validating these interventions in clinical settings to advance precision medicine and enhance outcomes for individuals affected by neurodevelopmental disorders.展开更多
Traditional stealth materials do not fulfill the requirements of high absorption for radar waves and low emissivity for infrared waves.Furthermore,they can be detected by various technologies,considerably threatening ...Traditional stealth materials do not fulfill the requirements of high absorption for radar waves and low emissivity for infrared waves.Furthermore,they can be detected by various technologies,considerably threatening weapon safety.Therefore,a stealth material compatible with radar and infrared was designed based on the photonic bandgap characteristics of photonic crystals.The radar stealth lay-er(bottom layer)is a composite of carbonyl iron/silicon dioxide/epoxy resin,and the infrared stealth layer(top layer)is a 1D photonic crystal with alternately and periodically stacked germanium and silicon nitride.Through composition optimization and structural adjust-ment,the effective absorption bandwidth of the compatible stealth material with a reflection loss of less than-10 dB has reached 4.95 GHz.The average infrared emissivity of the proposed design is 0.1063,indicating good stealth performance.The theoretical analysis proves that photonic crystals with this structural design can produce infrared waves within the photonic bandgap,achieving high radar wave transmittance and low infrared emissivity.Infrared stealth is achieved without affecting the absorption performance of the radar stealth layer,and the conflict between radar and infrared stealth performance is resolved.This work aims to promote the application of photonic crystals in compatible stealth materials and the development of stealth technology and to provide a design and theoretical found-ation for related experiments and research.展开更多
The Electro–Hydrostatic Actuator(EHA)is applied to drive the control surface in flightcontrol system of more electric aircraft.In EHA,the Oil-Immersed Motor Pump(OMP)serves asthe core as a power assembly.However,the ...The Electro–Hydrostatic Actuator(EHA)is applied to drive the control surface in flightcontrol system of more electric aircraft.In EHA,the Oil-Immersed Motor Pump(OMP)serves asthe core as a power assembly.However,the compact integration of the OMP presents challenges inefficiently dissipating internal heat,leading to a performance degradation of the EHA due to ele-vated temperatures.Therefore,accurately modeling and predicting the internal thermal dynamicsof the OMP hold considerable significance for monitoring the operational condition of the EHA.In view of this,a modeling method considering cumulative thermal coupling was hereby proposed.Based on the proposed method,the thermal models of the motor and the pump were established,taking into account heat accumulation and transfer.Taking the leakage oil as the heat couplingpoint between the motor and the pump,the dynamic thermal coupling model of the OMP wasdeveloped,with the thermal characteristics of the oil considered.Additionally,the comparativeexperiments were conducted to illustrate the efficiency of the proposed model.The experimentalresults demonstrate that the proposed dynamic thermal coupling model accurately captured thethermal behavior of OMP,outperforming the static thermal parameter model.Overall,thisadvancement is crucial for effectively monitoring the health of EHA and ensuring flight safety.展开更多
This editorial discusses a case report recently published in the World Journal of Clinical Cases.The report describes the clinical presentation,imaging,diagnosis,and treatment of a patient with tuberous sclerosis comp...This editorial discusses a case report recently published in the World Journal of Clinical Cases.The report describes the clinical presentation,imaging,diagnosis,and treatment of a patient with tuberous sclerosis complex(TSC)combined with primary lymphedema(PLE).Additionally,it retrospectively analyzes the data of 16 previously reported cases of children with TSC combined with PLE to summarize the epidemiology,genetic diagnosis,and current main treatments of these patients.The report also speculates on the pathological and physiological mechanisms underlying TSC combined with PLE.TSC combined with PLE is rare;therefore,the report provides a theoretical basis for understanding the pathophysiological mechanisms and treatment options for patients with TSC and PLE.Comprehensive clinical management of TSC is essential due to the diverse and multiorgan nature of its manifestations,often requiring a multidisciplinary approach for newly diagnosed cases.展开更多
文摘Mitochondrial dysfunction has emerged as a critical factor in the etiology of various neurodevelopmental disorders, including autism spectrum disorders, attention-deficit/hyperactivity disorder, and Rett syndrome. Although these conditions differ in clinical presentation, they share fundamental pathological features that may stem from abnormal mitochondrial dynamics and impaired autophagic clearance, which contribute to redox imbalance and oxidative stress in neurons. This review aimed to elucidate the relationship between mitochondrial dynamics dysfunction and neurodevelopmental disorders. Mitochondria are highly dynamic organelles that undergo continuous fusion and fission to meet the substantial energy demands of neural cells. Dysregulation of these processes, as observed in certain neurodevelopmental disorders, causes accumulation of damaged mitochondria, exacerbating oxidative damage and impairing neuronal function. The phosphatase and tensin homolog-induced putative kinase 1/E3 ubiquitin-protein ligase pathway is crucial for mitophagy, the process of selectively removing malfunctioning mitochondria. Mutations in genes encoding mitochondrial fusion proteins have been identified in autism spectrum disorders, linking disruptions in the fusion-fission equilibrium to neurodevelopmental impairments. Additionally, animal models of Rett syndrome have shown pronounced defects in mitophagy, reinforcing the notion that mitochondrial quality control is indispensable for neuronal health. Clinical studies have highlighted the importance of mitochondrial disturbances in neurodevelopmental disorders. In autism spectrum disorders, elevated oxidative stress markers and mitochondrial DNA deletions indicate compromised mitochondrial function. Attention-deficit/hyperactivity disorder has also been associated with cognitive deficits linked to mitochondrial dysfunction and oxidative stress. Moreover, induced pluripotent stem cell models derived from patients with Rett syndrome have shown impaired mitochondrial dynamics and heightened vulnerability to oxidative injury, suggesting the role of defective mitochondrial homeostasis in these disorders. From a translational standpoint, multiple therapeutic approaches targeting mitochondrial pathways show promise. Interventions aimed at preserving normal fusion-fission cycles or enhancing mitophagy can reduce oxidative damage by limiting the accumulation of defective mitochondria. Pharmacological modulation of mitochondrial permeability and upregulation of peroxisome proliferator-activated receptor gamma coactivator 1-alpha, an essential regulator of mitochondrial biogenesis, may also ameliorate cellular energy deficits. Identifying early biomarkers of mitochondrial impairment is crucial for precision medicine, since it can help clinicians tailor interventions to individual patient profiles and improve prognoses. Furthermore, integrating mitochondria-focused strategies with established therapies, such as antioxidants or behavioral interventions, may enhance treatment efficacy and yield better clinical outcomes. Leveraging these pathways could open avenues for regenerative strategies, given the influence of mitochondria on neuronal repair and plasticity. In conclusion, this review indicates mitochondrial homeostasis as a unifying therapeutic axis within neurodevelopmental pathophysiology. Disruptions in mitochondrial dynamics and autophagic clearance converge on oxidative stress, and researchers should prioritize validating these interventions in clinical settings to advance precision medicine and enhance outcomes for individuals affected by neurodevelopmental disorders.
基金supported by the National Natural Science Foundation of China(Nos.52071053,U1704253,and 52103334).
文摘Traditional stealth materials do not fulfill the requirements of high absorption for radar waves and low emissivity for infrared waves.Furthermore,they can be detected by various technologies,considerably threatening weapon safety.Therefore,a stealth material compatible with radar and infrared was designed based on the photonic bandgap characteristics of photonic crystals.The radar stealth lay-er(bottom layer)is a composite of carbonyl iron/silicon dioxide/epoxy resin,and the infrared stealth layer(top layer)is a 1D photonic crystal with alternately and periodically stacked germanium and silicon nitride.Through composition optimization and structural adjust-ment,the effective absorption bandwidth of the compatible stealth material with a reflection loss of less than-10 dB has reached 4.95 GHz.The average infrared emissivity of the proposed design is 0.1063,indicating good stealth performance.The theoretical analysis proves that photonic crystals with this structural design can produce infrared waves within the photonic bandgap,achieving high radar wave transmittance and low infrared emissivity.Infrared stealth is achieved without affecting the absorption performance of the radar stealth layer,and the conflict between radar and infrared stealth performance is resolved.This work aims to promote the application of photonic crystals in compatible stealth materials and the development of stealth technology and to provide a design and theoretical found-ation for related experiments and research.
基金supported by the National Key R&D Program of China(No.2021YFB2011300)the National Natural Science Foundation of China(Nos.52275044,U2233212)。
文摘The Electro–Hydrostatic Actuator(EHA)is applied to drive the control surface in flightcontrol system of more electric aircraft.In EHA,the Oil-Immersed Motor Pump(OMP)serves asthe core as a power assembly.However,the compact integration of the OMP presents challenges inefficiently dissipating internal heat,leading to a performance degradation of the EHA due to ele-vated temperatures.Therefore,accurately modeling and predicting the internal thermal dynamicsof the OMP hold considerable significance for monitoring the operational condition of the EHA.In view of this,a modeling method considering cumulative thermal coupling was hereby proposed.Based on the proposed method,the thermal models of the motor and the pump were established,taking into account heat accumulation and transfer.Taking the leakage oil as the heat couplingpoint between the motor and the pump,the dynamic thermal coupling model of the OMP wasdeveloped,with the thermal characteristics of the oil considered.Additionally,the comparativeexperiments were conducted to illustrate the efficiency of the proposed model.The experimentalresults demonstrate that the proposed dynamic thermal coupling model accurately captured thethermal behavior of OMP,outperforming the static thermal parameter model.Overall,thisadvancement is crucial for effectively monitoring the health of EHA and ensuring flight safety.
文摘This editorial discusses a case report recently published in the World Journal of Clinical Cases.The report describes the clinical presentation,imaging,diagnosis,and treatment of a patient with tuberous sclerosis complex(TSC)combined with primary lymphedema(PLE).Additionally,it retrospectively analyzes the data of 16 previously reported cases of children with TSC combined with PLE to summarize the epidemiology,genetic diagnosis,and current main treatments of these patients.The report also speculates on the pathological and physiological mechanisms underlying TSC combined with PLE.TSC combined with PLE is rare;therefore,the report provides a theoretical basis for understanding the pathophysiological mechanisms and treatment options for patients with TSC and PLE.Comprehensive clinical management of TSC is essential due to the diverse and multiorgan nature of its manifestations,often requiring a multidisciplinary approach for newly diagnosed cases.
