Oxytocin is classically termed a‘prosocial neuropeptide’because of its evolutionarily conserved role in promoting affiliative behaviors.Endogenous oxytocin is mainly synthesized by hypothalamic oxytocin neurons and ...Oxytocin is classically termed a‘prosocial neuropeptide’because of its evolutionarily conserved role in promoting affiliative behaviors.Endogenous oxytocin is mainly synthesized by hypothalamic oxytocin neurons and signals through oxytocin receptors(OxtRs).Recent studies with cell type-specific and circuit-specific interrogation have uncovered that oxytocin signals exert pleiotropic neuromodulatory effects through anatomically widespread axonal projections and ubiquitously distributed OxtRs.Dysfunctions of oxytocin signals are closely relevant to brain disorders/diseases.While intranasal oxytocin administration has been demonstrated to be one potential strategy to alleviate some brain disorders/diseases,such as autism,obesity,and anxiety,conflicting clinical outcomes highlight the imperative for precision-targeted neuromodulation strategies.Dissecting the molecular,cellular,and neural circuitry mechanisms underlying oxytocinergic modulation is a prerequisite to achieving this goal.This review provides an overview of the current understanding of the oxytocin system in terms of anatomical structure,neuronal modulation,and signal pathways,and discusses the modulatory roles of oxytocin in social,feeding,emotional,and sensory-related brain functions and brain diseases.展开更多
Gas injection-enhanced underground coal combustion for heat extraction represents a disruptive chemical fluidized extraction method of coal resources.Coal seam combustion dynamics provide crucial underpinnings for eng...Gas injection-enhanced underground coal combustion for heat extraction represents a disruptive chemical fluidized extraction method of coal resources.Coal seam combustion dynamics provide crucial underpinnings for engineering realization.This study establishes an experimental system for monitoring temperature field evolution during gas-assisted combustion in cylindrical coal cores,investigating the influence of moisture content(0%,16%,24%)on gas-assisted combustion kinetics.Results showed moisture content significantly influences combustion:higher levels(16%-24%)delay high-temperature expansion(0-1 h)due to evaporation energy absorption,but subsequently enhance efficiency through pore formation and oxygen diffusion,achieving 1120-1230°C peaks.Dry coal exhibits rapid initial combustion(peak temperature of 1130°C within 1 h)but weaker sustained reactions.The temperature field evolves from localized hotspots to an elliptical high-temperature zone,with axial expansion rates surpassing radial rates,driven by thermal buoyancy and convective heat transfer.Moisture’s dual role is revealed:initially as a thermodynamic inhibitor and later as a promoter by increasing pore diameter and oxygen diffusion coefficients.An optimal moisture content of 16%balances initial heat loss with enhanced reactivity,offering practical insights for optimizing gas injection and thermal recovery in underground coal combustion.展开更多
基金supported by grants from the Noncommunicable Chronic Diseases-National Science and Technology Major Project(2023ZD0506800)the National Natural Science Foundation of China(32371058,81970727,31900738)+3 种基金the Open Research Fund of Basic Medicine College(JCKFKT-MS-010)the Autism Research Fund of the Zhejiang Foundation for Disabled Persons(2024002)Shanghai Municipal Science and Technology Major Project(2018SHZDZX01)ZJ Lab,and Shanghai Center for Brain Science and Brain-Inspired Technology.
文摘Oxytocin is classically termed a‘prosocial neuropeptide’because of its evolutionarily conserved role in promoting affiliative behaviors.Endogenous oxytocin is mainly synthesized by hypothalamic oxytocin neurons and signals through oxytocin receptors(OxtRs).Recent studies with cell type-specific and circuit-specific interrogation have uncovered that oxytocin signals exert pleiotropic neuromodulatory effects through anatomically widespread axonal projections and ubiquitously distributed OxtRs.Dysfunctions of oxytocin signals are closely relevant to brain disorders/diseases.While intranasal oxytocin administration has been demonstrated to be one potential strategy to alleviate some brain disorders/diseases,such as autism,obesity,and anxiety,conflicting clinical outcomes highlight the imperative for precision-targeted neuromodulation strategies.Dissecting the molecular,cellular,and neural circuitry mechanisms underlying oxytocinergic modulation is a prerequisite to achieving this goal.This review provides an overview of the current understanding of the oxytocin system in terms of anatomical structure,neuronal modulation,and signal pathways,and discusses the modulatory roles of oxytocin in social,feeding,emotional,and sensory-related brain functions and brain diseases.
基金supported by the Key Project of Chongqing Special Program for Technological Innovation and Application Development(CSTB2024TIAD-KPX0099)the Graduate Research Innovation Project of Chongqing,China(CYB240050),the Fundamental Research Funds for the Central Universities(2025CDJZKKYJH-14)the State Key Laboratory of Coal Mine Disaster Dynamics and Control for 2030 major project(2011DA105287-MX2030-202101).
文摘Gas injection-enhanced underground coal combustion for heat extraction represents a disruptive chemical fluidized extraction method of coal resources.Coal seam combustion dynamics provide crucial underpinnings for engineering realization.This study establishes an experimental system for monitoring temperature field evolution during gas-assisted combustion in cylindrical coal cores,investigating the influence of moisture content(0%,16%,24%)on gas-assisted combustion kinetics.Results showed moisture content significantly influences combustion:higher levels(16%-24%)delay high-temperature expansion(0-1 h)due to evaporation energy absorption,but subsequently enhance efficiency through pore formation and oxygen diffusion,achieving 1120-1230°C peaks.Dry coal exhibits rapid initial combustion(peak temperature of 1130°C within 1 h)but weaker sustained reactions.The temperature field evolves from localized hotspots to an elliptical high-temperature zone,with axial expansion rates surpassing radial rates,driven by thermal buoyancy and convective heat transfer.Moisture’s dual role is revealed:initially as a thermodynamic inhibitor and later as a promoter by increasing pore diameter and oxygen diffusion coefficients.An optimal moisture content of 16%balances initial heat loss with enhanced reactivity,offering practical insights for optimizing gas injection and thermal recovery in underground coal combustion.
