Red petal spots are beneficial for attracting cotton pollinators and producing hybrid seeds,and the anthocyanin pathway is generally regarded as a metabolic cause of petal coloration.The current study identified an MY...Red petal spots are beneficial for attracting cotton pollinators and producing hybrid seeds,and the anthocyanin pathway is generally regarded as a metabolic cause of petal coloration.The current study identified an MYB-encoding gene(Gar07G09390,Ga MYB)as a candidate gene involved in cotton coloration by map-based cloning,and this MYB could positively regulate a candidate glutathione S transferase gene(Gar07G08900,Ga GST).To unveil potentially involved genes within the Ga MYB-regulating-Ga GST route,color metabolites of both Ga MYB-and Ga GST-virus-induced gene silencing(VIGS)petals were investigated,revealing that they were largely glycosyl-decorated flavonoids.Accordingly,a transcriptomic survey of both VIGS petals identified a glycosyl-transferase gene(Ga GT,Gar02G15390).Notably,this Ga GT is adjacent to one of the genome-wide association study loci concerning petal spots in Gossypium arboreum,and it is also positively regulated by Ga MYB.This new regulatory route including both GST and GT regulated by MYB is conserved among the three cotton species examined in this study(Gossypium arboreum,Gossypium hirsutum,and Gossypium barbadense).Accordingly,comprehensively evaluating the influence of these candidates and their homologs on cotton coloration may provide a more in-depth understanding of cotton coloration,ultimately facilitating the breeding of more colorful cotton.展开更多
Hydrogen peroxide(H_(2)O_(2)),as a prevalently green oxidant in the chemical industry,confronts many bottlenecks in the conventional anthraquinone-based methods,such as organic solvents dependency,energy-intensive com...Hydrogen peroxide(H_(2)O_(2)),as a prevalently green oxidant in the chemical industry,confronts many bottlenecks in the conventional anthraquinone-based methods,such as organic solvents dependency,energy-intensive complex operations and inherent safety risks from centralized production.The direct synthesis route from H_(2) coupled with O_(2) presents a promising alternative,but remains constrained by the safety requirement and the reaction control demand.This article systematically reviews breakthroughs in non-hydrogen catalytic systems for in situ synthesis of H_(2)O_(2).Through elucidating the mechanism of two-electron oxygen reduction pathways,renewable hydrogen substitutes with enhanced safety including CO,HCOOH,glucose and alcohols have been highlighted.Their efficient conversion of O_(2) to H_(2)O_(2) and the integration with sustainable processes such as selective oxidation are also discussed.It is expected to provide fundamental insights into the synergistic mechanism in heterogeneous catalysis and offer a new viewpoint for developing a decentralized H_(2)O_(2) synthesis system for practical applications,moving toward a greener and more economical H_(2)O_(2) production approach.展开更多
The beam energy measurement system is significant and profit for both BES-III detector and BEPC-II accelerator. The detection of the high energy scattering photons is realized by virtue of the Compton backscattering p...The beam energy measurement system is significant and profit for both BES-III detector and BEPC-II accelerator. The detection of the high energy scattering photons is realized by virtue of the Compton backscattering principle. Many advanced techniques and precise instruments are employed to acquire the highly accurate measurement of positron/electron beam energy. During five years’ running period, in order to satisfy the requirement of data taking and enhance the capacity of measurement itself, the upgradation of system is continued, which involves the components reformation of laser and optics subsystem, replacement of view-port of the laser to vacuum insertion subsystem, the usage of electric cooling system for high purity germanium detector, and the refinement of data acquisition and processing subsystem. The upgrading of system guarantees the smooth and effective measuring of beam energy at BEPC-II and accommodates the accurate offline energy values for further physics analysis at BES-III.展开更多
BACKGROUND Mycoplasma hominis(M.hominis),which causes central nervous system infections in adults,is very rare.It is also relatively difficult to culture mycoplasma and culturing requires special media,resulting in a ...BACKGROUND Mycoplasma hominis(M.hominis),which causes central nervous system infections in adults,is very rare.It is also relatively difficult to culture mycoplasma and culturing requires special media,resulting in a high rate of clinical underdiagnosis.Therefore,clinicians often treat patients based on their own experience before obtaining pathogenic results and may ignore infections with atypical pathogens,thus delaying the diagnosis and treatment of patients and increasing the length of hospital stay and costs.CASE SUMMARY A 44-year-old man presented to the hospital complaining of recurrent dizziness for 1 year,which had worsened in the last week.After admission,brain magnetic resonance imaging(MRI)revealed a 7.0 cm×6.0 cm×6.1 cm lesion at the skull base,which was irregular in shape and had a midline shift to the left.Based on imaging findings,meningioma was our primary consideration.After lesion resection,the patient had persistent fever and a diagnosis of suppurative meningitis based on cerebrospinal fluid(CSF)examination.The patient was treated with the highest level of antibiotics(meropenem and linezolid),but the response was ineffective.Finally,M.hominis was detected by next-generation metagenomic sequencing(mNGS)in the CSF.Therefore,we changed the antibiotics to moxifloxacin 0.4 g daily combined with doxycycline 0.1 g twice a day for 2 wk,and the patient had a normal temperature the next day.CONCLUSION Mycoplasma meningitis after neurosurgery is rare.We can use mNGS to detect M.hominis in the CSF and then provide targeted treatment.展开更多
NPR1 is an intersection of different disease resistance pathways and plays a key role in systemic-acquired resistance and induced systemic resistance. NPR1 regulates constitutive resistance and disease resistance dete...NPR1 is an intersection of different disease resistance pathways and plays a key role in systemic-acquired resistance and induced systemic resistance. NPR1 regulates constitutive resistance and disease resistance determined by resistant genes. In this paper, the mechanism of disease resistance of NPR1 genes and its analogs were described. The research status and progress of NPR1 transgenic crops were systematically discussed. The application prospect of NPR1 transgenic crops was also forecasted.展开更多
A new colorimetric and fluorimetric chemosensor for F detection based on 1H-imidazo[4,5-b]phenazine derivative has been designed and synthesized.It shows excellent fluorescent specific selectivity and sensitivity for ...A new colorimetric and fluorimetric chemosensor for F detection based on 1H-imidazo[4,5-b]phenazine derivative has been designed and synthesized.It shows excellent fluorescent specific selectivity and sensitivity for F^- in DMSO solution.Upon addition of F^- to the solution of probe 1,a remarkable color change from yellow to red could be observed easily by the naked-eye.The detection limit of this probe toward F^- is 6.2× 10 ^-6mol/L.Analysis by^1 H NMR proved that the imidazolyl N–H could be hydrogen-bonded with added fluoride anions,and results in the difference of colors.展开更多
Two cryogenic systems of high purity germanium detector, liquid nitrogen and mechanical cooler, are expounded, to- gether with explanations of merits and demerits for each kind of cooling methods. The resolutions of d...Two cryogenic systems of high purity germanium detector, liquid nitrogen and mechanical cooler, are expounded, to- gether with explanations of merits and demerits for each kind of cooling methods. The resolutions of detector to the characteristic lines of 152Eu under different cooling conditions are studied. The laboratory results indicate that the me- chanical cooler (X-Cooler II) is an ideal replacement candidate for the liquid nitrogen cooling system that is being util- ized by BEMS at BEPC-II.展开更多
Plasmon-induced hot-electron transfer from metal nanostructures is being intensely pursed in current photocatalytic research,however it remains elusive whether molecular-like metal clusters with excitonic behavior can...Plasmon-induced hot-electron transfer from metal nanostructures is being intensely pursed in current photocatalytic research,however it remains elusive whether molecular-like metal clusters with excitonic behavior can be used as light-harvesting materials in solar energy utilization such as photocatalytic methanol steam reforming.In this work,we report an atomically precise Cu_(13)cluster protected by dual ligands of thiolate and phosphine that can be viewed as the assembly of one top Cu atom and three Cu_(4)tetrahedra.The Cu_(13)H_(10)(SR)_(3)(PR’_(3))_(7)(SR=2,4-dichlorobenzenethiol,PR’_(3)=P(4-FC_(6)H_(4))_(3))cluster can give rise to highly efficient light-driven activity for methanol steam reforming toward H_(2)production.展开更多
To protect superconducting qubits and enable rapid readout, optimally designed Purcell filters are essential. To suppress the off-resonant driving of untargeted readout resonators, individual Purcell filters are used ...To protect superconducting qubits and enable rapid readout, optimally designed Purcell filters are essential. To suppress the off-resonant driving of untargeted readout resonators, individual Purcell filters are used for each readout resonator.However, achieving consistent frequency between a readout resonator and a Purcell filter is a significant challenge. A systematic computational analysis is conducted to investigate how fabrication variation affects filter performance, through focusing on the coupling capacitor structure and coplanar waveguide(CPW) transmission line specifications. The results indicate that the T-type enclosing capacitor(EC), which exhibits lower structural sensitivity, is more advantageous for achieving target capacitance than the C-type EC and the interdigital capacitor(IDC). By utilizing a large-sized CPW with the T-type EC structure, fluctuations in the effective coupling strength can be reduced to 10%, given typical micro-nanofabrication variances. The numerical simulations presented in this work minimize the influence of fabrication deviations, thereby significantly improving the reliability of Purcell filter designs.展开更多
Shales of the Wufeng-Longmaxi formations in the basin-margin transition zone of southeastern Chongqing,China are characterized by high organic matter content and a significant presence of pyrite development.By examini...Shales of the Wufeng-Longmaxi formations in the basin-margin transition zone of southeastern Chongqing,China are characterized by high organic matter content and a significant presence of pyrite development.By examining numerous scanning electron microscope(SEM)images and considering the crystal and aggregate characteristics of minerals,we identified four types of pyrite in the study area:euhedral crystals,irregular aggregates,framboidal aggregates,and metasomatized organisms.Among these types,framboidal aggregates are the most prevalent.The formation mechanism of framboidal pyrite can be categorized into inorganic and organic origins.As inferred from the pyrite characteristics in the study area,the formation mechanism of the metasomatized organisms aligns with the biologically induced mineralization mode of organic origin,whereas the framboidal aggregates are more associated with the biologically controlled mineralization mode of organic origin.This underscores a close relationship between the pyrite formation and organic matter,which in turn indicates that an organic origin is more consistent with the pyrite characteristics observed in this study area.The pyrite morphology can reflect reactive iron concentration.Euhedral pyrite crystals tend to form under a low reactive iron concentration,whereas the formation of framboidal pyrite requires a high reactive iron concentration.Additionally,the type and grain size of pyrite aggregates can reflect variations in the redox conditions of the depositional environment.Pyrite produces positive effects on reservoir storage space,with intercrystalline organic pores,intercrystalline pores,and mold pores associated with pyrite contributing greatly to the storage spaces.展开更多
Objective:To study the correlation of miR-106b in nasopharyngeal carcinoma with cell cycle progression and cell invasion.Methods: Patients who were diagnosed with nasopharyngeal carcinoma by pathological biopsy in She...Objective:To study the correlation of miR-106b in nasopharyngeal carcinoma with cell cycle progression and cell invasion.Methods: Patients who were diagnosed with nasopharyngeal carcinoma by pathological biopsy in Shenmu Hospital between March 2013 and February 2018 were included in the study, and the nasopharyngeal carcinoma tissue and tissue adjacent to nasopharyngeal carcinoma obtained from biopsy were collected, miRNA was extracted to determine miR-106b expression, and RNA was extracted to determine the mRNA expression of cell cycle-related genes and cell invasion-related genes.Results: miR-106b expression as well as FOXC1, CyclinD1, CyclinE, TRIM27, uPAR, PARP1 and MTA1 mRNA expression in nasopharyngeal carcinoma tissues were higher than those in adjacent tissues, CYB5R2, p16, IRF5 and E-cadherin mRNA expression were significantly lower than those in adjacent tissues whereas;CYB5R2, p16, IRF5 and E-cadherin mRNA expression in nasopharyngeal carcinoma tissues with high miR-106b expression were lower than those in nasopharyngeal carcinoma tissues with low miR-106b expression whereas FOXC1, CyclinD1, CyclinE, TRIM27, uPAR, PARP1 and MTA1 mRNA expression were higher than those in nasopharyngeal carcinoma tissues with low miR-106b expression.Conclusion:The lowly expressed miR-106b in nasopharyngeal carcinoma can promote the cell cycle progression and cell invasion in the lesion.展开更多
High purity germanium detectors have important applications in many fields. Detector’s performance deteriorated significantly due to radiation of neutron. The annealing of damaged HPGe detector is expounded in this m...High purity germanium detectors have important applications in many fields. Detector’s performance deteriorated significantly due to radiation of neutron. The annealing of damaged HPGe detector is expounded in this monograph. The experiment results indicate that raising the temperature to 70°C for five days, the restoration efficiency can reach 90%.展开更多
Background Ultrasound and serum matrix metalloproteinase-7(MMP-7)hold great value in distinguishing biliary atresia(BA)from other cholestatic diseases.This study aims to assess the accuracy of an artificial intelligen...Background Ultrasound and serum matrix metalloproteinase-7(MMP-7)hold great value in distinguishing biliary atresia(BA)from other cholestatic diseases.This study aims to assess the accuracy of an artificial intelligence(AI)based diagnostic model of ultrasound combined with serum MMP-7 in discriminative diagnosis of BA.Methods This is a multicenter diagnostic study involving six medical centers in China.Patients with obstructive jaundice were enrolled.A set of morphological operators were employed to extract features of the ultrasound images to construct an AI algorithm.Logistic regression model was established with validation.Results Two cohorts with a total of 348 children with obstructive jaundice were recruited from January 2020 to April 2023.A retrospective cohort of 187 infants served as a training cohort;this included 56 BA and 131 non-BA patients.Serum MMP-7 testing model yielded an area under the receiver-operating characteristic curve(AUROC)of 0.916[95%confidence interval(CI)=0.876–0.956],sensitivity of 94.6%(95%CI=85.1%–98.9%),specificity of 88.6%(95%CI=81.8%–93.5%),and accuracy of 90.4%(95%CI=85.2%–94.2%).Values for ultrasound testing model were 0.945(95%CI=0.902–0.987),98.2%(95%CI=90.5%–99.9%),91.6%(95%CI=85.5%–95.7%),and 93.6%(95%CI=89.1%–96.6%),respectively.The combined AI model obtained an AUROC of 0.985(95%CI=0.971–0.999),sensitivity of 98.2%(95%CI=90.5%–99.9%),specificity of 93.1%(95%CI=84.4%–96.4%),and accuracy of 94.7%(95%CI=90.4%–97.4%),respectively.Performance was confirmed using a multicenter prospective validation cohort of 161 patients that included 100 BA cases.Conclusion An AI model combining ultrasound and serum MMP-7 demonstrated robust high sensitivity and specificity in the differential diagnosis of BA.展开更多
Identifying catalytically active sites and understanding the role of the environment surrounding the active sites on heterogeneous catalysis remains a challenge.Here we show the cooperative,multisite reactivity within...Identifying catalytically active sites and understanding the role of the environment surrounding the active sites on heterogeneous catalysis remains a challenge.Here we show the cooperative,multisite reactivity within an atomically precise nanocluster Ag_(4)Pt_(2)(SR)_(8)(SR=2,4-dimethylbenzenethiol)for electrochemical hydrogen evolution reaction.Our spectroscopic analysis coupled with the computational modeling indicate that the hydrogen production proceeds via a stepwise mechanism,with the hydrogen intermediate initially presenting on the apical sites of the S atoms sequentially to bind at the pyramidally shaped location containing Ag-Pt-Ag linkages.The adsorption of hydrogen species on surrounding ligands is found to perturb the electronic structure of catalytic sites and further regulate the affinity of hydrogen species with the metal center.More notably,the subtle interplay between the catalytic function and the surrounding environment indeed facilitates the hydrogen evolution on the Ag_(4)Pt_(2)(SR)_(8) catalyst with an overpotential of only 23.3 mV at a current density of 10 mA·cm^(−2),which not only overperforms most metal nanoclusters reported but is also comparable to a typical Pt/C catalyst under identical conditions.展开更多
As a new class of luminescent material,atomically precise Au-/Ag-based nanoclusters(NCs)have recently sparked increasing interest in the nanoscience community.The tunability of metal NCs in composition,structure,and s...As a new class of luminescent material,atomically precise Au-/Ag-based nanoclusters(NCs)have recently sparked increasing interest in the nanoscience community.The tunability of metal NCs in composition,structure,and size endows them with distinct advantages in luminescent properties,such as the wide emission wavelength from visible to nearinfrared region.Besides,their well-defined structures provide an excellent opportunity to decipher the photoluminescence(PL)mechanism and its structural dependence.However,most luminescent metal NCs exhibit weak PL emissions with low quantum yields,which greatly impedes their applications.It is thus of paramount importance to develop various strategies to improve the PL intensity and quantum yield.Based on the advances of atomically modified metal NCs with light-emitting enhancement,this minireview summarizes the recent progress of some effective strategies to enhance PL efficiency from three aspects:(1)Heteroatom doping into the template NCs for PL enhancement,illustrated by doped cases with an icosahedral/cubo-octahedral kernel;(2)Surface engineering,including ligand type variation,ligand modification,and surface motif reconstruction;and(3)Structural isomerization,exemplified by the pairs of Au_(25)-sphere/Au_(25)-rod,Au_(38)/Au_(38)S_(2),and fcc-Au_(42)/non-fcc-Au_(42) NCs with quasi-isomeric structures.Finally,several perspectives on the further development of luminescent metal NCs are provided.展开更多
基金supported by Major Projects in Agricultural Biological Breeding(2023ZD0403902)the HAAFS Science and Technology Innovation Special Project(2022KJCXZX-MHS-1)。
文摘Red petal spots are beneficial for attracting cotton pollinators and producing hybrid seeds,and the anthocyanin pathway is generally regarded as a metabolic cause of petal coloration.The current study identified an MYB-encoding gene(Gar07G09390,Ga MYB)as a candidate gene involved in cotton coloration by map-based cloning,and this MYB could positively regulate a candidate glutathione S transferase gene(Gar07G08900,Ga GST).To unveil potentially involved genes within the Ga MYB-regulating-Ga GST route,color metabolites of both Ga MYB-and Ga GST-virus-induced gene silencing(VIGS)petals were investigated,revealing that they were largely glycosyl-decorated flavonoids.Accordingly,a transcriptomic survey of both VIGS petals identified a glycosyl-transferase gene(Ga GT,Gar02G15390).Notably,this Ga GT is adjacent to one of the genome-wide association study loci concerning petal spots in Gossypium arboreum,and it is also positively regulated by Ga MYB.This new regulatory route including both GST and GT regulated by MYB is conserved among the three cotton species examined in this study(Gossypium arboreum,Gossypium hirsutum,and Gossypium barbadense).Accordingly,comprehensively evaluating the influence of these candidates and their homologs on cotton coloration may provide a more in-depth understanding of cotton coloration,ultimately facilitating the breeding of more colorful cotton.
基金the National Natural Science Foundation of China(22125202,92461312,U24A20487,22302091,92361201)Natural Science Foundation of Jiangsu Province(BK20220033)+1 种基金Programs for high-level entrepreneurial and innovative talents of Jiangsu ProvinceChina Postdoctoral Science Foundation(2024T170400,2022M721551).
文摘Hydrogen peroxide(H_(2)O_(2)),as a prevalently green oxidant in the chemical industry,confronts many bottlenecks in the conventional anthraquinone-based methods,such as organic solvents dependency,energy-intensive complex operations and inherent safety risks from centralized production.The direct synthesis route from H_(2) coupled with O_(2) presents a promising alternative,but remains constrained by the safety requirement and the reaction control demand.This article systematically reviews breakthroughs in non-hydrogen catalytic systems for in situ synthesis of H_(2)O_(2).Through elucidating the mechanism of two-electron oxygen reduction pathways,renewable hydrogen substitutes with enhanced safety including CO,HCOOH,glucose and alcohols have been highlighted.Their efficient conversion of O_(2) to H_(2)O_(2) and the integration with sustainable processes such as selective oxidation are also discussed.It is expected to provide fundamental insights into the synergistic mechanism in heterogeneous catalysis and offer a new viewpoint for developing a decentralized H_(2)O_(2) synthesis system for practical applications,moving toward a greener and more economical H_(2)O_(2) production approach.
文摘The beam energy measurement system is significant and profit for both BES-III detector and BEPC-II accelerator. The detection of the high energy scattering photons is realized by virtue of the Compton backscattering principle. Many advanced techniques and precise instruments are employed to acquire the highly accurate measurement of positron/electron beam energy. During five years’ running period, in order to satisfy the requirement of data taking and enhance the capacity of measurement itself, the upgradation of system is continued, which involves the components reformation of laser and optics subsystem, replacement of view-port of the laser to vacuum insertion subsystem, the usage of electric cooling system for high purity germanium detector, and the refinement of data acquisition and processing subsystem. The upgrading of system guarantees the smooth and effective measuring of beam energy at BEPC-II and accommodates the accurate offline energy values for further physics analysis at BES-III.
文摘BACKGROUND Mycoplasma hominis(M.hominis),which causes central nervous system infections in adults,is very rare.It is also relatively difficult to culture mycoplasma and culturing requires special media,resulting in a high rate of clinical underdiagnosis.Therefore,clinicians often treat patients based on their own experience before obtaining pathogenic results and may ignore infections with atypical pathogens,thus delaying the diagnosis and treatment of patients and increasing the length of hospital stay and costs.CASE SUMMARY A 44-year-old man presented to the hospital complaining of recurrent dizziness for 1 year,which had worsened in the last week.After admission,brain magnetic resonance imaging(MRI)revealed a 7.0 cm×6.0 cm×6.1 cm lesion at the skull base,which was irregular in shape and had a midline shift to the left.Based on imaging findings,meningioma was our primary consideration.After lesion resection,the patient had persistent fever and a diagnosis of suppurative meningitis based on cerebrospinal fluid(CSF)examination.The patient was treated with the highest level of antibiotics(meropenem and linezolid),but the response was ineffective.Finally,M.hominis was detected by next-generation metagenomic sequencing(mNGS)in the CSF.Therefore,we changed the antibiotics to moxifloxacin 0.4 g daily combined with doxycycline 0.1 g twice a day for 2 wk,and the patient had a normal temperature the next day.CONCLUSION Mycoplasma meningitis after neurosurgery is rare.We can use mNGS to detect M.hominis in the CSF and then provide targeted treatment.
基金Supported by Natural Science Foundation of Hebei Province(C2013301069)Financial Special Projects of Hebei Province(2012055004,2014055205,F16R2016024592)+2 种基金Key Technology Support Program of Hebei Province(16226303D-3)The Industry System of Hebei Province(HBCT2013030207)The State Key Laboratory of Cotton Biology(CB2016A19)~~
文摘NPR1 is an intersection of different disease resistance pathways and plays a key role in systemic-acquired resistance and induced systemic resistance. NPR1 regulates constitutive resistance and disease resistance determined by resistant genes. In this paper, the mechanism of disease resistance of NPR1 genes and its analogs were described. The research status and progress of NPR1 transgenic crops were systematically discussed. The application prospect of NPR1 transgenic crops was also forecasted.
基金support in part by Natural Science Foundation of the Jiangsu Higher Education Institutions of China (No.13KJB150018)Natural Science Foundation of Jiangsu Province (No.BK20130926)+1 种基金Innovation program of Shanghai institute of technical physics of the Chinese Academy of Sciences (No.2013,Q-DX-36,Q-DX-37)Postgraduate Innovation Fund of Jiangsu Province (No.2013,CXZZ13_0459)
文摘A new colorimetric and fluorimetric chemosensor for F detection based on 1H-imidazo[4,5-b]phenazine derivative has been designed and synthesized.It shows excellent fluorescent specific selectivity and sensitivity for F^- in DMSO solution.Upon addition of F^- to the solution of probe 1,a remarkable color change from yellow to red could be observed easily by the naked-eye.The detection limit of this probe toward F^- is 6.2× 10 ^-6mol/L.Analysis by^1 H NMR proved that the imidazolyl N–H could be hydrogen-bonded with added fluoride anions,and results in the difference of colors.
文摘Two cryogenic systems of high purity germanium detector, liquid nitrogen and mechanical cooler, are expounded, to- gether with explanations of merits and demerits for each kind of cooling methods. The resolutions of detector to the characteristic lines of 152Eu under different cooling conditions are studied. The laboratory results indicate that the me- chanical cooler (X-Cooler II) is an ideal replacement candidate for the liquid nitrogen cooling system that is being util- ized by BEMS at BEPC-II.
基金financial support from National Natural Science Foundation of China(22125202,21932004,22101128)Natural Science Foundation of Jiangsu Province(BK20220033)。
文摘Plasmon-induced hot-electron transfer from metal nanostructures is being intensely pursed in current photocatalytic research,however it remains elusive whether molecular-like metal clusters with excitonic behavior can be used as light-harvesting materials in solar energy utilization such as photocatalytic methanol steam reforming.In this work,we report an atomically precise Cu_(13)cluster protected by dual ligands of thiolate and phosphine that can be viewed as the assembly of one top Cu atom and three Cu_(4)tetrahedra.The Cu_(13)H_(10)(SR)_(3)(PR’_(3))_(7)(SR=2,4-dichlorobenzenethiol,PR’_(3)=P(4-FC_(6)H_(4))_(3))cluster can give rise to highly efficient light-driven activity for methanol steam reforming toward H_(2)production.
基金Project support by the Youth Innovation Promotion Association of the Chinese Academy of Sciences (CAS) (Grant No. 2019319)the Start-up Foundation of Suzhou Institute of Nano-Tech and Nano-Bionics, CAS, Suzhou, China (Grant No. Y9AAD110)+1 种基金the Innovative and Entrepreneurial Talents Project of Jiangsu Province, China (Grant No. JSSCBS20221743)the Excellent Postdoctoral Talent Program of Jiangsu Province, China (Grant No. 2023ZB816)。
文摘To protect superconducting qubits and enable rapid readout, optimally designed Purcell filters are essential. To suppress the off-resonant driving of untargeted readout resonators, individual Purcell filters are used for each readout resonator.However, achieving consistent frequency between a readout resonator and a Purcell filter is a significant challenge. A systematic computational analysis is conducted to investigate how fabrication variation affects filter performance, through focusing on the coupling capacitor structure and coplanar waveguide(CPW) transmission line specifications. The results indicate that the T-type enclosing capacitor(EC), which exhibits lower structural sensitivity, is more advantageous for achieving target capacitance than the C-type EC and the interdigital capacitor(IDC). By utilizing a large-sized CPW with the T-type EC structure, fluctuations in the effective coupling strength can be reduced to 10%, given typical micro-nanofabrication variances. The numerical simulations presented in this work minimize the influence of fabrication deviations, thereby significantly improving the reliability of Purcell filter designs.
基金funded by SINOPEC(scientific research project P21087-6).
文摘Shales of the Wufeng-Longmaxi formations in the basin-margin transition zone of southeastern Chongqing,China are characterized by high organic matter content and a significant presence of pyrite development.By examining numerous scanning electron microscope(SEM)images and considering the crystal and aggregate characteristics of minerals,we identified four types of pyrite in the study area:euhedral crystals,irregular aggregates,framboidal aggregates,and metasomatized organisms.Among these types,framboidal aggregates are the most prevalent.The formation mechanism of framboidal pyrite can be categorized into inorganic and organic origins.As inferred from the pyrite characteristics in the study area,the formation mechanism of the metasomatized organisms aligns with the biologically induced mineralization mode of organic origin,whereas the framboidal aggregates are more associated with the biologically controlled mineralization mode of organic origin.This underscores a close relationship between the pyrite formation and organic matter,which in turn indicates that an organic origin is more consistent with the pyrite characteristics observed in this study area.The pyrite morphology can reflect reactive iron concentration.Euhedral pyrite crystals tend to form under a low reactive iron concentration,whereas the formation of framboidal pyrite requires a high reactive iron concentration.Additionally,the type and grain size of pyrite aggregates can reflect variations in the redox conditions of the depositional environment.Pyrite produces positive effects on reservoir storage space,with intercrystalline organic pores,intercrystalline pores,and mold pores associated with pyrite contributing greatly to the storage spaces.
文摘Objective:To study the correlation of miR-106b in nasopharyngeal carcinoma with cell cycle progression and cell invasion.Methods: Patients who were diagnosed with nasopharyngeal carcinoma by pathological biopsy in Shenmu Hospital between March 2013 and February 2018 were included in the study, and the nasopharyngeal carcinoma tissue and tissue adjacent to nasopharyngeal carcinoma obtained from biopsy were collected, miRNA was extracted to determine miR-106b expression, and RNA was extracted to determine the mRNA expression of cell cycle-related genes and cell invasion-related genes.Results: miR-106b expression as well as FOXC1, CyclinD1, CyclinE, TRIM27, uPAR, PARP1 and MTA1 mRNA expression in nasopharyngeal carcinoma tissues were higher than those in adjacent tissues, CYB5R2, p16, IRF5 and E-cadherin mRNA expression were significantly lower than those in adjacent tissues whereas;CYB5R2, p16, IRF5 and E-cadherin mRNA expression in nasopharyngeal carcinoma tissues with high miR-106b expression were lower than those in nasopharyngeal carcinoma tissues with low miR-106b expression whereas FOXC1, CyclinD1, CyclinE, TRIM27, uPAR, PARP1 and MTA1 mRNA expression were higher than those in nasopharyngeal carcinoma tissues with low miR-106b expression.Conclusion:The lowly expressed miR-106b in nasopharyngeal carcinoma can promote the cell cycle progression and cell invasion in the lesion.
文摘High purity germanium detectors have important applications in many fields. Detector’s performance deteriorated significantly due to radiation of neutron. The annealing of damaged HPGe detector is expounded in this monograph. The experiment results indicate that raising the temperature to 70°C for five days, the restoration efficiency can reach 90%.
基金financial support from National Clinical Key Specialty Construction Project(10000015Z155080000004)Shanghai Municipal Key Clinical Specialty(shslczdzk05703)+1 种基金National Natural Science Foundation of China(82270541)Children's Hospital of Fudan University(EKQM202402).
文摘Background Ultrasound and serum matrix metalloproteinase-7(MMP-7)hold great value in distinguishing biliary atresia(BA)from other cholestatic diseases.This study aims to assess the accuracy of an artificial intelligence(AI)based diagnostic model of ultrasound combined with serum MMP-7 in discriminative diagnosis of BA.Methods This is a multicenter diagnostic study involving six medical centers in China.Patients with obstructive jaundice were enrolled.A set of morphological operators were employed to extract features of the ultrasound images to construct an AI algorithm.Logistic regression model was established with validation.Results Two cohorts with a total of 348 children with obstructive jaundice were recruited from January 2020 to April 2023.A retrospective cohort of 187 infants served as a training cohort;this included 56 BA and 131 non-BA patients.Serum MMP-7 testing model yielded an area under the receiver-operating characteristic curve(AUROC)of 0.916[95%confidence interval(CI)=0.876–0.956],sensitivity of 94.6%(95%CI=85.1%–98.9%),specificity of 88.6%(95%CI=81.8%–93.5%),and accuracy of 90.4%(95%CI=85.2%–94.2%).Values for ultrasound testing model were 0.945(95%CI=0.902–0.987),98.2%(95%CI=90.5%–99.9%),91.6%(95%CI=85.5%–95.7%),and 93.6%(95%CI=89.1%–96.6%),respectively.The combined AI model obtained an AUROC of 0.985(95%CI=0.971–0.999),sensitivity of 98.2%(95%CI=90.5%–99.9%),specificity of 93.1%(95%CI=84.4%–96.4%),and accuracy of 94.7%(95%CI=90.4%–97.4%),respectively.Performance was confirmed using a multicenter prospective validation cohort of 161 patients that included 100 BA cases.Conclusion An AI model combining ultrasound and serum MMP-7 demonstrated robust high sensitivity and specificity in the differential diagnosis of BA.
基金support from the National Natural Science Foundation of China(grant nos.22125202,21932004,and 22302091)Natural Science Foundation of Jiangsu Province(grant no.BK20220033)Programs for high-level entrepreneurial and innovative talents introduction of Jiangsu Province,and China Postdoctoral Science Foundation(grant no.2022M721551).
文摘Identifying catalytically active sites and understanding the role of the environment surrounding the active sites on heterogeneous catalysis remains a challenge.Here we show the cooperative,multisite reactivity within an atomically precise nanocluster Ag_(4)Pt_(2)(SR)_(8)(SR=2,4-dimethylbenzenethiol)for electrochemical hydrogen evolution reaction.Our spectroscopic analysis coupled with the computational modeling indicate that the hydrogen production proceeds via a stepwise mechanism,with the hydrogen intermediate initially presenting on the apical sites of the S atoms sequentially to bind at the pyramidally shaped location containing Ag-Pt-Ag linkages.The adsorption of hydrogen species on surrounding ligands is found to perturb the electronic structure of catalytic sites and further regulate the affinity of hydrogen species with the metal center.More notably,the subtle interplay between the catalytic function and the surrounding environment indeed facilitates the hydrogen evolution on the Ag_(4)Pt_(2)(SR)_(8) catalyst with an overpotential of only 23.3 mV at a current density of 10 mA·cm^(−2),which not only overperforms most metal nanoclusters reported but is also comparable to a typical Pt/C catalyst under identical conditions.
基金support from the National Natural Science Foundation of China(grant nos.22125202 and 22101128)the International Cooperation and Exchanges of NSFC(grant no.22361132540).
文摘As a new class of luminescent material,atomically precise Au-/Ag-based nanoclusters(NCs)have recently sparked increasing interest in the nanoscience community.The tunability of metal NCs in composition,structure,and size endows them with distinct advantages in luminescent properties,such as the wide emission wavelength from visible to nearinfrared region.Besides,their well-defined structures provide an excellent opportunity to decipher the photoluminescence(PL)mechanism and its structural dependence.However,most luminescent metal NCs exhibit weak PL emissions with low quantum yields,which greatly impedes their applications.It is thus of paramount importance to develop various strategies to improve the PL intensity and quantum yield.Based on the advances of atomically modified metal NCs with light-emitting enhancement,this minireview summarizes the recent progress of some effective strategies to enhance PL efficiency from three aspects:(1)Heteroatom doping into the template NCs for PL enhancement,illustrated by doped cases with an icosahedral/cubo-octahedral kernel;(2)Surface engineering,including ligand type variation,ligand modification,and surface motif reconstruction;and(3)Structural isomerization,exemplified by the pairs of Au_(25)-sphere/Au_(25)-rod,Au_(38)/Au_(38)S_(2),and fcc-Au_(42)/non-fcc-Au_(42) NCs with quasi-isomeric structures.Finally,several perspectives on the further development of luminescent metal NCs are provided.
