The change of drug quality of Yuxingcao injection after formulation is considered as one of the causes for adverse reactions. In this study, orthogonal experimental design was used to investigate the influencing facto...The change of drug quality of Yuxingcao injection after formulation is considered as one of the causes for adverse reactions. In this study, orthogonal experimental design was used to investigate the influencing factors on the pH stability of Yuxingcao injection. Two methods of accelerated tests were carried out in the experiments. The results showed that using Tween 80 as the solubilizer could significantly decrease the pH value of Yuxingcao injection after accelerated tests. There was no significant difference in the pH value after the accelerated tests when the other 6 factors varied, including the type of liquid processed, the dosage of activated carbon, heating temperature, reagents for pH adjustment, pH value range after adjustment, and sterilization conditions. In order to improve the quality stability of Yuxingcao injection, the quality of Tween 80 should be strictly controlled to minimize the change of pH value of Yuxingcao injection.展开更多
Continuous manufacturing is considered as one of the future trends of pharmaceutical engineering. In this work, continuous liquid-liquid extraction for sinomenine purification was realized with the usage of centrifuga...Continuous manufacturing is considered as one of the future trends of pharmaceutical engineering. In this work, continuous liquid-liquid extraction for sinomenine purification was realized with the usage of centrifugal extractors. Chloroform was used as the extractant because of the high distribution coefficient (>100). Higher extraction ratio can be obtained when using the centrifugal extractor of Model CWL50-N. The extraction ratio of the second-stage extraction was higher than that of the first-stage extraction. The extraction ratio of the second-stage countercurrent extraction was higher than that of second-stage cross-flow extraction. When chloroform phase was recycled for liquid-liquid extraction, the extraction ratio was also higher than 95%. This work can also be an example of continuous liquid-liquid extraction for the separation of other Chinese medicine components.展开更多
In order to deeply research the structure discrepancy and modeling mechanism among different grey prediction models, the equivalence and unbiasedness of grey prediction models are analyzed and verified. The results sh...In order to deeply research the structure discrepancy and modeling mechanism among different grey prediction models, the equivalence and unbiasedness of grey prediction models are analyzed and verified. The results show that all the grey prediction models that are strictly derived from x^（0）（k） ＋az^（1）（k） = b have the identical model structure and simulation precision. Moreover, the unbiased simulation for the homogeneous exponential sequence can be accomplished. However, the models derived from dx^（1）/dt ＋ ax^（1）= b are only close to those derived from x^（0）（k） ＋ az^（1）（k） = b provided that ｜a｜ has to satisfy｜a｜ 0.1; neither could the unbiased simulation for the homogeneous exponential sequence be achieved. The above conclusions are proved and verified through some theorems and examples.展开更多
This paper studies the Browder-Tikhonov regularization of a second-order evolution hemivariational inequality （SOEHVI） with non-coercive operators. With duality mapping, the regularized formulations and a derived fi...This paper studies the Browder-Tikhonov regularization of a second-order evolution hemivariational inequality （SOEHVI） with non-coercive operators. With duality mapping, the regularized formulations and a derived first-order evolution hemivariational inequality （FOEHVI） for the problem considered are presented. By applying the Browder-Tikhonov regularization method to the derived FOEHVI, a sequence of regularized solutions to the regularized SOEHVI is constructed, and the strong convergence of the whole sequence of regularized solutions to a solution to the problem is proved.展开更多
文摘The change of drug quality of Yuxingcao injection after formulation is considered as one of the causes for adverse reactions. In this study, orthogonal experimental design was used to investigate the influencing factors on the pH stability of Yuxingcao injection. Two methods of accelerated tests were carried out in the experiments. The results showed that using Tween 80 as the solubilizer could significantly decrease the pH value of Yuxingcao injection after accelerated tests. There was no significant difference in the pH value after the accelerated tests when the other 6 factors varied, including the type of liquid processed, the dosage of activated carbon, heating temperature, reagents for pH adjustment, pH value range after adjustment, and sterilization conditions. In order to improve the quality stability of Yuxingcao injection, the quality of Tween 80 should be strictly controlled to minimize the change of pH value of Yuxingcao injection.
文摘Continuous manufacturing is considered as one of the future trends of pharmaceutical engineering. In this work, continuous liquid-liquid extraction for sinomenine purification was realized with the usage of centrifugal extractors. Chloroform was used as the extractant because of the high distribution coefficient (>100). Higher extraction ratio can be obtained when using the centrifugal extractor of Model CWL50-N. The extraction ratio of the second-stage extraction was higher than that of the first-stage extraction. The extraction ratio of the second-stage countercurrent extraction was higher than that of second-stage cross-flow extraction. When chloroform phase was recycled for liquid-liquid extraction, the extraction ratio was also higher than 95%. This work can also be an example of continuous liquid-liquid extraction for the separation of other Chinese medicine components.
基金supported by the National Natural Science Foundation of China(1147105951375517+5 种基金71271226)the China Postdoctoral Science Foundation Funded Project(2014M560712)Chongqing Frontier and Applied Basic Research Project(cstc2014jcyj A00024)the Ministry of Education of Humanities and Social Sciences Youth Foundation(14YJAZH033)the Chongqing Municipal Education Scientific Planning Project(2012-GX-142)the Higher School Teaching Reform Research Project in Chongqing(1202010)
文摘In order to deeply research the structure discrepancy and modeling mechanism among different grey prediction models, the equivalence and unbiasedness of grey prediction models are analyzed and verified. The results show that all the grey prediction models that are strictly derived from x^（0）（k） ＋az^（1）（k） = b have the identical model structure and simulation precision. Moreover, the unbiased simulation for the homogeneous exponential sequence can be accomplished. However, the models derived from dx^（1）/dt ＋ ax^（1）= b are only close to those derived from x^（0）（k） ＋ az^（1）（k） = b provided that ｜a｜ has to satisfy｜a｜ 0.1; neither could the unbiased simulation for the homogeneous exponential sequence be achieved. The above conclusions are proved and verified through some theorems and examples.
基金supported by the National Natural Science Foundation of China(Nos.11101069,11171237,11471059,and 81171411)the China Postdoctoral Science Foundation(Nos.2014M552328 and2015T80967)the Scientific Research Foundation for the Returned Overseas Chinese Scholars,State Education Ministry
文摘This paper studies the Browder-Tikhonov regularization of a second-order evolution hemivariational inequality （SOEHVI） with non-coercive operators. With duality mapping, the regularized formulations and a derived first-order evolution hemivariational inequality （FOEHVI） for the problem considered are presented. By applying the Browder-Tikhonov regularization method to the derived FOEHVI, a sequence of regularized solutions to the regularized SOEHVI is constructed, and the strong convergence of the whole sequence of regularized solutions to a solution to the problem is proved.
