The aggregation ofα-synuclein(ɑ-syn)coupled with overexpressed neuroinflammation instigates the degeneration of dopaminergic neurons,thereby aggravating the progression of Parkinson’s disease(PD).Herein,we introduc...The aggregation ofα-synuclein(ɑ-syn)coupled with overexpressed neuroinflammation instigates the degeneration of dopaminergic neurons,thereby aggravating the progression of Parkinson’s disease(PD).Herein,we introduced a series of hydrophobic amino acid-based carbon dots(CDs)for inhibitingɑ-syn aggregation and mitigating the inflammation in PD neurons.Significantly,we show that phenylalanine CDs(Phe-CDs)could strongly bind withɑ-syn monomers and dimers via hydrophobic force,maintain their stability,and inhibit their further aggregation in situ and in vitro,finally conferring neuroprotection in PD by rescuing synaptic loss,ameliorating mitochondrial dysfunctions,and modulating Ca^(2+)flux.Importantly,Phe-CDs demonstrate the ability to penetrate the blood-brain barrier,significantly improving motor performance in PD mice.Our findings suggest that Phe-CDs hold great promise as a therapeutic agent for PD and the related neurodegenerative disease.展开更多
The aggregation ofα-synuclein(ɑ-syn)coupled with overexpressed neuroinflammation instigates the degeneration of dopaminer-gic neurons,thereby aggravating the progression of Parkinson’s disease(PD).Herein,we introdu...The aggregation ofα-synuclein(ɑ-syn)coupled with overexpressed neuroinflammation instigates the degeneration of dopaminer-gic neurons,thereby aggravating the progression of Parkinson’s disease(PD).Herein,we introduced a series of hydrophobic amino acid–based carbon dots(CDs)for inhibitingɑ-syn aggregation and mitigating the inflammation in PD neurons.Significantly,we show phenylalanine CDs(Phe-CDs)could strongly bind withɑ-syn monomers and dimers via hydrophobic force,maintain their stability,and inhibit their further aggregates in situ and in vitro,finally conferring neuroprotection in PD by rescuing synaptic loss,ameliorating mitochondrial dysfunctions,and modulating Ca^(2+) flux.Importantly,Phe-CDs demonstrate the ability to penetrate the blood–brain barrier(BBB),significantly improving motor performance in PD mice.Our findings suggest that Phe-CDs hold great promise as a therapeutic agent for PD and the relative neurodegenerative disease.展开更多
文摘The aggregation ofα-synuclein(ɑ-syn)coupled with overexpressed neuroinflammation instigates the degeneration of dopaminergic neurons,thereby aggravating the progression of Parkinson’s disease(PD).Herein,we introduced a series of hydrophobic amino acid-based carbon dots(CDs)for inhibitingɑ-syn aggregation and mitigating the inflammation in PD neurons.Significantly,we show that phenylalanine CDs(Phe-CDs)could strongly bind withɑ-syn monomers and dimers via hydrophobic force,maintain their stability,and inhibit their further aggregation in situ and in vitro,finally conferring neuroprotection in PD by rescuing synaptic loss,ameliorating mitochondrial dysfunctions,and modulating Ca^(2+)flux.Importantly,Phe-CDs demonstrate the ability to penetrate the blood-brain barrier,significantly improving motor performance in PD mice.Our findings suggest that Phe-CDs hold great promise as a therapeutic agent for PD and the related neurodegenerative disease.
基金supported by the National Natural Science Foundation of China(Grant 52002133).
文摘The aggregation ofα-synuclein(ɑ-syn)coupled with overexpressed neuroinflammation instigates the degeneration of dopaminer-gic neurons,thereby aggravating the progression of Parkinson’s disease(PD).Herein,we introduced a series of hydrophobic amino acid–based carbon dots(CDs)for inhibitingɑ-syn aggregation and mitigating the inflammation in PD neurons.Significantly,we show phenylalanine CDs(Phe-CDs)could strongly bind withɑ-syn monomers and dimers via hydrophobic force,maintain their stability,and inhibit their further aggregates in situ and in vitro,finally conferring neuroprotection in PD by rescuing synaptic loss,ameliorating mitochondrial dysfunctions,and modulating Ca^(2+) flux.Importantly,Phe-CDs demonstrate the ability to penetrate the blood–brain barrier(BBB),significantly improving motor performance in PD mice.Our findings suggest that Phe-CDs hold great promise as a therapeutic agent for PD and the relative neurodegenerative disease.
