Objective： Low rate of medication usage and blood pressure （BP） control, bad lifestyle, poor cognition to hypertension, have been obstacles in prevention from hypertensive disease and complication in Chinese cohort...Objective： Low rate of medication usage and blood pressure （BP） control, bad lifestyle, poor cognition to hypertension, have been obstacles in prevention from hypertensive disease and complication in Chinese cohort. Health education appears to be an impendent measure to improve this situation. To study the effect of health education on the rate of medication usage and BP control, the lifestyle, and the incidence of complication among patients with hypertension. Methods ： 284 hypertensive inpatients were divided randomly into two groups： the control group was intervened with routine medication; the education group was intervened with routine medication in combination with intensive health education according to the investigation on the risk factors of cardiocerebrovascular diseases and cognitive levels of hypertensive .disease. During 12.16 ± 1.95 months of following up, the status of lifestyle, the rate of medication usage and BP control, and incidence of complications between two groups were analyzed. Results： In education group, the rate of smoking, alcohol intake, lower-salt ingesting, exercise, medication usage and BP control were improved after intervention and significantly different from those before intervention （P 〈 0.01）. After intervention, the incidence of complications in education group and control group was 10.9% and 30.5% respectively （P 〈 0.01 ）. Conclusion ： Intensive health education is an important measure in preventing from hypertension.展开更多
Intestinal fibrosis is a significant clinical challenge in inflammatory bowel diseases,but no effective anti-fibrotic therapy is currently available.Glucagon receptor(GCGR)and glucagon-like peptide 1 receptor(GLP1R)ar...Intestinal fibrosis is a significant clinical challenge in inflammatory bowel diseases,but no effective anti-fibrotic therapy is currently available.Glucagon receptor(GCGR)and glucagon-like peptide 1 receptor(GLP1R)are both peptide hormone receptors involved in energy metabolism of epithelial cells.However,their role in intestinal fibrosis and the underlying mechanisms remain largely unexplored.Herein GCGR and GLP1R were found to be reduced in the stenotic ileum of patients with Crohn’s disease as well as in the fibrotic colon of mice with chronic colitis.The downregulation of GCGR and GLP1R led to the accumulation of the metabolic byproduct lactate,resulting in histone H3K9 lactylation and exacerbated intestinal fibrosis through epithelial-to-mesenchymal transition(EMT).Dual activating GCGR and GLP1R by peptide 1907B reduced the H3K9 lactylation in epithelial cells and ameliorated intestinal fibrosis in vivo.We uncovered the role of GCGR/GLP1R in regulating EMT involved in intestinal fibrosis via histone lactylation.Simultaneously activating GCGR/GLP1R with the novel dual agonist peptide 1907B holds promise as a treatment strategy for alleviating intestinal fibrosis.展开更多
Extensive immune adaptations occur during pregnancy to ensure successful delivery.However,these changes can increase the risk of disease in the mother.Here,we conducted single-cell RNA sequencing on peripheral blood m...Extensive immune adaptations occur during pregnancy to ensure successful delivery.However,these changes can increase the risk of disease in the mother.Here,we conducted single-cell RNA sequencing on peripheral blood mononuclear cells from pregnant women at different stages of pregnancy to elucidate the dynamic transcriptional changes in the maternal immune system.Gradual reduced cytotoxicity phenotype in highly variable cytotoxic T and natural killer cell types were observed during pregnancy.Reduced T-and B-cell response-related MHC-II and CD40 signaling as well as enhanced protolerance inducible costimulator and activin signaling may underlie the pregnancy-related weakening of adaptive immunity.Conversely,pro-inflammatory genes and pathways were upregulated in monocytes,possibly to compensate for the reduced T-cell response.Moreover,the transition from adaptive immune reduction to activation in late pregnancy in dendritic cells and CD4^(+)T cells was also detected.Notably,we proposed a novel view of the pro-aging effect of pregnancy from the perspective of immunity,and this effect may be restored postpartum.This work expands our knowledge of pregnancy immunity and may provide insights into the altered disease risks during pregnancy.展开更多
文摘Objective： Low rate of medication usage and blood pressure （BP） control, bad lifestyle, poor cognition to hypertension, have been obstacles in prevention from hypertensive disease and complication in Chinese cohort. Health education appears to be an impendent measure to improve this situation. To study the effect of health education on the rate of medication usage and BP control, the lifestyle, and the incidence of complication among patients with hypertension. Methods ： 284 hypertensive inpatients were divided randomly into two groups： the control group was intervened with routine medication; the education group was intervened with routine medication in combination with intensive health education according to the investigation on the risk factors of cardiocerebrovascular diseases and cognitive levels of hypertensive .disease. During 12.16 ± 1.95 months of following up, the status of lifestyle, the rate of medication usage and BP control, and incidence of complications between two groups were analyzed. Results： In education group, the rate of smoking, alcohol intake, lower-salt ingesting, exercise, medication usage and BP control were improved after intervention and significantly different from those before intervention （P 〈 0.01）. After intervention, the incidence of complications in education group and control group was 10.9% and 30.5% respectively （P 〈 0.01 ）. Conclusion ： Intensive health education is an important measure in preventing from hypertension.
基金supported by the National Key R&D Program of China(2023YFC2507300)the National Natural Science Foundation of China(82273761,81970483,82170537 and 82222010)the Medical Innovation and Development Project of Lanzhou University(lzuyxcx-2022-156,China).
文摘Intestinal fibrosis is a significant clinical challenge in inflammatory bowel diseases,but no effective anti-fibrotic therapy is currently available.Glucagon receptor(GCGR)and glucagon-like peptide 1 receptor(GLP1R)are both peptide hormone receptors involved in energy metabolism of epithelial cells.However,their role in intestinal fibrosis and the underlying mechanisms remain largely unexplored.Herein GCGR and GLP1R were found to be reduced in the stenotic ileum of patients with Crohn’s disease as well as in the fibrotic colon of mice with chronic colitis.The downregulation of GCGR and GLP1R led to the accumulation of the metabolic byproduct lactate,resulting in histone H3K9 lactylation and exacerbated intestinal fibrosis through epithelial-to-mesenchymal transition(EMT).Dual activating GCGR and GLP1R by peptide 1907B reduced the H3K9 lactylation in epithelial cells and ameliorated intestinal fibrosis in vivo.We uncovered the role of GCGR/GLP1R in regulating EMT involved in intestinal fibrosis via histone lactylation.Simultaneously activating GCGR/GLP1R with the novel dual agonist peptide 1907B holds promise as a treatment strategy for alleviating intestinal fibrosis.
基金supported by the National Natural Science Foundation of China Excellent Young Scientists Fund(82122016)the National Key Research and Development Program of China(2017YFA0105804).
文摘Extensive immune adaptations occur during pregnancy to ensure successful delivery.However,these changes can increase the risk of disease in the mother.Here,we conducted single-cell RNA sequencing on peripheral blood mononuclear cells from pregnant women at different stages of pregnancy to elucidate the dynamic transcriptional changes in the maternal immune system.Gradual reduced cytotoxicity phenotype in highly variable cytotoxic T and natural killer cell types were observed during pregnancy.Reduced T-and B-cell response-related MHC-II and CD40 signaling as well as enhanced protolerance inducible costimulator and activin signaling may underlie the pregnancy-related weakening of adaptive immunity.Conversely,pro-inflammatory genes and pathways were upregulated in monocytes,possibly to compensate for the reduced T-cell response.Moreover,the transition from adaptive immune reduction to activation in late pregnancy in dendritic cells and CD4^(+)T cells was also detected.Notably,we proposed a novel view of the pro-aging effect of pregnancy from the perspective of immunity,and this effect may be restored postpartum.This work expands our knowledge of pregnancy immunity and may provide insights into the altered disease risks during pregnancy.
