Detection and mitigation of radio frequency interference （RFI） is the first and also the key step for data processing in radio observations, especially for ongoing low frequency radio experiments towards the detecti...Detection and mitigation of radio frequency interference （RFI） is the first and also the key step for data processing in radio observations, especially for ongoing low frequency radio experiments towards the detection of the cosmic dawn and epoch of reionization （EoR）. In this paper we demonstrate the tech- nique and efficiency of RFI identification and mitigation for the 21 Centimeter Array （21CMA）, a radio interferometer dedicated to the statistical measurement of EoR. For terrestrial, man-made RFI, we concen- trate mainly on a statistical approach by identifying and then excising non-Gaussian signatures, in the sense that the extremely weak cosmic signal is actually buried under thermal and therefore Gaussian noise. We also introduce the so-called visibility correlation coefficient instead of conventional visibility, which allows a further suppression of rapidly time-varying RFI. Finally, we briefly discuss removals of the sky RFI, the leakage of sidelobes from off-field strong radio sources with time-invariant power and a featureless spec- trum. It turns out that state of the art technique should allow us to detect and mitigate RFI to a satisfactory level in present low frequency interferometer observations such as those acquired with the 21CMA, and the accuracy and efficiency can be greatly improved with the employment of low-cost, high-speed computing facilities for data acquisition and processing.展开更多
TIRF microscopy has provided a means to view mobile granules within 100 nm in size in two dimensions.However quantitative analysis of the position and motion of those granules requires an appropriate tracking method.I...TIRF microscopy has provided a means to view mobile granules within 100 nm in size in two dimensions.However quantitative analysis of the position and motion of those granules requires an appropriate tracking method.In this paper,we present a new tracking algorithm combined with the unique features of TIRF.Firstly a fluorescence correction procedure was processed to solve the problem of fluorescence bleaching over time.Mobile granules were then segmented from a time-lapse image stack by an adaptive background subtraction method.Kalman filter was introduced to estimate and track the granules that allowed reducing searching range and hence greater reliability in tracking process.After the tracked granules were located in x-y plane,the z-position was indirectly inferred from the changes in their intensities.In the experiments the algorithm was applied in tracking GLUT4 vesicles in living adipose cells.The results indicate that the algorithm has achieved robust estimation and tracking of the vesicles in three dimensions.展开更多
We present a conceptual design study of external calibrators in the 21 cm experiment towards detecting the globally averaged radiation of the epoch of reionization(EoR).Employment of external calibrator instead of int...We present a conceptual design study of external calibrators in the 21 cm experiment towards detecting the globally averaged radiation of the epoch of reionization(EoR).Employment of external calibrator instead of internal calibrator commonly used in current EoR experiments allows removing instrumental effects such as beam pattern,receiver gain and instability of the system if the conventional three-position switch measurements are implemented in a short time interval.Furthermore,in the new design the antenna system is placed in an underground anechoic chamber with an open/closing ceiling to maximally reduce the environmental effect such as RFI and ground radiation/reflection.It appears that three of the four external calibrators proposed in this paper,including two indoor artificial transmitters and one outdoor celestial radiation(the Galactic polarization),fail to meet our purpose.Diurnal motion of the Galactic diffuse emission turns out to be the most probable source as an external calibrator,for which we have discussed the observational strategy and the algorithm of extracting the EoR signal.展开更多
Objective:To study the ventilation function after sublingual dermatophagoides farinae drops combined with loratadine treatment of children with asthma and allergic rhinitis and the influence on serum biochemical index...Objective:To study the ventilation function after sublingual dermatophagoides farinae drops combined with loratadine treatment of children with asthma and allergic rhinitis and the influence on serum biochemical indexes.Methods: A total of 40 children with asthma and allergic rhinitis treated in our hospital between September 2013 and March 2015 were collected and divided into the control group (n=22) who accepted loratadine therapy alone and the observation group (n=18) who accepted sublingual dermatophagoides farinae drops combined with loratadine therapy after the treatment was reviewed. Before treatment and after 6 months and 1 year of treatment, spirometer was used to test ventilation function indexes;ELISA method was used to determine the contents of inflammatory mediators;RIA method was used to determine the contents of airway remodeling indicators.Results:Before treatment, differences in ventilation function index levels as well as inflammatory mediator and airway remodeling index contents were not statistically significant between two groups of children. After 6 months and 1 year of treatment, FEV1, FVC and PEF levels of observation group were higher than those of control group;serum IL-2 content was higher than that of control group while IL-5, IL-17 and IL-33 contents were lower than those of control group;serum PDGF-BB, TGF-β1 and NF-κB contents were lower than those of control group.Conclusion:Sublingual dermatophagoides farinae drops combined with loratadine therapy can optimize the ventilation function, reduce the systemic inflammatory response and inhibit airway remodeling in children with asthma and allergic rhinitis.展开更多
Organic semiconductor materials with low reorganization energy have various applications such as in organic light-emitting diodes (OLEDs),organic field-effect transistor (OFETs) and organic solar cells (OSCs).In this ...Organic semiconductor materials with low reorganization energy have various applications such as in organic light-emitting diodes (OLEDs),organic field-effect transistor (OFETs) and organic solar cells (OSCs).In this work,we have designed a new class of gridspiroarenes (GS-SFX and GS-SITF) with #-shaped structures,which have novel crisscross geometrical structures compared to widely used spirocyclic arenes-SFX and SITF.The structure electronic properties,adiabatic ionization potentials (IPa),adiabatic electron affinities (EAa) and reorganization energies (λ) of GS-SFX and GS-SITF have been calculated using density functional theory (DFT) method.The calculated HOMO and LUMO spatial distributions suggest that GS-SFX and GS-SITF have better transport properties.The noncovalent interaction analysis shows the weak intramolecular interactions between their arms.The results indicate that the reorganization energies of GS-SFX and GS-SITF are significantly reduced compared to the dimer structures-DSFX and DSITF.Furthermore,the GS-SITF1 which is one of the isomers of GS-SITF exhibits the lowest values for λ(h)(0.067 eV) and λ(e)(0.153 eV).Therefore,we believe the predicted structure,electronic property,and reorganization energy are good indicator for transport materials.This work has systematically studied the effect of gridization,which provides insights to design organic semiconductor materials with excellent charge transport properties.展开更多
基金partially supported by the National Natural Science Foundation of China(Grant No.11433002)support by a Marsden Fund grant in New Zealand
文摘Detection and mitigation of radio frequency interference （RFI） is the first and also the key step for data processing in radio observations, especially for ongoing low frequency radio experiments towards the detection of the cosmic dawn and epoch of reionization （EoR）. In this paper we demonstrate the tech- nique and efficiency of RFI identification and mitigation for the 21 Centimeter Array （21CMA）, a radio interferometer dedicated to the statistical measurement of EoR. For terrestrial, man-made RFI, we concen- trate mainly on a statistical approach by identifying and then excising non-Gaussian signatures, in the sense that the extremely weak cosmic signal is actually buried under thermal and therefore Gaussian noise. We also introduce the so-called visibility correlation coefficient instead of conventional visibility, which allows a further suppression of rapidly time-varying RFI. Finally, we briefly discuss removals of the sky RFI, the leakage of sidelobes from off-field strong radio sources with time-invariant power and a featureless spec- trum. It turns out that state of the art technique should allow us to detect and mitigate RFI to a satisfactory level in present low frequency interferometer observations such as those acquired with the 21CMA, and the accuracy and efficiency can be greatly improved with the employment of low-cost, high-speed computing facilities for data acquisition and processing.
基金Project supported by the National Natural Science Foundation ofChina (No. 30770596)the Key Laboratory for Biomedical En-gineering of Ministry of Education of China
文摘TIRF microscopy has provided a means to view mobile granules within 100 nm in size in two dimensions.However quantitative analysis of the position and motion of those granules requires an appropriate tracking method.In this paper,we present a new tracking algorithm combined with the unique features of TIRF.Firstly a fluorescence correction procedure was processed to solve the problem of fluorescence bleaching over time.Mobile granules were then segmented from a time-lapse image stack by an adaptive background subtraction method.Kalman filter was introduced to estimate and track the granules that allowed reducing searching range and hence greater reliability in tracking process.After the tracked granules were located in x-y plane,the z-position was indirectly inferred from the changes in their intensities.In the experiments the algorithm was applied in tracking GLUT4 vesicles in living adipose cells.The results indicate that the algorithm has achieved robust estimation and tracking of the vesicles in three dimensions.
基金supported by the Key Projects of Frontier Science of Chinese Academy of Sciences(Grant No.QYZDY-SSW-SLH022)the Strategic Priority Research Program of Chinese Academy of Sciences(Grant No.XDB23000000)the National Key R&D Program of China(Grant No.2018YFA0404601)。
文摘We present a conceptual design study of external calibrators in the 21 cm experiment towards detecting the globally averaged radiation of the epoch of reionization(EoR).Employment of external calibrator instead of internal calibrator commonly used in current EoR experiments allows removing instrumental effects such as beam pattern,receiver gain and instability of the system if the conventional three-position switch measurements are implemented in a short time interval.Furthermore,in the new design the antenna system is placed in an underground anechoic chamber with an open/closing ceiling to maximally reduce the environmental effect such as RFI and ground radiation/reflection.It appears that three of the four external calibrators proposed in this paper,including two indoor artificial transmitters and one outdoor celestial radiation(the Galactic polarization),fail to meet our purpose.Diurnal motion of the Galactic diffuse emission turns out to be the most probable source as an external calibrator,for which we have discussed the observational strategy and the algorithm of extracting the EoR signal.
文摘Objective:To study the ventilation function after sublingual dermatophagoides farinae drops combined with loratadine treatment of children with asthma and allergic rhinitis and the influence on serum biochemical indexes.Methods: A total of 40 children with asthma and allergic rhinitis treated in our hospital between September 2013 and March 2015 were collected and divided into the control group (n=22) who accepted loratadine therapy alone and the observation group (n=18) who accepted sublingual dermatophagoides farinae drops combined with loratadine therapy after the treatment was reviewed. Before treatment and after 6 months and 1 year of treatment, spirometer was used to test ventilation function indexes;ELISA method was used to determine the contents of inflammatory mediators;RIA method was used to determine the contents of airway remodeling indicators.Results:Before treatment, differences in ventilation function index levels as well as inflammatory mediator and airway remodeling index contents were not statistically significant between two groups of children. After 6 months and 1 year of treatment, FEV1, FVC and PEF levels of observation group were higher than those of control group;serum IL-2 content was higher than that of control group while IL-5, IL-17 and IL-33 contents were lower than those of control group;serum PDGF-BB, TGF-β1 and NF-κB contents were lower than those of control group.Conclusion:Sublingual dermatophagoides farinae drops combined with loratadine therapy can optimize the ventilation function, reduce the systemic inflammatory response and inhibit airway remodeling in children with asthma and allergic rhinitis.
基金This work was supported by the National Natural Science Foundation of China (Nos. 21503114, 21774061, 61605090, 91833306)Synergetic Innovation Centre for Organic Electronics and In formation Displays, Nanji ng Un iversity of Posts a nd Telecommunications Scientific Foundation NUPTSF (NY215056, NY21417& NY215172, 2016XSG03)the Six Peak Talents Foundation of Jiangsu Province (XCL-CXTD-009), and the High Performanee Computing Center of Nanjing Tech University.
文摘Organic semiconductor materials with low reorganization energy have various applications such as in organic light-emitting diodes (OLEDs),organic field-effect transistor (OFETs) and organic solar cells (OSCs).In this work,we have designed a new class of gridspiroarenes (GS-SFX and GS-SITF) with #-shaped structures,which have novel crisscross geometrical structures compared to widely used spirocyclic arenes-SFX and SITF.The structure electronic properties,adiabatic ionization potentials (IPa),adiabatic electron affinities (EAa) and reorganization energies (λ) of GS-SFX and GS-SITF have been calculated using density functional theory (DFT) method.The calculated HOMO and LUMO spatial distributions suggest that GS-SFX and GS-SITF have better transport properties.The noncovalent interaction analysis shows the weak intramolecular interactions between their arms.The results indicate that the reorganization energies of GS-SFX and GS-SITF are significantly reduced compared to the dimer structures-DSFX and DSITF.Furthermore,the GS-SITF1 which is one of the isomers of GS-SITF exhibits the lowest values for λ(h)(0.067 eV) and λ(e)(0.153 eV).Therefore,we believe the predicted structure,electronic property,and reorganization energy are good indicator for transport materials.This work has systematically studied the effect of gridization,which provides insights to design organic semiconductor materials with excellent charge transport properties.
