Dear Editor,Descemet’s membrane detachment(DMD)is considered as a potential sight-threatening complication following various intraocular surgeries,particularly cataract surgery[1].The labile adhesion between the Desc...Dear Editor,Descemet’s membrane detachment(DMD)is considered as a potential sight-threatening complication following various intraocular surgeries,particularly cataract surgery[1].The labile adhesion between the Descemet’s membrane(DM)and the posterior corneal stromal layer can be easily separated with minimal mechanical force.Several risk factors have been associated with the development of DMD including old age,improper intraoperative operation,corneal ectatic disorders,and endothelial disorders and so on[1-4].展开更多
P-stereogenic compounds play pivotal roles in natural products,pharmaceuticals,bioactive molecules,and catalysts/ligands,making their synthesis a highly researched area.Current studies have predominantly concentrated ...P-stereogenic compounds play pivotal roles in natural products,pharmaceuticals,bioactive molecules,and catalysts/ligands,making their synthesis a highly researched area.Current studies have predominantly concentrated on fully carbon-substituted P-stereogenic species,despite the fact that many therapeutically relevant compounds feature P-O,P-N,or P-S bonds.The catalytic and stereoselective nucleophilic substitution at the P-center is acknowledged as a highly efficient and straightforward approach for constructing high-value P-stereogenic compounds,offering significant potential for further development.This review provides an overview of advancements in the construction of P-stereogenic centers based on Pcentered nucleophilic substitution,highlighting key challenges,breakthroughs,and future opportunities in the field.展开更多
AIM:To evaluate the influence of ocular biometric parameters on the performance of actual near-add power in the spectacle plane of multifocal intraocular lenses(MIOLs).METHODS:This retrospective study defined predicti...AIM:To evaluate the influence of ocular biometric parameters on the performance of actual near-add power in the spectacle plane of multifocal intraocular lenses(MIOLs).METHODS:This retrospective study defined prediction error(PE)as the difference between actual postoperative near-add power and manufacturer-predicted values.Linear regression assessed PE correlations with axial length(AL),mean keratometry(K),pupil size,anterior chamber depth(ACD),lens thickness(LT),ACD+0.5×LT,and back-calculated IOL power.Differences in PE across MIOLs types,AL,K,pupil size,ACD,LT,ACD+0.5×LT,and back-calculated IOL power groups were compared.RESULTS:Totally 250 eyes of 250 patients(116 males and 134 females,mean age 56.22±12.31y)who underwent phacoemulsification with MIOL implantation were reviewed.PE showed no significant correlation with most parameters but had a weak positive correlation with LT.The mean predicted error(MPE)in the AL≤22,26–27,and 27–28 mm groups were 0.83(0.51,1.01)D,0.78(0.51,1.07)D,and 0.72(0.57,0.94)D respectively(P<0.001).The MPE in the K between the 45–46 D groups was 0.78(0.37,1.07)D(P=0.0004).The MPE in the LT between the 4.5–5.0 mm groups and≥5 mm was 0.72(0.50,1.01)D and 0.72(0.51,1.01)D respectively(P<0.001).The MPE in the back-calculated IOL power≥25 D was 0.86(0.60,1.01)D(P<0.001).CONCLUSION:Although there is no significant linear relationship between near-add power and most ocular biometry parameters,and specific segments of AL,K,LT,and IOL power have a significant impact on the near-add power of MIOLs.These factors should be taken into account in preoperative evaluations.展开更多
In our previous work, it was found that large electrospun from chlorinated polypropylene solution doped Bird＇s Nest patterned nanofibrous membranes can be simply with an ionic liquid, and a plausible formation mechan...In our previous work, it was found that large electrospun from chlorinated polypropylene solution doped Bird＇s Nest patterned nanofibrous membranes can be simply with an ionic liquid, and a plausible formation mechanism of Bird＇s Nest patterned architectures was proposed. Here, we use Ansoft Maxwell version 12 software （3D, electrostatic solver） to simulate the electrical field distribution of the electrospinning setup, and to clarify the rationality of proposed formation mechanism. Calculation results clearly show that the introduction of charged nanofibrous bundles would produce a similar patterned electrical field distribution, which definitely confirms the important role of surface residual charges. The proposed mechanism can be well extended to other polymer systems including polystyrene, poly（acrylonitrile-co-acrylic acid） and chitosan/poly（ethylene oxide）.展开更多
基金Supported by the Natural Science Foundation of Fujian Province(No.2024J011318No.2024J011321)Fuzhou Science and Technology Program(No.2023-S-005).
文摘Dear Editor,Descemet’s membrane detachment(DMD)is considered as a potential sight-threatening complication following various intraocular surgeries,particularly cataract surgery[1].The labile adhesion between the Descemet’s membrane(DM)and the posterior corneal stromal layer can be easily separated with minimal mechanical force.Several risk factors have been associated with the development of DMD including old age,improper intraoperative operation,corneal ectatic disorders,and endothelial disorders and so on[1-4].
基金financial support from the National Natural Science Foundation of China(Nos.22171187 and 22001173)the Project of Department of Education of Guangdong Province(No.2020KTSCX116)+3 种基金the Shenzhen Science and Technology Foundation(Nos.20200812202943001 and KQJSCX20180328100401788)Frontiers Science Center for Asymmetric Synthesis and Medicinal Molecules,Department of Education,Guizhou Province(No.Qianjiaohe KY(2020)004)the Central Government Guides Local Science and Technology Development Fund Projects(Nos.Qiankehezhongyindi(2024)007,(2023)001)Singapore National Research Foundation under its NRF Competitive Research Program(No.NRFCRP22–2019–0002)。
文摘P-stereogenic compounds play pivotal roles in natural products,pharmaceuticals,bioactive molecules,and catalysts/ligands,making their synthesis a highly researched area.Current studies have predominantly concentrated on fully carbon-substituted P-stereogenic species,despite the fact that many therapeutically relevant compounds feature P-O,P-N,or P-S bonds.The catalytic and stereoselective nucleophilic substitution at the P-center is acknowledged as a highly efficient and straightforward approach for constructing high-value P-stereogenic compounds,offering significant potential for further development.This review provides an overview of advancements in the construction of P-stereogenic centers based on Pcentered nucleophilic substitution,highlighting key challenges,breakthroughs,and future opportunities in the field.
基金Supported by the Fuzhou Science and Technology Program(No.2023-S-005).
文摘AIM:To evaluate the influence of ocular biometric parameters on the performance of actual near-add power in the spectacle plane of multifocal intraocular lenses(MIOLs).METHODS:This retrospective study defined prediction error(PE)as the difference between actual postoperative near-add power and manufacturer-predicted values.Linear regression assessed PE correlations with axial length(AL),mean keratometry(K),pupil size,anterior chamber depth(ACD),lens thickness(LT),ACD+0.5×LT,and back-calculated IOL power.Differences in PE across MIOLs types,AL,K,pupil size,ACD,LT,ACD+0.5×LT,and back-calculated IOL power groups were compared.RESULTS:Totally 250 eyes of 250 patients(116 males and 134 females,mean age 56.22±12.31y)who underwent phacoemulsification with MIOL implantation were reviewed.PE showed no significant correlation with most parameters but had a weak positive correlation with LT.The mean predicted error(MPE)in the AL≤22,26–27,and 27–28 mm groups were 0.83(0.51,1.01)D,0.78(0.51,1.07)D,and 0.72(0.57,0.94)D respectively(P<0.001).The MPE in the K between the 45–46 D groups was 0.78(0.37,1.07)D(P=0.0004).The MPE in the LT between the 4.5–5.0 mm groups and≥5 mm was 0.72(0.50,1.01)D and 0.72(0.51,1.01)D respectively(P<0.001).The MPE in the back-calculated IOL power≥25 D was 0.86(0.60,1.01)D(P<0.001).CONCLUSION:Although there is no significant linear relationship between near-add power and most ocular biometry parameters,and specific segments of AL,K,LT,and IOL power have a significant impact on the near-add power of MIOLs.These factors should be taken into account in preoperative evaluations.
基金financially supported by the National Natural Science Foundation of China (No.50933006)Zhejiang Provincial Innovative Research Team (No.2009R50004)
文摘In our previous work, it was found that large electrospun from chlorinated polypropylene solution doped Bird＇s Nest patterned nanofibrous membranes can be simply with an ionic liquid, and a plausible formation mechanism of Bird＇s Nest patterned architectures was proposed. Here, we use Ansoft Maxwell version 12 software （3D, electrostatic solver） to simulate the electrical field distribution of the electrospinning setup, and to clarify the rationality of proposed formation mechanism. Calculation results clearly show that the introduction of charged nanofibrous bundles would produce a similar patterned electrical field distribution, which definitely confirms the important role of surface residual charges. The proposed mechanism can be well extended to other polymer systems including polystyrene, poly（acrylonitrile-co-acrylic acid） and chitosan/poly（ethylene oxide）.
