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外泌体源性miRNA在眼部疾病中的研究进展 被引量:3
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作者 朱妍 姚牧笛 +1 位作者 孟祥瑞 蒋沁 《国际眼科杂志》 CAS 北大核心 2021年第11期1887-1891,共5页
外泌体是直径为30~200nm的细胞外泌性囊泡,可由多种细胞释放至细胞外空间。研究证实,外泌体中含有蛋白质、mRNA、microRNA(miRNA)等多种功能活性物质。miRNA是一类短链非编码RNA,可在转录后水平调控基因表达,参与细胞的增殖、迁移、分... 外泌体是直径为30~200nm的细胞外泌性囊泡,可由多种细胞释放至细胞外空间。研究证实,外泌体中含有蛋白质、mRNA、microRNA(miRNA)等多种功能活性物质。miRNA是一类短链非编码RNA,可在转录后水平调控基因表达,参与细胞的增殖、迁移、分化等生命活动。外泌体源性miRNA可被选择性组装入外泌体,传递至邻近或远处的细胞,并调节受体细胞的功能。研究表明,外泌体源性miRNA与多种眼科疾病病的发生、发展和转归密切相关,有潜力作为新型生物标志物以指示疾病状态。本文就外泌体源性miRNA的基本特征及其在眼部疾病中的研究进展进行系统综述。 展开更多
关键词 外泌体 MIRNA 外泌体源性miRNA 眼部疾病 生物标志物
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Online asymmetry estimation for whole angle mode coriolis vibratory gyroscopes by high frequency injection 被引量:1
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作者 xiang-rui meng Chong Li Yu-chen Wang 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2023年第6期314-325,共12页
The whole angle mode gyroscope(WAMG)is considered to be the next generation architecture,but it is suffered from the asymmetry errors to conduct real products.This paper proposes a novel high frequency injection based... The whole angle mode gyroscope(WAMG)is considered to be the next generation architecture,but it is suffered from the asymmetry errors to conduct real products.This paper proposes a novel high frequency injection based approach for the error parameters online identification for the WAMG.The significance is that it can separate physical and error fingerprints to enable online calibration.The nonlinear WAMG dynamics are discretized to meet the requirement of numerical precision and computation efficiency.The optimized estimation methods are then constructed and compared to track asymmetry error parameters continuously.In the validation part,its results firstly prove that the proposed scheme can accurately identify constant asymmetry parameters with an overall tracking error of less than 1 ppm and the extreme numerical convergence can reach 10^(-12)ppm.Under the dynamic asymmetry variation condition,the root mean square errors(RMSE)indicate that the tracking accuracy can reach the level of10^(-3),which shows the robustness of the proposed scheme.In summary,the proposed method can effectively estimate the WAMG asymmetry errors online with satisfied performance and practical values. 展开更多
关键词 Rate-integrating gyroscope(RIG) Whole angle mode gyroscope(WAMG) Coriolis vibrating gyroscope(CVG) Online calibration Online identification Online estimation
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Generation of and countermeasures against time-delayed rockbursts
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作者 Ben-Guo He Hong-Pu Li +4 位作者 Xia-Ting Feng Zi-Hui Zhu Han-Yi Liu Heng-Yuan Zhang xiang-rui meng 《Deep Resources Engineering》 2025年第3期42-53,I0001,共13页
Time-delayed rockbursts abruptly release huge energy,characterized by suddenness,randomness,and destructiveness,leading to substantial damage to both lives and property.This study explores the occurrence of time-delay... Time-delayed rockbursts abruptly release huge energy,characterized by suddenness,randomness,and destructiveness,leading to substantial damage to both lives and property.This study explores the occurrence of time-delayed rockbursts through statistical analysis of case studies in deep tunnels,including an extremely intensive time-delayed rockburst case.Through on-site surveys,blasting vibration tests,numerical calculations,and true triaxial compression experiments,this study analyzes the main factors and prevention and control strategies of time-delayed rockbursts based on an extremely intense time-delayed rockburst case.The results show that most time-delayed rockbursts are of high intensity.Paramount factors influencing their occurrence consider in-situ stresses,structural planes,and dynamic disturbances.Both high in-situ stress and its gradients provide the necessary conditions for such events,while the presence of abundant structural planes and frequent dynamic disturbances largely increase the risk of rockburst potential.To mitigate the risk of time-delayed rockbursts,energy control strategies are essential,incorporating measures such as energy reduction,prerelease,energy transformation,and energy absorption.Additionally,wave-absorbed support technology can reduce the amplitude and frequency of dynamic disturbances,further decreasing the likelihood of a rockburst occurring.Time-delayed rockburst occurrence requires long disturbance durations,compared to immediate rockbursts.Long-term,continuous,and multiple dynamic events will cause significant damage accumulation and formation of microcracks in hard rock.This study offers insights into the mechanisms underpinning time-delayed rockbursts and proposes prevention strategies for their control. 展开更多
关键词 Time-delayed rockburst Wave-absorbed technology In-situ stress Geological structure Dynamic disturbance
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