OBJECTIVES: To describe real-world use of tigecycline in cIAIs patients. METHODS: A retrospective, observational study enrolled cIAIs patients hospitalized in The First Affiliated Hospital, Sun Yat-sen University from...OBJECTIVES: To describe real-world use of tigecycline in cIAIs patients. METHODS: A retrospective, observational study enrolled cIAIs patients hospitalized in The First Affiliated Hospital, Sun Yat-sen University from January 1, 2013 to June 30, 2017 was conducted. Patients’ data were collected and matched based on age, gender, and Acute Physiologic Assessment and Chronic Health Evaluation II (APACHE II) score according to receiving first-line, later-line, or no tigecycline during hospitalization. RESULTS: Data were collected for 52 patients. 82.6% were male. Mean age was 57.8 years and APACHE II score was 14.8. The incidence of both extended-spectrum beta-lactamase producing and carbapenem-resistant pathogens was high on initial culture;however, few patients received first-line tigecycline. No significant difference in mortality rate was identified among first-line, later-line and no tigecycline users. Of surviving patients, shorter hospital length of stay was observed for patients receiving first- vs later-line or no tigecycline, respectively. ICU length-of-stay was shorter in patients receiving first- vs later-line or no tigecycline. CONCLUSIONS: First-line tigecycline use was rare in our surgical intensive care unit. Resistant organisms were commonly cultured from initial specimens. Although these results are limited by small patient numbers and single center, our results suggest that early tigecycline use may have significant benefits with similar mortality. Further research is warranted to demonstrate the values of early tigecycline use in cIAIs patients.展开更多
Background: Hemodynamic instability is common in critical patients and not all patients respond to fluid challenge, so we need accurate and rapid hemodynamic techniques to help the clinicians to guide fluid treatment....Background: Hemodynamic instability is common in critical patients and not all patients respond to fluid challenge, so we need accurate and rapid hemodynamic techniques to help the clinicians to guide fluid treatment. Numerous hemodynamic techniques have been used to predict fluid responsiveness till now. Transthoracic echocardiography (TTE) appears to have the ability to predict fluid responsiveness, but there is no consensus on whether it can be used by passive leg raising (PLR). Methods: We performed a literature search using MEDLINE (source PubMed, from 1947), EMBASE (from 1974) and the Cochrane Database of Systematic Reviews for prospective studies with no restrictions. Pooled effect estimates were obtained by using random-effects meta-analysis. Results: 7 prospective studies involving 261 patients and 285 boluses were identified. The pooled sensitivity and specificity of TTE are 86% (79% - 91%) and 90% (83% - 94%), respectively. The summary receiver operating characteristic (sROC) curve shows an optimum joint sensitivity and specificity of 0.88, with area under the sROC curve (AUC) of 0.94. The result of diagnostic odds ratio (DOR) is 50.62 (95% confidence interval [CI]: 23.70 - 108.12). The results of positive likelihood ratio (+LR) and negative likelihood ratio (?LR) are 7.07 (95% CI: 4.39 - 11.38) and 0.19 (95% CI: 0.13 - 0.28), which indicated strong diagnostic evidence. Conclusions: TTE is a repeatable and reliable noninvasive tool to predict fluid responsiveness in the critically ill during PLR with good test performance. This meta-analysis brings evidence to employ well-trained clinician-echocardiographers to assess patients’ volume statue via TTE to benefit daily work in intensive care units (ICUs).展开更多
Objective: To analyze the accuracy and specificity of recent studies to compare the ability of predicting fluid responsiveness with Passive Leg Raising (PLR) by using invasive or non-invasive techniques during passive...Objective: To analyze the accuracy and specificity of recent studies to compare the ability of predicting fluid responsiveness with Passive Leg Raising (PLR) by using invasive or non-invasive techniques during passive leg raising. Data Sources: MEDLINE, EMBASE and the Cochrane Database of Systematic Reviews were systematically searched. Study Selection: Clinical trials that reported the sensitivity, specificity and area under the receiver operating characteristic curve (AUC) between the responder and non-responder induced by passive leg raising and Volume Expansion (VE) in critical ill patients were selected. 246 studies were screened, 14 studies were included for data extraction, which met our inclusion criteria. Data Extraction: Data were abstracted on study characteristics, patient population, type and amount of VE, time of VE, definition of responders, position, techniques used for measuring hemodynamic change, number and percentage of responders, the correlation coefficient, sensitivity, specificity, best threshold and area under the ROC curve (AUC). Meta-analytic techniques were used to summarize the data. Data Synthesis: A total of 524 critical ill patients from 14 studies were analyzed. Data are reported as point estimate (95% confidence intervals). The pooled sensitivity and specificity of invasive techniques were 80% (73% - 85%) and 89% (84% - 93%) respectively with the area under the sROC of 0.94. While, the pooled sensitivity and specificity of non-invasive techniques were 88% (84% - 92%) and 91% (86% - 94%) respectively with the area under the sROC of 0.95. The pooled DOR of invasive techniques was 32.2 (13.6 - 76.8), which was much lower than that of non-invasive techniques with the value of 64.3 (33.9 - 121.7). Conclusions: The hemodynamic indexes changes induced by PLR could reliably predict fluid responsiveness. Non-invasive hemodynamic techniques with their accuracy and safety can benefit the daily work in ICUs. Because the number of patients included in the present trials was small, further studies should be undertaken to confirm these findings.展开更多
Purpose: Respiratory variation in inferior vena cava (ΔIVC) has been extensively studied in predicting fluid responsiveness, but the results are conflicting. We performed a systemic review and meta-analysis ...Purpose: Respiratory variation in inferior vena cava (ΔIVC) has been extensively studied in predicting fluid responsiveness, but the results are conflicting. We performed a systemic review and meta-analysis of studies aiming at investigating the diagnostic accuracy of ΔIVC in predicting fluid responsiveness. Methods: MEDLINE, EMBASE, Cochrane Database and Web of Science were screened for relevant original and review articles from inception to July 2016. The meta-analysis determined the pooled sensitivity, specificity, diagnostic odds ratio (DOR) and area under the ROC curve (AUROC). In addition, subgroup analyses were performed in mechanically ventilated patients and spontaneously breathing patients. Results: A total of 20 studies involving 635 patients were included. Cutoff values of ΔIVC varied from 12% to 42%, the pooled sensitivity and specificity was 0.68 (0.62 - 0.75) and 0.80 (0.75 - 0.85), respectively. The DOR was 14.2 (6.0 - 33.6) and the AUROC was 0.86 (0.78 - 0.93). Subgroup analysis showed better diagnostic performance in patients on mechanical ventilation than in spontaneously breathing patients with higher sensitivity (0.75 vs. 0.56), specificity (0.82 vs. 0.78), DOR (22.9 vs. 7.9) and AUROC (0.90 vs. 0.80). The best threshold of ΔIVC in patients on mechanical ventilation was IVC distensibility index (ΔIVC ≥17% ±4%), compared to IVC collapsibility index (ΔcIVC ≥33% ±12%) in spontaneously breathing patients. Conclusion: ΔIVC is not an accurate predictor of fluid responsiveness in patients with acute circulatory failure. In patients on mechanical ventilation, the predicting ability of ΔIVC was moderate with acceptable sensitivity and specificity;in spontaneously breathing patients, the specificity remains acceptable but its sensitivity is poor.展开更多
Background: To explore the application and reliability of Caprini thromboembolism risk assessment scale in the risk assessment of venous thromboembolism in acute and severe uygur patients. Methods: 160 cases of acute ...Background: To explore the application and reliability of Caprini thromboembolism risk assessment scale in the risk assessment of venous thromboembolism in acute and severe uygur patients. Methods: 160 cases of acute and severe Uighur patients with venous thrombo embolism (VTE) that were treated in our hospital from December 2017 to December 2018 were selected as the research group. 160 cases of acute and severe uygur patients without VTE admitted to our hospital in the same period were selected as the control group. Caprini thrombus risk assessment scale and Padua thrombus risk assessment scale were used to evaluate in both groups. The general data of the two groups were compared. The results of the two groups were consistent using Caprini and Padua blood clot risk assessment scales. Clinical efficacy of two different thrombosis risk assessment scales in risk assessment of VTE. Results: Group and control group in the gender distribution, backlog of red blood cells and platelet count have no significant difference (P > 0.05), the team average age, average hospitalization days were significantly less than control group (P P P 2 = 6.956, P P (P P > 0.05). Conclusion: The sensitivity, negative predictive value and positive predictive value of Caprini thrombosis risk assessment scale in VTE risk assessment of acute and severe uygur patients are very prominent, and the clinical efficacy is better, which is worthy of application.展开更多
Introduction:The prevalence of depression and anxiety among older adults has become a significant public health concern.This study aimed to identify the key demographic and health-related correlates of these mental he...Introduction:The prevalence of depression and anxiety among older adults has become a significant public health concern.This study aimed to identify the key demographic and health-related correlates of these mental health issues.Methods:A cross-sectional survey of seven provincial-level administrative divisions(PLADs)in China was conducted in 2024.The Patient Health Questionnaire-9(PHQ-9)and Generalized Anxiety Disorder-7(GAD-7)scales were used to assess the mental health status of older adults.In total,20,113 participants aged≥60 years were included in this study.Results:The analysis revealed a prevalence rate of 13.8%[95%confidence interval(CI):12.1%–15.5%]for depression and 8.0%(95%CI:7.0%,9.0%)for anxiety.Depression and anxiety symptoms are more common among older adults who are older,female,and have comorbid chronic diseases,lack of physical activity,and poor sleep quality.Compared with good sleep quality,the odds ratio(OR)(95%CI)for depression for those with poor sleep quality was 7.88(6.33,9.79),and for anxiety was 6.42(5.02,8.22),respectively.Conclusions:Early screening for depression and anxiety,lifestyle interventions and chronic disease management should be strengthened to promote the mental health of older adults.展开更多
Background:Passive leg raising (PLR) represents a "self-volume expansion (VE)" that could predict fluid responsiveness,but the influence of systolic cardiac function on PLR has seldom been reported.This stud...Background:Passive leg raising (PLR) represents a "self-volume expansion (VE)" that could predict fluid responsiveness,but the influence of systolic cardiac function on PLR has seldom been reported.This study aimed to investigate whether systolic cardiac function,estimated by the global ejection fraction (GEF) from transpulmonary-thermodilution,could influence the diagnostic value of PLR.Methods:This prospective,observational study was carried out in the surgical Intensive Care Unit of the First Affiliated Hospital of Sun Yat-sen University from December 2013 to July 2015.Seventy-eight mechanically ventilated patients considered for VE were prospectively included and divided into a low-GEF (〈20%) and a near-normal-GEF (〉20%) group.Within each group,baseline hemodynamics,after PLR and after VE (250 ml 5% albumin over 30 min),were recorded.PLR-induced hemodynamic changes (PLR-△) were calculated.Fluid responders were defined by a 15% increase of stroke volume (SV) after VE.Results:Twenty-five out of 38 patients were responders in the GEF 〈20% group,compared to 26 out of 40 patients in the GEF 〉20% group.The thresholds of PLR-△SV and PLR-△ cardiac output (PLR-△CO) for predicting fluid responsiveness were higher in the GEF 〉20% group than in the GEF 〈20% group (△SV:12% vs.8%;△CO:7% vs.6%),with increased sensitivity (△SV:92% vs.92%;△CO:81% vs.80%) and specificity (△SV:86% vs.70%;△CO:86% vs.77%),respectively PLR-△ heart rate could predict fluid responsiveness in the GEF 〉20% group with a threshold value of-5% (sensitivity 65%,specificity 93%) but could not in the GEF 〈20% group.The pressure index changes were poor predictors.Conclusions:In the critically ill patients on mechanical ventilation,the diagnostic value of PLR for predicting fluid responsiveness depends on cardiac systolic function.Thus,cardiac systolic function must be considered when using PLR.Trial Registration:Chinese Clinical Trial Register,ChiCTR-OCH-13004027;http://www.chictr.org.cn/showproj.aspx?proj=5540.展开更多
To the Editor:Lung ultrasound(LUS)may be a promising technique to assess lung injury from coronavirus disease 2019(COVID-19).However,the LUS characteristics and their assessment value have not been well described.We a...To the Editor:Lung ultrasound(LUS)may be a promising technique to assess lung injury from coronavirus disease 2019(COVID-19).However,the LUS characteristics and their assessment value have not been well described.We aimed to explore the LUS characteristics and their assessment value in COVID-19 patients with different levels of disease severity.展开更多
What is already known on this topic?Healthy aging among Chinese older people has low prevalence.Some sociodemographic and lifestyle factors were shown to be associated with healthy aging.What is added by this report?T...What is already known on this topic?Healthy aging among Chinese older people has low prevalence.Some sociodemographic and lifestyle factors were shown to be associated with healthy aging.What is added by this report?The age-adjusted prevalence of healthy aging in the 6 provincial-level administrative divisions(PLADs)of China is 15.8%in 2019.County-level factors,such as the prevalence of healthy communities in a county,as well as some sociodemographic variables and physical exercise,are potential factors of healthy aging.What are the implications for public health practice?These findings showed that more targeted actions,including generalizing healthy communities and individual-level interventions,may be of great importance for healthy aging.展开更多
文摘OBJECTIVES: To describe real-world use of tigecycline in cIAIs patients. METHODS: A retrospective, observational study enrolled cIAIs patients hospitalized in The First Affiliated Hospital, Sun Yat-sen University from January 1, 2013 to June 30, 2017 was conducted. Patients’ data were collected and matched based on age, gender, and Acute Physiologic Assessment and Chronic Health Evaluation II (APACHE II) score according to receiving first-line, later-line, or no tigecycline during hospitalization. RESULTS: Data were collected for 52 patients. 82.6% were male. Mean age was 57.8 years and APACHE II score was 14.8. The incidence of both extended-spectrum beta-lactamase producing and carbapenem-resistant pathogens was high on initial culture;however, few patients received first-line tigecycline. No significant difference in mortality rate was identified among first-line, later-line and no tigecycline users. Of surviving patients, shorter hospital length of stay was observed for patients receiving first- vs later-line or no tigecycline, respectively. ICU length-of-stay was shorter in patients receiving first- vs later-line or no tigecycline. CONCLUSIONS: First-line tigecycline use was rare in our surgical intensive care unit. Resistant organisms were commonly cultured from initial specimens. Although these results are limited by small patient numbers and single center, our results suggest that early tigecycline use may have significant benefits with similar mortality. Further research is warranted to demonstrate the values of early tigecycline use in cIAIs patients.
文摘Background: Hemodynamic instability is common in critical patients and not all patients respond to fluid challenge, so we need accurate and rapid hemodynamic techniques to help the clinicians to guide fluid treatment. Numerous hemodynamic techniques have been used to predict fluid responsiveness till now. Transthoracic echocardiography (TTE) appears to have the ability to predict fluid responsiveness, but there is no consensus on whether it can be used by passive leg raising (PLR). Methods: We performed a literature search using MEDLINE (source PubMed, from 1947), EMBASE (from 1974) and the Cochrane Database of Systematic Reviews for prospective studies with no restrictions. Pooled effect estimates were obtained by using random-effects meta-analysis. Results: 7 prospective studies involving 261 patients and 285 boluses were identified. The pooled sensitivity and specificity of TTE are 86% (79% - 91%) and 90% (83% - 94%), respectively. The summary receiver operating characteristic (sROC) curve shows an optimum joint sensitivity and specificity of 0.88, with area under the sROC curve (AUC) of 0.94. The result of diagnostic odds ratio (DOR) is 50.62 (95% confidence interval [CI]: 23.70 - 108.12). The results of positive likelihood ratio (+LR) and negative likelihood ratio (?LR) are 7.07 (95% CI: 4.39 - 11.38) and 0.19 (95% CI: 0.13 - 0.28), which indicated strong diagnostic evidence. Conclusions: TTE is a repeatable and reliable noninvasive tool to predict fluid responsiveness in the critically ill during PLR with good test performance. This meta-analysis brings evidence to employ well-trained clinician-echocardiographers to assess patients’ volume statue via TTE to benefit daily work in intensive care units (ICUs).
文摘Objective: To analyze the accuracy and specificity of recent studies to compare the ability of predicting fluid responsiveness with Passive Leg Raising (PLR) by using invasive or non-invasive techniques during passive leg raising. Data Sources: MEDLINE, EMBASE and the Cochrane Database of Systematic Reviews were systematically searched. Study Selection: Clinical trials that reported the sensitivity, specificity and area under the receiver operating characteristic curve (AUC) between the responder and non-responder induced by passive leg raising and Volume Expansion (VE) in critical ill patients were selected. 246 studies were screened, 14 studies were included for data extraction, which met our inclusion criteria. Data Extraction: Data were abstracted on study characteristics, patient population, type and amount of VE, time of VE, definition of responders, position, techniques used for measuring hemodynamic change, number and percentage of responders, the correlation coefficient, sensitivity, specificity, best threshold and area under the ROC curve (AUC). Meta-analytic techniques were used to summarize the data. Data Synthesis: A total of 524 critical ill patients from 14 studies were analyzed. Data are reported as point estimate (95% confidence intervals). The pooled sensitivity and specificity of invasive techniques were 80% (73% - 85%) and 89% (84% - 93%) respectively with the area under the sROC of 0.94. While, the pooled sensitivity and specificity of non-invasive techniques were 88% (84% - 92%) and 91% (86% - 94%) respectively with the area under the sROC of 0.95. The pooled DOR of invasive techniques was 32.2 (13.6 - 76.8), which was much lower than that of non-invasive techniques with the value of 64.3 (33.9 - 121.7). Conclusions: The hemodynamic indexes changes induced by PLR could reliably predict fluid responsiveness. Non-invasive hemodynamic techniques with their accuracy and safety can benefit the daily work in ICUs. Because the number of patients included in the present trials was small, further studies should be undertaken to confirm these findings.
文摘Purpose: Respiratory variation in inferior vena cava (ΔIVC) has been extensively studied in predicting fluid responsiveness, but the results are conflicting. We performed a systemic review and meta-analysis of studies aiming at investigating the diagnostic accuracy of ΔIVC in predicting fluid responsiveness. Methods: MEDLINE, EMBASE, Cochrane Database and Web of Science were screened for relevant original and review articles from inception to July 2016. The meta-analysis determined the pooled sensitivity, specificity, diagnostic odds ratio (DOR) and area under the ROC curve (AUROC). In addition, subgroup analyses were performed in mechanically ventilated patients and spontaneously breathing patients. Results: A total of 20 studies involving 635 patients were included. Cutoff values of ΔIVC varied from 12% to 42%, the pooled sensitivity and specificity was 0.68 (0.62 - 0.75) and 0.80 (0.75 - 0.85), respectively. The DOR was 14.2 (6.0 - 33.6) and the AUROC was 0.86 (0.78 - 0.93). Subgroup analysis showed better diagnostic performance in patients on mechanical ventilation than in spontaneously breathing patients with higher sensitivity (0.75 vs. 0.56), specificity (0.82 vs. 0.78), DOR (22.9 vs. 7.9) and AUROC (0.90 vs. 0.80). The best threshold of ΔIVC in patients on mechanical ventilation was IVC distensibility index (ΔIVC ≥17% ±4%), compared to IVC collapsibility index (ΔcIVC ≥33% ±12%) in spontaneously breathing patients. Conclusion: ΔIVC is not an accurate predictor of fluid responsiveness in patients with acute circulatory failure. In patients on mechanical ventilation, the predicting ability of ΔIVC was moderate with acceptable sensitivity and specificity;in spontaneously breathing patients, the specificity remains acceptable but its sensitivity is poor.
文摘Background: To explore the application and reliability of Caprini thromboembolism risk assessment scale in the risk assessment of venous thromboembolism in acute and severe uygur patients. Methods: 160 cases of acute and severe Uighur patients with venous thrombo embolism (VTE) that were treated in our hospital from December 2017 to December 2018 were selected as the research group. 160 cases of acute and severe uygur patients without VTE admitted to our hospital in the same period were selected as the control group. Caprini thrombus risk assessment scale and Padua thrombus risk assessment scale were used to evaluate in both groups. The general data of the two groups were compared. The results of the two groups were consistent using Caprini and Padua blood clot risk assessment scales. Clinical efficacy of two different thrombosis risk assessment scales in risk assessment of VTE. Results: Group and control group in the gender distribution, backlog of red blood cells and platelet count have no significant difference (P > 0.05), the team average age, average hospitalization days were significantly less than control group (P P P 2 = 6.956, P P (P P > 0.05). Conclusion: The sensitivity, negative predictive value and positive predictive value of Caprini thrombosis risk assessment scale in VTE risk assessment of acute and severe uygur patients are very prominent, and the clinical efficacy is better, which is worthy of application.
基金Supported by the National Natural Science Foundation of China[grant number 81872721]the Chinese Sleep Research Society through the project“Study on the Effect of Smoking on Sleep Disorders”.
文摘Introduction:The prevalence of depression and anxiety among older adults has become a significant public health concern.This study aimed to identify the key demographic and health-related correlates of these mental health issues.Methods:A cross-sectional survey of seven provincial-level administrative divisions(PLADs)in China was conducted in 2024.The Patient Health Questionnaire-9(PHQ-9)and Generalized Anxiety Disorder-7(GAD-7)scales were used to assess the mental health status of older adults.In total,20,113 participants aged≥60 years were included in this study.Results:The analysis revealed a prevalence rate of 13.8%[95%confidence interval(CI):12.1%–15.5%]for depression and 8.0%(95%CI:7.0%,9.0%)for anxiety.Depression and anxiety symptoms are more common among older adults who are older,female,and have comorbid chronic diseases,lack of physical activity,and poor sleep quality.Compared with good sleep quality,the odds ratio(OR)(95%CI)for depression for those with poor sleep quality was 7.88(6.33,9.79),and for anxiety was 6.42(5.02,8.22),respectively.Conclusions:Early screening for depression and anxiety,lifestyle interventions and chronic disease management should be strengthened to promote the mental health of older adults.
基金This work was supported by the grants from the Fundamental Research Funds for the Central Universities(No.15ykpy 14)Sun Yat-sen University Clinical Research 5010Program(No.2007015).
文摘Background:Passive leg raising (PLR) represents a "self-volume expansion (VE)" that could predict fluid responsiveness,but the influence of systolic cardiac function on PLR has seldom been reported.This study aimed to investigate whether systolic cardiac function,estimated by the global ejection fraction (GEF) from transpulmonary-thermodilution,could influence the diagnostic value of PLR.Methods:This prospective,observational study was carried out in the surgical Intensive Care Unit of the First Affiliated Hospital of Sun Yat-sen University from December 2013 to July 2015.Seventy-eight mechanically ventilated patients considered for VE were prospectively included and divided into a low-GEF (〈20%) and a near-normal-GEF (〉20%) group.Within each group,baseline hemodynamics,after PLR and after VE (250 ml 5% albumin over 30 min),were recorded.PLR-induced hemodynamic changes (PLR-△) were calculated.Fluid responders were defined by a 15% increase of stroke volume (SV) after VE.Results:Twenty-five out of 38 patients were responders in the GEF 〈20% group,compared to 26 out of 40 patients in the GEF 〉20% group.The thresholds of PLR-△SV and PLR-△ cardiac output (PLR-△CO) for predicting fluid responsiveness were higher in the GEF 〉20% group than in the GEF 〈20% group (△SV:12% vs.8%;△CO:7% vs.6%),with increased sensitivity (△SV:92% vs.92%;△CO:81% vs.80%) and specificity (△SV:86% vs.70%;△CO:86% vs.77%),respectively PLR-△ heart rate could predict fluid responsiveness in the GEF 〉20% group with a threshold value of-5% (sensitivity 65%,specificity 93%) but could not in the GEF 〈20% group.The pressure index changes were poor predictors.Conclusions:In the critically ill patients on mechanical ventilation,the diagnostic value of PLR for predicting fluid responsiveness depends on cardiac systolic function.Thus,cardiac systolic function must be considered when using PLR.Trial Registration:Chinese Clinical Trial Register,ChiCTR-OCH-13004027;http://www.chictr.org.cn/showproj.aspx?proj=5540.
基金The study was supported by the grants from Wu Jieping Medical Foundation(Nos.320.6750.18037,320.6750.18068)Guangdong Medical Research Foundation(No.A2020300)。
文摘To the Editor:Lung ultrasound(LUS)may be a promising technique to assess lung injury from coronavirus disease 2019(COVID-19).However,the LUS characteristics and their assessment value have not been well described.We aimed to explore the LUS characteristics and their assessment value in COVID-19 patients with different levels of disease severity.
基金National Key R&D Program of China(2020YFC2003000)China CDC’s NCD and tobacco control program(131031001000190010).
文摘What is already known on this topic?Healthy aging among Chinese older people has low prevalence.Some sociodemographic and lifestyle factors were shown to be associated with healthy aging.What is added by this report?The age-adjusted prevalence of healthy aging in the 6 provincial-level administrative divisions(PLADs)of China is 15.8%in 2019.County-level factors,such as the prevalence of healthy communities in a county,as well as some sociodemographic variables and physical exercise,are potential factors of healthy aging.What are the implications for public health practice?These findings showed that more targeted actions,including generalizing healthy communities and individual-level interventions,may be of great importance for healthy aging.
