Background:Breast cancer is more common among young women in China than in developed countries.This study analyzes the clinicopathological features and prognosis of young women with breast cancer in southwest China.Ma...Background:Breast cancer is more common among young women in China than in developed countries.This study analyzes the clinicopathological features and prognosis of young women with breast cancer in southwest China.Materials and Methods:We reviewed the records of 406 breast cancer patients≤35 years old from 2008 to 2017 in southwest China,investigating their biological characteristics and prognosis.Results:In southwest China,8.77%of breast cancer patients were young women.Although the number of breast cancer cases increased over time,the proportion of young women declined.Patients in stages III and IV accounted for 32%of cases.Young women with breast cancer often experienced local and regional recurrence and had a poor prognosis(5-year disease-free survival rate of 54.9%and 5-year overall survival rate of 71.3%).T and N stages were significantly related to disease-free survival and overall survival.Hormone receptor status was associated with overall survival.Conclusions:In southwest China,young women with breast cancer tend to present with late-stage clinical features,and the prognosis remains poor.展开更多
Background:Ultrasound‑guided vacuum-assisted excision(UGVAE)and breast biopsy are widely used for the diagnosis and treatment of both benign and suspicious breast lesions.In this retrospective study,we aimed to determ...Background:Ultrasound‑guided vacuum-assisted excision(UGVAE)and breast biopsy are widely used for the diagnosis and treatment of both benign and suspicious breast lesions.In this retrospective study,we aimed to determine the safety of UGVAE for benign breast lesions and provide guidance for clinical practice.Methods:We analyzed clinical and pathological data of female patients who had undergone UGVAE between January 2015 and December 2017 at our institution.All breast lesions were categorized according to the Breast Imaging Reporting and Data System(BI-RADS)before performing UGVAE.Results:In our study cohort,UGVAE was used to resect 10,378 breast lesions from 5789 patients,and selected clinical and histopathological data were analyzed.The most common adverse events were postoperative bleeding(0.24%)and skin hypersensitivity(0.67%).The residual lesion rate was 2.27%.Fibroadenomas accounted for most of the benign lesions(7932 of 10,193;77.82%).Breast cancer was diagnosed in 150 lesions from 128 patients.Multivariable binary logistic regression analyses showed that older age(odds ratio[OR]=2.034,95%confidence interval[CI]:1.668–2.480,p<0.001),higher BI-RADS category(OR=9.514,95%CI:6.790–13.332,p<0.001),and larger legion size(OR=1.048,95%CI:1.019–1.077,p=0.001)were associated with an increased likelihood of breast cancer.Ninety-six patients with breast cancer had undergone follow-up treatment,achieving a 3-year disease-free survival rate of 97.2%and a 3-year overall survival rate of 100%.Conclusions:UGVAE is a safe and effective means of removing benign breast lesions,causing minimal postoperative trauma and fewer complications compared with open surgery.Moreover,UGVAE had little impact on the follow-up treatment and survival of patients diagnosed with breast cancer.展开更多
文摘Background:Breast cancer is more common among young women in China than in developed countries.This study analyzes the clinicopathological features and prognosis of young women with breast cancer in southwest China.Materials and Methods:We reviewed the records of 406 breast cancer patients≤35 years old from 2008 to 2017 in southwest China,investigating their biological characteristics and prognosis.Results:In southwest China,8.77%of breast cancer patients were young women.Although the number of breast cancer cases increased over time,the proportion of young women declined.Patients in stages III and IV accounted for 32%of cases.Young women with breast cancer often experienced local and regional recurrence and had a poor prognosis(5-year disease-free survival rate of 54.9%and 5-year overall survival rate of 71.3%).T and N stages were significantly related to disease-free survival and overall survival.Hormone receptor status was associated with overall survival.Conclusions:In southwest China,young women with breast cancer tend to present with late-stage clinical features,and the prognosis remains poor.
基金Military Key Clinical Speciality(Grants:51561Z23612)Chongqing Talent Program Project(Grants:cstc2022ycjh-bgzxm0091)+1 种基金Chongqing Major Medical Research Program(Joint Program of Chongqing Municipal Health Commission and Science and Technology Bureau)(Grants:2024DBXM001)Chongqing Clinical Diagnosis and Treatment Center of Breast Cancer(Grants:425Z2a1).
文摘Background:Ultrasound‑guided vacuum-assisted excision(UGVAE)and breast biopsy are widely used for the diagnosis and treatment of both benign and suspicious breast lesions.In this retrospective study,we aimed to determine the safety of UGVAE for benign breast lesions and provide guidance for clinical practice.Methods:We analyzed clinical and pathological data of female patients who had undergone UGVAE between January 2015 and December 2017 at our institution.All breast lesions were categorized according to the Breast Imaging Reporting and Data System(BI-RADS)before performing UGVAE.Results:In our study cohort,UGVAE was used to resect 10,378 breast lesions from 5789 patients,and selected clinical and histopathological data were analyzed.The most common adverse events were postoperative bleeding(0.24%)and skin hypersensitivity(0.67%).The residual lesion rate was 2.27%.Fibroadenomas accounted for most of the benign lesions(7932 of 10,193;77.82%).Breast cancer was diagnosed in 150 lesions from 128 patients.Multivariable binary logistic regression analyses showed that older age(odds ratio[OR]=2.034,95%confidence interval[CI]:1.668–2.480,p<0.001),higher BI-RADS category(OR=9.514,95%CI:6.790–13.332,p<0.001),and larger legion size(OR=1.048,95%CI:1.019–1.077,p=0.001)were associated with an increased likelihood of breast cancer.Ninety-six patients with breast cancer had undergone follow-up treatment,achieving a 3-year disease-free survival rate of 97.2%and a 3-year overall survival rate of 100%.Conclusions:UGVAE is a safe and effective means of removing benign breast lesions,causing minimal postoperative trauma and fewer complications compared with open surgery.Moreover,UGVAE had little impact on the follow-up treatment and survival of patients diagnosed with breast cancer.
