BACKGROUND Postpartum hemorrhoids are common complications in women after childbirth,with an incidence rate of 37.9%.Progesterone levels increase during pregnancy,which can lead to constipation.Abdominal pressure surg...BACKGROUND Postpartum hemorrhoids are common complications in women after childbirth,with an incidence rate of 37.9%.Progesterone levels increase during pregnancy,which can lead to constipation.Abdominal pressure surges sharply during delivery,which can block the venous return of the rectum and result in hemorrhoids,pain,and edema.Tongyangxiao lotion and Ziyu ointment,traditional Chinese medicinal preparations,have the efficacy of subduing swelling,relieving itching,and promoting healing;however,their combined application in treating postpartum hemorrhoids is less studied.AIM To investigate effects of Tongyangxiao lotion sitz bath therapy combined with Ziyu ointment on postpartum hemorrhoidal pain,edema,anxiety,and depression.METHODS A retrospective analysis was conducted at Hebei Hospital of Traditional Chinese Medicine on 268 patients with hemorrhoids(September 2023 to February 2025).They were divided according to treatment method into control(wet compress with magnesium sulfate+Ziyu ointment)and observation(Tongyangxiao lotion sitz bath therapy+Ziyu ointment)groups(n=134 in each group).Degree of pain,comfort level,compliance behavior with medical care,psychological state,therapeutic effect,hemorrhoid edema score,incidence of adverse reactions,and hemorrhoid diameter were compared.RESULTS No statistically significant difference was observed in the diameter of the hemorrhoids or edema between the two groups before treatment.Hemorrhoid diameter and degree of edema were significantly smaller in the observation group than those in the control group 14 days post treatment.No statistically significant difference was observed in the scores of the General Comfort Questionnaire(GCQ)dimensions and participants’compliance before treatment.All GCQ dimension scores were significantly higher in the observation group than those in the control group 7 and 14 days post treatment.The compliance rate was significantly higher in the observation group than that of the control group.No statistically significant difference was observed in the incidence of adverse reactions between the two groups(P>0.05).CONCLUSION Tongyangxiao lotion combined with Ziyu ointment can improve patients’surface edema,postpartum hemorrhoid pain,treatment adherence,and comfort,reducing negative emotions.This is relatively safe and worthy of clinical promotion.展开更多
Although flexible,stretchable,and conductive core-sheath structured smart fibers have propelled to the forefront research in wearable strain sensors and self-powered electronics,challenges related to scalability,compl...Although flexible,stretchable,and conductive core-sheath structured smart fibers have propelled to the forefront research in wearable strain sensors and self-powered electronics,challenges related to scalability,complexity,and mechanical durability remain.In this study,we propose a strategy for the scalable production of conductive coaxial fiber(CCF)with superior durability through one-step direct wet spinning coherent solutions.By introducing the polystyrene-block-polyisoprene-block-polystyrene phase in both inner and outer layers,CCFs feature an interleaved topology and share a similar modulus,successfully resolving the issue of layer separation over time.They can endure up to 15,000 cycles with no damage at a strain of 100%.In addition,the topological entanglement CCF as a strain sensor exhibits a broad operational range of up to 398.3%strain,outstanding sensitivity(i.e.,gauge factor=6713 at 398.3%strain)and swift response time(248 ms).Enhanced by machine learning,the system achieves a high accuracy rate of 95%in gait recognition and 100%in American Sign Language identification.Furthermore,the CCF can function as a wearable triboelectric nanogenerator(TENG)for self-powered sensing and mechanical energy harvesting.This study represents a significant step toward the development of multifunctional micro-wearable electronic devices,which hold immense promise for medical sensing and energy harvesting in smart wearable electronics,human-computer interaction,and artificial intelligence.展开更多
Recombinant tissue plasminogen activator is commonly used for hematoma evacuation in minimally invasive surgery following intracerebral hemorrhage.However,during minimally invasive surgery,recombinant tissue plasminog...Recombinant tissue plasminogen activator is commonly used for hematoma evacuation in minimally invasive surgery following intracerebral hemorrhage.However,during minimally invasive surgery,recombinant tissue plasminogen activator may come into contact with brain tissue.Therefore,a thorough assessment of its safety is required.In this study,we established a mouse model of intracerebral hemorrhage induced by type VII collagenase.We observed that the administration of recombinant tissue plasminogen activator without hematoma aspiration significantly improved the neurological function of mice with intracerebral hemorrhage,reduced pathological damage,and lowered the levels of apoptosis and autophagy in the tissue surrounding the hematoma.In an in vitro model of intracerebral hemorrhage using primary cortical neurons induced by hemin,the administration of recombinant tissue plasminogen activator suppressed neuronal apoptosis,autophagy,and endoplasmic reticulum stress.Transcriptome sequencing analysis revealed that recombinant tissue plasminogen activator upregulated the phosphoinositide 3-kinase/RAC-alpha serine/threonine-protein kinase/mammalian target of rapamycin pathway in neurons.Moreover,the phosphoinositide 3-kinase inhibitor LY294002 abrogated the neuroprotective effects of recombinant tissue plasminogen activator in inhibiting excessive apoptosis,autophagy,and endoplasmic reticulum stress.Furthermore,to specify the domain of recombinant tissue plasminogen activator responsible for its neuroprotective effects,various inhibitors were used to target distinct domains.It has been revealed that the epidermal growth factor receptor inhibitor AG-1478 reversed the effect of recombinant tissue plasminogen activator on the phosphoinositide 3-kinase/RAC-alpha serine/threonineprotein kinase/mammalian target of rapamycin pathway.These findings suggest that recombinant tissue plasminogen activator exerts a direct neuroprotective effect on neurons following intracerebral hemorrhage,possibly through activation of the phosphoinositide 3-kinase/RAC-alpha serine/threonine-protein kinase/mammalian target of rapamycin pathway.展开更多
Vortex-induced vibration(VIV)of an underwater manipulator in pulsating flow presents a notable engineering problem in precise control due to the velocity variation in the flow.This study investigates the VIV response ...Vortex-induced vibration(VIV)of an underwater manipulator in pulsating flow presents a notable engineering problem in precise control due to the velocity variation in the flow.This study investigates the VIV response of an underwater manipulator subjected to pulsating flow,focusing on how different postures affect the behavior of the system.The effects of pulsating parameters and manipulator arrangement on the hydrodynamic coefficient,vibration response,motion trajectory,and vortex shedding behaviors were analyzed.Results indicated that the cross flow vibration displacement in pulsating flow increased by 32.14%compared to uniform flow,inducing a shift in the motion trajectory from a crescent shape to a sideward vase shape.In the absence of interference between the upper and lower arms,the lift coefficient of the manipulator substantially increased with rising pulsating frequency,reaching a maximum increment of 67.0%.This increase in the lift coefficient led to a 67.05%rise in the vibration frequency of the manipulator in the in-line direction.As the pulsating amplitude increased,the drag coefficient of the underwater manipulator rose by 36.79%,but the vibration frequency in the cross-flow direction decreased by 56.26%.Additionally,when the upper and lower arms remained in a state of mutual interference,the cross-flow vibration amplitudes of the upper and lower arms were approximately 1.84 and 4.82 times higher in a circular-elliptical arrangement compared to an elliptical-circular arrangement,respectively.Consequently,the flow field shifted from a P+S pattern to a disordered pattern,disrupting the regularity of the motion trajectory.展开更多
AIM： To explore if ischemic preconditioning （IPC） can enhance the survival of retinal ganglion cells （RGCs） after optic nerve axotomy. METHODS： Twenty-four hours prior to retinal ischemia 60min or axotomy, IPC ...AIM： To explore if ischemic preconditioning （IPC） can enhance the survival of retinal ganglion cells （RGCs） after optic nerve axotomy. METHODS： Twenty-four hours prior to retinal ischemia 60min or axotomy, IPC was applied for ten minutes in groups of （n=72） animals. The survival of RGCs, the cellular expression of heat shock protein 27 （HSP27） and heat shock protein 70 （HSP70） and the numbers of retinal microglia in the different groups were quantified at 7 and 14d post-injury. The cellular expression of HSP27 and HSP70 and changes in the numbers of retinal microglia were quantified to detect the possible mechanism of the protection of the IPC. RESULTS： Ten minutes of IPC promoted RGC survival in both the optic nerve injury （IPC-ONT） and the retinal ischemia 60min （IPC-IR60） groups, examined at 7d and 14d post-injury. Microglial proliferation showed little correlation with the extent of benefit effects of IPC on the rescue of RGCs. The number of HSP27-positive RGCs was significantly higher in the IPC-ONT group than in the sham IPC-ONT group, although the percentage of HSP27-positive RGCs did not significantly differ between groups. For the IPC-IR60 group, neither the number nor the percentage ofthe HSP27-positive RGCs differed significantly between the IPC and the sham-operated groups. The number of HSP70-positive RGCs was significantly higher for both the IPC-ONT and the IPC-IR60 experimental groups, but the percentages did not differ. CONCLUSION： The induction of IPC enhances the survival of RGCs against both axotomy and retinal ischemia.展开更多
<strong>Objective:</strong> Abnormal miRNA expression is observed in several human tumors;moreover, normal cell regulation can be disrupted by tumor-suppressive or oncogenic miRNAs. We aimed to investigate...<strong>Objective:</strong> Abnormal miRNA expression is observed in several human tumors;moreover, normal cell regulation can be disrupted by tumor-suppressive or oncogenic miRNAs. We aimed to investigate the role of miR-637 in gliomas. <strong>Methods: </strong>We assessed miR-637 expression in 98 and 16 gliomas and non-tumoral brain tissues, respectively, using in situ hybridization. We calculated receiver operating characteristic curves to determine the specificity and sensitivity of miR-637 biomarkers. Next, the effects of miR-637 on glioma cell migration and invasion were determined by using the transwell assay. Candidate target genes were identified through Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis. <strong>Results: </strong>There was significant miR-637 downregulation in glioma tissues (P < 0.001). Further, it showed potential as a diagnostic biomarker for gliomas. In addition, miR-637 suppressed glioma cell migration and invasion. <strong>Conclusions: </strong>Our findings suggest that miR-637 inhibits glioma invasion and migration and could be a potential diagnostic marker for gliomas. Future studies should examine the potential mechanisms underlying miR-637 as a diagnostic marker and therapeutic target for gliomas.展开更多
Defect engineering holds significant promise for addressing the low conductivity and limited adsorption of reactant molecules in hydrogen generation catalysts.Herein,theoretical predictions based on the d-band center ...Defect engineering holds significant promise for addressing the low conductivity and limited adsorption of reactant molecules in hydrogen generation catalysts.Herein,theoretical predictions based on the d-band center and electron localization function(ELF)calculations indicate that the introduction of Ce induces charge rearrangement,enhancing charge enrichment on Pt atoms.Inspired by these theoretical predictions,a series of PtCeOx/CoNi-LDH catalysts were fabricated for efficient hydrogen generation.The experimental results indicate that introducing metal defects will induce lattice expansion in CeOx doping,leading to the elongation of Pt–O bonds,which effectively reduces the bond energy of Pt–O bonds.The reduction in Pt–O bond energy facilitates the capture and adsorption of reactant molecules,thus exhibiting outstanding catalytic activity with a NaBH_(4) hydrogen generation rate(HGR)of 8992 mL min–1 gcat–1.Density functional theory(DFT)calculations show that the adsorption-free energy of the rate-determining step in the PtCeOx/CoNi-LDH catalyst is ca.–3.59 eV,which is lower than the reaction barrier of PtOx/CoNi-LDH(–3.25 eV).This indicates that the PtCeOx/CoNi-LDH catalyst more effectively facilitates the formation of transition state intermediates.Guided by DFT predictions,the successful fabrication of high-efficiency PtCeOx/CoNi-LDH catalysts establishes a strong foundation for the design and development of future hydrogen generation catalysts.展开更多
Pulsating flow is a common condition for under water manipulators in Bohai Bay.This study aimed to investigate the effects of pulsation frequency and amplitude on the hydrodynamic characteristics of an underwater mani...Pulsating flow is a common condition for under water manipulators in Bohai Bay.This study aimed to investigate the effects of pulsation frequency and amplitude on the hydrodynamic characteristics of an underwater manipulator with different postures using the user-defined function (UDF) method. The lift coefficient (C_(L)), drag coefficient (C_(D)), and vortex shedding of the underwater manipulator in single-and dualarm forms were obtained. Results indicated that the maximum increase in the lift and drag coefficients subjected to the pulsation parameters was 24.45%and 28%, respectively, when the fluid flowed past a single arm. Compared with the single arm, the lift and drag coefficients of the arms were higher than those of the single arm when arm 2 was located upstream. Additionally, the pulsation frequency had no obvious effect on the manipulator, but the C_(L) and C_(D) of arm 2 showed an obvious increasing trend with an increase in pulsation amplitude. Meanwhile, when arm 2 was located downstream, the C_(L) and C_(D) of arm 2 were reduced by 16.38%and 1.15%, respectively, with an increase in the pulse frequency,and the maximum increase in the lift and dragcoefficients was 33.33%and 16.78%,respectively,with increasing pulsation amplitude.Moreover, the downstream wake morphology changed significantly, and a combined vortex phenomenon appeared. Finally, a theoretical basis for examining the hydrodynamic characteristics of marine engineering equipment was established to aid future marine resource exploitation.展开更多
Calorific value is one of the most important properties of coal.Machine learning(ML)can be used in the prediction of calorific value to reduce experimental costs.China is one of the world’s largest coal production co...Calorific value is one of the most important properties of coal.Machine learning(ML)can be used in the prediction of calorific value to reduce experimental costs.China is one of the world’s largest coal production countries and coal occupies an important position in its national energy structure.However,ML models with a large database for the overall regions of China are still missing.Based on the extensive coal gasification practices in East China University of Science and Technology,we have built ML models with a large database for overall regions of China.An AutoML model was proposed and achieved a minimum MSE of 1.021.SHAP method was used to increase the model interpretability,and model validity was proved with literature data and additional in-house experiments.The model adaptability was discussed based on the databases of China and USA,showing that geography-specific ML models are essential.This study integrated a large coal database and AutoML method for accurate calorific value prediction and could offer key tools for Chinese coal industry.展开更多
Demand for high-performance power devices continues to grow with the continuous development of power electronics and high-end field applications.Although packaging materials based on epoxy resins and silica gels have ...Demand for high-performance power devices continues to grow with the continuous development of power electronics and high-end field applications.Although packaging materials based on epoxy resins and silica gels have been widely developed,higher operating temperatures and operating voltages are still critical to the performance of power devices.Here,a composite film containing functionalized meso-porous hollow silica particles(MH-SiO_(2))and polyimide(PI)was prepared by a template method and layer-by-layer coating strategy to address the current bottlenecks in packaging material development.The electrical breakdown strength of the prepared PI/SiO_(2) composite film was 323.41 kV/mm,while the mass fraction of MH-SiO_(2) was only 5%.This indicates that the mesoporous structure can effectively inhibit electron collisions with nano-restricted domains.The simulation results also indicate that the size variation of inorganic fillers and the interaction of organic/inorganic heterogeneous interfaces are the main reasons affecting the performance of the composites.Meanwhile,the PI/SiO_(2) composite films achieved other properties required for practical applications,such as matched coefficient of thermal ex-pansion(CTE)(23.5 ppm/℃),excellent thermal stability(T_(5)%=559.0℃)and low dielectric constant(2.27@1 M Hz).These results highlight the great potential of inorganic phase-specific structural designs for the preparation of high-performance power device packaging materials.展开更多
基金Supported by Hebei Administration of Traditional Chinese Medicine,No.2024233.
文摘BACKGROUND Postpartum hemorrhoids are common complications in women after childbirth,with an incidence rate of 37.9%.Progesterone levels increase during pregnancy,which can lead to constipation.Abdominal pressure surges sharply during delivery,which can block the venous return of the rectum and result in hemorrhoids,pain,and edema.Tongyangxiao lotion and Ziyu ointment,traditional Chinese medicinal preparations,have the efficacy of subduing swelling,relieving itching,and promoting healing;however,their combined application in treating postpartum hemorrhoids is less studied.AIM To investigate effects of Tongyangxiao lotion sitz bath therapy combined with Ziyu ointment on postpartum hemorrhoidal pain,edema,anxiety,and depression.METHODS A retrospective analysis was conducted at Hebei Hospital of Traditional Chinese Medicine on 268 patients with hemorrhoids(September 2023 to February 2025).They were divided according to treatment method into control(wet compress with magnesium sulfate+Ziyu ointment)and observation(Tongyangxiao lotion sitz bath therapy+Ziyu ointment)groups(n=134 in each group).Degree of pain,comfort level,compliance behavior with medical care,psychological state,therapeutic effect,hemorrhoid edema score,incidence of adverse reactions,and hemorrhoid diameter were compared.RESULTS No statistically significant difference was observed in the diameter of the hemorrhoids or edema between the two groups before treatment.Hemorrhoid diameter and degree of edema were significantly smaller in the observation group than those in the control group 14 days post treatment.No statistically significant difference was observed in the scores of the General Comfort Questionnaire(GCQ)dimensions and participants’compliance before treatment.All GCQ dimension scores were significantly higher in the observation group than those in the control group 7 and 14 days post treatment.The compliance rate was significantly higher in the observation group than that of the control group.No statistically significant difference was observed in the incidence of adverse reactions between the two groups(P>0.05).CONCLUSION Tongyangxiao lotion combined with Ziyu ointment can improve patients’surface edema,postpartum hemorrhoid pain,treatment adherence,and comfort,reducing negative emotions.This is relatively safe and worthy of clinical promotion.
基金supported by the National Natural Science Foundation of China(Nos.52073032 and 52192611)the National Key R&D Project from Ministry of Science and Technology,China(No.2021YFA1201603)the Fundamental Research Funds for the Central Universities.
文摘Although flexible,stretchable,and conductive core-sheath structured smart fibers have propelled to the forefront research in wearable strain sensors and self-powered electronics,challenges related to scalability,complexity,and mechanical durability remain.In this study,we propose a strategy for the scalable production of conductive coaxial fiber(CCF)with superior durability through one-step direct wet spinning coherent solutions.By introducing the polystyrene-block-polyisoprene-block-polystyrene phase in both inner and outer layers,CCFs feature an interleaved topology and share a similar modulus,successfully resolving the issue of layer separation over time.They can endure up to 15,000 cycles with no damage at a strain of 100%.In addition,the topological entanglement CCF as a strain sensor exhibits a broad operational range of up to 398.3%strain,outstanding sensitivity(i.e.,gauge factor=6713 at 398.3%strain)and swift response time(248 ms).Enhanced by machine learning,the system achieves a high accuracy rate of 95%in gait recognition and 100%in American Sign Language identification.Furthermore,the CCF can function as a wearable triboelectric nanogenerator(TENG)for self-powered sensing and mechanical energy harvesting.This study represents a significant step toward the development of multifunctional micro-wearable electronic devices,which hold immense promise for medical sensing and energy harvesting in smart wearable electronics,human-computer interaction,and artificial intelligence.
基金supported by the National Natural Science Foundation of China,Nos.92148206,82071330(both to ZT)a grant from the Major Program of Hubei Province,No.2023BAA005(to ZT)+1 种基金a grant from the Key Research and Discovery Program of Hubei Province,No.2021BCA109(to ZT)the Research Foundation of Tongji Hospital,No.2022B37(to PZ)。
文摘Recombinant tissue plasminogen activator is commonly used for hematoma evacuation in minimally invasive surgery following intracerebral hemorrhage.However,during minimally invasive surgery,recombinant tissue plasminogen activator may come into contact with brain tissue.Therefore,a thorough assessment of its safety is required.In this study,we established a mouse model of intracerebral hemorrhage induced by type VII collagenase.We observed that the administration of recombinant tissue plasminogen activator without hematoma aspiration significantly improved the neurological function of mice with intracerebral hemorrhage,reduced pathological damage,and lowered the levels of apoptosis and autophagy in the tissue surrounding the hematoma.In an in vitro model of intracerebral hemorrhage using primary cortical neurons induced by hemin,the administration of recombinant tissue plasminogen activator suppressed neuronal apoptosis,autophagy,and endoplasmic reticulum stress.Transcriptome sequencing analysis revealed that recombinant tissue plasminogen activator upregulated the phosphoinositide 3-kinase/RAC-alpha serine/threonine-protein kinase/mammalian target of rapamycin pathway in neurons.Moreover,the phosphoinositide 3-kinase inhibitor LY294002 abrogated the neuroprotective effects of recombinant tissue plasminogen activator in inhibiting excessive apoptosis,autophagy,and endoplasmic reticulum stress.Furthermore,to specify the domain of recombinant tissue plasminogen activator responsible for its neuroprotective effects,various inhibitors were used to target distinct domains.It has been revealed that the epidermal growth factor receptor inhibitor AG-1478 reversed the effect of recombinant tissue plasminogen activator on the phosphoinositide 3-kinase/RAC-alpha serine/threonineprotein kinase/mammalian target of rapamycin pathway.These findings suggest that recombinant tissue plasminogen activator exerts a direct neuroprotective effect on neurons following intracerebral hemorrhage,possibly through activation of the phosphoinositide 3-kinase/RAC-alpha serine/threonine-protein kinase/mammalian target of rapamycin pathway.
基金Supported by the National Natural Science Foundation of China(No.51905211)A Project of the“20 Regulations for New Universities”Funding Program of Jinan(No.202228116).
文摘Vortex-induced vibration(VIV)of an underwater manipulator in pulsating flow presents a notable engineering problem in precise control due to the velocity variation in the flow.This study investigates the VIV response of an underwater manipulator subjected to pulsating flow,focusing on how different postures affect the behavior of the system.The effects of pulsating parameters and manipulator arrangement on the hydrodynamic coefficient,vibration response,motion trajectory,and vortex shedding behaviors were analyzed.Results indicated that the cross flow vibration displacement in pulsating flow increased by 32.14%compared to uniform flow,inducing a shift in the motion trajectory from a crescent shape to a sideward vase shape.In the absence of interference between the upper and lower arms,the lift coefficient of the manipulator substantially increased with rising pulsating frequency,reaching a maximum increment of 67.0%.This increase in the lift coefficient led to a 67.05%rise in the vibration frequency of the manipulator in the in-line direction.As the pulsating amplitude increased,the drag coefficient of the underwater manipulator rose by 36.79%,but the vibration frequency in the cross-flow direction decreased by 56.26%.Additionally,when the upper and lower arms remained in a state of mutual interference,the cross-flow vibration amplitudes of the upper and lower arms were approximately 1.84 and 4.82 times higher in a circular-elliptical arrangement compared to an elliptical-circular arrangement,respectively.Consequently,the flow field shifted from a P+S pattern to a disordered pattern,disrupting the regularity of the motion trajectory.
文摘AIM： To explore if ischemic preconditioning （IPC） can enhance the survival of retinal ganglion cells （RGCs） after optic nerve axotomy. METHODS： Twenty-four hours prior to retinal ischemia 60min or axotomy, IPC was applied for ten minutes in groups of （n=72） animals. The survival of RGCs, the cellular expression of heat shock protein 27 （HSP27） and heat shock protein 70 （HSP70） and the numbers of retinal microglia in the different groups were quantified at 7 and 14d post-injury. The cellular expression of HSP27 and HSP70 and changes in the numbers of retinal microglia were quantified to detect the possible mechanism of the protection of the IPC. RESULTS： Ten minutes of IPC promoted RGC survival in both the optic nerve injury （IPC-ONT） and the retinal ischemia 60min （IPC-IR60） groups, examined at 7d and 14d post-injury. Microglial proliferation showed little correlation with the extent of benefit effects of IPC on the rescue of RGCs. The number of HSP27-positive RGCs was significantly higher in the IPC-ONT group than in the sham IPC-ONT group, although the percentage of HSP27-positive RGCs did not significantly differ between groups. For the IPC-IR60 group, neither the number nor the percentage ofthe HSP27-positive RGCs differed significantly between the IPC and the sham-operated groups. The number of HSP70-positive RGCs was significantly higher for both the IPC-ONT and the IPC-IR60 experimental groups, but the percentages did not differ. CONCLUSION： The induction of IPC enhances the survival of RGCs against both axotomy and retinal ischemia.
文摘<strong>Objective:</strong> Abnormal miRNA expression is observed in several human tumors;moreover, normal cell regulation can be disrupted by tumor-suppressive or oncogenic miRNAs. We aimed to investigate the role of miR-637 in gliomas. <strong>Methods: </strong>We assessed miR-637 expression in 98 and 16 gliomas and non-tumoral brain tissues, respectively, using in situ hybridization. We calculated receiver operating characteristic curves to determine the specificity and sensitivity of miR-637 biomarkers. Next, the effects of miR-637 on glioma cell migration and invasion were determined by using the transwell assay. Candidate target genes were identified through Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis. <strong>Results: </strong>There was significant miR-637 downregulation in glioma tissues (P < 0.001). Further, it showed potential as a diagnostic biomarker for gliomas. In addition, miR-637 suppressed glioma cell migration and invasion. <strong>Conclusions: </strong>Our findings suggest that miR-637 inhibits glioma invasion and migration and could be a potential diagnostic marker for gliomas. Future studies should examine the potential mechanisms underlying miR-637 as a diagnostic marker and therapeutic target for gliomas.
基金financially supported by the Hebei Province Nat-ural Science Foundation(No.B2023108012)the National Natural Science Foundation of China(No.62004143)+2 种基金the Key R&D Program of Hubei Province(No.2022BAA084)the Science Research Project of Hebei Education Department(No.BJK2024137)the S&T Pro-gram of Xingtai(No.2023ZZ096).
文摘Defect engineering holds significant promise for addressing the low conductivity and limited adsorption of reactant molecules in hydrogen generation catalysts.Herein,theoretical predictions based on the d-band center and electron localization function(ELF)calculations indicate that the introduction of Ce induces charge rearrangement,enhancing charge enrichment on Pt atoms.Inspired by these theoretical predictions,a series of PtCeOx/CoNi-LDH catalysts were fabricated for efficient hydrogen generation.The experimental results indicate that introducing metal defects will induce lattice expansion in CeOx doping,leading to the elongation of Pt–O bonds,which effectively reduces the bond energy of Pt–O bonds.The reduction in Pt–O bond energy facilitates the capture and adsorption of reactant molecules,thus exhibiting outstanding catalytic activity with a NaBH_(4) hydrogen generation rate(HGR)of 8992 mL min–1 gcat–1.Density functional theory(DFT)calculations show that the adsorption-free energy of the rate-determining step in the PtCeOx/CoNi-LDH catalyst is ca.–3.59 eV,which is lower than the reaction barrier of PtOx/CoNi-LDH(–3.25 eV).This indicates that the PtCeOx/CoNi-LDH catalyst more effectively facilitates the formation of transition state intermediates.Guided by DFT predictions,the successful fabrication of high-efficiency PtCeOx/CoNi-LDH catalysts establishes a strong foundation for the design and development of future hydrogen generation catalysts.
基金the National Natural Science Foundation of China (No. 51905211)China Postdoctoral Science Foundation (Grant No. 2020M672128)+1 种基金University of Jinan Research Startup and Discipline Construction Fund (Grant No.1009435)a Project of the “20 Regulations for New Universities” funding program of Jinan (No.202228116)。
文摘Pulsating flow is a common condition for under water manipulators in Bohai Bay.This study aimed to investigate the effects of pulsation frequency and amplitude on the hydrodynamic characteristics of an underwater manipulator with different postures using the user-defined function (UDF) method. The lift coefficient (C_(L)), drag coefficient (C_(D)), and vortex shedding of the underwater manipulator in single-and dualarm forms were obtained. Results indicated that the maximum increase in the lift and drag coefficients subjected to the pulsation parameters was 24.45%and 28%, respectively, when the fluid flowed past a single arm. Compared with the single arm, the lift and drag coefficients of the arms were higher than those of the single arm when arm 2 was located upstream. Additionally, the pulsation frequency had no obvious effect on the manipulator, but the C_(L) and C_(D) of arm 2 showed an obvious increasing trend with an increase in pulsation amplitude. Meanwhile, when arm 2 was located downstream, the C_(L) and C_(D) of arm 2 were reduced by 16.38%and 1.15%, respectively, with an increase in the pulse frequency,and the maximum increase in the lift and dragcoefficients was 33.33%and 16.78%,respectively,with increasing pulsation amplitude.Moreover, the downstream wake morphology changed significantly, and a combined vortex phenomenon appeared. Finally, a theoretical basis for examining the hydrodynamic characteristics of marine engineering equipment was established to aid future marine resource exploitation.
基金Shanghai Yangfan Program,22YF1410300,Yunfei GaoNational Natural Science Foundation of China,22208104,Yunfei Gao+1 种基金Shanghai Chenguang Program,21CGA35,Yunfei GaoNational Key Research and Development Program of China,2022YFA1504701,Yunfei Gao,2022YFB4101900,Yunfei Gao。
文摘Calorific value is one of the most important properties of coal.Machine learning(ML)can be used in the prediction of calorific value to reduce experimental costs.China is one of the world’s largest coal production countries and coal occupies an important position in its national energy structure.However,ML models with a large database for the overall regions of China are still missing.Based on the extensive coal gasification practices in East China University of Science and Technology,we have built ML models with a large database for overall regions of China.An AutoML model was proposed and achieved a minimum MSE of 1.021.SHAP method was used to increase the model interpretability,and model validity was proved with literature data and additional in-house experiments.The model adaptability was discussed based on the databases of China and USA,showing that geography-specific ML models are essential.This study integrated a large coal database and AutoML method for accurate calorific value prediction and could offer key tools for Chinese coal industry.
基金supported by the National Natural Science Foundation of China(Nos.52377026 and 52301192)the Taishan Scholars and Young Experts Program of Shandong Province(No.tsqn202103057)+1 种基金the Natural Science Foundation of Shandong Province(Nos.ZR2024ME046 and ZR2024QE313)the China Postdoctoral Science Foundation(No.2024M761554).
文摘Demand for high-performance power devices continues to grow with the continuous development of power electronics and high-end field applications.Although packaging materials based on epoxy resins and silica gels have been widely developed,higher operating temperatures and operating voltages are still critical to the performance of power devices.Here,a composite film containing functionalized meso-porous hollow silica particles(MH-SiO_(2))and polyimide(PI)was prepared by a template method and layer-by-layer coating strategy to address the current bottlenecks in packaging material development.The electrical breakdown strength of the prepared PI/SiO_(2) composite film was 323.41 kV/mm,while the mass fraction of MH-SiO_(2) was only 5%.This indicates that the mesoporous structure can effectively inhibit electron collisions with nano-restricted domains.The simulation results also indicate that the size variation of inorganic fillers and the interaction of organic/inorganic heterogeneous interfaces are the main reasons affecting the performance of the composites.Meanwhile,the PI/SiO_(2) composite films achieved other properties required for practical applications,such as matched coefficient of thermal ex-pansion(CTE)(23.5 ppm/℃),excellent thermal stability(T_(5)%=559.0℃)and low dielectric constant(2.27@1 M Hz).These results highlight the great potential of inorganic phase-specific structural designs for the preparation of high-performance power device packaging materials.
