目的分析与评价浙江省中医院钱塘院区甘草酸单铵半胱氨酸氯化钠注射液的临床应用情况,为临床合理安全用药提供依据。方法回顾性分析2024年7月1日至12月31日使用甘草酸单铵半胱氨酸氯化钠注射液的出院患者病历资料486例,对其使用适应证...目的分析与评价浙江省中医院钱塘院区甘草酸单铵半胱氨酸氯化钠注射液的临床应用情况,为临床合理安全用药提供依据。方法回顾性分析2024年7月1日至12月31日使用甘草酸单铵半胱氨酸氯化钠注射液的出院患者病历资料486例,对其使用适应证、用药频率、剂量、疗程、联合用药、禁忌证等进行分析。结果486例患者共使用甘草酸单铵半胱氨酸氯化钠注射液6787瓶,血液内科、感染科和泌尿外科使用量排名前三,男性使用占比大于女性,患者年龄平均(53±17)岁;用于化疗预防性护肝107例(22.0%),其次是肝功能不全93例(19.1%),手术后护肝86例(17.7%);药物使用频率分别为1次/d,2次/d和每12 h 1次,用药剂量为100~200 ml,符合说明书要求。48.6%的病例联合用药中,二联用药占35.2%、三联用药占13.4%,包括熊去氧胆酸、双环醇、多烯磷脂酰胆碱、复方甘草酸苷以及其他利尿剂螺内酯、呋塞米和托拉塞米,各科室用药时间2.2~21.5 d;用药禁忌上,高血压病、慢性肾衰竭、低钾血症患者分别占比21.0%、3.6%、1.9%。结论该注射液在浙江省中医院钱塘院区使用量较大、用药目的不适宜、联合用药较多,存在用药禁忌情况,药师通过分析该院区注射液情况,为临床合理用药提供借鉴。展开更多
Background There have been numerous intervention studies focusing on the development of preterm infants,but there has been limited investigation into the home environment as a determinant of developmental outcomes in ...Background There have been numerous intervention studies focusing on the development of preterm infants,but there has been limited investigation into the home environment as a determinant of developmental outcomes in preterm infants.The aspects and extent to which the home environment affects the early(18 months corrected age)neuropsychological development of preterm infants are still unclear.Aims This study aimed to analyse the effect of the home environment on the neuropsychiatric development of preterm infants at 18 months corrected age after discharge from the neonatal intensive care unit(NICU).It also sought to provide a basis for promoting neuropsychiatric development among preterm infants by improving the home environment.Methods In this retrospective cross-sectional study,275 preterm infants born between January 2019 and January 2022 were followed up for systematic management after discharge from the NICU at Shanghai Children's Hospital.The Home Nurture Environment Questionnaire was used to assess the home environment of the infants and analyse its impact on the developmental quotient(evaluated by the Gesell Developmental Scale)and the rate of developmental delays at 18 months corrected age.Results A total of 41.454%of the infants were extremely preterm.The developmental quotient scores at 18 months corrected age were in the middle of the scale.The language domain had the highest rate of developmental delay(46.182%),followed by the adaptive domain(37.091%).Multiple logistic regression analyses showed that compared with infants in supportive home environments,infants with moderate/unsupportive home environments had significantly elevated risks of development delay:2.162-fold for global(odds ratio(OR)2.162,95% confidence interval(Cl)1.274 to 3.665,p=0.004),2.193-fold for fine motor(OR 2.193,95%CI 1.161 to 4.140,p=0.016),2.249-fold for language(0R 2.249,95%CI 1.336 to 3.786,p=0.002)and 2.042-fold for personal-social(OR 2.042,95%CI 1.149 to 3.628,p=0.015).Conclusions A supportive home environment is a crucial protective factor for the neuropsychological development of preterm infants.It is associated with higher developmental quotient scores and protects against neuropsychiatric delays.Incorporating evaluation and continuous improvement of the home environment into the management framework for preterm infants to promote optimal neurodevelopment is essential.展开更多
AIM:To investigate the causal relationship between dietary intake and myopia using Mendelian randomization(MR)analysis.METHODS:Genome-wide association study(GWAS)data from the IEU Open GWAS database were utilized to e...AIM:To investigate the causal relationship between dietary intake and myopia using Mendelian randomization(MR)analysis.METHODS:Genome-wide association study(GWAS)data from the IEU Open GWAS database were utilized to examine associations between myopia and various dietary factors.MR analysis,incorporating both univariable and multivariable approaches,assessed the impact of food intake on myopia risk through five analytical methods,with inverse variance weighted(IVW)serving as the primary reference.Sensitivity analyses,including heterogeneity assessment,horizontal pleiotropy evaluation,and leave-oneout analysis,were conducted to validate the MR findings.RESULTS:Univariable MR analysis identified a causal link between food intake and myopia.Consumption of breaded fish,canned soup,sweet biscuits,and certain fruits correlated with a lower risk of myopia,whereas intake of low-calorie hot chocolate and cereal was associated with an increased risk.Multivariable MR analysis further confirmed that breaded fish consumption exerted a direct protective effect against myopia,particularly when consumed alongside other dietary components.These findings highlight the intricate interplay between specific dietary factors and myopia development,offering valuable insights for further research.CONCLUSION:MR analysis provides evidence supporting a potential causal relationship between breaded fish intake and myopia,underscoring its relevance in targeted myopia prevention strategies.展开更多
文摘目的分析与评价浙江省中医院钱塘院区甘草酸单铵半胱氨酸氯化钠注射液的临床应用情况,为临床合理安全用药提供依据。方法回顾性分析2024年7月1日至12月31日使用甘草酸单铵半胱氨酸氯化钠注射液的出院患者病历资料486例,对其使用适应证、用药频率、剂量、疗程、联合用药、禁忌证等进行分析。结果486例患者共使用甘草酸单铵半胱氨酸氯化钠注射液6787瓶,血液内科、感染科和泌尿外科使用量排名前三,男性使用占比大于女性,患者年龄平均(53±17)岁;用于化疗预防性护肝107例(22.0%),其次是肝功能不全93例(19.1%),手术后护肝86例(17.7%);药物使用频率分别为1次/d,2次/d和每12 h 1次,用药剂量为100~200 ml,符合说明书要求。48.6%的病例联合用药中,二联用药占35.2%、三联用药占13.4%,包括熊去氧胆酸、双环醇、多烯磷脂酰胆碱、复方甘草酸苷以及其他利尿剂螺内酯、呋塞米和托拉塞米,各科室用药时间2.2~21.5 d;用药禁忌上,高血压病、慢性肾衰竭、低钾血症患者分别占比21.0%、3.6%、1.9%。结论该注射液在浙江省中医院钱塘院区使用量较大、用药目的不适宜、联合用药较多,存在用药禁忌情况,药师通过分析该院区注射液情况,为临床合理用药提供借鉴。
基金funded by Shanghai Municipal Health and Wellness Commission Health Industry Clinical Research Special Project(202140299).
文摘Background There have been numerous intervention studies focusing on the development of preterm infants,but there has been limited investigation into the home environment as a determinant of developmental outcomes in preterm infants.The aspects and extent to which the home environment affects the early(18 months corrected age)neuropsychological development of preterm infants are still unclear.Aims This study aimed to analyse the effect of the home environment on the neuropsychiatric development of preterm infants at 18 months corrected age after discharge from the neonatal intensive care unit(NICU).It also sought to provide a basis for promoting neuropsychiatric development among preterm infants by improving the home environment.Methods In this retrospective cross-sectional study,275 preterm infants born between January 2019 and January 2022 were followed up for systematic management after discharge from the NICU at Shanghai Children's Hospital.The Home Nurture Environment Questionnaire was used to assess the home environment of the infants and analyse its impact on the developmental quotient(evaluated by the Gesell Developmental Scale)and the rate of developmental delays at 18 months corrected age.Results A total of 41.454%of the infants were extremely preterm.The developmental quotient scores at 18 months corrected age were in the middle of the scale.The language domain had the highest rate of developmental delay(46.182%),followed by the adaptive domain(37.091%).Multiple logistic regression analyses showed that compared with infants in supportive home environments,infants with moderate/unsupportive home environments had significantly elevated risks of development delay:2.162-fold for global(odds ratio(OR)2.162,95% confidence interval(Cl)1.274 to 3.665,p=0.004),2.193-fold for fine motor(OR 2.193,95%CI 1.161 to 4.140,p=0.016),2.249-fold for language(0R 2.249,95%CI 1.336 to 3.786,p=0.002)and 2.042-fold for personal-social(OR 2.042,95%CI 1.149 to 3.628,p=0.015).Conclusions A supportive home environment is a crucial protective factor for the neuropsychological development of preterm infants.It is associated with higher developmental quotient scores and protects against neuropsychiatric delays.Incorporating evaluation and continuous improvement of the home environment into the management framework for preterm infants to promote optimal neurodevelopment is essential.
基金Supported by Xi’an Science and Technology Program Project(No.24YXYJ0108)Support Projects of Xi’an Children’s Hospital(No.2024I07).
文摘AIM:To investigate the causal relationship between dietary intake and myopia using Mendelian randomization(MR)analysis.METHODS:Genome-wide association study(GWAS)data from the IEU Open GWAS database were utilized to examine associations between myopia and various dietary factors.MR analysis,incorporating both univariable and multivariable approaches,assessed the impact of food intake on myopia risk through five analytical methods,with inverse variance weighted(IVW)serving as the primary reference.Sensitivity analyses,including heterogeneity assessment,horizontal pleiotropy evaluation,and leave-oneout analysis,were conducted to validate the MR findings.RESULTS:Univariable MR analysis identified a causal link between food intake and myopia.Consumption of breaded fish,canned soup,sweet biscuits,and certain fruits correlated with a lower risk of myopia,whereas intake of low-calorie hot chocolate and cereal was associated with an increased risk.Multivariable MR analysis further confirmed that breaded fish consumption exerted a direct protective effect against myopia,particularly when consumed alongside other dietary components.These findings highlight the intricate interplay between specific dietary factors and myopia development,offering valuable insights for further research.CONCLUSION:MR analysis provides evidence supporting a potential causal relationship between breaded fish intake and myopia,underscoring its relevance in targeted myopia prevention strategies.
